Abstract
Circulating
tumor
cells
(CTCs)
are
cancer
that
shed
from
the
primary
and
enter
into
body
fluids
of
patient,
where
they
travel
to
distant
sites
ultimately
form
metastasis.
Understanding
biology
CTCs,
in
particular
at
critical
stages
their
itinerary,
holds
promises
for
better
cure.
Since
beginning
this
century,
liquid
biopsy
has
steadily
grown
be
a
keen
area
research
due
its
non-invasive
features.
As
one
most
promising
biomarkers,
CTCs
have
shown
great
potential
diagnosis,
prognosis,
treatment
response
monitoring,
exploration
biological
mechanisms.
Although
various
types
isolation
detection
technologies
emerge
constantly,
rarity
heterogeneity
still
pose
huge
challenges
these
methods
make
them
inefficient.
In
addition,
clinical
practice
different
lacks
reasonable
uniform
standards.
review,
we
provide
detailed
overview
enrichment
strategies
as
well
advantages
limitations.
By
summarizing
current
status
suggesting
future
areas
research,
hope
continue
concerted
effort
pushing
forward
application
which
may
represent
paradigm
shift
theranostics
future.
Graphical
Cancers,
Journal Year:
2024,
Volume and Issue:
16(7), P. 1377 - 1377
Published: March 31, 2024
Cancer
remains
a
leading
cause
of
mortality
worldwide,
with
metastasis
significantly
contributing
to
its
lethality.
The
metastatic
spread
tumor
cells,
primarily
through
the
bloodstream,
underscores
importance
circulating
cells
(CTCs)
in
oncological
research.
As
critical
component
liquid
biopsies,
CTCs
offer
non-invasive
and
dynamic
window
into
biology,
providing
invaluable
insights
cancer
dissemination,
disease
progression,
response
treatment.
This
review
article
delves
recent
advancements
CTC
research,
highlighting
their
emerging
role
as
biomarker
various
types.
We
explore
latest
technologies
methods
for
isolation
detection,
alongside
novel
approaches
characterizing
biology
genomics,
transcriptomics,
proteomics,
epigenetic
profiling.
Additionally,
we
examine
clinical
implementation
these
findings,
assessing
how
are
transforming
landscape
diagnosis,
prognosis,
management.
By
offering
comprehensive
overview
current
developments
potential
future
directions,
this
significance
enhancing
our
understanding
shaping
personalized
therapeutic
strategies,
particularly
patients
disease.
Frontiers in Chemistry,
Journal Year:
2025,
Volume and Issue:
13
Published: March 26, 2025
Exosomes,
released
from
diverse
cells
as
nanoscale
lipid
bilayer
vesicles,
mediate
intercellular
communication
and
participate
in
various
physiological
pathological
processes.
Thereinto,
tumor-derived
exosomes
(T-EXOs)
with
molecular
cargoes
of
parent
tumor
act
attractive
biomarkers
for
liquid
biopsy.
The
amount
T-EXOs
their
levels
contained
specific
proteins
nucleic
acids
are
closely
associated
cancer
burden
classification.
Nevertheless,
the
size
relatively
low
abundance
exosomes,
well
complex
body
matrix
pose
daunting
challenges
efficient
isolation
sensitive
detection
T-EXOs.
Biosensing
fast,
convenient
accurate
method,
has
been
widely
employed
over
past
decades.
Among
them,
electrochemical
sensors
can
sensitively
detect
by
measuring
change
electrical
signal
caused
oxidation
or
reduction
at
working
electrode
surface.
This
review
aims
to
summarize
recent
advance
biosensors
quantification,
protein
RNA
analysis
exosomes.
Further,
future
perspectives
exosome-based
biopsy
have
discussed.
Journal of Surgical Oncology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
ABSTRACT
Circulating
tumor
cells
(CTCs)
are
that
detach
from
the
primary
site
and
enter
bloodstream.
They
hold
significant
value
for
early
detection,
diagnosis,
treatment
of
tumors.
