Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102734 - 102734
Published: March 1, 2025
Language: Английский
Life Sciences, Journal Year: 2023, Volume and Issue: 334, P. 122257 - 122257
Published: Nov. 8, 2023
Language: Английский
Citations
48
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2698 - 2698
Published: Feb. 26, 2024
Oxidative stress (OS) and inflammation are two important well-studied pathological hallmarks of neurodegenerative diseases (NDDs). Due to elevated oxygen consumption, the high presence easily oxidizable polyunsaturated fatty acids weak antioxidant defenses, brain is particularly vulnerable oxidative injury. Uncertainty exists over whether these deficits contribute development NDDs or solely a consequence neuronal degeneration. Furthermore, linked, it known that OS can affect inflammatory response. In this review, we will overview last findings about pathways in principal NDDs. Moreover, focus more depth on amyotrophic lateral sclerosis (ALS) understand how anti-inflammatory antioxidants drugs have been used for treatment still incurable motor neuron (MN) disease. Finally, analyze past actual clinical trials future perspectives study mechanisms.
Language: Английский
Citations
45
Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 602 - 602
Published: May 14, 2024
Reactive oxygen species (ROS) are highly reactive derivatives that include free radicals such as superoxide anion radical (O2•−) and hydroxyl (HO•), well non-radical molecules hydrogen peroxide (H2O2), peroxynitrite (ONOO−), hypochlorous acid (HOCl) [...]
Language: Английский
Citations
44
Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 934 - 934
Published: April 15, 2023
Mitochondria are one of the organelles undergoing rapid alteration during senescence process. Senescent cells show an increase in mitochondrial size, which is attributed to accumulation defective mitochondria, causes oxidative stress. Defective mitochondria also targets stress, and vicious cycle between stress contributes onset development aging age-related diseases. Based on findings, strategies reduce have been suggested for effective treatment In this article, we discuss alterations consequent Then, causal role investigated by examining how diseases exacerbated induced Furthermore, assess importance targeting regulation suggest different therapeutic Therefore, review will not only shed light a new perspective but provide through
Language: Английский
Citations
28
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: July 24, 2023
Abstract Oxidative stress plays a crucial role in the pathogenesis of hepatic encephalopathy (HE), but mechanism remains unclear. GABAergic neurons substantia nigra pars reticulata (SNr) contribute to motor deficit HE. The present study aims investigate effects oxidative on HE male mice. results validate existence both liver and SNr across two murine models induced by thioacetamide (TAA) bile duct ligation (BDL). Systemic mitochondria-targeted antioxidative drug mitoquinone (Mito-Q) rescues mitochondrial dysfunction injury SNr, so as restore locomotor impairment TAA BDL Furthermore, GAD2-expressing population (SNr GAD2 ) is activated Both overexpression uncoupling protein 2 (UCP2) targeted -targeted chemogenetic inhibition rescue TAA-induced These define key
Language: Английский
Citations
23
International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 53(5)
Published: April 2, 2024
Chronic neuroinflammation serves a key role in the onset and progression of neurodegenerative disorders. Mitochondria serve as central regulators neuroinflammation. In addition to providing energy cells, mitochondria also participate immunoinflammatory response disorders including Alzheimer's disease, Parkinson's multiple sclerosis epilepsy, by regulating processes such cell death inflammasome activation. Under inflammatory conditions, mitochondrial oxidative stress, epigenetics, dynamics calcium homeostasis imbalance may underlying regulatory mechanisms for these diseases. Therefore, investigating related dysfunction result therapeutic strategies against chronic neurodegeneration. The present review summarizes neuroinflammatory diseases current treatment approaches that target
Language: Английский
Citations
15
Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)
Published: Aug. 21, 2024
Abstract Mitochondria play a crucial role in maintaining the normal physiological state of cells. Hence, ensuring mitochondrial quality control is imperative for prevention and treatment numerous diseases. Previous reviews on this topic have however been inconsistencies lack systematic organization. Therefore, review aims to provide comprehensive overview explore possibility targeting same major This systematically summarizes three fundamental characteristics control, including morphology dynamics, function metabolism, protein expression regulation. It also extensively examines how imbalances are linked diseases, such as ischemia-hypoxia, inflammatory disorders, viral infections, metabolic dysregulations, degenerative conditions, tumors. Additionally, explores innovative approaches target using small molecule drugs that regulate critical steps quality, nanomolecular materials designed precise mitochondria, novel cellular therapies, vesicle therapy transplantation. offers perspective comprehending shared mechanisms underlying occurrence progression diseases provides theoretical support practical guidance clinical implementation therapeutic strategies treating
Language: Английский
Citations
12
Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(1)
Published: Jan. 1, 2025
ABSTRACT Neurodegenerative diseases are significant health concerns that have a profound impact on the quality and duration of life for millions individuals. These characterized by pathological changes in various brain regions, specific genetic mutations associated with disease, deposits abnormal proteins, degeneration neurological cells. As neurodegenerative disorders vary their epidemiological characteristics vulnerability neurons, treatment these is usually aimed at slowing disease progression. The heterogeneity environmental factors involved process neurodegeneration makes current methods inadequate. However, existence common molecular mechanisms pathogenesis may allow development new targeted therapeutic strategies. Oxidative nitrosative stress damages membrane components accumulating ROS RNS disrupting redox balance. This results induction apoptosis, which important through oxidative stress. Studies conducted using postmortem human samples, animal models, cell cultures demonstrated stress, apoptosis crucial such as Alzheimer's, Parkinson's, Multiple Sclerosis, amyotrophic lateral sclerosis, Huntington's disease. excessive production reactive oxygen nitrogen species, elevated levels free radicals, heightened mitochondrial disturbances energy metabolism, oxidation nitrosylation cellular macromolecules recognized triggers neuronal death. Challenges managing treating require better understanding this field level. Therefore, review elaborates apoptosis.
Language: Английский
Citations
1
Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)
Published: Feb. 7, 2025
Mitochondrial dysfunction is a pivotal instigator of neuroinflammation, with mitochondrial DNA (mtDNA) leakage as critical intermediary. This review delineates the intricate pathways leading to mtDNA release, which include membrane permeabilization, vesicular trafficking, disruption homeostatic regulation, and abnormalities in dynamics. The escaped activates cytosolic sensors, especially cyclic gmp-amp synthase (cGAS) signalling inflammasome, initiating neuroinflammatory cascades via pathways, exacerbating spectrum neurological pathologies. therapeutic promise targeting discussed detail, underscoring necessity for multifaceted strategy that encompasses preservation homeostasis, prevention leakage, reestablishment dynamics, inhibition activation sensors. Advancing our understanding complex interplay between neuroinflammation imperative developing precision interventions disorders.
Language: Английский
Citations
1
Antioxidants, Journal Year: 2023, Volume and Issue: 12(12), P. 2091 - 2091
Published: Dec. 8, 2023
Metabolic syndrome (MS) is a growing disorder affecting thousands of people worldwide, especially in industrialised countries, increasing mortality. Oxidative stress, hyperglycaemia, insulin resistance, inflammation, dysbiosis, abdominal obesity, atherogenic dyslipidaemia and hypertension are important factors linked to MS clusters different pathologies, such as diabesity, cardiovascular diseases neurological disorders. All biochemical changes observed MS, dysregulation the glucose lipid metabolism, immune response, endothelial cell function intestinal microbiota, promote pathological bridges between metabolic syndrome, diabesity neurodegenerative This review aims summarise syndrome's involvement highlight link diseases. A better understanding could novel strategic approach reduce comorbidities.
Language: Английский
Citations
22