Mitochondria-Targeted Antioxidants, an Innovative Class of Antioxidant Compounds for Neurodegenerative Diseases: Perspectives and Limitations

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3739 - 3739

Published: Feb. 13, 2023

Neurodegenerative diseases comprise a wide spectrum of pathologies characterized by progressive loss neuronal functions and structures. Despite having different genetic backgrounds etiology, in recent years, many studies have highlighted point convergence the mechanisms leading to neurodegeneration: mitochondrial dysfunction oxidative stress been observed pathologies, their detrimental effects on neurons contribute exacerbation pathological phenotype at various degrees. In this context, increasing relevance has acquired antioxidant therapies, with purpose restoring order revert damage. However, conventional antioxidants were not able specifically accumulate diseased mitochondria, often eliciting harmful whole body. last decades, novel, precise, mitochondria-targeted (MTA) compounds developed studied, both vitro vivo, address need counter mitochondria restore energy supply membrane potentials neurons. review, we focus activity therapeutic perspectives MitoQ, SkQ1, MitoVitE MitoTEMPO, most studied belonging class MTA conjugated lipophilic cations, reach compartment.

Language: Английский

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Association between Mediterranean diet and dementia and Alzheimer disease: a systematic review with meta-analysis

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: March 22, 2024

Abstract Background Dementia affects 5–8% of the population aged over 65 years (~50 million worldwide). Several factors are associated with increased risk, including diet. The Mediterranean diet (MedDiet) has shown potential protective effects against several chronic diseases. Aims This systematic review meta-analysis aim was to assess association between adherence MedDiet and risk dementia in elderly. Methods PRISMA-2020 guidelines were followed. PubMed/MEDLINE Scopus searched on 17 July 2023. Newcastle–Ottawa Scale tool used bias. protocol pre-registered PROSPERO (registration number: CRD 42023444368). Heterogeneity assessed using I 2 test. Publication bias by visual inspection funnel plot Egger’s regression asymmetry final effect size reported as OR or HR, depending study design included studies. Results Out 682 records, 21 analysis. pooled 0.89 (95% CI = 0.84–0.94) based 65,955 participants ( 69.94). When only cohort studies included, HR 0.84 0.76–0.94) 55,205 89.70). Alzheimer Disease considered 0.73 0.62–0.85) 38,292 63.85). Discussion Despite relatively low reduction higher among elderly, it should be that this is most affected. Conclusions Adherence could an effective non-pharmacological measure reduce burden dementia, even

Language: Английский

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Human Serum Albumin Based Nanodrug Delivery Systems: Recent Advances and Future Perspective

Polymers, Journal Year: 2023, Volume and Issue: 15(16), P. 3354 - 3354

Published: Aug. 10, 2023

With the success of several clinical trials products based on human serum albumin (HSA) and rapid development nanotechnology, HSA-based nanodrug delivery systems (HBNDSs) have received extensive attention in field nanomedicine. However, there is still a lack comprehensive reviews exploring broader scope HBNDSs biomedical applications beyond cancer therapy. To address this gap, review takes systematic approach. Firstly, it focuses crystal structure potential binding sites HSA. Additionally, provides summary recent progresses for various over past five years, categorized according to type therapeutic drugs loaded onto These categories include small-molecule drugs, inorganic materials bioactive ingredients. Finally, summarizes characteristics current application status drug delivery, also discusses challenges that need be addressed transformation HSA formulations offers future perspectives field.

Language: Английский

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Relationship between cognitive function and weight-adjusted waist index in people ≥ 60 years old in NHANES 2011–2014

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: Feb. 9, 2024

Abstract Background Widespread attention has been given to the detrimental effects of obesity on cognitive function. However, there is no evidence connection between low performance and WWI (weight-adjusted waist index). This study looked into poor in senior Americans. Methods A cross-sectional research was carried out with information from NHANES 2011–2014. With multivariate linear regression models, pertinence function persons older than 60 years examined. The nonlinear link described using threshold effect analyses fitted smoothed curves. Interaction tests subgroup analysis were also conducted. Results had 2762 individuals all, subjects higher values at greater risk for In completely adjusted model, positively connected assessed by CERAD W-L (OR = 1.22, 95% CI 1.03–1.45, p 0.0239), AFT 1.30, 1.09–1.54, 0.0029), DSST 1.59, 1.30–1.94, < 0.0001). each positive correlation not significant. as determined a (log-likelihood ratio 0.05). Conclusion Among adults United States, may be related WWI.

