Journal of the Serbian Chemical Society,
Journal Year:
2023,
Volume and Issue:
89(7-8), P. 1039 - 1051
Published: Dec. 12, 2023
Inflammation,
a
widespread
biological
process
linked
to
various
diseases,
poses
significant
global
health
challenge.
Recent
research
targeting
the
development
of
new
anti-inflammatory
drugs
has
prioritized
plant-derived
compounds
due
their
cost-effectiveness
and
minimal
side
effects
compared
synthetic
drugs.
Flavonoids,
polyphenolic
in
plants,
show
potential
for
treating
inflammation-related
diseases.
This
study
evaluates
antiinflammatory
activity
flavonoids
from
Knema
genus,
member
Myristicaceae
family.
We
focused
on
inhibiting
two
pro-inflammatory
proteins,
human
murine
interleukin-1B
(IL-1)
interleukin-6
(IL-6).
Molecular
docking
ADMET
prediction
identified
sulfuretin
(?)-catechin
with
high
binding
affinity
IL-6,
whereas
4'-hydroxy-7-methoxyflavanone
7,2'-dihydroxy-6,8-dimethyl-4',5'-methylenedioxyflavan
stably
bind
IL-6.
interaction
analyses
revealed
that
hydrogen
???
bonds
contribute
interaction.
Notably,
these
exhibited
affinities
comparable
celecoxib.
Our
computational
predictions
support
suitability
as
drug
candidates,
indicating
promise
natural
agents
capable
modulating
signaling
pathways.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(8), P. 7646 - 7646
Published: April 21, 2023
Epimedium
(EM),
also
known
as
barrenwort,
is
a
traditional
medicinal
plant
rich
in
isopentenyl
flavonols,
which
have
beneficial
biological
activities
and
can
improve
human
animal
health,
but
its
mechanism
still
unclear.
In
this
study,
ultra-high-performance
liquid
chromatography/quadrupole-time-of-flight-mass
spectrometry
(UHPLC-Q-TOF/MS)
chromatography
triple-quadrupole
mass
(UHPLC-QqQ-MS/MS)
were
used
to
analyse
the
main
components
of
EM,
flavonols
such
Epimedin
A,
B,
C
well
Icariin
major
EM.
Meanwhile,
broilers
selected
model
animals
illuminate
(EMIE)
on
gut
health.
The
results
showed
that
supplementation
with
200
mg/kg
EM
improved
immune
response,
increased
cecum
short-chain
fatty
acids
(SCFAs)
lactate
concentrations,
nutrient
digestibility
broilers.
addition,
16S
rRNA
sequencing
EMIE
altered
composition
cecal
microbiome,
increasing
relative
abundance
bacteria
(Candidatus
Soleaferrea
Lachbospiraceae
NC2004
group
Butyricioccus)
reducing
harmful
(UBA1819,
Negativibacillus,
Eisenbergiella).
Metabolomic
analysis
identified
48
differential
metabolites,
Erosnin
Tyrosyl-Tryptophan
core
biomarkers.
tyrosyl-tryptophan
are
potential
biomarkers
evaluate
effects
EMIE.
This
shows
may
regulate
microbiota
through
Butyricicoccus,
changes
genera
Eisenbergiella
Un.
Peptostreptococcaceae
affecting
serum
metabolite
levels
host.
an
excellent
health
product,
dietary
bioactive
components,
by
altering
structure
plasma
profiles.
study
provides
scientific
basis
for
future
application
diets.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 1956 - 1956
Published: Feb. 6, 2024
Sirtuins
(SIRTs)
belong
to
the
family
of
nicotine
adenine
dinucleotide
(NAD+)-dependent
class
III
histone
deacetylases,
which
come
into
play
in
regulation
epigenetic
processes
through
deacetylation
histones
and
other
substrates.
The
human
genome
encodes
for
seven
homologs
(SIRT1-7),
are
localized
nucleus,
cytoplasm,
mitochondria,
with
different
enzymatic
activities
regulatory
mechanisms.
