Deleted Journal,
Journal Year:
2024,
Volume and Issue:
1(2), P. 105 - 116
Published: Oct. 16, 2024
Background:
Lipids
encompass
a
diverse
group
of
biomolecules
that
are
crucial
for
maintaining
the
body’s
internal
equilibrium
and
range
functions,
including
energy
storage,
maintenance
cellular
membranes,
signalling.
Their
synthesis
metabolism
intricately
linked
to
hormonal
regulation,
particularly
by
thyroid
hormones,
which
influence
lipid
modulating
gene
expression,
enzyme
activity,
mitochondrial
function.
Thyroid
hormones
enhance
metabolic
rate,
clearance,
cholesterol
conversion
bile
acids,
regulated
through
feedback
mechanisms
involving
hypothalamic–pituitary–thyroid
axis.
Subclinical
hypothyroidism
(SCH)
presents
complex
challenge
in
understanding
metabolism.
Methods:
Research
on
SCH’s
impact
profiles
has
yielded
conflicting
results.
Some
studies
indicate
SCH
is
associated
with
increased
levels
triglycerides,
while
others
report
no
significant
changes.
These
discrepancies
underline
necessity
more
comprehensive
clarify
how
affects
its
potential
cardiovascular
implications.
Conclusions:
This
review
aims
consolidate
existing
knowledge,
exploring
biochemical
pathways
clinical
evidence
link
dysfunction
abnormalities
health
risks.
It
emphasizes
critical
need
further
research
elucidate
full
broader
effects
health,
guiding
future
interventions
treatment
strategies.
Plants,
Journal Year:
2024,
Volume and Issue:
13(4), P. 523 - 523
Published: Feb. 15, 2024
Inflammation
is
the
immune
system’s
first
biological
response
to
infection,
injury,
or
irritation.
Evidence
suggests
that
anti-inflammatory
effect
mediated
by
regulation
of
various
inflammatory
cytokines,
such
as
nitric
oxide,
interleukins,
tumor
necrosis
factor
alpha-α,
interferon
gamma-γ,
well
non-cytokine
mediator,
prostaglandin
E2.
Currently,
mechanism
action
and
clinical
usefulness
phytochemicals
known;
their
on
activity
free
radicals,
oxidative
stress.
The
latter
are
great
relevance
in
development
diseases,
evidence
collected
demonstrates
beneficial
effects
maintaining
health.
Epidemiological
indicates
regular
consumption
fruits
vegetables
related
a
low
risk
developing
cancer
other
chronic
diseases.
ABSTRACT
Phytochemicals
are
bioactive
compounds
found
in
plants
that
play
a
key
role
promoting
health
and
preventing
diseases.
Present
fruits,
vegetables,
grains,
seed
oils,
these
considered
safe
for
consumption
due
to
the
co‐evolution
adaptation
between
mammals
plants.
Due
their
wide‐ranging
biological
effects,
they
have
attracted
considerable
research
interest.
This
comprehensive
review
explores
mechanisms
of
action,
benefits,
applications
dietary
phytochemicals,
with
particular
focus
on
groups
such
as
polyphenols,
flavonoids,
carotenoids.
Research
shows
phytochemicals
interact
nuclear
membrane
receptors,
influence
metabolic
pathways,
affect
epigenetic
modifications.
Our
highlights
broad
range
activities
compounds,
including
antioxidant,
antibacterial,
anti‐inflammatory,
anti‐diabetic,
anticancer
all
which
contribute
health‐promoting
properties.
Clinical
evidence
supports
prevention
management
diseases
cardiovascular
disorders,
conditions,
cancer,
diets
rich
being
linked
lower
risk
disease.
also
at
cutting
edge
food
preservation,
supplements,
emerging
medical
treatments.
Additionally,
we
identified
advancements
extraction
identification
techniques,
particularly
metabolomics,
further
enhance
areas.
Despite
promising
challenges
bioavailability,
regulatory
barriers,
need
robust
clinical
trials
persist.
However,
innovative
delivery
systems
like
nanoparticles,
liposomes,
encapsulation
offer
potential
solutions
bioavailability
by
improving
absorption
stability.
