Epigenetic mechanisms in cardiovascular complications of diabetes: towards future therapies DOI Creative Commons

Giulia Damiano,

Raffaella Rinaldi, Angela Raucci

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Sept. 27, 2024

Abstract The pathophysiological mechanisms of cardiovascular disease and microvascular complications in diabetes have been extensively studied, but effective methods prevention treatment are still lacking. In recent years, DNA methylation, histone modifications, non-coding RNAs arisen as possible involved the development, maintenance, progression micro- macro-vascular diabetes. Epigenetic changes characteristic being heritable or deletable. For this reason, they now studied a therapeutic target for slowing down its complications, aiming to alleviate personal social burden disease. This review addresses current knowledge links between focusing on role epigenetic including methylation modifications. addition, although with “epidrugs” is far from reality faces several challenges, we present most promising molecules approaches field.

Language: Английский

miR-200c inhibition and catalase accelerate diabetic wound healing DOI Creative Commons
M D'agostino, Sara Sileno,

Daniela Lulli

et al.

Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)

Published: Feb. 14, 2025

Abstract Background Reactive oxygen species (ROS) are increased in diabetic conditions and play a causal role foot ulcers (DFU). We previously showed that ROS up-regulate miR-200c expression, turns causes apoptosis, senescence, upregulation nitric oxide decrease, leading to endothelial disfunction. Methods The aim of this study is dissect DFU explore the potential anti-miR-200c antioxidant catalase (CAT) promoting wound healing (WH). inhibition CAT treatment were performed either immortalized keratinocytes (HaCaT) or primary fibroblasts (FBs) (KCs) deriving from patients (pts) undergoing amputations. Primary cells pts saphenectomies used as controls. blockade was via lentiviral particles bearing an sequence locked nucleic acid (LNA) oligos. Equine administered on cell medium. WH assay vivo (db/db) mice by topical with LNA wounds dissolved Pluronic gel mixture, every three days. Results found levels different stimuli known induce ROS, such ultraviolet radiation (UV), hydrogen peroxide (H 2 O ), high glucose HaCaT. also upregulated skin biopsies, FBs KCs isolated vs Forced expression induced both KCs, reduced it. improved HaCaT, under basal after UV H treatment, simultaneous accelerated pts, increasing its protein targets: sirtuin 1 (SIRT1), transcription factors FOXO1 ZEB1 decreasing p66Shc phosphorylation at Ser-36, co-treatment synergistic effects reducing cytotoxicity. Interestingly, decreased pts. Topical administration model closure. Conclusions Anti-miR-200c could be considered novel for and, possibly, other types non-diabetic ulcers.

Language: Английский

Citations

3
Advanced Glycation End-Products Acting as Immunomodulators for Chronic Inflammation, Inflammaging and Carcinogenesis in Patients with Diabetes and Immune-Related Diseases DOI Creative Commons
Chieh‐Yu Shen,

Cheng‐Hsun Lu,

Chiao‐Feng Cheng

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1699 - 1699

Published: July 31, 2024

Increased production of advanced glycation end products (AGEs) among reducing sugars (glucose, fructose, galactose, or ribose) and amino acids/proteins via non-enzymatic Maillard reaction can be found in lifestyle-related disease (LSRD), metabolic syndrome (MetS), obesity immune-related diseases. serum levels AGEs may induce aging, diabetic complications, cardiovascular diseases (CVD), neurodegenerative (NDD), cancer, inflamm-aging (inflammation with immunosenescence). The also occur lipoproteins DNAs to alter their structure immunogenicity/genotoxicity for carcinogenesis. AGEs, as danger-associated molecular pattern molecules (DAMPs), operate binding receptor AGE (RAGE) other scavenger receptors on cell surface activate PI3K-Akt-, P38-MAPK-, ERK1/2-JNK-, MyD88-induced NF-κB signaling pathways mediate various pathological effects. Recently, the concept "inflamm-aging" became more defined, we have unveiled some interesting findings relation it. purpose present review is dissect potential basis patients diabetes immune-mediated caused by different AGEs.

Language: Английский

Citations

5
Glycemic control and cancer outcomes in oncologic patients with diabetes: an Italian Association of Medical Oncology (AIOM), Italian Association of Medical Diabetologists (AMD), Italian Society of Diabetology (SID), Italian Society of Endocrinology (SIE), Italian Society of Pharmacology (SIF) multidisciplinary critical view DOI Creative Commons
Annalisa Natalicchio, Nicola Marrano, Monica Montagnani

et al.

