The Ketogenic Diet and Cardiovascular Diseases

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3368 - 3368

Published: July 28, 2023

The most common and increasing causes of death worldwide are cardiovascular diseases (CVD). Taking into account the fact that diet is a key factor, it worth exploring this aspect CVD prevention therapy. aim article to assess potential ketogenic in treatment CVD. comprehensive, meticulous analysis literature area, taking recent studies currently available. has been shown have multifaceted effect on Among other aspects, beneficial blood lipid profile, even compared diets. It shows strong anti-inflammatory cardioprotective potential, which due, among factors, properties state ketosis, elimination simple sugars, restriction total carbohydrates supply omega-3 fatty acids. In addition, ketone bodies provide "rescue fuel" for diseased heart by affecting its metabolism. They also function vascular endothelium, including improving inhibiting premature ageing. pressure risk factors through, weight loss. evidence cited often superior standard diets, making likely advantages over dietary models diseases. There legitimate need further research area.

Language: Английский

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Inflammatory Mediators of Endothelial Dysfunction

Life, Journal Year: 2023, Volume and Issue: 13(6), P. 1420 - 1420

Published: June 20, 2023

Endothelial dysfunction (ED) is characterized by imbalanced vasodilation and vasoconstriction, elevated reactive oxygen species (ROS), inflammatory factors, as well deficiency of nitric oxide (NO) bioavailability. It has been reported that the maintenance endothelial cell integrity serves a significant role in human health disease due to involvement endothelium several processes, such regulation vascular tone, hemostasis thrombosis, adhesion, smooth muscle proliferation, inflammation. Inflammatory modulators/biomarkers, IL-1α, IL-1β, IL-6, IL-12, IL-15, IL-18, tumor necrosis factor α, or alternative anti-inflammatory cytokine IL-10, adhesion molecules (ICAM-1, VCAM-1), involved atherosclerosis progression have shown predict cardiovascular diseases. Furthermore, signaling pathways, NLRP3 inflammasome, are associated with response disrupted H2S bioavailability postulated be new indicators for inflammation its dysfunction. In this review, we summarize knowledge plethora reviews, research articles, clinical trials concerning key modulators pathways

Language: Английский

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The predictive value of the hs-CRP/HDL-C ratio, an inflammation-lipid composite marker, for cardiovascular disease in middle-aged and elderly people: evidence from a large national cohort study

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: March 1, 2024

Abstract Background and aims Cardiovascular disease (CVD) is associated with inflammation abnormal lipid metabolism. However, a single inflammatory index or cannot accurately predict the prognosis of CVD independently because it prone to be affected by various confounding factors. Methods This population-based cohort study included 6,554 participants from China Health Retirement Longitudinal Study (CHARLS) investigate correlations. In present study, occurrence events such as stroke heart was evaluated considering self-reported diagnoses at beginning during wave 4, restricted cubic spline model used potential nonlinear relationships in addition multivariate logistic regression models. Stratified analyses were performed examine how sociodemographic characteristics may influence results. Results Seven years follow-up (2011–2018) revealed that 786 people (11.99%) developed CVD. According adjusted model, high-sensitivity C-reactive protein (hs-CRP)-to-high-density lipoprotein cholesterol (HDL-C) ratio contributing factor risk (OR 1.31, 95% CI 1.05–1.64). addition, relationship observed between hs-CRP/HDL-C new CVD, stroke, cardiac issues ( P overall <0.05, Pnonlinear <0.05). Moreover, noteworthy associations age detected stratified analysis = 0.048), indicating younger had more negative effects high ratio. Conclusions significant for problems. Early intervention patients increased ratios further reduce incidence focusing on independent markers markers.

Language: Английский

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Prognostic implications of systemic immune-inflammation index in myocardial infarction patients with and without diabetes: insights from the NOAFCAMI-SH registry

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Jan. 22, 2024

Abstract Background It is well-known that systemic inflammation plays a crucial role in the pathogenesis and prognosis of acute myocardial infarction (AMI). The immune-inflammation index (SII, platelet × neutrophil/lymphocyte ratio) novel used for characterization severity inflammation. Recent studies have identified high SII level as an independent predictor poor outcomes patients with AMI. We aimed to investigate prognostic implications AMI without diabetes mellitus (DM). Methods included 2111 from February 2014 March 2018. Multivariable Cox regression analyses were performed estimate hazard ratios (HRs) 95% confidence intervals (CIs) all-cause death cardiovascular (CV) death. Multiple imputation was missing covariates. Results Of (mean age: 65.2 ± 12.2 years, 77.5% males) analyzed, 789 (37.4%) had DM. Generalized additive model showed increased, C-reactive protein peak TnT elevated while LVEF declined, these associations similar During median 2.5 years follow-up, 210 deaths 154 CV occurred. When treating continuous variable, higher log-transformed significantly associated increased mortality (HR: 1.57, 95%CI: 1.02–2.43) 1.85, 95%CI 1.12–3.05), such association also significant diabetics (HRs 95%CIs 2.90 [1.40–6.01] 3.28 [1.43–7.57], respectively) not nondiabetics (P interaction 0.019 0.049, respectively). Additionally, compared lowest tertiles SII, those highest possessed 1.82, 1.19–2.79) after multivariable adjustment, this relationship remained pronounced 2.00 [1.13–3.55] 2.09 [1.10–3.98], but observed 1.21 [0.75–1.97] 1.60 [0.89–2.90], Our restricted cubic splines indicated linear between only diabetics. Conclusions In DM, survival may be helpful patient’s risk stratification.

