A‐type proanthocyanidins: Sources, structure, bioactivity, processing, nutrition, and potential applications

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(3)

Published: April 18, 2024

A-type proanthocyanidins (PAs) are a subgroup of PAs that differ from B-type by the presence an ether bond between two consecutive constitutive units. This additional C-O-C gives them more stable and hydrophobic character. They increasing interest due to their potential multiple nutritional effects with low toxicity in food processing supplement development. have been identified several plants. However, role PAs, especially complex polymeric form (degree polymerization linkage), has not specifically discussed explored. Therefore, recent advances physicochemical structural changes functional properties during extraction, processing, storing evaluated. In addition, discussions on sources, structures, bioactivities, applications industry, future research trends derivatives highlighted. Litchis, cranberries, avocados, persimmons all favorable plant sources. Α-type contribute directly or indirectly human nutrition via regulation different degrees bonding types. Thermal could negative impact amount structure matrix. More attention should be focused nonthermal technologies better preserve architecture structure. The diversity complexity these compounds, as well difficulty isolating purifying natural remain obstacles further applications. received widespread acceptance industry but yet achieved maximum for food. Further development therefore needed.

Language: Английский

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The Brain–Gut–Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects

Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)

Published: Aug. 9, 2024

Neurodegenerative diseases are global health challenges characterized by the progressive degeneration of nerve cells, leading to cognitive and motor impairments. The brain-gut-bone axis, a complex network that modulates multiple physiological systems, has gained increasing attention owing its profound effects on occurrence development neurodegenerative diseases. No comprehensive review been conducted clarify triangular relationship involving axis potential for innovative therapies disorders. In light this, new perspective is aimed propose interplay between brain, gut, bone highlighting their dynamic communication in diseases, as they modulate including nervous, immune, endocrine, metabolic systems. Therapeutic strategies maintaining balance brain regulation, intestinal microbiota improving skeletal health, also explored. intricate interactions within pose challenge effective treatments can comprehensively target this system. Furthermore, safety these requires further evaluation. This offers novel insights prevention treatment which have important implications clinical practice patient well-being.

Language: Английский

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Dietary proanthocyanidins for improving gut immune health

Current Opinion in Food Science, Journal Year: 2024, Volume and Issue: 56, P. 101133 - 101133

Published: Feb. 2, 2024

Language: Английский

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Dietary supplementation with proanthocyanidins and rutin alleviates the symptoms of type 2 diabetes mice and regulates gut microbiota

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Obesity and high fasting blood glucose (FBG) resulting from high-fat diets (HFDs) have emerged as significant public health concerns, garnering increasing attention. Recently, gut microbiota has been linked with metabolic diseases such type 2 diabetes (T2DM), its mediating role in dietary supplements confirmed. Seeking various to lose body weight (BW) decrease FBG explaining the underlying mechanism become research hotspots T2DM studies. In this study, rutin proanthocyanidins (PA) were selected (200 mg/kg × day, oral gavage, 6 weeks) mice induced HFD assess their efficacy loss, reduction, alterations, associated mechanisms. Our findings indicate that was more effective than PA relieving inflammation fat hypertrophy, although both significantly reduced BW within weeks after intervention. Analysis of 16S rRNA amplicons revealed substantial alterations microbial community composition administered compared HFD-fed mice. Importantly, several core microbes, particularly a series probiotics, Akkermansia, Lactococcus, Odoribacter, Faecalibaculum, Roseburia identified, which correlated changes FBG. Overall, our study highlights can reduce BW, FBG, by modulating composition, providing novel perspectives for managing treating concerns obesity patients through clinical treatment.

Language: Английский

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Exploring the potential of apple (poly)phenols: A systematic review of randomized controlled trials on metabolic diseases prevention

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: 147, P. 104419 - 104419

Published: March 6, 2024

Language: Английский

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Natural products for gastric carcinoma prevention and treatment: Focus on their antioxidant stress actions in the Correa's cascade

Phytomedicine, Journal Year: 2023, Volume and Issue: 123, P. 155253 - 155253

Published: Dec. 2, 2023

Language: Английский

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Multi-Omics Analysis to Understand the Effects of Dietary Proanthocyanidins on Antioxidant Capacity, Muscle Nutrients, Lipid Metabolism, and Intestinal Microbiota in Cyprinus carpio

Antioxidants, Journal Year: 2023, Volume and Issue: 12(12), P. 2095 - 2095

Published: Dec. 10, 2023

Proanthocyanidins (Pros), a natural polyphenolic compound found in grape seed and other plants, have received significant attention as additives animal feed. However, the specific mechanism by which Pros affect fish health remains unclear. Therefore, aim of this study was to investigate potential effects dietary Pro on common carp evaluating biochemical parameters multi-omics analysis. The results showed that supplementation improved antioxidant capacity contents polyunsaturated fatty acids (n-3 n-6) several bioactive compounds. Transcriptomic analysis demonstrated caused an upregulation sphingolipid catabolic process lysosome pathway, while simultaneously downregulating intestinal cholesterol absorption PPAR signaling pathway intestines. Compared normal control (NC) group, group exhibited higher diversity microbiota increased relative abundance Cetobacterium Pirellula. Furthermore, had lower Firmicutes/Bacteroidetes ratio decreased potentially pathogenic bacteria. Collectively, ability, muscle nutrients, composition microbiota. regulation lipid metabolism improvement nutrients were linked with changes

Language: Английский

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Antioxidative Effects of Black Currant and Cornelian Cherry Juices in Different Tissues of an Experimental Model of Metabolic Syndrome in Rats

Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1148 - 1148

Published: May 24, 2023

A Western-style diet, rich in fat and simple sugars, is the main risk factor for a significant number of chronic diseases disorders, as well progression metabolic syndrome (MetS). One key mechanisms involved MetS development increased oxidative stress caused by accumulation body fat. Some dietary polyphenols have shown protective role preventing oxidative-stress-induced damage. We investigated difference response plasma, liver, visceral adipose tissue rats fed with high-fat high-fructose (HFF) diet ten weeks, effectiveness polyphenol-rich juices (black currant (BC) cornelian cherry (CC)) HFF-diet-induced prevention. The most prominent impact HFF on redox parameters was recorded whereas showed potent protection against stress. Consumption both decreased advanced oxidation protein product (AOPP) level paraoxonase1 (PON1) activity significantly total status (TOS) tissue. BC exerted stronger antioxidative potential than CC superoxide anion radical (O2•-) liver. It also reduced TOS, (TAS), malondialdehyde (MDA) concentration multiple linear regression analysis has that best predictors development, estimated through increase adiposity, were dismutase (SOD), AOPP, TAS. consumption may provide convenient approach systemic reduction parameters.

Language: Английский

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Arbuscular mycorrhizal fungi acting as biostimulants of proanthocyanidins accumulation – What is there to know?

Rhizosphere, Journal Year: 2023, Volume and Issue: 27, P. 100762 - 100762

Published: July 28, 2023

Language: Английский

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Supplementation with a cranberry extract favors the establishment of butyrogenic guilds in the human fermentation SHIME system

Microbiome Research Reports, Journal Year: 2024, Volume and Issue: 3(3)

Published: June 14, 2024

Proanthocyanidins (PAC) and oligosaccharides from cranberry exhibit multiple bioactive health properties persist intact in the colon post-ingestion. They display a complex bidirectional interaction with microbiome, which varies based on both time specific regions of gut; nature this remains inadequately understood. Therefore, we aimed to investigate impact extract gut microbiota ecology function.

Language: Английский

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