Smoking and High‐Altitude Exposure Affect Intrinsic Neural Activity: A fMRI Study of Interactive Effects DOI Creative Commons
Qingqing Lv, Minghe Wang,

Chunxiao Bu

et al.

Addiction Biology, Journal Year: 2025, Volume and Issue: 30(4)

Published: April 1, 2025

ABSTRACT Smoking and high‐altitude (HA) exposure both adversely affect human health, with smoking linked to various cancers environments causing physiological neurological changes. Although the effects of HA on brain structure function have been studied separately, their combined impact is still rarely explored. This study aims investigate interactive intrinsic activity using resting‐state functional magnetic resonance imaging (rs‐fMRI) analysed by amplitude low‐frequency fluctuations (ALFF) method. We used a mixed sample design, including four groups: (i) smokers ( n = 22); (ii) nonsmokers (iii) sea‐level (SL) 26); (iv) SL 26), for total 96 male participants. All subjects underwent imaging. ALFF was assess differences in among groups. Two‐way analysis variance (ANOVA) conducted analyse smoking, interaction ALFF. As main effect elevated found right superior frontal gyrus, middle inferior cingulate cortex precentral gyrus. exposure, putamen, insula, temporal gyrus fusiform. A significant between observed Post hoc showed significantly increased groups versus smokers; nonsmokers; nonsmokers. Our findings demonstrate that independently influence spontaneous activity, two factors modulating function. These results offer neuroimaging‐based perspective substance addiction populations contribute deeper understanding adaptation.

Language: Английский

Altitude illnesses DOI
Hannes Gatterer, Francisco C. Villafuerte, Silvia Ulrich

et al.

Nature Reviews Disease Primers, Journal Year: 2024, Volume and Issue: 10(1)

Published: June 20, 2024

Language: Английский

Citations

24
High altitude retinopathy: An overview and new insights DOI Creative Commons
Cong Han, Xingxing Zheng, W Zhang

et al.

Travel Medicine and Infectious Disease, Journal Year: 2024, Volume and Issue: 58, P. 102689 - 102689

Published: Feb. 1, 2024

High altitude retinopathy (HAR) is a common ocular disorder that occurs on ascent to high altitude. There are many clinical symptoms, retinal vascular dilatation, edema and hemorrhage common. These usually do not or slightly affect vision; rarely, severe cases develop serious permanent vision loss. At present, the research progress of HAR mainly focuses hemodynamic changes, blood-retinal barrier damage, oxidative stress inflammatory response. Although related studies limited, it shows still belongs hypoxia, hypobaric hypoxia plays an aggravating role in promoting development disease. Various have demonstrated correlation with acute mountain sickness (AMS) high-altitude cerebral (HACE), so deeper understanding important. The slow rates key preventing any sickness. Research traditional chinese medicine (TCM) western has been gradually carried out. Further exploration pathogenesis prevention strategies will provide better guidance for doctors travelers.

Language: Английский

Citations

10
Effects of hypoxia on the heart of the juvenile four-finger threadfin (Eleutheronema tetradactylum) based on physiological indicators and transcriptome analysis DOI Creative Commons
Yi Lu, Eric Amenyogbe, Ye Yang

et al.

Frontiers in Marine Science, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 5, 2025

This study evaluated the effects of hypoxia on heart juvenile four-finger threadfin ( Eleutheronema tetradactylum ) through physiological and transcriptome analysis. Juveniles with an average weight 122.82 g length 24.60 cm were used. Hypoxia significantly increased serum myocardial enzyme activities, including creatine kinase (CK), kinase-MB isoenzyme, lactate dehydrogenase (LDH), α-hydroxybutyrate (HDBH). These indicators initially rose then declined, reflecting cardiac stress suggesting their potential as early biomarkers for real-time aquaculture monitoring. Histological analysis revealed structural damage in fibers under hypoxia, increasing severity over time. underscores need to minimize oxygen fluctuations prevent tissue degeneration. Transcriptome identified upregulated genes involved cell communication, immune responses, intracellular signaling, offering targets breeding hypoxia-tolerant species. Kyoto Encyclopedia Genes Genomes pathway enrichment highlighted key pathways such mitogen-activated protein (MAPK), hypoxia-inducible factor-1 (HIF-1), endocytosis, phagosome formation. The MAPK plays a critical role cellular survival, proliferation, apoptosis. Hypoxia-induced activation MAPKs like ERK, JNK, p38 regulates stress-responsive genes. HIF-1 signaling homeostasis, HIF-1α stabilizing hypoxia-responsive VEGFA, which promotes vascular remodeling enhances delivery. findings collectively offer practical applications enhancing management, monitoring biochemical markers, adopting breeding, adjusting environmental conditions mitigate stress, ensuring better productivity sustainability. research provides foundation further studies molecular mechanisms

Language: Английский

Citations

1
High altitude hypoxia and oxidative stress: The new hope brought by free radical scavengers DOI
Xuefeng Li, Jilei Zhang, Guoan Liu

et al.

Life Sciences, Journal Year: 2023, Volume and Issue: 336, P. 122319 - 122319

Published: Nov. 29, 2023

Language: Английский

Citations

22
The Brain at High Altitude: From Molecular Signaling to Cognitive Performance DOI Open Access
Mostafa A. Aboouf, Markus Thiersch, Jorge Soliz

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10179 - 10179

Published: June 15, 2023

The brain requires over one-fifth of the total body oxygen demand for normal functioning. At high altitude (HA), lower atmospheric pressure inevitably challenges brain, affecting voluntary spatial attention, cognitive processing, and attention speed after short-term, long-term, or lifespan exposure. Molecular responses to HA are controlled mainly by hypoxia-inducible factors. This review aims summarize cellular, metabolic, functional alterations in at with a focus on role factors controlling hypoxic ventilatory response, neuronal survival, metabolism, neurogenesis, synaptogenesis, plasticity.

