Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases DOI Creative Commons
Meng Zhang, Wei Jin, Chang He

et al.

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: Dec. 18, 2024

Abstract Mitochondria are versatile and complex organelles that can continuously communicate interact with the cellular milieu. Deregulated communication between mitochondria host cells/organelles has significant consequences is an underlying factor of many pathophysiological conditions, including process aging. During aging, lose function, mitocellular pathways break down; mitochondrial dysfunction interacts dyscommunication, forming a vicious circle. Therefore, strategies to protect function promote effective increase healthy lifespan longevity, which might be new treatment paradigm for age-related disorders. In this review, we comprehensively discuss signal transduction mechanisms inter- intracellular communication, as well interactions hallmarks This review emphasizes indispensable position in aging organisms, crucial signaling hubs. addition, also specifically focus on status mitochondria-targeted interventions provide potential therapeutic targets diseases. Graphical

Language: Английский

Mitochondria in aging and age-associated diseases DOI Creative Commons
Sonu Pahal, Nirjal Mainali, Meenakshisundaram Balasubramaniam

et al.

Mitochondrion, Journal Year: 2025, Volume and Issue: 82, P. 102022 - 102022

Published: Feb. 27, 2025

Mitochondria, essential for cellular energy, are crucial in neurodegenerative disorders (NDDs) and their age-related progression. This review highlights mitochondrial dynamics, mitovesicles, homeostasis, organelle communication. We examine impacts from aging NDDs, focusing on protein aggregation dysfunction. Prospective therapeutic approaches include enhancing mitophagy, improving respiratory chain function, maintaining calcium lipid balance, using microRNAs, transfer to protect function. These strategies underscore the role of health neuronal survival cognitive functions, offering new opportunities.

Language: Английский

Citations

3
Advances in mesenchymal stem/stromal cell-based therapy and their extracellular vesicles for skin wound healing DOI
Mohamed J. Saadh,

Andrés Alexis Ramírez‐Coronel,

Ravinder Saini

et al.

Human Cell, Journal Year: 2023, Volume and Issue: 36(4), P. 1253 - 1264

Published: April 17, 2023

Language: Английский

Citations

20
“Whole genome bisulfite sequencing of serum extracellular vesicle DNA Identifies alterations in mitochondrial DNA methylation in early onset preeclampsia” DOI

Uma Shinde,

Kushaan Khambata,

Sanketa Raut

et al.

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120168 - 120168

Published: Jan. 1, 2025

Language: Английский

Citations

1
Roles and Potential Mechanisms of Endothelial Cell-Derived Extracellular Vesicles in Ischemic Stroke DOI
Xinyuan Yu, Yiwei Huang,

Changxin Li

et al.

Translational Stroke Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

Citations

1
The Research Progress of Mitochondrial Transplantation in the Treatment of Mitochondrial Defective Diseases DOI Open Access

Cuilan Hu,

Zheng Shi, Xiongxiong Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1175 - 1175

Published: Jan. 18, 2024

Mitochondria are double-membrane organelles that involved in energy production, apoptosis, and signaling eukaryotic cells. Several studies conducted over the past decades have correlated mitochondrial dysfunction with various diseases, including cerebral ischemia, myocardial ischemia-reperfusion, cancer. Mitochondrial transplantation entails importing intact mitochondria from healthy tissues into diseased damaged to rescue injured In this review, different techniques their clinical applications been discussed. addition, challenges future directions pertaining its potential treatment of diseases defective summarized.

Language: Английский

Citations

5
Mitochondrial Extracellular Vesicles: A Promising Avenue for Diagnosing and Treating Lung Diseases DOI

Fengxia Ding,

Mi Zhou,

Yinying Ren

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(37), P. 25372 - 25404

Published: Sept. 3, 2024

Mitochondria, pivotal organelles governing cellular biosynthesis, energy metabolism, and signal transduction, maintain dynamic equilibrium through processes such as biogenesis, fusion, fission, mitophagy. Growing evidence implicates mitochondrial dysfunction in a spectrum of respiratory diseases including acute lung injury/acute distress syndrome, bronchial asthma, pulmonary fibrosis, chronic obstructive disease, cancer. Consequently, identifying methods capable ameliorating damaged function is crucial for the treatment diseases. Extracellular vesicles (EVs), nanosized membrane released by cells into extracellular space, facilitate intercellular communication transferring bioactive substances or signals between organs. Recent studies have identified abundant components within specific subsets EVs, termed (mitoEVs), whose contents compositions vary with disease progression. Moreover, mitoEVs demonstrated reparative functions injured recipient cells. However, comprehensive understanding currently lacking, limiting their clinical translation prospects. This Review explores classification, functional cargo, biological effects mitoEVs, focus on role Emphasis placed potential markers innovative therapeutic strategies diseases, offering fresh insights mechanistic drug development various disorders.

