Molecules,
Journal Year:
2024,
Volume and Issue:
29(4), P. 865 - 865
Published: Feb. 15, 2024
The
biochemical
characteristics
of
polyphenols
contribute
to
their
numerous
advantageous
impacts
on
human
health.
existing
research
suggests
that
plant
phenolics,
whether
consumed
orally
or
applied
directly
the
skin,
can
be
beneficial
in
alleviating
symptoms
and
avoiding
development
many
skin
disorders.
Phenolic
compounds,
which
are
both
harmless
naturally
present,
exhibit
significant
potential
terms
counteracting
effects
damage,
aging,
diseases,
wounds,
burns.
Moreover,
play
a
preventive
role
possess
ability
delay
progression
several
disorders,
ranging
from
small
discomforting
severe
potentially
life-threatening
ones.
This
article
provides
concise
overview
recent
therapeutic
application
for
conditions.
It
specifically
highlights
studies
have
investigated
clinical
trials
use
polyphenol-based
nanoformulations
treatment
different
ailments.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(9), P. 1109 - 1109
Published: Sept. 13, 2024
Oxidative
stress
is
the
result
of
imbalance
between
reactive
oxygen
and
nitrogen
species
(RONS),
which
are
produced
by
several
endogenous
exogenous
processes,
antioxidant
defenses
consisting
molecules
that
protect
biological
systems
from
free
radical
toxicity.
a
major
factor
in
aging
process,
contributing
to
accumulation
cellular
damage
over
time.
biomolecules,
leads
DNA
alterations,
lipid
peroxidation,
protein
oxidation,
mitochondrial
dysfunction
resulting
senescence,
immune
system
tissue
dysfunctions,
increased
susceptibility
age-related
pathologies,
such
as
inflammatory
disorders,
cardiovascular
neurodegenerative
diseases,
diabetes,
cancer.
stress-driven
mutations,
or
methylation
histone
modification,
alter
gene
expression,
key
determinants
tumor
initiation,
angiogenesis,
metastasis,
therapy
resistance.
Accumulation
genetic
epigenetic
damage,
oxidative
contributes,
eventually
unrestrained
cell
proliferation,
inhibition
differentiation,
evasion
death,
providing
favorable
conditions
for
tumorigenesis.
Colorectal,
breast,
lung,
prostate,
skin
cancers
most
frequent
aging-associated
malignancies,
implicated
their
pathogenesis
behavior.
Our
aim
shed
light
on
molecular
mechanisms
link
stress,
aging,
cancers,
highlighting
impact
both
RONS
antioxidants,
provided
diet
exercise,
immunity,
development
an
antitumor
response.
The
dual
role
ROS
physiological
regulators
signaling
responsible
well
its
use
anti-tumor
therapeutic
purposes,
will
also
be
discussed.
Managing
crucial
promoting
healthy
reducing
risk
tumors.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(10), P. 2292 - 2292
Published: May 12, 2023
Natural
products
have
proven
their
value
as
drugs
that
can
be
therapeutically
beneficial
in
the
treatment
of
various
diseases.
However,
most
natural
low
solubility
and
poor
bioavailability,
which
pose
significant
challenges.
To
solve
these
issues,
several
drug
nanocarriers
been
developed.
Among
methods,
dendrimers
emerged
vectors
for
due
to
superior
advantages,
such
a
controlled
molecular
structure,
narrow
polydispersity
index,
availability
multiple
functional
groups.
This
review
summarizes
current
knowledge
on
structures
dendrimer-based
compounds,
with
particular
focus
applications
alkaloids
polyphenols.
Additionally,
it
highlights
challenges
perspectives
future
development
clinical
therapy.
Oncogene,
Journal Year:
2023,
Volume and Issue:
42(46), P. 3371 - 3384
Published: Oct. 17, 2023
Abstract
Epithelial
tissue
homeostasis
is
closely
associated
with
the
self-renewal
and
differentiation
behaviors
of
epithelial
stem
cells
(ESCs).
p63,
a
well-known
marker
ESCs,
an
indispensable
factor
for
their
biological
activities
during
development.
The
diversity
p63
isoforms
expressed
in
distinct
tissues
allows
this
transcription
to
have
wide
array
effects.
coordinates
genes
involved
cell
survival,
self-renewal,
migration,
differentiation,
epithelial-to-mesenchymal
transition.
Through
regulation
these
processes,
contributes
to,
not
only
normal
development,
but
also
epithelium-derived
cancer
pathogenesis.
