Cell Calcium, Journal Year: 2023, Volume and Issue: 115, P. 102799 - 102799
Published: Sept. 11, 2023
Language: Английский
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(8), P. 2381 - 2381
Published: April 19, 2024
Changes in trace element concentrations are being wildly considered when it comes to neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. This study aims present the role that elements play central nervous system. Moreover, we reviewed mechanisms involved their neurotoxicity. Low zinc concentrations, well high levels of copper, manganese, iron, activate signalling pathways inflammatory, oxidative nitrosative stress response. Neurodegeneration occurs due association between metals proteins, which is then followed by aggregate formation, mitochondrial disorder, and, ultimately, cell death. In disease, low Zn suppress neurotoxicity induced β-amyloid through selective precipitation aggregation intermediates. High iron manganese cause intracellular α-synuclein, results synaptic dysfunction axonal transport disruption. caused accumulation Fe midbrain dopaminergic nucleus, pathogenesis multiple sclerosis derives from deficiency, leading an imbalance T functions. Aluminium disturbs homeostasis other a rise production oxygen reactive forms, leads cellular Selenium, with plays distinct process ferroptosis. Outlining influence have on oxidoreduction processes crucial recognising pathophysiology diseases may provide possible new methods for both avoidance therapy.
Language: Английский
Citations
19
Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 9, 2024
Autism spectrum disorder (ASD) is a multifaceted developmental condition that commonly appears during early childhood. The etiology of ASD remains multifactorial and not yet fully understood. identification biomarkers may provide insights into the underlying mechanisms pathophysiology disorder. present study aimed to explore causes by investigating key biomedical markers, trace elements, microbiota factors between children with autism control subjects.
Language: Английский
Citations
10
Poultry Science, Journal Year: 2025, Volume and Issue: 104(2), P. 104797 - 104797
Published: Jan. 9, 2025
This study aimed to investigate the effects of reducing inorganic trace minerals (ITM) by supplementing compound organic (OTM) chelates on growth performance, fecal mineral excretion, intestinal health, and cecal microbiota yellow-feathered broilers. A total 960 one day old male broilers were randomly assigned 6 treatments, among which birds fed with basal diets (negative control, NC), or supplemented 1,000 mg/kg (positive PC), 300, 500 ITM OTM, respectively. Dietary supplementation OTM significantly increased average daily gain (ADG) during 22-53 d 1-53 d, reduced emissions Fe, Cu, Zn, Mn Chinese (P < 0.05). Furthermore, OTM300 group crypt depth in duodenum, ratio villus height (V/C) duodenum jejunum The mRNA expression TGF-β, Bcl-2, CAT, GPX4 as well tight junction proteins (occludin, ZO-1, claudin-1, claudin-5) mucosa when comparing ITM300 Moreover, dietary changed Chao1 index β diversity abundances Firmicutes (phylum), Eubacterium_coprostanoligenes_group (family) Oscillibacter (genus) increased, while Bacteroidetes (phylum) Rikenellaceae RC9 decreased treatment. Spearman correlation analysis showed that occludin jejunal V/C positively correlated abundance but negatively Bacteroidota (phylum). In addition, was TGF-β. PICRUST prediction microbial function revealed treatment enriched pathways related amino acid metabolism DNA replication. conclusion, at lower levels replace could improve performance reduce excretion elements modulation community
Language: Английский
Citations
1
Metallomics, Journal Year: 2024, Volume and Issue: 16(3)
Published: Feb. 28, 2024
Abstract Ischemic stroke is a leading cause of death and disability worldwide, presently, there no effective neuroprotective therapy. Zinc an essential trace element that plays important physiological roles in the central nervous system. Free zinc concentration tightly regulated by zinc-related proteins brain under normal conditions. Disruption homeostasis, however, has been found to play role mechanism injury following ischemic stroke. A large free releases from storage sites after cerebral ischemia, which affects functions survival nerve cells, including neurons, astrocytes, microglia, resulting cell death. Ischemia-triggered intracellular accumulation also disrupts function blood–brain barrier via increasing its permeability, impairing endothelial function, altering tight junction levels. Oxidative stress neuroinflammation have reported be as major pathological mechanisms ischemia/reperfusion injury. Studies showed could impair mitochondrial result oxidative stress, form positive feedback loop between reactive oxygen species production, leads series harmful reactions. Meanwhile, elevated neuroinflammation. Recent studies autophagy one toxicity Interrupting will reduce ischemia improve neurological outcomes. This review summarizes cellular tissue damage focusing on about inflammation, autophagy.