Indeed,
SIRTs
involved
physio-pathological
responsible
onset
several
illnesses,
such
as
cardiovascular
neurodegenerative
diseases,
obesity
diabetes,
age-related
disorders,
cancer.
Nowadays,
it
is
well-known
that
Citrus
fruits,
typical
Mediterranean
diet,
an
important
source
bioactive
compounds,
polyphenols.
Among
these,
flavonoids
recognized
potential
agents
endowed
a
wide
range
beneficial
properties,
including
antioxidant,
anti-inflammatory,
hypolipidemic,
antitumoral
ones.
On
these
bases,
we
offer
comprehensive
overview
on
biological
effects
exerted
by
via
targeting
SIRTs,
acted
modulator
signaling
pathways.
According
reported
studies,
appear
be
promising
SIRT
modulators
many
pathologies,
role
might
potentially
evaluated
future
therapies,
along
encouraging
study
those
members
still
lack
proper
evidence
their
support.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(23), P. 7837 - 7837
Published: Nov. 29, 2023
Inflammation
plays
an
important
role
in
the
immune
defense
against
injury
and
infection
agents.
However,
inflammatory
chronic
process
may
lead
to
neurodegenerative
diseases,
atherosclerosis,
bowel
or
cancer.
Flavanones
present
citrus
fruits
exhibit
biological
activities,
including
anti-oxidative
anti-inflammatory
properties.
The
beneficial
effects
of
flavanones
have
been
found
based
on
vitro
cell
cultures
animal
studies.
A
suitable
model
for
studying
are
macrophages
(RAW264.7
line)
because,
after
stimulation
using
lipopolysaccharide
(LPS),
they
release
cytokines
involved
response.
We
determined
nitrite
concentration
macrophage
culture
detected
ROS
chemiluminescence.
Additionally,
we
measured
production
selected
Bio-Plex
Magnetic
Luminex
Assay
Bio-PlexTM
200
System.
For
first
time,
shown
that
methyl
derivatives
flavanone
inhibit
NO
chemiluminescence
generated
via
LPS-stimulated
macrophages.
Moreover,
tested
compounds
at
1-20
µM
dose-dependently
modulate
proinflammatory
cytokine
(IL-1β,
IL-6,
IL-12p40,
IL-12p70,
TNF-α)
stimulated
RAW264.7
cells.
2'-methylflavanone
(5B)
3'-methylflavanone
(6B)
possess
strongest
activity
among
all
derivatives.
These
reduce
IL12p70
compared
core
structure.
reduces
TNF-α,
IL-1β
secreted
by
Biochimie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
Traditionally
recognised
as
the
energy
reservoir
and
main
site
of
adaptive
thermogenesis,
white
brown
adipose
tissues
are
complex
endocrine
organs
regulating
systemic
metabolism
via
secretion
bioactive
molecules,
termed
"adipokines"
"batokines",
respectively.
Due
to
its
significant
role
in
whole-body
other
physiological
processes,
tissue
has
been
increasingly
explored
a
feasible
therapeutic
target
for
obesity.
Flavonoids
one
most
plant
polyphenolic
compounds
holding
great
potential
agents
combating
However,
understanding
their
mechanisms
action
remains
largely
insufficient
formulate
theories.
This
review
critically
discusses
scientific
evidence
highlighting
flavonoids
ameliorating
obesity-related
metabolic
complications,
including
dysfunction,
inflammation,
insulin
resistance,
hepatic
steatosis,
cardiovascular
comorbidities
part
by
modulating
release
adipokines
batokines.
Further
discussion
advocates
use
therapeutics
targeting
these
molecules
avenue
developing
effective
treatment
obesity
adverse
diseases
such
type
2
diabetes.
Cardiovascular Therapeutics,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Background:
The
research
is
aimed
at
exploring
the
potential
of
marigold
petal
tea
(MPT),
rich
in
polyphenol
contents,
against
oxidative
stress
and
obesity
a
rat
model
following
high‐fat‐sugar
diet
(HFSD).