CTC
detection
methods
can
be
classified
into
in
vivo
vitro
techniques.
Compared
to
traditional
methods,
causes
less
harm
body
allows
earlier
identification
malignant
tumors,
thereby
enabling
timely
improving
patient
survival
rates.
In
recent
years,
has
been
widely
used
assess
effectiveness
immunotherapy.
Dynamic
monitoring
CTCs
help
optimize
clinical
strategies.
This
review
summarizes
latest
discusses
their
applications
immunotherapy
various
common
aiming
provide
better
guidance
support
practice.
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
15
Published: May 21, 2025
Cancer
remains
one
of
the
most
common
and
deadliest
diseases
worldwide.
Among
endocrine
neoplasms,
incidence
thyroid
malignancies
has
been
rising
in
recent
years.
Papillary
carcinoma
(PTC),
frequently
observed
histological
subtype
cancer
(THCA),
typically
yields
favorable
clinical
outcomes
for
affected
individuals.
However,
this
raised
concerns
about
overdiagnosis
underdetermination
prognostic
factors
PTC
cases.
As
a
result,
researchers
now
advocate
patient
stratification
tailored
therapeutic
approaches
cases,
with
goal
minimizing
unnecessary
surgical
procedures
radioiodine
treatments.
These
treatments
can
lead
to
complications
impose
avoidable
physiological
psychological
stress
on
patients.
Multiple
biomarkers
have
identified
PTC,
which
play
critical
role
predicting
informing
treatment
decisions.
This
review
examines
both
established
molecular
tools
advancements
determination
prognosis
papillary
carcinoma.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(6)
Published: Nov. 22, 2023
Abstract
Cancer
of
the
central
nervous
system
(CNS)
can
crosstalk
systemically
and
locally
in
tumor
microenvironment
has
become
a
topic
attention
for
initiation
advancement.
Recently
studied
neuronal
cancer
interaction
fundamentally
altered
knowledge
about
glioma
metastases,
indicating
how
cancers
invade
complex
networks.
This
review
systematically
discussed
interactions
between
neurons
elucidates
new
therapeutic
avenues.
We
have
overviewed
current
understanding
direct
or
indirect
communications
cells
with
mechanisms
associated
invasion.
Besides,
tumor‐associated
dysfunction
influence
therapies
on
CNS
are
highlighted.
Furthermore,
peripheral
various
also
been
separately.
Intriguingly
importantly,
it
cannot
be
ignored
that
exosomes
could
mediate
“wireless
communications”
cancer.
Finally,
promising
future
strategies
targeting
neuronal–brain
were
reviewed.
A
great
deal
work
remains
to
done
elucidate
neuroscience
cancer,
more
research
should
directed
toward
clarifying
precise
neuroscience,
which
hold
enormous
promise
improve
outcomes
wide
range
malignancies.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(18), P. 3129 - 3129
Published: Sept. 11, 2024
Recent
data
have
shown
a
continued
rise
in
the
worldwide
annual
incidence
and
mortality
rates
of
head
neck
cancers.
The
present
standard
for
diagnosis
monitoring
disease
recurrence
or
progression
involves
clinical
examination,
imaging,
invasive
biopsy
techniques
lesions
suspected
being
malignant.
In
addition
to
limitations
relating
cost,
time,
patient
discomfort,
these
methodologies
inherent
inaccuracies
detecting
recurrence.
view
limitations,
analysis
bodily
fluid
samples
via
liquid
proposes
cost-effective
convenient
alternative,
which
provides
insight
on
biogenetic
biomolecular
underpinnings
oncologic
processes.
biomarkers
cancer
biopsy,
including
circulating
tumor
DNA,
cells,
cell-free
RNA,
has
utility
screening,
diagnosis,
prognostication,
patients
with
various
forms
cancer.
review
will
provide
an
update
current
literature
examining
use
care
applicability
potential
biomarkers,
focus
viral
non-viral
DNA.
Possible
future
avenues
research
address
specific
shortcomings
be
discussed.
