PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(2), P. e0315927 - e0315927
Published: Feb. 6, 2025
Despite
the
availability
of
various
treatment
options,
glioblastoma
(GBM)
remains
an
extremely
aggressive
form
glioma
with
a
poor
prognosis.
In
recent
studies,
regulatory
cell
death
(RCD)
has
been
identified
as
effective
mechanism
to
suppress
glioma.
Cuproptosis,
caused
by
intracellular
copper,
is
novel
RCD
process
that
affects
chemotherapy
efficacy
and
progression;
however,
precise
function
cuproptosis-related
lncRNAs
(CRLs)
genes
(CRGs)
in
GBM
uncertain.
To
determine
whether
CRLs
CRGs
have
prognostic
significance,
cohort
TCGA
build
risk
model.
Two
high-risk
(AC091182.2,
AC005229.4)
their
co-expression
(
LIPT2
,
GLS
)
were
verified
constitute
independent
indicator
GBM.
RT-qPCR
analysis
confirmed
highly
expressed
cells
compared
normal
astrocytes.
By
constructing
mouse
model,
found
be
at
higher
levels
tumor
tissues.
Furthermore,
verify
these
are
associated
cuproptosis,
cuproptosis
models
constucted
lines
astrocyte
using
Elesclomol
CuCl
2
.
It
was
expression
decreased
upon
cuproptosis-induced
cells.
Interestingly,
astrocytes
less
sensitive
than
cuproptosis-inducing
drugs,
effects
drugs
on
opposite
conclusion,
two
identified.
Their
specific
pointing
demonstrated
through
variety
experiments.
These
might
serve
markers
indicators
for
provide
theoretical
support
future
treatment.
Brain Sciences,
Journal Year:
2023,
Volume and Issue:
13(6), P. 911 - 911
Published: June 5, 2023
Recent
data
on
the
distribution
and
influence
of
copper,
zinc
cadmium
in
glial
cells
are
summarized.
This
review
also
examines
relationship
between
those
metals
their
role
neurodegenerative
diseases
like
Alzheimer
disease,
multiple
sclerosis,
Parkinson
disease
Amyotrophic
lateral
which
have
become
a
great
challenge
for
today’s
physicians.
The
studies
suggest
that
among
cells,
iron
has
highest
concentration
oligodendrocytes,
copper
astrocytes
glia
hippocampus
cortex.
Previous
shown
neurotoxic
effects
manganese,
while
can
bidirectional
effect,
i.e.,
but
neuroprotective
depending
dose
state.
point
to
association
with
neurodegeneration
through
modulation
protein
aggregation.
Metals
accumulate
brain
aging
may
be
associated
age-related
diseases.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(9), P. 2067 - 2067
Published: April 25, 2023
Trace
elements
such
as
iron
(Fe),
zinc
(Zn),
copper
(Cu),
and
manganese
(Mn)
are
absorbed
from
food
via
the
gastrointestinal
tract,
transported
into
brain,
play
central
roles
in
normal
brain
functions.
An
excess
of
these
trace
often
produces
reactive
oxygen
species
damages
brain.
Moreover,
increasing
evidence
suggests
that
dyshomeostasis
metals
is
involved
pathogenesis
neurodegenerative
diseases,
including
Alzheimer’s
disease,
prion
Lewy
body
diseases.
The
disease-related
amyloidogenic
proteins
can
regulate
metal
homeostasis
at
synapses,
thus
loss
protective
functions
causes
neurodegeneration.
Meanwhile,
metal-induced
conformational
changes
contribute
to
enhancing
their
neurotoxicity.
Zn
Cu
vascular-type
senile
dementia.
Here,
we
present
an
overview
intake,
absorption,
transport
four
essential
(Fe,
Zn,
Cu,
Mn)
one
non-essential
element
(aluminum:
Al)
connections
with
diseases
based
on
metal–protein,
metal–metal
cross-talk.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(2), P. 855 - 862
Published: Jan. 1, 2024
Copper
deficiency
can
trigger
various
diseases
such
as
Amyotrophic
Lateral
Sclerosis
(ALS),
Parkinson's
disease
(PD)
and
even
compromise
the
development
of
living
beings,
manifested
in
Menkes
(MS).
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(11)
Published: Nov. 20, 2024
Abstract
Copper
(Cu),
an
indispensable
micronutrient
for
the
sustenance
of
living
organisms,
contributes
significantly
to
a
vast
array
fundamental
metabolic
processes.
The
human
body
maintains
relatively
low
concentration
copper,
which
is
mostly
found
in
bones,
liver,
and
brain.
Despite
its
concentration,
Cu
plays
crucial
role
as
element
progression
pathogenesis
central
nervous
system
(CNS)
diseases.
Extensive
studies
have
been
conducted
recent
years
on
copper
homeostasis
copper-induced
cell
death
CNS
disorders,
including
glioma,
Alzheimer’s
disease,
Amyotrophic
lateral
sclerosis,
Huntington’s
stroke.
Cuproptosis,
novel
pathway
distinct
from
apoptosis,
necrosis,
pyroptosis,
ferroptosis,
has
identified
potentially
intricately
linked
pathogenic
mechanisms
underlying
various
Therefore,
systematic
review
cuproptosis
their
relationship
with
disorders
could
deepen
our
understanding
these
In
addition,
it
may
provide
new
insights
strategies
treatment
disorders.
RSC Chemical Biology,
Journal Year:
2023,
Volume and Issue:
4(8), P. 548 - 563
Published: Jan. 1, 2023
Neurodegeneration
is
characterized
by
a
disturbance
in
neurotransmitter-mediated
signaling
pathways.
Recent
studies
have
highlighted
the
significant
role
of
transition
metal
ions,
including
Cu(i/ii),
Zn(ii),
and
Fe(ii/iii),
neurotransmission,
thereby
making
coordination
chemistry
neurotransmitters
growing
field
interest
understanding
signal
dysfunction.
This
review
outlines
physiological
functions
ions
neurotransmitters,
with
metal-binding
properties
small
molecule-based
neuropeptides.
Additionally,
we
discuss
structural
conformational
changes
induced
redox-active
such
as
Cu(i/ii)
briefly
describe
outcomes
arising
from
their
oxidation,
polymerization,
aggregation.
These
observations
important
implications
for
neurodegeneration
emphasize
need
further
research
to
develop
potential
therapeutic
strategies.
Frontiers in Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: Aug. 7, 2023
Copper
(Cu)
is
an
essential
trace
element
in
the
brain
and
serves
as
important
cofactor
for
numerous
enzymes
involved
a
wide
range
of
biochemical
processes
including
neurobehavioral,
mitochondrial
respiration,
antioxidant
effects.
Recent
studies
have
demonstrated
that
copper
dyshomeostasis
tightly
associated
with
development
depression
by
inducing
oxidative
stress
inflammatory
responses.
However,
these
findings
remained
controversial
so
far.
Cumulative
shown
positive
association,
while
some
other
showed
no
association
even
negative
between
serum/plasma
level
depression.
Based
on
conflicted
results,
was
speculated
to
be
due
clinical
features
population,
stages
disease,
severity
excess,
types
specimens
detected
studies.
In
addition,
there
inverse
dietary
intake
Furthermore,
increasing
could
influence
zinc
iron
prevent
treat
Thus,
supplementation
may
good
measure
manage
This
review
provided
deeper
understanding
potential
applicability
prevention
treatment