Methods:
MPT
was
prepared
through
customary
method
decoction
subjected
to
analysis
for
its
composition
using
reversed‐phase
high‐performance
liquid
chromatography
(RP‐HPLC).
Two
specific
doses
MPT,
namely,
250
500
mg/kg
body
weight
(BW),
were
chosen
study—referred
as
MPT‐250
MPT‐500,
respectively.
Result:
main
phenolic
acids
flavonoids
identified
with
concentrations
exceeding
10
mg/100
mL
tea,
included
catechin,
rutin,
salicylic
acid,
gallic
sinapic
chlorogenic
cinnamic
ellagic
acid.
total
(TP)
flavonoid
(TF)
contents
measured
be
5.53
7.73
mg/g,
Additionally,
demonstrated
57.2%
scavenging
capacity
2,2‐diphenyl‐1‐picrylhydrazyl
radical.
Notably,
administration
higher
dose
(MPT‐500)
showed
significant
reduction
mass
index
(BMI)
51.24%
rate
increase
BW
compared
HFSD
group.
findings
indicated
that
all
treatment
groups,
is,
orlistat
(OT),
MPT‐250,
MPT‐500
experienced
reduced
levels
serum
cholesterol
(TC),
triglyceride
(TG),
markers
lipoproteins
contrast
Moreover,
helped
restore
malondialdehyde
(MDA),
superoxide
dismutase
(SOD),
glutathione
(GSH),
thereby
demonstrating
combating
stress.
group
also
displayed
decreased
liver
kidney
weights
an
improved
atherogenic
when
Conclusion:
results
clearly
indicate
high
dosage
antiobesity
activity
which
comparable
same
effects
produced
by
conventional
drug
orlistat.
Laboratory Animal Research,
Journal Year:
2024,
Volume and Issue:
40(1)
Published: Sept. 5, 2024
Abstract
Ischemic
heart
disease
is
the
most
prevalent
cause
of
death
worldwide
affecting
both
gender
all
age
groups.
The
high
mortality
rate
due
to
damage
myocardial
tissue
that
emanates
at
time
ischemia
and
re-oxygenation,
thus
averting
reperfusion
injury
recognized
as
a
potential
way
reduce
acute
cardiac
subsequent
mortality.
Flavonoids
are
polyphenol
derivatives
plant
origin
empirical
shreds
evidence
substantiate
their
numerous
activities
such
antioxidant,
anti-inflammatory,
anti-apoptotic,
anti-thrombotic
activity,
leading
role
in
cardio
protection.
Recent
investigations
have
unveiled
capacity
flavonoids
impede
pivotal
regulatory
enzymes,
signaling
molecules,
transcription
factors
orchestrate
mediators
participating
inflammatory
cascade.
present
comprehensive
review,
dwells
on
preclinical
studies
effectiveness
from
year
2007
2023,
for
prevention
therapeutics
ischemia-reperfusion
injury.
Graphical
Marine Drugs,
Journal Year:
2024,
Volume and Issue:
22(9), P. 412 - 412
Published: Sept. 10, 2024
Cyanobacteria
are
rich
producers
of
secondary
metabolites,
excreting
some
these
to
the
culture
media.
However,
exometabolome
cyanobacteria
has
been
poorly
studied,
and
few
studies
have
dwelled
on
its
characterization
bioactivity
assessment.
In
this
work,
exometabolomes
56
cyanobacterial
strains
were
characterized
by
HR-ESI-LC-MS/MS.
Cytotoxicity
was
assessed
two
carcinoma
cell
lines,
HepG2
HCT116,
while
reduction
in
lipids
tested
zebrafish
larvae
a
steatosis
model
with
fatty
acid-overloaded
human
liver
cells.
The
analysis
using
GNPS
revealed
many
complex
clusters
unique
compounds
several
strains,
no
identifications
public
databases.
Three
reduced
viability
HCT116
cells,
namely
Tolypotrichaceae
BACA0428
(30.45%),
Aphanizomenonaceae
BACA0025
(40.84%),
Microchaetaceae
BACA0110
(46.61%).
Lipid
only
observed
exposure
