Journal of Prosthetic Dentistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Pharmacological Reports, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Clinical and Preventive Medicine, Journal Year: 2025, Volume and Issue: 2, P. 152 - 161
Published: April 17, 2025
Aim. To conduct a generalization of scientific research on the history use medications for correction dyslipidemia in clinical practice. Materials and methods. The analysis articles, guidelines recommendations justification implementation appointment hypolipidemic drugs treatment prevention cardiovascular diseases (CVD) was carried out. methods used were: systematic approach, bibliosemantic, analytical. Results. Hypotheses regarding role hypercholesterolemia development atherosclerotic lesions system were proposed as early second half 19th century, approaches need to correct substantiated only with introduction concept risk factors 20th century. However, it took almost two decades CVD into first pharmacological drug that began be practice nicotinic acid (niacin). Bile sequestrants (cholestyramine, colestipol, colesevelam) became group, fibrates (fenofibrate, bezafibrate, gemfibrozil, ciprofibrate) third group therapy drugs. Later, these gave way statins, whose effectiveness higher safety profile better. Statin is generally well tolerated adverse reactions occur less than 5% randomized trials. At current stage, statins remain first-line lipid metabolism. evidence base significant, results trials have demonstrated this secondary primary CVD. Since end 90s there has been steady increase prescription Сonclusions. Medications since Niacin, fibrates, bile now replaced by which
Language: Английский
Citations
0
Microbial Cell Factories, Journal Year: 2024, Volume and Issue: 23(1)
Published: May 9, 2024
Abstract Background Lovastatin has widespread applications thanks to its multiple pharmacological effects. Fermentation by filamentous fungi represents the major way of lovastatin production. However, current productivity fungal fermentation is limited and needs be improved. Results In this study, lovastatin-producing strains Aspergillus terreus from marine environment were screened, their productions further improved genetic engineering. Five A . isolated various environments. Their secondary metabolites profiled metabolomics analysis using Ultra Performance Liquid Chromatography–Mass spectrometry (UPLC–MS) with Global Natural Products Social Molecular Networking (GNPS), revealing that production was variable among different strains. Remarkably, strain MJ106 could principally biosynthesize target drug lovastatin, which confirmed High Chromatography (HPLC) gene expression analysis. By one-factor experiment, lactose found best carbon source for produce lovastatin. To improve titer in MJ106, engineering applied strain. Firstly, a series strong promoters identified transcriptomic green fluorescent protein reporter Then, three selected used overexpress transcription factor lovE encoding transactivator lov cluster expression. The results revealed compared all over-expression mutants exhibited significantly more higher One them, LovE-b19, showed highest at 1512 mg/L, level reported Conclusion Our data suggested combination screen powerful tool improving metabolites, adopted large-scale marine-derived
Language: Английский
Citations
3
Pharmacological Research, Journal Year: 2024, Volume and Issue: 209, P. 107446 - 107446
Published: Oct. 1, 2024
Language: Английский
Citations
3
Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1255 - 1255
Published: July 25, 2024
Cholesterol is required to maintain the functional integrity of cellular membrane systems and signalling pathways, but its supply must be closely dynamically regulated because excess cholesterol toxic. Sterol regulatory element-binding protein 2 (SREBP2) ER-resident HMG-CoA reductase (HMGCR) are key regulators biosynthesis. Here, we assessed mechanistic aspects their regulation in hepatic cells. Unexpectedly, found that transcriptionally active fragment SREBP2 (N-SREBP2) was produced constitutively. Moreover, absence an exogenous supply, nuclear N-SREBP2 became resistant proteasome-mediated degradation. This resistance paired with increased occupancy at HMGCR promoter expression. Inhibiting degradation did not increase RNA levels; this depletion. Our findings, combined previous physiological biophysical investigations, suggest a new model SREBP2-mediated biosynthesis organ handles large rapid fluctuations dietary lipid. Specifically, nucleus, ubiquitin–proteasome system provide short-loop modulates rate via turnover findings have important implications for maintaining homeostasis lowering blood SREBP2-HMGCR axis.
