Recent Advancements in Bone Tissue Engineering: Integrating Smart Scaffold Technologies and Bio-Responsive Systems for Enhanced Regeneration

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6012 - 6012

Published: May 30, 2024

In exploring the challenges of bone repair and regeneration, this review evaluates potential tissue engineering (BTE) as a viable alternative to traditional methods, such autografts allografts. Key developments in biomaterials scaffold fabrication techniques, additive manufacturing cell bioactive molecule-laden scaffolds, are discussed, along with integration bio-responsive which can respond physical chemical stimuli. These advancements collectively aim mimic natural microenvironment bone, thereby enhancing osteogenesis facilitating formation new tissue. Through comprehensive combination vitro vivo studies, we scrutinize biocompatibility, osteoinductivity, osteoconductivity these engineered well their interactions critical cellular players healing processes. Findings from techniques scaffolds indicate that incorporating nanostructured materials compounds is particularly effective promoting recruitment differentiation osteoprogenitor cells. The therapeutic advanced clinical settings widely recognized paper advocates continued research into multi-responsive systems.

Language: Английский

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Chitosan as a tool for tissue engineering and rehabilitation: Recent developments and future perspectives – A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134172 - 134172

Published: Aug. 5, 2024

Language: Английский

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An Overview on the Big Players in Bone Tissue Engineering: Biomaterials, Scaffolds and Cells

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3836 - 3836

Published: March 29, 2024

Presently, millions worldwide suffer from degenerative and inflammatory bone joint issues, comprising roughly half of chronic ailments in those over 50, leading to prolonged discomfort physical limitations. These conditions become more prevalent with age lifestyle factors, escalating due the growing elderly populace. Addressing these challenges often entails surgical interventions utilizing implants or grafts, though treatments may entail complications such as pain tissue death at donor sites for along immune rejection. To surmount challenges, engineering has emerged a promising avenue injury repair reconstruction. It involves use different biomaterials development three-dimensional porous matrices scaffolds, alongside osteoprogenitor cells growth factors stimulate natural regeneration. This review compiles methodologies that can be used develop are important replacement Biomaterials orthopedic implants, several scaffold types production methods, well techniques assess biomaterials’ suitability human use—both laboratory settings within living organisms—are discussed. Even researchers have had some success, there is still room improvements their processing techniques, especially ones make scaffolds mechanically stronger without weakening biological characteristics. Bone therefore area rise bone-related injuries.

Language: Английский

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Fabrication Strategies for Bioceramic Scaffolds in Bone Tissue Engineering with Generative Design Applications

Biomimetics, Journal Year: 2024, Volume and Issue: 9(7), P. 409 - 409

Published: July 5, 2024

The aim of this study is to provide an overview the current state-of-the-art in fabrication bioceramic scaffolds for bone tissue engineering, with emphasis on use three-dimensional (3D) technologies coupled generative design principles. field modern medicine has witnessed remarkable advancements and continuous innovation recent decades, driven by a relentless desire improve patient outcomes quality life. Central progress which holds immense promise regenerative applications. Scaffolds are integral engineering serve as 3D frameworks that support cell attachment, proliferation, differentiation. A wide array materials been explored scaffolds, including bioceramics (i.e., hydroxyapatite, beta-tricalcium phosphate, bioglasses) bioceramic–polymer composites, each offering unique properties functionalities tailored specific Several methods, such thermal-induced phase separation, electrospinning, freeze-drying, gas foaming, particle leaching/solvent casting, fused deposition modeling, printing, stereolithography selective laser sintering, will be introduced thoroughly analyzed discussed from point view their characteristics, have proven invaluable obtaining scaffolds. Moreover, highlighting important role scaffold optimization, review seeks pave way development innovative strategies personalized solutions address significant gaps literature, mainly related complex defects engineering.

Language: Английский

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Recent advances in biomaterials for tissue-engineered constructs: Essential factors and engineering techniques

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 37, P. 102016 - 102016

Published: April 1, 2024

Tissue-engineered constructs can replicate the structural and physiological properties of natural tissues. The be designed to address transplantation issues affected by shortage donor tissues organs. One major concerns in tissue engineering is design development structures that improve interaction between materials cells provide an ideal platform for form functional tissue. Several contributing factors need considered fabricate constructs, including biomaterials, biological, topographical, biophysical, morphological either alone or combination. Here, we review application, advancement, future directions these essential designing developing regeneration. In particular, focus on original approaches tools construct parameters engineering.

Language: Английский

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Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2809 - 2809

Published: Feb. 28, 2024

This review focuses on the latest advancements in magnetic hydroxyapatite (mHA) nanoparticles and their potential applications nanomedicine regenerative medicine. mHA have gained significant interest over last few years for great potential, offering advanced multi-therapeutic strategies because of biocompatibility, bioactivity, unique physicochemical features, enabling on-demand activation control. The most relevant synthetic methods to obtain apatite-based materials, either form iron-doped HA showing intrinsic properties or composite/hybrid compounds between superparamagnetic metal oxide nanoparticles, are described as highlighting structure–property correlations. Following this, this discusses application various nanomaterials bone regeneration nanomedicine. Finally, novel perspectives investigated with respect ability improve nanocarriers homogeneous structures promote multifunctional biological applications, such cell stimulation instruction, antimicrobial activity, drug release triggering.

