Advancements in innate immune regulation strategies in islet transplantation DOI Creative Commons

Kehang Duan,

Jiao Liu, Jian Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 15, 2024

As a newly emerging organ transplantation technique, islet has shown the advantages of minimal trauma and high safety since it was first carried out. The proposal Edmonton protocol, which been widely applied, breakthrough in this method. However, direct contact between islets portal vein blood will cause robust innate immune response leading to massive apoptosis graft, macrophages play an essential role response. Therefore, therapeutic strategies targeting have become popular research topic recent years. This paper summarize analyze on for regulating immunity, primarily focusing macrophages, field transplantation, including drug therapy, optimization preparation process, engineering Mesenchymal stem cells cotransplantation. We also expounded heterogeneity, plasticity activation mechanism providing theoretical basis further research.

Language: Английский

Drug Delivery System Targeting Cancer-Associated Fibroblast for Improving Immunotherapy DOI Creative Commons

Zhongsong Zhang,

Rong Wang, Long Chen

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 483 - 503

Published: Jan. 1, 2025

Abstract: Cancer-associated fibroblasts (CAFs) are a heterogeneous population of non-malignant cells that play crucial role in the tumor microenvironment, increasingly recognized as key contributors to cancer progression, metastasis, and treatment resistance. So, targeting CAFs has always been considered an important part immunotherapy. However, improve efficacy therapy is currently major challenge. Nanomaterials show their unique advantages whole process. At present, nanomaterials have achieved significant accomplishments medical applications, particularly field cancer-targeted therapy, showing enormous potential. It confirmed can not only directly target CAFs, but also interact with microenvironment (TME) immune affect tumorigenesis. As for treatment, could enhance therapeutic effect many ways. Therefore, this review, we first summarized current understanding complex interactions between TME, cells, cells. Next, discussed common modern medicine respective impacts on tumors. Finally, focus application nano drug delivery system therapy. Keywords: cancer-associated fibroblasts, delivery, nanomedicine, immunotherapy

Language: Английский

Citations

3
Biodegradable and Stimuli-Responsive Nanomaterials for Targeted Drug Delivery in Autoimmune Diseases DOI Creative Commons
Nargish Parvin, Sang Woo Joo, Tapas Kumar Mandal

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 24 - 24

Published: Jan. 14, 2025

Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation avoid adverse side effects. Recent advancements in biodegradable stimuli-responsive nanomaterials have opened new avenues targeted drug delivery systems capable of addressing these challenges. This review provides a comprehensive analysis state-of-the-art nanocarriers such as polymeric nanoparticles, liposomes, hydrogels engineered autoimmune therapies. These are designed degrade safely the body while releasing agents response specific stimuli, including pH, temperature, redox conditions, enzymatic activity. By achieving localized controlled release anti-inflammatory immunosuppressive agents, minimize toxicity enhance efficacy. We discuss underlying mechanisms nanomaterials, recent applications treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, design considerations essential clinical translation. Additionally, we address current challenges, biocompatibility, scalability, regulatory hurdles, well future directions integrating advanced nanotechnology with personalized medicine treatment. highlights transformative potential presenting them promising strategy advance precision improve patient outcomes disease management.

Language: Английский

Citations

2
Transforming Medicine: Cutting-Edge Applications of Nanoscale Materials in Drug Delivery DOI Creative Commons
Rumiana Koynova, Kevin J. Hughes,

Magesh Ganesan

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Since their inception in the early 1960s, development and use of nanoscale materials have progressed tremendously, roles diverse fields ranging from human health to energy electronics are undeniable. The application nanotechnology inventions has revolutionized many aspects everyday life including various medical applications specifically drug delivery systems, maximizing therapeutic efficacy contained drugs by means bioavailability enhancement or minimization adverse effects. In this review, we utilize CAS Content Collection, a vast repository scientific information extracted journal patent publications, analyze trends nanoscience research relevant an effort provide comprehensive detailed picture field. We examine publication landscape area insights into current knowledge advances developments. review major classes nanosized routes, targeted diseases. outline most discussed concepts assess advantages nanocarriers. objective is broad overview evolving regarding challenges, evaluate growth opportunities. merit stems extensive, wide-ranging coverage up-to-date information, allowing unmatched breadth analysis in-depth insights.

