BMC Women s Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: Jan. 3, 2024
The aim of this study was to investigate the association between fasting blood glucose and osteoporosis in women with diabetes, anemia, renal function.
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Oct. 14, 2024
Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against
Language: Английский
Citations
64
Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown
Published: May 1, 2024
Iron deficiency is globally prevalent, causing an array of developmental, haematological, immunological, neurological, and cardiometabolic impairments, associated with symptoms ranging from chronic fatigue to hair loss. Within cells, iron utilised in a variety ways by hundreds different proteins. Here, we review links between molecular activities regulated the pathophysiological effects deficiency. We identify specific enzyme groups, biochemical pathways, cellular functions, cell lineages that are particularly dependent. provide examples how deprivation influences multiple key systems tissues, including immunity, hormone synthesis, cholesterol metabolism. propose greater mechanistic understanding physiological processes may lead new therapeutic opportunities across range diseases.
Language: Английский
Citations
17
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0313842 - e0313842
Published: Jan. 9, 2025
Background Predicting mortality and morbidity poses a significant challenge to physicians, leading the development of various scoring systems. Among these, hemoglobin, albumin, lymphocyte platelet (HALP) score evaluates patient’s nutritional immune status. The primary aim this study was determine predictive effect HALP on 30-day 1-year in elderly patients with proximal femoral fractures (PFFs). Materials methods Patient demographic, clinical, laboratory, prognostic data were obtained. categorized into two groups: survival nonsurvival at endpoints. calculated compared among groups other biomarkers such as C-reactive protein (CRP) albumin ratio (CAR). ability predict between groups. risk also optimal threshold. Results had statistically endpoints lower non-surviving group. cut-off value (17.975) superb, sensitivity 0.66 specificity 0.86 (AUC: 0.826, 95% CI: 0.784–0.868). In addition, power differentiate survivors non-survivors more than that indices (p < 0.001). Patients ≤ 17.975 11.794 times ≥ (Odds ratio: 11.794, CI [7.194–19.338], p Conclusion results indicate demonstrates efficacy utility predicting PFFs.
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 25, 2025
Abstract Hydroxyapatite (HA) is an important constituent of natural bone. The properties HA can be enhanced with the help various ionic substitutions in crystal lattice HA. Iron (Fe) a vital element present bones and teeth. In this study, iron-doped was synthesized using refluxing-based sol-gel route varying concentrations iron (1–9 M%). Samples were analyzed X-ray diffractometer (XRD), UV–Vis Spectrophotometer, Fourier-transform infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM) Scanning Electron Microscope (SEM). biological assessment carried out by hemolytic assay, anti-bacterial activity in-vitro biocompatibility. XRD data confirmed evolution hexagonal structure reduction crystallinity crystallite size. All characteristic bands FT-IR which also further proved existence A-type carbonated apatite. spectra band gap energies owing to substitution iron. SEM results showed change shape samples increasing concentration. magnetic behavior altered from diamagnetic ferromagnetic due doping heating efficiency. found hemocompatible. antibacterial efficacy higher for E. coli (gram-negative) bacteria compared S. aureus (gram-positive) bacteria. Moreover, superior cell viability MG-63 (osteoblast-like) cells observed Fe-doped HA, attributed MTT assay revealed osteoblast-like These strongly emphasize potential developed bone regeneration applications.
Language: Английский
Citations
1
Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 437 - 437
Published: Jan. 25, 2025
Background: Insects like Gryllus assimilis have an excellent nutritional profile, including iron. However, the bioavailability of this iron and its effects on intestinal health oxidative balance remain unclear. To enhance acceptance, insects can be used in powder form combined with common flours. Objective: This study evaluates powder, alone or soy flour, bioavailability, health, rodents. Methods: Using hemoglobin depletion/repletion method, 32 male Wistar rats were divided into four groups: A (standard diet + ferrous sulfate), B (diet flour), C assimilis), D flour). Hemoglobin levels, regeneration efficiency, biological value, serum markers, assessed. Results: Food intake, weight gain, measures showed no differences. group higher weekly final levels than alone. combination also improved acetic acid fecal moisture, balance, increasing superoxide dismutase activity while reducing peroxidation products compared to Conclusion: These findings highlight potential benefits combining flour for overall health.
Language: Английский
Citations
1
Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 51, P. 312 - 328
Published: March 1, 2025
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 489, P. 151372 - 151372
Published: April 17, 2024
Language: Английский
Citations
7
Biomaterials Advances, Journal Year: 2024, Volume and Issue: 160, P. 213848 - 213848
Published: April 2, 2024
Language: Английский
Citations
6
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152317 - 152317
Published: May 24, 2024
Language: Английский
Citations
6
Engineered Regeneration, Journal Year: 2024, Volume and Issue: 5(3), P. 375 - 408
Published: Jan. 21, 2024
Biometal ions are crucial in the structure and function of living organisms have extensively been employed to promote bone tissue regeneration. Nevertheless, biological functions biometal underlying mechanisms responsible for their pro-regenerative effects remain incompletely understood, since repair is an intricate physiological process involving multiple cell types signals. Recent accomplishments osteoimmunological field revealed momentous involvement immune system mediating therapeutic ions. The inflammatory factors secreted by cells contribute migration, activation, proliferation. This review summarizes its constituent cells, followed current perspective on immunomodulation during healing. Next, physicochemical properties various ions, including lithium, sodium, potassium, magnesium, calcium, strontium, vanadium, iron, cobalt, copper, zinc, thoroughly reviewed. In addition, interactions between discussed, aiming provide insights into prospective development novel approaches regeneration harnessing potential these
Language: Английский
Citations
4