Language: Английский
Citations
2
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: July 23, 2024
Dyslipidemia refers to the change in normal levels of one or more lipid components bloodstream, which include triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), and low-density (LDL-C). represents a substantial source danger for cardiovascular disease (CVD). Effectively managing dyslipidemia involves thorough strategy that includes changing one's lifestyle using medications are specifically designed target complex processes involved metabolism. Lipid-lowering treatments play crucial role this approach, providing wide range developed different dyslipidemia. Statins main drug among these medications. Other drugs used with statin as monotherapy fibrates, omega-3 fatty acids (OM3FAs), ezetimibe, bile acid sequestrants, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, bempedoic acid. Using PubMed database, we reviewed literature about dyslipidemia, treating their efficacy parameters, common adverse events. We also international guidelines discussed future lipid-lowering More trials experiments still required verify effectiveness many know events be able manage them properly.
Language: Английский
Citations
1
Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(9), P. 10130 - 10139
Published: Sept. 13, 2024
Statins inhibit 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme of mevalonate pathway, and reduce cholesterol synthesis. They also have been demonstrated to improve prognosis in patients with various cancers, suggesting a potential anti-cancer effect statins. However, there is no consensus on molecular targets statins for their effects. Docetaxel (DOC) microtubule-stabilizing agent currently used as chemotherapeutic drug several including lung cancer. Interestingly, effects either that are related abnormal or wild-type TP53 gene implied. Therefore, sensitivity DOC lovastatin human cancer cells was evaluated. We found H1355 (mutant TP53-E285K), CL1 TP53-R248W), H1299 (TP53-null) non-small cell were more sensitive than A549 H460 expressing TP53. Conversely, showed higher cells, by MTT assay. When endogenous activity inhibited pifithrin-α sensitivities significantly increased, viabilities markedly reduced. These results indicate status associated cells. Mutated null correlated statin sensitivity. Furthermore, DOC-resistant (H1299/D8) significant treatment compared (A549/D16) indicating application statins/chemotherapy combination therapy control TP53-containing tumors.
Language: Английский
Citations
1
Current Atherosclerosis Reports, Journal Year: 2024, Volume and Issue: 27(1)
Published: Nov. 18, 2024
Language: Английский
Citations
1
Toxicology Reports, Journal Year: 2024, Volume and Issue: 14, P. 101861 - 101861
Published: Dec. 10, 2024
Atorvastatin and fenofibrate are well-known lipid-lowering drugs. acts by reducing the production of cholesterol through inhibition 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG Co-A reductase) enzyme, whereas is a PPAR-α agonist. Piperine an alkaloid mostly found in black pepper fruits. The present study was planned to evaluate activities atorvastatin, fenofibrate, piperine on male reproductive system. total 35 Wistar rats were obtained for experiment. Rats randomly divided into 7 groups, each group with 5 rats. experiment run 28 days. Group I rat got normal meals days; II received atorvastatin (08 mg/kg/day); III (10 IV (20 mg/kg/day). V (8 mg/kg/day) VI VII mg/kg bw/day) After sacrifice, serum testicular testosterone levels assessed ELISA, ROS generation analysed using flow cytometry, MDA, SOD, catalase measured. Histological, sperm-parameter analysis, spermatogenic evaluations also done. Activities revealed toxicity upon treatment. Fenofibrate treatment, along piperine, showed protective effects. In conclusion, affected potential, might have efficacy against piperine-induced toxicity.
Language: Английский
Citations
1
Fermentation, Journal Year: 2024, Volume and Issue: 10(7), P. 367 - 367
Published: July 18, 2024
Simvastatin, a semisynthetic drug widely used to lower cholesterol, is among the most prescribed statins worldwide. This study focuses on direct production of simvastatin-like biomolecule using alternative substrates by Aspergillus spp. strains. Two species, A. terreus UCP 1276 and flavus 0316, were initially evaluated in synthetic media as control. Subsequently, carbon nitrogen sources replaced agro-industrial substrates, resulting five modified media. Cultures maintained at 28 °C, pH 6.5, 180 rpm for 21 days. Fungal growth kinetics 23 full-factorial design (FFD) was investigate influence substrate concentration statin yield. Presence inhibitors confirmed bioassay, UV–visible spectrophotometry, thin-layer chromatography (TLC). According results, yielded 0.24 mg/g condition 2 FFD (medium containing 4.5% soluble starch saline base), suggesting it promising candidate biomolecule. Statistical analysis showed significant effect inhibitor production, making viable profitable substrate. Moreover, isolated exhibited broad-spectrum antimicrobial activity, including efficacy against Gram-negative Gram-positive bacteria yeasts, indicating therapeutic potential resistance.
Language: Английский
Citations
0