Language: Английский

Citations

2
Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts DOI Creative Commons

Zhongsong Zhang,

Long Chen

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 17, 2025

Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.

Language: Английский

Citations

2
Comprehensive insights into mechanism of nanotoxicity, assessment methods and regulatory challenges of nanomedicines DOI Creative Commons
Ujwal Havelikar,

Kabirdas B. Ghorpade,

Amit Kumar

et al.

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: Oct. 4, 2024

Nanomedicine has the potential to transform healthcare by offering targeted therapies, precise diagnostics, and enhanced drug delivery systems. The National Institutes of Health coined term "nanomedicine" describe use nanotechnology in biological system monitoring, control, diagnosis, treatment. continues receive increasing interest for rationalized therapeutics pharmaceutical agents achieve required response while reducing its side effects. However, as advance, concerns about toxicological effects have also grown. This review explores current state nanomedicine, focusing on types nanoparticles used their associated properties that contribute nanotoxicity. It examines mechanisms through which exert toxicity, encompassing various cellular molecular interactions. Furthermore, it discusses assessment methods employed evaluate nanotoxicity, in-vitro in-vivo models, well emerging techniques. addresses regulatory issues surrounding nanotoxicology, highlighting challenges developing standardized guidelines ensuring secure translation nanomedicine into clinical settings. ethical with understanding safety profile is essential effective therapeutic applications.

Language: Английский

Citations

14
Toward the scale-up production of polymeric nanotherapeutics for cancer clinical trials DOI

Md. Musavvir Mahmud,

Nikhil Pandey, Jeffrey A. Winkles

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102314 - 102314

Published: May 18, 2024

Language: Английский

Citations

13
Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases DOI Creative Commons
Adriana Jiménez, Enrique Estudillo, Mara A. Guzmán‐Ruiz

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 281 - 281

Published: Feb. 20, 2025

The blood–brain barrier (BBB) is a critical structure that maintains brain homeostasis by selectively regulating nutrient influx and waste efflux. Not surprisingly, it often compromised in neurodegenerative diseases. In addition to its involvement these pathologies, the BBB also represents significant challenge for drug delivery into central nervous system. Nanoparticles (NPs) have been widely explored as carriers capable of overcoming this effectively transporting therapies brain. However, their potential directly address ameliorate dysfunction has received limited attention. review, we examine how NPs enhance across treat diseases explore emerging strategies restore integrity vital structure.

Language: Английский

Citations

1
Harnessing the immunomodulatory potential of chitosan and its derivatives for advanced biomedical applications DOI
Doğukan Duymaz, Aybaran Olca Kebabci, Seda Kızılel

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142055 - 142055

Published: March 1, 2025

Language: Английский

Citations

1
Application and Safety Research of Nanotechnology in Cosmetics: Current Status, Challenges, and Future Prospects DOI
Xuexue Pan,

Huiru Zhou,

Zhirui Li

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: March 22, 2025

Language: Английский

Citations

1
Advances in treatment strategies based on scavenging reactive oxygen species of nanoparticles for atherosclerosis DOI Creative Commons

Chengxi Wu,

Jingying Mao,

Xueqin Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 17, 2023

Abstract The development of atherosclerosis (AS) is closely linked to changes in the plaque microenvironment, which consists primarily cells that form and associated factors they secrete. onset inflammation, lipid deposition, various pathological cellular metabolism accompany microenvironment will promote AS. Numerous studies have shown oxidative stress an important condition promotes accumulation reactive oxygen species (ROS) stress’s most change. In turn, effects ROS on are complex varied, these ultimately reflected promotion or inhibition This article reviews atherosclerotic plaques their impact disease progression over past five years focuses progress treatment strategies based scavenging nanoparticles for Finally, we also discuss prospects challenges AS treatment.

Language: Английский

Citations

21