Language: Английский

Citations

21
Longitudinal multi-omics analysis uncovers the altered landscape of gut microbiota and plasma metabolome in response to high altitude DOI Creative Commons
Yang Han, Xiaoshuang Liu, Qian Jia

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: April 5, 2024

Abstract Background Gut microbiota is significantly influenced by altitude. However, the dynamics of gut in relation to altitude remains undisclosed. Methods In this study, we investigated microbiome profile 610 healthy young men from three different places China, grouped altitude, duration residence, and ethnicity. We conducted widely targeted metabolomic profiling clinical testing explore metabolic characteristics. Results Our findings revealed that as Han individuals migrated low high latitude, gradually converged towards Tibetan populations but reversed upon returning lower Across cohorts, identified 51 species specifically enriched during acclimatization 57 deacclimatization Notably, Prevotella copri was found be most taxon both after ascending Furthermore, significant variations host plasma metabolome indices at could largely explained changes composition. Similar Tibetans, 41 metabolites, such lactic acid, sphingosine-1-phosphate, taurine, inositol, were elevated Germ-free animal experiments demonstrated certain species, Escherichia coli Klebsiella pneumoniae , which exhibited altitude-dependent human populations, might play crucial roles purine metabolism. Conclusions This study provides insights into with respect changes, indicating their may have implications for health contribute adaptation.

Language: Английский

Citations

8
Hypoxia Sensing and Responses in Parkinson’s Disease DOI Open Access
Johannes Burtscher, Yves Duderstadt, Hannes Gatterer

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1759 - 1759

Published: Feb. 1, 2024

Parkinson’s disease (PD) is associated with various deficits in sensing and responding to reductions oxygen availability (hypoxia). Here we summarize the evidence pointing a central role of hypoxia PD, discuss relation dependence pathological hallmarks including mitochondrial dysfunction, dopaminergic vulnerability, alpha-synuclein-related pathology, highlight link cellular systemic sensing. We describe cases suggesting that may trigger Parkinsonian symptoms but also emphasize endogenous systems protect from can be harnessed PD. Finally, provide examples preclinical clinical research substantiating this potential.

Language: Английский

Citations

5
AQP4- and Kir4.1-Mediated Müller Cell Oedema Is Involved in Retinal Injury Induced By Hypobaric Hypoxia DOI
Cong Han, Yuting Li, Xingxing Zheng

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: July 26, 2024

Language: Английский

Citations

5
Hypoxia and the Aging Cardiovascular System DOI Creative Commons
Antoine Raberin, Johannes Burtscher, Martin Burtscher

et al.

Aging and Disease, Journal Year: 2023, Volume and Issue: 14(6), P. 2051 - 2051

Published: Jan. 1, 2023

Older individuals represent a growing population, in industrialized countries, particularly those with cardiovascular diseases, which remain the leading cause of death western societies. Aging constitutes one largest risks for diseases. On other hand, oxygen consumption is foundation cardiorespiratory fitness, turn linearly related to mortality, quality life and numerous morbidities. Therefore, hypoxia stressor that induces beneficial or harmful adaptations, depending on dose. While severe can exert detrimental effects, such as high-altitude illnesses, moderate controlled exposure potentially be used therapeutically. It improve pathological conditions, including vascular abnormalities, slows down progression various age-related disorders. Hypoxia effects inflammation, oxidative stress, mitochondrial functions, cell survival, are all increased age have been discussed main promotors aging. This narrative review discusses specificities aging system hypoxia. draws upon an extensive literature search hypoxia/altitude interventions (acute, prolonged, intermittent exposure) older (over 50 years old). Special attention directed toward use health individuals.

Language: Английский

Citations

12
Inflammation severity, rather than respiratory failure, is strongly associated with mortality of ARDS patients in high-altitude ICUs DOI Creative Commons
Daniel Molano-Franco,

Joan Ramón Masclans Enviz,

Antonio Viruez‐Soto

et al.

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 15, 2025

Introduction In high-altitude cities located above 2,500 m, hospitals face a concerning mortality rate of over 50% among intensive care unit (ICU) patients with acute respiratory distress syndrome (ARDS). This elevated is largely due to the absence altitude-specific medical protocols that consider unique physiological adaptations residents hypoxic conditions. study addresses this critical gap by analyzing demographic, clinical, sex-specific, and preclinical data from ICUs in Bogotá, Colombia (2,650 m) El Alto, Bolivia (4,150 m). Methods A cohort seventy ARDS patients, aged 18 older, was evaluated within 24 h ICU admission. Data collected included demographic information (age, sex), clinical characteristics (primary pathology, weight, height), vital signs, variables, cardiorespiratory parameters, blood count results, inflammatory markers, severity assessment scores, comorbidities. Advanced statistical analyses, such as multivariate logistic regression principal component analysis, were utilized identify key predictors ARDS-related mortality. Results Our findings indicate ICUs, monitoring markers may be more beneficial for improving survival rates than emphasizing failure markers. Unexpectedly, we found no significant differences outcomes between altitudes 2,650 4,150 m or male female patients. Conclusion The concludes that, settings, patient closely associated managing responses focusing solely on parameters. Further large-scale studies are recommended validate impact marker ICUs.

Language: Английский

Citations

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