Journal of Endocrinological Investigation, Journal Year: 2024, Volume and Issue: 47(12), P. 2915 - 2928

Published: June 27, 2024

Abstract Background: Increasing evidence suggests that diabetes increases the risk of developing different types cancer. Hyperinsulinemia, hyperglycemia and chronic inflammation, characteristic diabetes, could represent possible mechanisms involved in cancer development diabetic patients. At same time, new-onset mainly caused by use specific anticancer therapies. Of note, has been associated with a ∼10% increase mortality for all cancers comparison subjects who did not have diabetes. Diabetes is worse prognosis patients cancer, more recent findings suggest key role poor glycemic control this regard. Nevertheless, association between outcomes oncologic remains unsettled poorly debated. Purpose: The current review seeks to summarize available on effect outcomes, as well possibility timely treatment improved may favorably affect outcomes.

Language: Английский

Citations

4
Mechanism of action and new developments in the study of curcumin in the treatment of osteoarthritis: a narrative review DOI
Yong-Ze Yang, Jidong Li, Jingguo Zhang

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Language: Английский

Citations

0
Advances in nephroprotection: the therapeutic role of selenium, silver, and gold nanoparticles in renal health DOI

Karthik K Karunakar,

Elizabeth Rani Edwin,

Meenaloshini Gopalakrishnan

et al.

International Urology and Nephrology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Language: Английский

Citations

2
Exploratory risk prediction of type II diabetes with isolation forests and novel biomarkers DOI Creative Commons

Hibba Yousef,

Samuel F. Feng, Herbert F. Jelinek

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 22, 2024

Type II diabetes mellitus (T2DM) is a rising global health burden due to its rapidly increasing prevalence worldwide, and can result in serious complications. Therefore, it of utmost importance identify individuals at risk as early possible avoid long-term T2DM In this study, we developed an interpretable machine learning model leveraging baseline levels biomarkers oxidative stress (OS), inflammation, mitochondrial dysfunction (MD) for identifying developing T2DM. particular, Isolation Forest (iForest) was applied anomaly detection algorithm address class imbalance. iForest trained on the control group data detect cases high development outliers. Two models were evaluated through ten-fold cross-validation, first traditional (BMI, blood glucose (BGL) triglycerides) alone second including additional aforementioned biomarkers. The outperformed across all evaluation metrics, particularly F1 score recall, which increased from 0.61 ± 0.05 0.81 0.57 0.06 0.08, respectively. feature scores identified novel combination biomarkers, interleukin-10 (IL-10), 8-isoprostane, humanin (HN), oxidized glutathione (GSSG), revealed be more influential than outcome prediction. These results reveal promising method simultaneously predicting understanding suggest pharmacological intervention inflammation OS disease progression.

Language: Английский

Citations

1
Demonstrating the effectiveness of intra-articular prolotherapy combined with peri-articular perineural injection in knee osteoarthritis: a randomized controlled trial DOI Creative Commons

Yiling Fu,

Yukun Du, Jianyi Li

et al.

Journal of Orthopaedic Surgery and Research, Journal Year: 2024, Volume and Issue: 19(1)

Published: May 5, 2024

Abstract Background This study aimed to compare the efficacy of intra-articular prolotherapy (IG) combined with peri-articular perineural injection (PG) in management knee osteoarthritis (KOA). Methods A total 60 patients diagnosis KOA were included this double-blinded randomized controlled clinical trials. The inclusion criteria as follow: (1) 48–80 years old; (2) diagnose KOA; (3) grade 2 and 3 Kellgern–Lawrence grading scale; (4) pain, crepitation, joint stiffness continuing for months at least. main exclusion any infection involving skin; history Influencing factors disease. All divided into three groups received either IG, PG I + under ultrasound guidance 2, 4 8 weeks follow-up data available. (IG n = 20 or 20, 20). Visual Analogue Scale (VAS), Western Ontario McMaster University Osteoarthritis Index (WOMAC) pressure pain threshold (PPT) used outcome measures baseline, weeks. Results There no statistically significant differences terms age, sex, BMI, duration current condition baseline assessments intensity, WOMAC scores PPT. After treatment, improvement VAS activity, PPT values was showed compared pre-treatment all ( p < 0.05). At after significantly lower than those difference improved IG 4, treatment. Conclusion guided 5% glucose seem be more effective alleviate improve function single therapy short term. Clinical rehabilitators could clinically try combination symptoms KOA.

Language: Английский

Citations

0
Epigenetic mechanisms in cardiovascular complications of diabetes: towards future therapies DOI Creative Commons

Giulia Damiano,

Raffaella Rinaldi, Angela Raucci

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Sept. 27, 2024

Abstract The pathophysiological mechanisms of cardiovascular disease and microvascular complications in diabetes have been extensively studied, but effective methods prevention treatment are still lacking. In recent years, DNA methylation, histone modifications, non-coding RNAs arisen as possible involved the development, maintenance, progression micro- macro-vascular diabetes. Epigenetic changes characteristic being heritable or deletable. For this reason, they now studied a therapeutic target for slowing down its complications, aiming to alleviate personal social burden disease. This review addresses current knowledge links between focusing on role epigenetic including methylation modifications. addition, although with “epidrugs” is far from reality faces several challenges, we present most promising molecules approaches field.

Language: Английский

Citations

0