DELETED, Journal Year: 2025, Volume and Issue: unknown
Published: June 5, 2025
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3835 - 3835
Published: March 29, 2024
Antimicrobial peptides (AMPs), as immune effectors synthesized by a variety of organisms, not only constitute robust defense mechanism against broad spectrum pathogens in the host but also show promising applications effective antimicrobial agents. Notably, insects are significant reservoirs natural AMPs. However, complex array variations types, quantities, activities, and production pathways AMPs, well evolution AMPs across insect species, presents challenge for immunity system understanding AMP applications. This review covers discoveries, classification, common properties, mechanisms action. Additionally, activities immune-related each model summarized. We conducted first comprehensive investigation into diversity, distribution, 20 types insects, employing phylogenetic analysis to describe their evolutionary relationships shed light on conserved distinctive families. Furthermore, we summarize regulatory through classical signaling additional associated with Nitric Oxide, insulin-like signaling, hormones. advances our guardians systems unlocks gateway resources, facilitating use address food safety concerns.
Language: Английский
Citations
15
Published: March 5, 2024
Antimicrobial Peptides (AMPs), as immune effectors synthesized by a variety of organisms, not only constitute robust defense mechanism against broad spectrum pathogens in the host, but also show promising applications effective antimicrobial agents. Notably, insects are significant reservoirs natural AMPs. However, complex array variations types, quantities, activities, production pathways AMPs, and evolution AMPs across insect species presents challenge for immunity system understanding AMP applications. This review covers discoveries, classification, common properties, mechanisms action. Additionally, we summarize activities im-mune-related each model insect. We conducted first comprehensive investigation into diversity, distribution, 20 types insects, employing phylogenetic analysis to describe their evolutionary relationships shed light on conserved distinctive families. Furthermore, regulatory through classical signaling additional associated with Nitric Oxide, insulin-like signaling, hormones. advances our guardians unlocks gateway resources, facilitating use address food safety concerns.
Language: Английский
Citations
7
Parasites & Vectors, Journal Year: 2025, Volume and Issue: 18(1)
Published: Feb. 3, 2025
Abstract Background Tick hemolymph is a sterile fluid that carries nutrients to maintain tick health. The creates hostile environment for invaders including the destruction of microorganisms by its circulating hemocytes. However, Babesia parasites escape and disseminate other organs through continue their transmission life cycle. Still, it unknown how hemocytes respond B. bovis or bigemina infection. In this study, we conducted transcriptomic analysis from female Rhipicephalus microplus ticks infected with understand gene expression changes during parasite Methods During acute infection, R. were fed on bovines acquire parasites. Engorged females collected incubated develop kinetes in hemolymph. was examined identify highly kinetes. Hemocyte cells replete perform high-throughput RNA-sequencing (RNA-Seq) analysis. Results This study identified major profile main groups hemocyte genes altered infection associated metabolism, immunity, cytoskeletal rearrangement. Upregulated mainly involved defense mechanisms, while downregulated related cell proliferation apoptosis. varied among species’ infections, reflected occurred tick’s physiology, growth, reproduction, skeletal muscle development. Conclusions differential revealed regulated upon apoptosis, development, reproduction. Additional research necessary further define exhibited varying levels findings will enhance our understanding survive perpetuate cycle, ultimately contributing spread bovine babesiosis. Graphical
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(8), P. 2091 - 2091
Published: Aug. 6, 2023
Membrane-active peptides (MAPs) possess unique properties that make them valuable tools for studying membrane structure and function promising candidates therapeutic applications. This review paper provides an overview of the fundamental aspects MAPs, focusing on their interaction mechanisms potential MAPs exhibit various structural features, including amphipathic structures specific amino acid residues, enabling selective with multiple membranes. Their action involve disrupting lipid bilayers through different pathways, depending peptide composition. The is significant. They have demonstrated antimicrobial activity against bacteria fungi, making alternatives to conventional antibiotics. can selectively target cancer cells induce apoptosis, opening new avenues in therapeutics. Additionally, serve as drug delivery vectors, facilitating transport cargoes across cell represent a fascinating class biomolecules significant basic research clinical Understanding designing enhanced selectivity efficacy will further expand utility diverse fields. Exploring holds promise developing novel strategies infections, cancer, challenges.
Language: Английский
Citations
14
Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 379(1901)
Published: March 18, 2024
Interactions between animals and microbes are ubiquitous in nature strongly impact animal physiology. These interactions shaped by the host immune system, which responds to infections contributes tailor associations with beneficial microorganisms. In many insects, symbiotic not only include gut commensals, but also intracellular bacteria, or endosymbionts. Endosymbionts housed within specialized cells, bacteriocytes, transmitted vertically across generations. Host–endosymbiont co-evolution shapes endosymbiont genome fights against microbial intruders, ensures preservation of endosymbionts control their load location. The cereal weevil Sitophilus spp. is a remarkable model study evolutionary adaptation system endosymbiosis owing its binary association unique, relatively recently acquired nutritional endosymbiont, Sodalis pierantonius . This Gram-negative bacterium has experienced size shrinkage observed long-term endosymbioses retained immunogenicity. We focus here on sixteen antimicrobial peptides (AMPs) identified oryzae expression patterns different tissues, along development upon challenges, address potential functions defensive response homeostasis insect life cycle. article part theme issue ‘Sculpting microbiome: how factors determine respond colonization’.
Language: Английский
Citations
5
Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e29874 - e29874
Published: April 18, 2024
Ischemia‒reperfusion (I/R) injury is a frequently observed complication after flap surgery, and it affects skin survival patient prognosis. Currently, there are no proven safe effective treatment options to treat I/R injury. Herein, the potential efficacies of bioactive peptide from maggots (BPM), as well its underlying mechanisms, were explored in rat model LPS- or H
Language: Английский
Citations
5
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(5), P. 167192 - 167192
Published: April 22, 2024
Several mutations in the SOD1 gene encoding for antioxidant enzyme Superoxide Dismutase 1, are associated with amyotrophic lateral sclerosis, a rare and devastating disease characterized by motor neuron degeneration patients' death within 2–5 years from diagnosis. Motor loss related symptomatology manifest mostly adult life and, to date, there is still gap of knowledge on precise cellular molecular events preceding neurodegeneration. To deepen our awareness early phases disease, we leveraged two Drosophila melanogaster models pan-neuronally expressing either mutation A4V or G85R human (hSOD1A4V hSOD1G85R). We demonstrate that pan-neuronal expression hSOD1A4V hSOD1G85R pathogenic construct impairs survival performance transgenic flies. Moreover, protein transcript analysis fly heads indicates mutant hSOD1 induction stimulates glial marker Repo, up-regulates IMD/Toll immune pathways through antimicrobial peptides interferes oxidative metabolism. Finally, cytological larval brains demonstrates hSOD1-induced chromosome aberrations. Of note, these parameters found modulated timeframe when neurodegeneration not detected. The novelty work twofold: have expressed first time all neurons confirmed some ALS-related pathological phenotypes flies, confirming power generating ALS-like phenotypes. pathogenesis aberrations up-regulation. These findings were unexplored SOD1-ALS field.
Language: Английский
Citations
5
Current Opinion in Insect Science, Journal Year: 2023, Volume and Issue: 58, P. 101054 - 101054
Published: May 18, 2023
Language: Английский
Citations
11
Parasitology Research, Journal Year: 2023, Volume and Issue: 123(1)
Published: Dec. 6, 2023
Language: Английский
Citations
11
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 330, P. 118215 - 118215
Published: April 17, 2024
Language: Английский
Citations
4