Effectiveness of Fecal Microbiota Transplantation in Nociplastic Pain Management: A Systematic Review DOI Creative Commons
Sebastián Eustaquio Martín Pérez,

Hakim Al Lal Abdel Lah,

Nelda Garcia

et al.

Gastrointestinal Disorders, Journal Year: 2025, Volume and Issue: 7(1), P. 5 - 5

Published: Jan. 8, 2025

Nociplastic pain, commonly observed in conditions such as Fibromyalgia, chronic fatigue syndrome, and irritable bowel arises from altered central pain processing involves complex mechanisms, including interactions between the gut–brain axis immune dysregulation. Conventional therapies often fail to address this type of effectively, leading interest alternative approaches fecal microbiota transplantation. This technique has been proposed restore gut microbial balance modulate systemic inflammation, neuroinflammation, neurotransmitter signaling. systematic review, conducted according Preferred Reporting Items for Systematic Reviews Meta-analyses guidelines registered International Prospective Register (CRD42024611939), evaluated 13 studies with n = 409 participants, clinical trials, case reports, retrospective analyses. A quality assessment was performed using appraisal tools Cochrane RoB 2, ROBINS-I, NOS, CARE. The results suggest that transplantation may reduce intensity improve life, particularly patients Fibromyalgia syndrome. However, outcomes Chronic Fatigue Syndrome psoriatic arthritis were inconsistent limited by methodological flaws, small sample sizes, variability protocols donor selection. Although adverse events minimal, current evidence is insufficient support widespread use. High-quality, standardized are needed confirm efficacy Until then, its application should remain experimental interpreted caution.

Language: Английский

Gut Microbiota Mediates Neuroinflammation in Alzheimer’s Disease: Unraveling Key Factors and Mechanistic Insights DOI
Junyi Liang,

Wang Yueyang,

Bin Liu

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Language: Английский

Citations

5
Gut-muscle-brain axis: Molecular mechanisms in neurodegenerative disorders and potential therapeutic efficacy of probiotic supplementation coupled with exercise DOI Creative Commons
Ilaria Morella, Massimo Negro, Maurizia Dossena

et al.

Neuropharmacology, Journal Year: 2023, Volume and Issue: 240, P. 109718 - 109718

Published: Sept. 27, 2023

Increased longevity is often associated with age-related conditions. The most common neurodegenerative disorders in the older population are Alzheimer's disease (AD) and Parkinson's (PD), progressive neuronal loss leading to functional cognitive impairments. Although symptomatic treatments available, there currently no cure for these Gut dysbiosis has been involved pathogenesis of AD PD, thus interventions targeting "gut-brain axis" could potentially prevent or delay pathologies. Recent evidence suggests that skeletal muscle gut microbiota can affect each other via "gut-muscle axis". Importantly, functions PD patients significantly benefit from physical activity. In this review, we aim provide a comprehensive picture crosstalk between brain, microbiota, introducing concept "gut-muscle-brain Moreover, discuss human animal studies exploring modulatory role exercise probiotics on cognition PD. Collectively, findings presented here support potential benefits activity probiotic supplementation Further will be needed develop targeted multimodal strategies, including lifestyle changes, course

Language: Английский

Citations

11
The Human Gut and Dietary Salt: The Bacteroides/Prevotella Ratio as a Potential Marker of Sodium Intake and Beyond DOI Open Access
Omololu Fagunwa,

Kirsty Davies,

Jane Bradbury

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 942 - 942

Published: March 25, 2024

The gut microbiota is a dynamic ecosystem that plays pivotal role in maintaining host health. perturbation of these microbes has been linked to several health conditions. Hence, they have emerged as promising targets for understanding and promoting good Despite the growing body research on sodium health, its effects human microbiome remain under-explored. Here, using nutrition metagenomics methods, we investigate influence dietary intake alterations microbiota. We found high-sodium diet (HSD) altered composition with significant reduction Bacteroides inverse increase Prevotella compared low-sodium (LSD). However, there no clear distinction Firmicutes/Bacteroidetes (F/B) ratio between two types. Metabolic pathway reconstruction revealed presence reabsorption genes HSD, but not LSD. Since it currently difficult studies confidently associate F/B what considered healthy (e.g., low sodium) or unhealthy high sodium), suggest use genus-based such Bacteroides/Prevotella (B/P) may be more beneficial application

Language: Английский

Citations

4
Fecal Microbiota Transplantation, a tool to transfer healthy longevity DOI Creative Commons
Marta G. Novelle,

Beatriz Naranjo-Martínez,

Juan L López-Cánovas

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 103, P. 102585 - 102585

Published: Nov. 23, 2024

The complex gut microbiome influences host aging and plays an important role in the manifestation of age-related diseases. Restoring a healthy via Fecal Microbiota Transplantation (FMT) is receiving extensive consideration to therapeutically transfer longevity. Herein, we comprehensively review benefits microbial rejuvenation - FMT promote aging, with few studies documenting life length properties. This explores how preconditioning donors standard lifestyle pharmacological antiaging interventions reshape microbiome, resulting being also FMT-transferable. Finally, expose current clinical uses context therapy address challenges regulatory landscape, protocol standardization, health risks that require refinement effectively utilize elderly.

Language: Английский

Citations

4
Effectiveness of Fecal Microbiota Transplantation in Nociplastic Pain Management: A Systematic Review DOI Creative Commons
Sebastián Eustaquio Martín Pérez,

Hakim Al Lal Abdel Lah,

Nelda Garcia

et al.

Gastrointestinal Disorders, Journal Year: 2025, Volume and Issue: 7(1), P. 5 - 5

Published: Jan. 8, 2025

Nociplastic pain, commonly observed in conditions such as Fibromyalgia, chronic fatigue syndrome, and irritable bowel arises from altered central pain processing involves complex mechanisms, including interactions between the gut–brain axis immune dysregulation. Conventional therapies often fail to address this type of effectively, leading interest alternative approaches fecal microbiota transplantation. This technique has been proposed restore gut microbial balance modulate systemic inflammation, neuroinflammation, neurotransmitter signaling. systematic review, conducted according Preferred Reporting Items for Systematic Reviews Meta-analyses guidelines registered International Prospective Register (CRD42024611939), evaluated 13 studies with n = 409 participants, clinical trials, case reports, retrospective analyses. A quality assessment was performed using appraisal tools Cochrane RoB 2, ROBINS-I, NOS, CARE. The results suggest that transplantation may reduce intensity improve life, particularly patients Fibromyalgia syndrome. However, outcomes Chronic Fatigue Syndrome psoriatic arthritis were inconsistent limited by methodological flaws, small sample sizes, variability protocols donor selection. Although adverse events minimal, current evidence is insufficient support widespread use. High-quality, standardized are needed confirm efficacy Until then, its application should remain experimental interpreted caution.

Language: Английский

Citations

0