In
review,
we
provide
overview
role
stemness
regulation,
including
proliferation,
senescence.
We
describe
differential
expression
TAp63
ΔNp63
functional
tumors.
Furthermore,
summarize
signaling
cascades
modulating
as
well
downstream
pathways
regulation.
Biology,
Journal Year:
2023,
Volume and Issue:
12(11), P. 1396 - 1396
Published: Nov. 2, 2023
With
its
unique
anatomical
location
facing
both
the
external
and
internal
environment,
skin
has
crucial
functions,
including
shielding
body
from
damage
caused
by
ultraviolet
radiation
chemicals,
preventing
water
loss,
acting
as
a
primary
barrier
against
pathogens,
participating
in
metabolic
processes
like
vitamin
D
production
temperature
control
relaying
information
to
through
sensory
proprioceptor
nerves.
Like
all
organ
systems,
is
known
undergo
multiple
changes
with
aging.
A
better
understanding
of
mechanisms
that
mediate
aging-related
dysfunction
may
allow
creation
targeted
therapeutics
have
beneficial
effects
not
only
on
aged
but
also
other
organs
tissues
experience
loss
or
decline
function
The
largest
can
contribute
serum
inflammatory
mediator
levels.
One
alteration
occur
age
an
impairment
function;
since
disruption
induce
inflammation,
be
major
contributor
sustained,
sub-clinical
systemic
inflammation
associated
Such
“inflamm-aging”
underlie
many
deleterious
observed
individuals.
This
review
explores
role
age-related
changes,
inflamm-aging.
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(11), P. 1600 - 1600
Published: Oct. 31, 2023
Aging
is
a
natural
and
inescapable
phenomenon
characterized
by
progressive
deterioration
of
physiological
functions,
leading
to
increased
vulnerability
chronic
diseases
death.
With
economic
medical
development,
the
elderly
population
gradually
increasing,
which
poses
great
burden
society,
economy
field.
Thus,
healthy
aging
has
now
become
common
aspiration
among
people
over
world.
Accumulating
evidence
indicates
that
substances
can
mediate
deteriorated
processes
are
highly
likely
have
potential
prolong
lifespan
improve
aging-associated
diseases.
Foods
from
sources
full
bioactive
compounds,
such
as
polysaccharides,
polyphenols,
carotenoids,
sterols,
terpenoids
vitamins.
These
compounds
their
derivatives
been
shown
be
able
delay
and/or
diseases,
thereby
prolonging
lifespan,
via
regulation
various
processes.
Here,
we
summarize
current
understanding
anti-aging
activities
vitamins
food
sources,
modes
action
in
delaying
improving
This
will
certainly
provide
reference
for
further
research
on
effects
sources.
PeerJ,
Journal Year:
2025,
Volume and Issue:
13, P. e18818 - e18818
Published: Jan. 14, 2025
Background
Psoriasis
is
a
chronic
inflammatory
skin
disease
affecting
2–3%
of
the
global
population,
characterised
by
red
scaly
patches
that
significantly
affect
patients’
quality
life.
Recent
studies
have
suggested
cell
senescence,
state
in
which
cells
cease
to
divide
and
secrete
mediators,
plays
critical
role
various
diseases,
including
psoriasis.
However,
involvement
mechanisms
action
senescence-related
genes
psoriasis
remain
unclear.
Methods
This
study
aimed
identify
associated
with
explore
their
molecular
mechanisms.
RNA
sequencing
data
from
control
samples
were
obtained
GEO
database.
Differential
expression
analysis
was
performed
using
DESeq2
differentially
expressed
(DEGs).
The
intersection
DEGs
CellAge
database
used
candidate
genes.
Protein-protein
interaction
networks,
Gene
Ontology,
Kyoto
Encyclopaedia
Genes
Genomes
(KEGG)
pathway
enrichment
analyses
conducted
functions
pathways
these
Machine
learning
algorithms,
Least
Absolute
Shrinkage
Selection
Operator
(LASSO)
regression
Support
vector
machine-recursive
feature
elimination
(SVE-RFE),
select
validated
qRT-PCR.
Additionally,
an
immune
infiltration
understand
roles
response
Results
identified
4,913
psoriasis,
46
related
senescence.
highlighted
four
key
genes,
CXCL1,
ID4,
CCND1,
IRF7,
as
significant.
These
qRT-PCR,
suggesting
potential
therapeutic
targets
for
Conclusions
involved
providing
insights
into
offering
foundation
developing
targeted
therapies
