Levels of neurotrophins in the brain of female rats in an experimental model of malignant tumor growth under conditions of hypothyroidism DOI Creative Commons
Е. И. Сурикова, E. M. Frantsiyants, В. А. Бандовкина

et al.

Research and Practical Medicine Journal, Journal Year: 2023, Volume and Issue: 10(3), P. 43 - 54

Published: Aug. 11, 2023

Objective . Studying the levels of brain-derived neurotrophic factor (BDNF), nerve growth (NGF-β), and neurotrophin 3 (NT3) in cerebral cortex subcortical substance female rats an experimental model extracerebral malignant tumor under conditions induced hypothyroidism. Materials methods An experiment was performed on 47 white non-linear rats: 10 each intact group, control group 1 (induced hypothyroidism), 2 (subcutaneous Guerin’s carcinoma), main (combination pathologies); 7 with subcutaneous to assess life expectancy. Hypothyroidism by per os administration thiamazole (mercazolil, Akrikhin, Russia), daily dose 2.5 mg/100 g body weight, course 30 days; total thyroxine thyroid stimulating hormone were determined blood serum RIA (Immunotech, Czech Republic). When persistent hypothyroidism achieved, carcinoma transplanted skin as standard. Aſter decapitation 18th day aſter transplantation, content BDNF, NGF-β, NT3 (R&D System, RayBiotech, USA) % homogenates subcortex brain USA). Results In groups 2, level BDNF 2.6- 1.6-fold lower, respectively, NGF-β 2.2-fold higher average than group. 3.0- lower substance, respectively. matter 2.4-fold 3.1-fold, only 1.7 times, values being intermediate between corresponding 2. Conclusion Changes all neurotrophins most pronounced cortex, while independent growth, changed most. pathologies combined, altered substance. Apparently, there is interaction CNS changes balance regulatory signals areas brain, that reflecting connection biological characteristics active or inhibited (in presence hypothyroidism) growth.

Language: Английский

The role of cytokines as predictors for NAFLD-related diseases: a bidirectional Mendelian randomization study DOI

Yijia He,

Miaomin Ye,

Yin Xia

et al.

Clinics and Research in Hepatology and Gastroenterology, Journal Year: 2025, Volume and Issue: unknown, P. 102545 - 102545

Published: Feb. 1, 2025

Language: Английский

Citations

1
Itch: from the skin to the brain – peripheral and central neural sensitization in chronic itch DOI Creative Commons
Omar Mahmoud, Olusola O. Oladipo, Rami H. Mahmoud

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: Oct. 2, 2023

Similar to chronic pain, itch is frequently linked neural sensitization, a phenomenon wherein the nervous system becomes hypersensitive stimuli. This process of sensitization orchestrated by various signaling pathways and mediators in both peripheral central systems. At level system, inflammation neuroimmune interactions induce plastic changes nerve fibers, thereby amplifying transmission signaling. Neural occurs at spinal cord brain levels. cord, it involves hyperactivity itch-activating pathways, dysfunction inhibitory circuits, attenuation descending supraspinal pathways. In brain, manifests as structural functional itch-associated areas networks. Currently, we have diverse array neuroimmune-modulating therapies targeting mechanisms help with providing relief patients itch. Itch research dynamic continually evolving field, grow our understanding mechanisms, so will therapeutic toolbox. Further studies exploring context are needed.

Language: Английский

Citations

17
Zhisou powder suppresses airway inflammation in LPS and CS-induced post-infectious cough model mice via TRPA1/TRPV1 channels DOI

Yuan Xu,

Shan Cao,

Shu-fei Wang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 324, P. 117741 - 117741

Published: Jan. 13, 2024

Language: Английский

Citations

4
TRPV1 Channel in Human Eosinophils: Functional Expression and Inflammatory Modulation DOI Open Access
Tobias Weihrauch, Natalie Gray, Daniela Wiebe

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1922 - 1922

Published: Feb. 5, 2024

The transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel expressed on sensory neurons and immune cells. We hypothesize that TRPV1 plays role in human eosinophil function modulated by inflammatory conditions. expression eosinophils was examined qPCR, flow cytometry, immunohistochemistry, respectively. functionality analyzed investigating calcium flux, apoptosis, modulation cytokines acidic pH, CD69 externalization using cytometry. Activation of induced influx prolonged survival. Although were not directly activated agonists, activation IL-3 or GM-CSF mainly restricted to TRPV1-positive eosinophils. surface content increased IL-3, IL-31, IL-33, TSLP, TNF-α, BDNF, NGF-β. Interestingly, also located proximity peripheral nerves atopic dermatitis (AD) skin. In conclusion, express functional channels which are extracellular acidification AD-related cytokines. Since AD skin, our results indicate an important for neuroimmune interaction mechanisms itchy, skin diseases, like AD.

Language: Английский

Citations

4
The airway neuro-immune axis as a therapeutic target in allergic airway diseases DOI Creative Commons

Wanhua Wu,

Jianing Li, Su Chen

et al.

Respiratory Research, Journal Year: 2024, Volume and Issue: 25(1)

Published: Feb. 8, 2024

Abstract Recent evidence has increasingly underscored the importance of neuro-immune axis in mediating allergic airway diseases, such as asthma and rhinitis. The intimate spatial relationship between neurons immune cells suggests that their interactions play a pivotal role regulating inflammation. Upon direct activation by allergens, engage interactions, during which neurotransmitters neuropeptides released modulate cell activity. Meanwhile, release inflammatory mediators histamine cytokines, stimulating amplifying neuropeptide production, thereby exacerbating dynamic interplay nervous systems targeting could represent novel approach to treating diseases. This review summarized recent on system’s regulatory mechanisms responses identified potential therapeutic targets along peripheral nerve-immune for findings will provide perspectives management diseases future.