Language: Английский

Citations

5
Role of Mitochondria in Reno-Cardiac Diseases: A Study of Bioenergetics, Biogenesis, and GSH Signaling in Disease Transition DOI Creative Commons
Jairo Lumpuy‐Castillo, Isabel Amador‐Martínez,

Miriam Díaz-Rojas

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 76, P. 103340 - 103340

Published: Sept. 6, 2024

Language: Английский

Citations

5
Immunometabolism, extracellular vesicles and cardiac injury DOI Creative Commons
Ana Carolina Mieko Omoto, Jussara M. do Carmo, Alexandre A. da Silva

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Recent evidence from our lab and others suggests that metabolic reprogramming of immune cells drives changes in cell phenotypes along the inflammatory-to-reparative spectrum plays a critical role mediating inflammatory responses to cardiac injury (e.g. hypertension, myocardial infarction). However, factors drive are not fully understood. Extracellular vesicles (EVs) recognized for their ability transfer cargo such as microRNAs remote sites influence remodeling. Furthermore, conditions obesity syndrome, which implicated majority cardiovascular disease (CVD) cases, can skew production EVs toward pro-inflammatory phenotypes. In this mini-review, we discuss mechanisms by may metabolism during associated with syndrome disrupt normal EV function. We also potential sources cardio-protective anti-inflammatory EVs, brown adipose tissue. Finally, implications future therapeutics.

Language: Английский

Citations

3
Immune system-related plasma extracellular vesicles in healthy aging DOI Creative Commons
Xin Zhang, Sisi Ma, Janet L. Huebner

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 3, 2024

To identify age-related plasma extracellular vehicle (EVs) phenotypes in healthy adults. EV proteomics by high-resolution mass spectrometry to evaluate protein stability and discover age-associated proteins (n=4 with 4 serial freeze-thaws each); validation flow cytometry cytokine quantification multiplex ELISA (n=28 donors, aged 18-83 years); of WI-38 fibroblast cell proliferation response co-culture PKH67-labeled young old EVs. The samples from these specimens were previously characterized for bilayer structure, intra-vesicle mitochondria cytokines, hematopoietic cell-related surface markers. Compared matched exo-EVs (EV-depleted supernatants), endo-EVs (EV-associated) had higher mean TNF-α IL-27, lower IL-6, IL-11, IFN-γ, IL-17A/F, similar IL-1β, IL-21, IL-22 concentrations. Some endo-EV exo-EV concentrations correlated, including TNF-α, but not IL-21 or IL-22. Endo-EV IFN-γ IL-17A/F declined age. By confirmed cytometry, we identified decline fibrinogen (FGA, FGB FGG) Age-related indicated predominant origins the liver innate immune system. cells (>95%) internalized amounts EVs, that PKH67-EVs, particularly underwent significantly greater proliferation. cytokines function as different biomarkers. observed aging phenotype reflected a downregulation subpopulations consistent absence pro-coagulant pro-inflammatory condition common disease.

Language: Английский

Citations

3
HSP90 N-terminal inhibition promotes mitochondria-derived vesicles related metastasis by reducing TFEB transcription via decreased HSP90AA1-HCFC1 interaction in liver cancer DOI

Lixia Liu,

Zhenming Zheng, Yaling Huang

et al.

Autophagy, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 26, 2024

Cancer cells compensate with increasing mitochondria-derived vesicles (MDVs) to maintain mitochondrial homeostasis, when canonical MAP1LC3B/LC3B (microtubule associated protein 1 light chain 3 beta)-mediated mitophagy is lacking. MDVs promote the transport of components into extracellular (EVs) and induce tumor metastasis. Although HSP90 (heat shock 90) chaperones hundreds client proteins its inhibitors suppress tumors, inhibitors-related chemotherapy unexpected Herein, we find that inhibitor causes damage but stimulates low LC3-induced release MDVs-derived EVs. However, why LC3 decreases what transcriptional regulatory mechanism formation under inhibition remain unknown. Because TFEB (transcription factor EB) most important transcription factor, HCFC1 (host cell C1) regulates

Language: Английский

Citations

3