Language: Английский

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Polystyrene microplastics enhance microcystin-LR-induced cardiovascular toxicity and oxidative stress in zebrafish embryos

Environmental Pollution, Journal Year: 2024, Volume and Issue: 352, P. 124022 - 124022

Published: April 26, 2024

Language: Английский

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Mechanisms of wogonoside in the treatment of atherosclerosis based on network pharmacology, molecular docking, and experimental validation

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 27, 2025

Atherosclerosis serves as the fundamental pathology for a variety of cardiovascular disorders, with its pathogenesis being closely tied to complex interplay among lipid metabolism, oxidative stress, and inflammation. Wogonoside is natural flavonoid extracted from Scutellaria baicalensis biological activities, including anti-inflammatory, hypolipidemic, cardiac function improvement properties. Despite these known effects, specific role wogonoside in context atherosclerosis remains be elucidated. To validate efficacy treatment investigate possible therapeutic mechanisms. Network pharmacology was used obtain core targets signaling pathways that may efficacious wogonoside, which were validated using molecular docking dynamics simulations. further pathway, we performed vivo experiments apolipoprotein E (ApoE)-/- mice. This included pathological morphology deposition analysis mouse aorta, serum level analysis, Elisa stress reactive oxygen species (ROS) fluorescence assay, immunohistochemical protein blot analysis. Predictions obtained has 31 targets, are mainly focused on such Toll-like receptor (TLR) pathway NF-kappa B (NF-κB ) pathway. Molecular simulations showed good binding properties targets. In experimental results significantly inhibited aortic inflammatory response deposition, reduced release levels total cholesterol (TC), triglycerides (TG), low-density-lipoprotein (LDL-C), oxidized low density (ox-LDL) free fatty acid (FFA), factors TNF-α, IL-1β, IL-6 ApoE-/- Further mechanism studies activation TLR4/NF-κB an effective drug monomer atherosclerosis, action related inhibition

Language: Английский

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Association between Biological Aging and Cardiovascular Health: Combined Evidence based on Cross-sectional and Prospective Study

Archives of Gerontology and Geriatrics, Journal Year: 2025, Volume and Issue: 132, P. 105785 - 105785

Published: Feb. 15, 2025

Language: Английский

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Association between composite dietary antioxidant index and coronary heart disease among US adults: a cross-sectional analysis

BMC Public Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 5, 2023

Abstract Background The Composite Dietary Antioxidant Index (CDAI) is a dietary antioxidant score that plays protective role in many diseases, including depression, osteoporosis, papillomavirus infection, etc. However, the association between CDAI and coronary heart disease (CHD) currently unclear. We aim to explore correlations risk of CHD. Methods Eligible participants were obtained from National Health Nutrition Examination Survey (NHANES) 1999 2018. All this cross-sectional study are required undergo two separate 24-h recall interviews. Average daily intakes antioxidants used calculate CDAI. CHD status was determined through questionnaire. Weighted multiple logistic regression models evaluate relationship Moreover, we also restricted cubic spline Non-linear correlations. Sensitivity analysis using unweighted subgroup demonstrate stability results. Results A total 34,699 eligible for analysis.Compared without CHD, with showed lower levels After adjusting confounding factors multivariate weighted model, inversely associated (Q4 vs. Q1, OR = 0.65 (0.51–0.82, P < 0.001). Restricted there negative non-linear correlation (L-shaped) suggesting potential saturation effect at higher levels, inflection point 0.16. results stable. No significant statistically interaction analysis. Conclusions There US adults. further prospective studies still needed reveal their relationship.

Language: Английский

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AIF1: Function and Connection with Inflammatory Diseases

Biology, Journal Year: 2023, Volume and Issue: 12(5), P. 694 - 694

Published: May 9, 2023

Macrophages are a type of immune cell distributed throughout all tissues an organism. Allograft inflammatory factor 1 (AIF1) is calcium-binding protein linked to the activation macrophages. AIF1 key intracellular signaling molecule that participates in phagocytosis, membrane ruffling and F-actin polymerization. Moreover, it has several type-specific functions. plays important roles development diseases: kidney disease, rheumatoid arthritis, cancer, cardiovascular diseases, metabolic diseases neurological disorders, transplants. In this review, we present comprehensive review known structure, functions role diseases.

Language: Английский

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The effect of a ketogenic diet on inflammation-related markers: a systematic review and meta-analysis of randomized controlled trials

Nutrition Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 14, 2024

Abstract Context Despite the important role of inflammation-related factors on occurrence chronic diseases, there is still conflicting evidence about effects ketogenic diet (KD) these factors. Objective In order to obtain a better viewpoint, this study aimed comprehensively investigate KD markers. Data Sources To find pertinent randomized controlled trials up August 2023, databases including PubMed/Medline, Web Science, Scopus, Cochrane Library, and Embase were searched. Extraction This included all investigating C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-8, IL-10 levels. Pooled weighted mean difference (WMD) 95% confidence intervals (CIs) achieved by random-effects model analysis for best estimation outcomes. Analysis Forty-four studies in article. The pooled findings showed that has an effect lowering TNF-α (WMD: −0.32 pg/mL; CI: −0.55, −0.09; P = 0.007) IL-6 −0.27 −0.52, −0.02; 0.036) compared with control groups. However, no significant was reported others inflammation marker–related results subgroup that, following ≤8 weeks people aged ≤50 years, reduction levels significantly higher than other addition, body mass index greater 30 kg/m2 ≤30 kg/m2, decreased extent after receiving KD. Conclusions Consequently, adherence appears improve some markers associated inflammation, IL-6.

Language: Английский

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