Language: Английский
Citations
6
Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1319, P. 139569 - 139569
Published: Aug. 5, 2024
Language: Английский
Citations
4
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Language: Английский
Citations
0
Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 867 - 867
Published: Feb. 28, 2025
Background/Objectives: Modern societal stressors have been linked to declining testosterone levels among young men, contributing somatic, psychological, and sexual health problems. Despite growing evidence suggesting a link between trace elements testosterone-related symptoms, there are only few comprehensive analyses on younger populations. This study's aim was examine how serum modulate the relationship symptom severity. Methods: cross-sectional study included 225 men seeking infertility consultation in Japan. Serum total free were measured, along with self-reported symptoms using Aging Males' Symptoms scale (somatic, sexual) Erection Hardness Score. The concentrations of 20 measured. We used unsupervised clustering classify participants based severity then compared distribution resulting clusters. Results: Three distinct clusters emerged: (1) lowest highest severity, (2) intermediate, (3) minimal symptoms. Interestingly, intermediate cluster displayed low but Eleven (phosphorus, sulfur, potassium, calcium, iron, zinc, arsenic, rubidium, strontium, molybdenum, cesium) identified as potential contributors dynamics. Weighted quantile sum regression indicated that phosphorus, molybdenum negatively influenced outcomes, whereas zinc beneficial. Conclusions: element profiles significantly associated men. Targeted interventions may address decline its implications. These findings help develop tailored strategies for optimizing male health.
Language: Английский
Citations
0
Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 322 - 322
Published: March 19, 2025
Alzheimer’s disease (AD) represents a significant challenge among neurodegenerative disorders, as effective treatments and therapies remain largely undeveloped. Despite extensive research efforts employing various methodologies diverse genetic models focused on amyloid-β (Aβ) pathology, the for therapeutic strategies remains inconclusive. The key pathological features of AD include Aβ senile plaques, neurofibrillary tangles (NFTs), activation neuroinflammatory pathways. Presently, investigations into assessing potential predominantly utilize transgenic models. Conversely, non-transgenic may provide valuable insights multifaceted states associated with AD. Thus, these serve practical complementary tools evaluating intervention strategies, since primary risk factors are most frequently modeled. This review aims to critically assess existing literature induced by streptozotocin, scopolamine, aging, mechanical stress, metals, dietary patterns enhance their application in research.
Language: Английский
Citations
0
Greener Journal of Biomedical and Health Sciences, Journal Year: 2025, Volume and Issue: 8(1), P. 16 - 27
Published: March 10, 2025
Biometals are essential to many physiological functions, including the normal functioning and development of brain. Notably, altered levels these biometals in body have been observed patients living with neurodegenerative conditions like Alzheimer’s, Huntington’s, Parkinson’s, Amyotrophic Lateral Sclerosis. This review will establish how can enter accumulate mechanisms for exhibiting neurotoxic effects. Correlations between level other non-essential metals existence diseases make them worthy study. Researchers looked toward biometal homeostasis as potential sources biomarkers, diagnostic breakthroughs, therapeutic solutions conditions. In addition, we explore benefit brain health, their role conditions, next frontiers biometal-based diagnostics therapy research.
Language: Английский
Citations
0
Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 773 - 773
Published: June 28, 2024
Zinc (Zn) and copper (Cu) are essential for normal brain functions. In particular, Zn Cu released to synaptic clefts during neuronal excitation. Synaptic regulate excitability, maintain calcium (Ca) homeostasis, play central roles in memory formation. However, pathological conditions such as transient global ischemia, excess is secreted clefts, which causes death can eventually trigger the pathogenesis of a vascular type senile dementia. We have previously investigated characteristics Zn-induced neurotoxicity demonstrated that low concentrations exacerbate neurotoxicity. Furthermore, our pharmacological approaches clarify molecular pathways Cu-enhanced neurotoxicity, we revealed involvement Ca homeostasis disruption. present review, discuss synapse, well crosstalk between Zn, Cu, Ca, study along with other recent studies suggest may underlie vascular-type
Language: Английский
Citations
2