The
concludes
emphasizing
personalized
nutrition
combination
therapies
benefits
while
stressing
methods,
trials,
bioavailability.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(10), P. 1354 - 1354
Published: Oct. 10, 2024
Metabolic-Associated
Fatty
Liver
Disease
(MAFLD)
is
a
clinical-pathological
scenario
that
occurs
due
to
the
accumulation
of
triglycerides
in
hepatocytes
which
considered
significant
cause
liver
conditions
and
contributes
an
increased
risk
death
worldwide.
Even
though
possible
causes
MAFLD
can
involve
interaction
genetics,
hormones,
nutrition,
lifestyle
(diet
sedentary
lifestyle)
most
influential
factor
developing
this
condition.
Polyphenols
comprise
many
natural
chemical
compounds
be
helpful
managing
metabolic
diseases.
Therefore,
aim
review
was
investigate
impact
oxidative
stress,
inflammation,
mitochondrial
dysfunction,
role
polyphenols
MAFLD.
Some
reverse
part
damage
related
or
among
them
are
anthocyanin,
baicalin,
catechin,
curcumin,
chlorogenic
acid,
didymin,
epigallocatechin-3-gallate,
luteolin,
mangiferin,
puerarin,
punicalagin,
resveratrol,
silymarin.
These
have
actions
reducing
plasma
enzymes,
body
mass
index,
waist
circumference,
adipose
visceral
indices,
lipids,
glycated
hemoglobin,
insulin
resistance,
HOMA
index.
They
also
reduce
nuclear
factor-KB
(NF-KB),
interleukin
(IL)-1β,
IL-6,
tumor
necrosis
factor-α
(TNF-α),
blood
pressure,
fat
content,
steatosis
fibrosis.
On
other
hand,
they
improve
HDL-c,
adiponectin
levels,
fibrogenesis
markers.
results
show
promising
prevention
treatment
Phytotherapy Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 4, 2025
ABSTRACT
Saponins
are
compounds
composed
of
lipophilic
aglycones
linked
to
hydrophilic
sugars.
Natural
saponins
isolated
from
plants
and
some
Marine
organisms.
As
important
cholesterol‐lowering
drugs,
natural
have
attracted
wide
attention
for
their
therapeutic
potential
in
a
variety
cholesterol‐related
metabolic
diseases.
To
review
the
effects
on
diseases,
deepen
understanding
mechanism
saponins.
The
literature
related
diseases
was
collected
using
keywords
“saponins”
“cholesterol”
PubMed,
Web
Science,
Google
Scholar
January
2000
May
2024.
total
number
articles
240
after
excluding
irrelevant
articles.
can
regulate
cholesterol
prevent
treat
such
as
atherosclerosis,
diabetes,
liver
disease,
hyperlipidemia,
cancer,
obesity.
Mechanistically,
synthesis
uptake
through
AMPK/SREBP2/3‐hydroxy‐3‐methyl‐glutaryl
coenzyme
A
reductase
pathway
PCSK9/LDLR
pathway,
efflux
esterification
targeting
Liver
X
receptor/ABC
ACAT
family.
broad
application
prospects
regulating
metabolism,
development
more
drugs
provides
new
train
thought.
However,
it
is
still
necessary
further
explore
molecular
expand
clinical
trials
provide
evidence.
Phytotherapy Research,
Journal Year:
2023,
Volume and Issue:
38(2), P. 592 - 619
Published: Nov. 6, 2023
Abstract
Sterols,
including
β‐sitosterol,
are
essential
components
of
cellular
membranes
in
both
plant
and
animal
cells.
Despite
being
a
major
phytosterol
various
materials,
comprehensive
scientific
knowledge
regarding
the
properties
β‐sitosterol
its
potential
applications
is
for
scholarly
pursuits
utilization
purposes.
shares
similar
chemical
characteristics
with
cholesterol
exhibits
several
pharmacological
activities
without
toxicity.
This
study
aims
to
bridge
gap
between
phytochemistry
current
evidence
focusing
on
anticancer
activity
other
biomedical
properties.
The
goal
provide
understanding
β‐sitosterol's
future
translational
approaches.
A
thorough
examination
literature
was
conducted
gather
relevant
information
biological
particularly
therapeutic
potential.
