A Systematic Review of the Efficacy and Safety of Mulberry Formulations for Chemotherapy- and/or Radiotherapy-Induced Oral Mucositis DOI Open Access

J. Raghunand Sindhe,

V Asha,

Arvind Muthukrishnan

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 15, 2024

Oral mucositis (OM) is one of the common side effects radiotherapy and chemotherapy. It an extremely painful condition characterized by erythema, edema, ulceration oral mucosa. Many plant-based chemical formulations are used to prevent OM. The aim study evaluate efficacy safety different black mulberry in chemotherapy and/or radiotherapy-induced A systematic search was performed using PubMed, Excerpta Medica database (Embase), Cochrane Library, Web Science databases for articles published until March 2023. We have included studies conducted on people undergoing compared effect any formulation with other interventions. Out 30 retrieved, four a cumulative sample size (N = 297) were review. Mulberry no intervention, grape molasses, chlorhexidine, sodium bicarbonate. articles, three showed significant decrease grade 2 3 OM also better prevention as intervention control groups, article, molasses more preventive occurrence dry mouth. improvement pain score quality life. incidence severity lower group than One article less weight loss, another gradual gain from use mulberries. From this, we conclude that effective treatment shows

Language: Английский

Comparative Analysis of Chemotherapy‐Induced Oral Mucositis, Nutritional Status, and Depression in Patients With Acute Leukemia DOI Creative Commons

Juhee Song,

Hannah Yu, Eunjung Ryu

et al.

European Journal of Cancer Care, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: Chemotherapy, a fundamental treatment modality for acute leukemia, is linked to significant adverse effects such as oral mucositis, nutritional decline, and depression, all of which markedly impact patient outcomes. Objective: This study aimed evaluate the progression chemotherapy‐induced mucositis its on status depression in patients with leukemia. Methods: In this prospective descriptive study, 123 aged 19–70 years diagnosed leukemia were recruited from tertiary hospital through convenience sampling. These scheduled remission‐induction, consolidation, or reinduction chemotherapy. Initially, 140 enrolled, participants included final analysis after accounting incomplete responses dropouts. Oral status, assessed using validated scales, follow‐up evaluations conducted 10 days post‐chemotherapy. was WHO Mucositis Grading Scale, symptom experiences measured MD Anderson Symptom Inventory, evaluated Patient‐Generated Subjective Global Assessment (PG‐SGA), 10‐item Center Epidemiological Studies Depression Scale (CES‐D‐10). Statistical analyses paired t ‐tests, ANOVA, multiple regression. Results: Compared baseline, variables evaluated—oral symptoms experiences, depression—were significantly worsened day Regression identified muscle weakness skin problems factors depression. Additionally, receiving remission‐induction therapy presented worse than those consolidation therapy. Conclusion: highlighted rapid deterioration chemotherapy underscores need multidisciplinary approach that emphasizes support, emotional evidence‐based nursing interventions tailored specific groups symptoms. Future research should explore educational delivered during initial hospitalization their effectiveness, particularly

Language: Английский

Citations

0
Evaluation of the efficacy of probiotics in the chemoradiotherapy of colorectal cancer: a meta-analysis of Randomized Controlled Trials DOI Creative Commons
Rong Yang, Wei Liu, Shu Cai

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 29, 2025

Language: Английский

Citations

0
Efficacy of nonpharmacological interventions for severe radiation‐induced oral mucositis among head and neck cancer patients: A network meta‐analysis of randomised controlled trials DOI
Shu Zhang, Juejin Li, Yun Zhang

et al.

Journal of Clinical Nursing, Journal Year: 2024, Volume and Issue: 33(6), P. 2030 - 2049

Published: March 7, 2024

Abstract Aims and Objectives To assess the effectiveness of different nonpharmacological treatments for severe radiation‐induced oral mucositis in patients with head neck cancer. Background Radiation‐induced is highly prevalent Current medications are limited susceptible to side effects, while there an increasing adoption interventions, optimal one remains unclear. Design Systematic review network meta‐analysis based on PRISMA‐NMA guidelines. Methods Six databases were searched. Two authors independently performed literature screening, data extraction methodological quality assessment included studies. Traditional pairwise was by R Studio. A then conducted effects interventions Results Fifty‐two studies involving seven types enrolled. The indicated that natural plant‐based therapies might be most effective, health education second honey third effective reducing incidence mucositis. For mucositis‐related pain, showed only effective. Conclusions Nonpharmacological management among Relevance clinical practice a category safe adjunctive should encouraged practice. Trial registration details CRD42023400745.

Language: Английский

Citations

3
Growth Suppression of Oral Squamous Cell Carcinoma Cells by Lactobacillus Acidophilus DOI Creative Commons
Adel Al‐Asfour,

Radhika G. Bhardwaj,

Maribasappa Karched

et al.