Language: Английский

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Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer’s Disease

Molecules, Journal Year: 2024, Volume and Issue: 29(2), P. 321 - 321

Published: Jan. 9, 2024

Effective therapeutics for Alzheimer's disease (AD) are in great demand worldwide. In our previous work, we responded to this need by synthesizing novel drug candidates consisting of 4-amino-2,3-polymethylenequinolines conjugated with butylated hydroxytoluene via fixed-length alkylimine or alkylamine linkers (spacers) and studying their bioactivities pertaining AD treatment. Here, report significant extensions these studies, including the use variable-length spacers more detailed biological characterizations. Conjugates were potent inhibitors acetylcholinesterase (AChE, most active was

Language: Английский

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Risk of Dementia and Alzheimer's Disease Associated With Antidiabetics: A Bayesian Network Meta-Analysis

American Journal of Preventive Medicine, Journal Year: 2024, Volume and Issue: 67(3), P. 434 - 443

Published: May 4, 2024

Language: Английский

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Proteomics-based aging clocks in midlife and late-life and risk of dementia

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Background: Biological age can be quantified by composite proteomic scores, called aging clocks. We investigated whether biological acceleration (a discrepancy between chronological and age) in midlife late-life is associated with cognitive function risk of dementia. Methods: used two population-based cohort studies: Atherosclerosis Risk Communities (ARIC) Study Multi-Ethnic (MESA). Proteomics-based clocks (PACs) were created ARIC at (mean age: 58 years, n=11,758) 77 n=4,934) using elastic net regression models two-thirds dementia-free participants validated the remaining one-third participants. Age (AA) was calculated as residuals after regressing PACs on age. PAC MESA 62 n=5,829). multivariable linear Cox proportional hazards to assess association AA dementia incidence, respectively. Results: In ARIC, every five years lower global function: difference: -0.11, 95% confidence interval (CI): -0.16, -0.06) -0.17, CI: -0.23, -0.12 AA. Consistently, higher (hazard ratio [HR]: 1.20 [CI: 1.04, 1.36]) more prominently when (HR: 2.14 [CI:1.67, 2.73]). Similar findings observed study: (difference: -0.08 -0.14, -0.03]) (HR:1.23 1.46]). Conclusion: Accelerated – defined plasma proteome predicts a late-life.

Language: Английский

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The brain structure underlying the nonlinear association between early-life tobacco smoke exposure and the risk for cognitive decline and dementia in adulthood: a large prospective cohort study

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 18, 2025

The impacts of early-life tobacco smoke exposure, including exposure during pregnancy and the initiation smoking childhood adolescence, on cognitive decline risk dementia in later life have not been investigated. We used data from UK Biobank (UKB) to assess utero age at which was initiated. Cox proportional-hazards regression models were employed gauge relationships between both adulthood. adjusted for potential confounding factors, age, gender, race, household income, alcohol consumption status, physical activity, family history dementia, education level, other relevant variables. This study 291,113 UKB participants 4,836 new cases over a median 13.26-year follow-up found that led significant adulthood, but higher risk. Those who began or adolescence had increased Early linked various brain structure changes, volumes hippocampus, lateral ventricles, white gray matter. is associated with an underscores significance educational campaigns targeting reduction among children, adolescents, pregnant women as effective strategy mitigate

Language: Английский

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Cognitive Screening Tools for Dementia Detection in Primary Healthcare Centers in India: A Scoping Review

Published: Jan. 24, 2025

BACKGROUND: Dementia is a growing public health concern in India, with an increasing prevalence among the elderly population. Early detection crucial for effective intervention. Primary healthcare (PHC) centres play vital role identifying cognitive impairment; however, effectiveness of screening tools these settings questionable. OBJECTIVE: This scoping review explores available dementia PHC assesses their effectiveness, and identifies need improvement adaptation. METHODS: A systematic search was conducted PubMed, Scopus, Google Scholar studies published up to October 2024. total 29 were identified, indicating that such as Mini-Mental State Examination (MMSE) Montreal Cognitive Assessment (MoCA) are frequently used. However, face significant challenges related educational background language comprehension, impacting effectiveness. CONCLUSION: There urgent culturally linguistically appropriate India enhance early dementia.

Language: Английский

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Tirzepatide mitigates cognitive decline in zebrafish model of type 2 diabetes mellitus induced by high-fat diet

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

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