Language: Английский

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Magnesium-based alloys with adapted interfaces for bone implants and tissue engineering

Regenerative Biomaterials, Journal Year: 2023, Volume and Issue: 10

Published: Jan. 1, 2023

Magnesium and its alloys are one of the most used materials for bone implants tissue engineering. They characterized by numerous advantages such as biodegradability, high biocompatibility mechanical properties with values close to human bone. Unfortunately, implant surface must be adequately tuned, or Mg-based alloyed other chemical elements due their increased corrosion effect in physiological media. This article reviews clinical challenges related repair regeneration, classifying defects presenting some modern therapies injuries, Ilizarov Masquelet techniques stem cell treatments. The interface new formation fracture healing, degradation hydrogen release. A detailed analysis during is extensively described based on different literature studies that included vitro vivo tests correlated material properties’ characterization. trauma plates screws, intramedullary nails, Herbert spine cages, rings joint treatment regenerative scaffolds presented, taking into consideration manufacturing technology, geometrical dimensions shape, type localization. Modern technologies modify adapt interfaces main microstructural modifications, physical deposition conversion coatings. last part provides recommendations from a translational perspective, identifies associated presents future opportunities. review outlines available describes control alloy rate cellular environment implant.

Language: Английский

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Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering

Computation, Journal Year: 2024, Volume and Issue: 12(4), P. 74 - 74

Published: April 4, 2024

Three-dimensional porous scaffolds are substitutes for traditional bone grafts in tissue engineering (BTE) applications to restore and treat injuries defects. The use of computational modelling is gaining momentum predict the parameters involved healing cell seeding procedures perfusion bioreactors reach final goal optimal growth. Computational based on finite element method (FEM) fluid dynamics (CFD) two standard methodologies utilised investigate equivalent mechanical properties scaffolds, as well flow characteristics inside respectively. success a simulation hinges selection relevant mathematical model with proper initial boundary conditions. This review paper aims provide insights researchers regarding appropriate (FE) models different materials CFD regimes bioreactors. Thus, these FEM/CFD may help create efficient designs by predicting their structural haemodynamic responses prior vitro vivo (TE) applications.

Language: Английский

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One‐dimensional nanomaterials for nerve tissue engineering to repair spinal cord injury

BMEMat, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 2, 2024

Abstract In recent years, tissue engineering has emerged as a cutting‐edge approach for the treatment of spinal cord injury (SCI) owing to its remarkable capabilities. It can create living tissues with robust vitality, achieve maximal repair minimal cell usage, and facilitate seamless reconstruction unmatched plasticity, all while addressing immune rejection issues. Among these advancements, one‐dimensional (1D) materials have garnered significant attention. Their morphology closely resembles extracellular matrix environment, thereby fostering elongation dendrites axons on neurons greatly enhancing prospects SCI repair. With keen focus latest advancements in application 1D nanomaterials nerve repair, this review delves into several key aspects. Firstly, it explores “bottom‐up” synthesizing nanomaterials. Secondly, examines mechanisms by which influence neural engineering. Thirdly, presents various strategies aimed at optimizing performance materials, efficiency Lastly, discusses current challenges future facing fascinating field. We aspire that comprehensive will provide profound understanding development inspire wider audience potential.

Language: Английский

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Experimental investigation of PCL‐based composite material fabricated using solvent‐cast 3D printing process

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(5)

Published: May 1, 2024

Abstract Bone tissue engineering relies on scaffolds with enhanced mechanical properties, achievable through 3D printing techniques. Our study focuses enhancing properties using a solvent‐cast method. For this, poly‐ε‐caprolactone (PCL) reinforced polyhydroxybutyrate (PHB), and synthetic fluorapatite (FHAp) nanopowders were utilized, immersed in solution of dichloromethane (DCM) dimethylformamide (DMF). Sol–gel method was used to synthesized FHAp, the XRD pattern confirmed crystalline FHAp presence, notable peaks at 2 θ values 31.937°, 33.128°, 32.268°, 25.864°. Moreover, composites exhibited nonchemical PCL‐PHB/FHAp interactions, PHB crystallographic planes evident. Surface roughness, assessed via RMS values, showed progressive increases higher content. Tensile strength peaked 19% wt/v PHB, varied effects FHAp. Compressive reached its apex 30% content consistently strength. Flexural notably increased peaking wt/v, further Young's modulus rose both Hardness Cell viability improved showing responses Hemocompatibility evaluations indicated low hemolysis percentages, especially balanced PHB/FHAp compositions. These findings highlight crucial role composite compositions tailoring biological for optimal bone scaffold design, promising advancements regeneration technologies.

Language: Английский

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