Language: Английский

Citations

4
The involvement of keratinocytes in pruritus of chronic inflammatory dermatosis DOI Creative Commons
Shiying Lin, Xin Liu, Jiang Jian

et al.

Experimental Dermatology, Journal Year: 2024, Volume and Issue: 33(7)

Published: July 1, 2024

Abstract Frequent itching and incessant scratching are commonly observed in various chronic inflammatory skin conditions, including atopic dermatitis psoriasis. The persistent prolonged nature of pruritus can worsen one's quality life. Keratinocytes (KCs), the predominant cells epidermis, have been confirmed to interact with sensory neurons immune be involved diseases associated pruritus. Initially, KCs form a unique synapse‐like connection within serving as structural foundation for their interaction. Additionally, several receptors, toll‐like receptors protease‐activated receptor 2, expressed on KCs, become activated an milieu. On one hand, sources pro‐inflammatory cytokines neurotrophic factors, such adenosine triphosphate, thymic stromal lymphopoietin, nerve growth factor, which directly or indirectly participate stimulating neurons, thereby contributing itch sensations. other also function primary transducers alongside intraepidermal endings, initiating pruritic responses. This review summarizes current literature highlights critical role development persistence disorders.

Language: Английский

Citations

4
Causal effects of Inflammatory cytokines on Cardiovascular diseases: Insights from genetic evidence DOI Creative Commons
Yuxiu Chen, Aifang Zhong

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35447 - e35447

Published: July 30, 2024

The causal relationship between inflammatory cytokines and cardiovascular diseases (CVDs) has not been fully elucidated. Exploring this circulating CVDs is crucial for early clinical diagnosis effective treatment.

Language: Английский

Citations

3
Causal association of circulating cytokines with sepsis: a Mendelian randomization study DOI Creative Commons
Shan Lin, Xueyan Mao,

Wanmei He

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 17, 2023

Observational studies have reported an association between circulating cytokines and sepsis. However, the precise causal relationship these factors remains unclear. The objective of this study was to explore link sepsis using genetic data within framework Mendelian Randomization (MR).We performed a two-sample MR analysis investigate causality in individuals European ancestry. publicly available genome-wide (GWAS) statistics were used. We selected eligible instrumental single nucleotide polymorphisms (SNPs) that significantly related cytokines. Multiple approaches carried out, which included inverse variance weighted (IVW), Weighted Median, MR-Egger, Mode, Simple pleiotropy residual sum outlier (MR-PRESSO) methods.We found evidence support role genetically predicted levels on decreased risk sepsis, including RANTES (OR = 0.920, 95% CI: 0.849-0.997, P 0.041) basic fibroblast growth factor (basic-FGF) 0.869, 0.766-0.986, 0.029). Additionally, positive beta-nerve (β-NGF) 1.120, 1.037-1.211, 0.004). results Mode methods consistent with IVW estimates. Sensitivity showed no horizontal bias estimates.This provides first novel RANTES, basic-FGF, β-NGF altered risk. findings shed light potential involvement pathogenesis. Although requiring additional confirmation, contribute new insights into cytokine mediators suggest promising future research directions.

Language: Английский

Citations

8
Neuroimmune communication in allergic rhinitis DOI Creative Commons
Yiting Zhou,

Ru Chen,

Lili Kong

et al.

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 21, 2023

The prevalence rate of allergic rhinitis (AR) is high worldwide. inhalation allergens induces AR, which an immunoglobulin E-mediated and type 2 inflammation-driven disease. Recently, the role neuroimmune communication in AR pathogenesis has piqued interest scientific community. Various neuropeptides, such as substance P (SP), vasoactive intestinal peptide (VIP), calcitonin gene-related (CGRP), nerve growth factor (NGF), neuromedin U (NMU), released via “axon reflexes” or “central sensitization” exert regulatory effects on immune cells to elicit “neurogenic inflammation,” contributes nasal hyperresponsiveness (NHR) AR. Additionally, neuropeptides can be produced cells. frequent colocalization neuronal at certain anatomical regions promotes establishment cell units, nerve-mast cells, nerve-type innate lymphoid (ILC2s), nerve-eosinophils nerve-basophils units. Receptors expressed both neurons, TRPV1, TRPA1, Mas-related G protein-coupled receptor X2 (MRGPRX2) mediate pathogenesis. This review focused elucidating mechanisms underlying

Language: Английский

Citations

7
Eosinophil extracellular vesicles and DNA traps in allergic inflammation DOI Creative Commons
Tobias Weihrauch, Rossana C. N. Melo, Natalie Gray

et al.

Frontiers in Allergy, Journal Year: 2024, Volume and Issue: 5

Published: Aug. 1, 2024

Eosinophil granulocytes, a specialized subset of white blood cells, have traditionally been associated with allergic responses and parasitic infections. However, recent research has unveiled their versatile roles in immune regulation beyond these classical functions. This review highlights the emerging field eosinophil biology, particular focus on release extracellular vesicles (EVs) DNA traps (EETs). It further explores potential implications eosinophil-derived EVs EETs for during inflammatory diseases. The EVs/EETs from eosinophils, which also affects eosinophils themselves, may influence both local systemic reactions, affecting pathophysiology conditions such as airway inflammation, chronic rhinosinusitis atopic dermatitis.

Language: Английский

Citations

2