International Dental Journal, Journal Year: 2024, Volume and Issue: 74(5), P. 1151 - 1160

Published: April 27, 2024

Oral squamous cell carcinoma (OSCC) is a highly aggressive form of oral cancer. Probiotic lactobacilli have demonstrated anticancer effects, whilst their interaction with Streptococcus mutans in this context remains unexplored. The objective study was to investigate the antiproliferative effect Lactobacillus acidophilus on OSCC and understand S OSCCs whether it affects potential L when co-exposed OSCC. human head neck cells cavity (HNO97 line) were exposed cultures separately combination. Further, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay performed assess viability HNO97 cells. Bacterial adhesion examined by confocal microscopy apoptosis Nexin staining. To underlying mechanism apoptosis, expression tumour necrosis factor (TNF)–related apoptosis-inducing ligand (TRAIL) gene protein determined real-time polymerase chain reaction quantitative enzyme-linked immunosorbent assay, respectively. A significant decrease (53%–56%) exposure acidophilus, mutans, 2 species together activity mutans. Both bacteria showed TRAIL increased 5-fold treatment which further ∼17-fold both present. Expression levels significantly (P < .05) bacteria-treated lysates. exhibited lower live intact percentages higher proportions early late apoptotic stages. exhibits against possibly partially via TRAIL-induced not affected presence These findings may encourage investigation into possible therapeutic application probiotic

Language: Английский

Citations

2
Efficacy of probiotics in the treatment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis DOI
Peixin Lin,

Jiafeng Zhuang,

Jing Lai

et al.

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 193, P. 106785 - 106785

Published: July 4, 2024

Language: Английский

Citations

2
Evaluating Alterations of the Oral Microbiome and Its Link to Oral Cancer among Betel Quid Chewers: Prospecting Reversal through Probiotic Intervention DOI Creative Commons
Prerna Diwan, Mohit Nirwan, Mayank Bahuguna

et al.

Pathogens, Journal Year: 2023, Volume and Issue: 12(8), P. 996 - 996

Published: July 30, 2023

Areca nut and slaked lime, with or without tobacco wrapped in Piper betle leaf, prepared as betel quid, is extensively consumed a masticatory product many countries across the world. Betel Quid can promote malignant transformation of oral lesions well trigger benign cellular molecular changes. In cavity, it causes changes at compositional level microbiota called dysbiosis. This dysbiosis may play an important role Oral Cancer quid chewers. The abnormal presence increase bacteria Fusobacterium nucleatum, Capnocytophaga gingivalis, Prevotella melaninogenica, Peptostreptococcus sp., Porphyromonas Streptococcus mitis saliva and/or other sites cancer patients has attracted frequent attention for its association development. present review, authors have analysed literature reports to revisit oncogenic potential microbiome alterations, evaluating both driver biomarker cancer. also shared perspective that restoration local become potentially therapeutic prophylactic strategy delay reversal lip cavity cancers, especially high-risk population groups.

Language: Английский

Citations

6
Evaluation of oral mucositis level and affecting factors in cancer patients receiving chemotherapy DOI
Seda Abali Pilas, Seda Kurt

Supportive Care in Cancer, Journal Year: 2024, Volume and Issue: 32(9)

Published: Aug. 20, 2024

Language: Английский

Citations

1
Role of Nutribiotics in Skin Care DOI Creative Commons
M. Lourdes Mourelle, Carmen P. Gómez, J.L. Legido

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(8), P. 3505 - 3505

Published: April 21, 2024

The study of the human microbiome has been a hot topic during recent decades. More recently, skin attracted great interest as well. So, scientific community become interested in role health and its relationship with different disorders, such atopic dermatitis, psoriasis, acne, rosacea, among others. Numerous studies investigations have performed to pre- probiotics nutraceuticals treatment diseases, growing evidence over ten years. This review gathers information on use “nutribiotics” care health, focusing main dermatological diseases other conditions. Clinical show that nutribiotics could be new tool improve pre-, pro-, syn-, post-, para-probiotics seem beneficial for several disorders well repairing barrier promoting wound healing. In conclusion, field potential develop innovative products manage diseases. Future advances this may facilitate dysbiosis, being suitable method care.

Language: Английский

Citations

1
The effect of probiotics supplementation on cancer-treatment complications: a critical umbrella review of interventional meta-analyses DOI
Zhao Yang, Shijie Zhang, Ying Lü

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 26

Published: July 13, 2024

Cancer-related complications pose significant challenges in the management and treatment of patients with malignancies. Several meta-analyses have indicated improving effects probiotics on cancer complications, while some studies reported contentious findings. The purpose present study was to evaluate efficacy addressing including diarrhea, mucositis, infections, following chemotherapy, radiotherapy, surgery. Relevant were searched PubMed, Scopus, Embase Web Science databases Google Scholar up September 2023. All all treatments-induced infection, diarrhea oral mucositis included. pooled results calculated using a random-effects model. Analyses subgroups, sensitivity publication bias also conducted. revealed that supplementation effective reduction total (OR:0.53; 95% CI: 0.44, 0.62,

Language: Английский

Citations

1
The Effect of Probiotics on Severe Oral Mucositis in Cancer Patients Undergoing Chemotherapy and/or Radiotherapy: A Meta-Analysis DOI Creative Commons

ZhiYi Zhu,

Wenting Pan,

Xianqing Ming

et al.

Journal of Stomatology Oral and Maxillofacial Surgery, Journal Year: 2024, Volume and Issue: 125(5), P. 101983 - 101983

Published: Aug. 24, 2024

Oral mucositis is a frequent adverse reaction in cancer treatment. Probiotics exhibit anti-inflammatory and immunomodulatory properties that could prevent the occurrence of severe oral (SOM) induced by chemotherapy or radiation therapy patients. This meta-analysis aimed to investigate influence probiotics on incidence SOM patients undergoing and/or radiotherapy.

Language: Английский

Citations

1