Various
databases
were
searched,
PubMed/MedLine,
Scopus,
Google
Scholar,
Web
Science
using
appropriate
keywords.
Studies
investigating
effects
different
types
cancer
analyzed,
mechanisms
action,
screening,
chemosensitizing
Modern
screening
studies
have
revealed
against
cancer,
leukemia,
lung,
stomach,
breast,
colon,
ovarian,
prostate
cancer.
has
demonstrated
cells,
interfering
multiple
cell
signaling
pathways
involved
proliferation,
cycle
arrest,
apoptosis,
survival,
metastasis
invasion,
angiogenesis,
inflammation.
Structural
derivatives
also
shown
anti‐cancer
effects.
However,
research
field
drug
delivery
detailed
mode
action
β‐sitosterol‐mediated
remains
limited.
as
non‐toxic
compound
significant
potential,
promising
types.
relatively
less
potent
than
conventional
chemotherapeutics,
holds
safe
effective
nutraceutical
Further
recommended
explore
develop
novel
formulations
use
treatment.
review
provides
foundation
investigations
highlights
need
further
superfood
combating
Marine Drugs,
Journal Year:
2023,
Volume and Issue:
21(11), P. 578 - 578
Published: Nov. 5, 2023
Diseases
such
as
obesity;
cardiovascular
diseases
high
blood
pressure,
myocardial
infarction
and
stroke;
digestive
celiac
disease;
certain
types
of
cancer
osteoporosis
are
related
to
food.
On
the
other
hand,
world’s
population
increases,
ability
current
food
production
system
produce
consistently
is
at
risk.
As
a
result,
intensive
agriculture
has
contributed
climate
change
major
environmental
impact.
Research
is,
therefore,
needed
find
new
sustainable
sources.
One
most
promising
sources
raw
materials
macroalgae.
Algae
crucial
solving
this
nutritional
deficiency
because
they
abundant
in
bioactive
substances
that
have
been
shown
combat
hyperglycemia,
diabetes,
obesity,
metabolic
disorders,
neurodegenerative
diseases.
Examples
these
include
polysaccharides
alginate,
fucoidan,
agar
carrageenan;
proteins
phycobiliproteins;
carotenoids
β-carotene
fucoxanthin;
phenolic
compounds;
vitamins
minerals.
Seaweed
already
considered
nutraceutical
since
it
higher
protein
values
than
legumes
soy
becoming
increasingly
common.
compounds
extracted
from
seaweed
used
industry
thickening
agents
stabilizers
improve
quality
final
product
extend
its
shelf
life;
also
demonstrated
antidiabetic
effects.
Among
present
macroalgae,
compounds,
pigments,
fatty
acids
stand
out
due
their
different
properties,
antidiabetics,
antimicrobials
antioxidants,
which
important
treatment
or
control
cholesterol,
hyperglycemia
That
said,
there
some
studies
macroalgae
(red,
green
brown)
incorporated
into
foods,
but
on
gluten-free
products
still
scarce,
only
potential
use
for
type
considered.
Considering
aforementioned
issues,
review
aims
analyze
how
can
be
foods
supplement,
well
describe
contain,
beneficial
properties
human
health.
In
way,
macroalgae-based
eminent
diseases,
disease,
more
common
diabetes
cholesterol
complications,
seen.
Poultry Science,
Journal Year:
2024,
Volume and Issue:
104(1), P. 104392 - 104392
Published: Oct. 9, 2024
This
study
aimed
to
discover
how
Echinacea
powder
extract
(EPE),
an
antioxidant,
affects
the
growth
rate,
body
composition,
and
blood
parameters
in
broilers
as
alternative
antibiotics.
In
a
completely
randomized
design
study,
4
experimental
groups
received
280
broiler
chicks,
5-days-old
(Cobb
500).
Each
group
was
distributed
into
7
replicates,
each
containing
ten
unsexed
chicks.
Four
were
randomly
selected
from
chicks;
first
(the
control
group)
given
drinking
water
only.
Conversely,
birds
treatments
2,
3,
supplemented
with
EPA
their
water.
They
1.0,
2.0,
3.0
cm
