The Inflammatory Signals Associated with Psychosis: Impact of Comorbid Drug Abuse DOI Creative Commons
Jesús Herrera-Imbroda, María Flores-López,

Paloma Ruiz-Sastre

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 454 - 454

Published: Feb. 4, 2023

Psychosis and substance use disorders are two diagnostic categories whose association has been studied for decades. In addition, both psychosis spectrum drug abuse have recently linked to multiple pro-inflammatory changes in the central nervous system. We carried out a narrative review of literature through holistic approach. used PubMed as our search engine. included all relevant studies looking at psychotic disorders. found that there relate various lipids proteins with disorders, an overlap between two. The main findings involve inflammatory mediators such cytokines, chemokines, endocannabinoids, eicosanoids, lysophospholipds and/or bacterial products. Many these present different phases cannabis, cocaine, methamphetamines, alcohol nicotine. may common origin abnormal neurodevelopment caused, among other factors, by neuroinflammatory process. A possible convergent pathway is which interrelates transcriptional factors NFκB PPARγ. This future clinical implications.

Language: Английский

Alteration patterns of peripheral concentrations of cytokines and associated inflammatory proteins in acute and chronic stages of schizophrenia: a systematic review and network meta-analysis DOI
Sean Halstead, Dan Siskind,

Michaela Amft

et al.

The Lancet Psychiatry, Journal Year: 2023, Volume and Issue: 10(4), P. 260 - 271

Published: Feb. 27, 2023

Language: Английский

Citations

121
Chemokine Dysregulation and Neuroinflammation in Schizophrenia: A Systematic Review DOI Open Access
Evgeny A. Ermakov, Irina A. Mednova, Anastasiia S. Boiko

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2215 - 2215

Published: Jan. 22, 2023

Chemokines are known to be immunoregulatory proteins involved not only in lymphocyte chemotaxis the site of inflammation, but also neuromodulation, neurogenesis, and neurotransmission. Multiple lines evidence suggest a peripheral proinflammatory state neuroinflammation at least third patients with schizophrenia. Therefore, chemokines can active players these processes. In this systematic review, we analyzed available data on chemokine dysregulation schizophrenia association neuroinflammation. It has been shown that there is genetic receptor gene polymorphisms Besides, most reliable confirmed by results meta-analyses showed an increase CXCL8/IL-8, CCL2/MCP-1, CCL4/MIP-1β, CCL11/eotaxin-1 blood An CXCL8 found cerebrospinal fluid, other have less well studied. Increased/decreased expression genes their receptors different areas brain immune cells. The may influence since regulated pro- anti-inflammatory cytokines. Mouse models CX3CL1-CX3CR1 CXCL12-CXCR4 axes. Altogether, contribute conclusion, indicates involvement neurobiological processes associated

Language: Английский

Citations

46
The intricate brain–body interaction in psychiatric and neurological diseases DOI Creative Commons
Francesco Di Gregorio, Simone Battaglia

Advances in Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 33(4), P. 321 - 326

Published: March 21, 2024

A harmonic brain-body communication is fundamental to individual wellbeing and the basis of human cognition behavior.In last 2 decades, interaction between brain body functioning has become a central area study for neurologists neuroscientists in clinical non-clinical contexts.Indeed, axis dysfunctions occur many psychiatric, neurological neurodegenerative diseases.This editorial will focus on recent advances future therapeutic perspectives studying interactions health diseases.

Language: Английский

Citations

22
CNS pharmacology of NKCC1 inhibitors DOI Creative Commons
Wolfgang Löscher, Kai Kaila

Neuropharmacology, Journal Year: 2021, Volume and Issue: 205, P. 108910 - 108910

Published: Dec. 6, 2021

The Na-K-2Cl cotransporter NKCC1 and the neuron-specific K-Cl KCC2 are considered attractive CNS drug targets because altered neuronal chloride regulation consequent effects on GABAergic signaling have been implicated in numerous disorders. While modulators not yet clinically available, loop diuretic bumetanide has used clinical studies to treat brain disorders as a tool for inhibition preclinical models. Bumetanide is known anticonvulsant neuroprotective under some pathophysiological conditions. However, shown several species from neonates adults (mice, rats, dogs, by extrapolation humans), at low doses of approved diuresis, this negligible access into CNS, reaching levels that much lower than what needed inhibit cells within parenchyma. Several discovery strategies over last ∼15 years develop brain-permeant compounds that, ideally, should be selective eliminate diuresis mediated renal NKCC2. employed improve pharmacokinetic pharmacodynamic properties blockers include evaluation other diuretics; development lipophilic prodrugs bumetanide; side-chain derivatives unbiased high-throughput screening approaches based large chemical compound libraries. main outcomes (1), non-acidic diuretics such azosemide torasemide may advantages inhibitors vs. (2), achieve significantly higher parent activity; (3), novel do exhibit any functionally relevant improvement accessibility or selectivity (4) discovered resolve inherent problems bumetanide, but achieved. Thus, further research optimize design inhibitors. Another major challenge identify mechanisms whereby various NKCC1-expressing cellular these (e.g., neurons, oligodendrocytes astrocytes) outside parenchyma blood-brain barrier, choroid plexus, endocrine immune system), well molecular off-target effects, might contribute their reported therapeutic adverse effects.

Language: Английский

Citations

59
Investigating the relationship between inflammatory cytokines and adolescent depression: a comparative analysis DOI Creative Commons
Mengqi Liu, Jie Tang,

Gaoyang Xu

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 6, 2025

Major depressive disorder (MDD) in adolescents poses a significant threat to physical health. Previous studies have indicated that with MDD exhibit immune activation. This study aimed compare cytokine levels healthy controls and assess their diagnostic value. cross-sectional included 58 adolescent patients depression from Beijing Anding Hospital (outpatients inpatients) 40 recruited the community. Multiplex analysis (Luminex xMAP) was used measure serum of several cytokines. Data performed using SPSS (version 26.0) between gender differences. Correlations demographic data, clinical features symptoms were also analyzed. The receiver operating characteristic (ROC) curves evaluate value Serum IL-4, IFN-γ, TNF-α significantly elevated group compared (p < 0.05). In group, age first onset females younger than males 0.05), female higher those BMI IL-4 positively correlated MDD. area under ROC curve for diagnosing 0.695 (95% confidence interval [CI]: 0.580 - 0.809; p sensitivity 0.793 specificity 0.675. Compared controls, demonstrated levels, indicating activation which female. Cytokines may promising depression, but further validation additional indicators is needed.

Language: Английский

Citations

1
Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells DOI Creative Commons
Amalie C.M. Couch, Shiden Solomon, Rodrigo R. R. Duarte

et al.

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 110, P. 43 - 59

Published: Feb. 11, 2023

Prenatal exposure to elevated interleukin (IL)-6 levels is associated with increased risk for psychiatric disorders a putative neurodevelopmental origin, such as schizophrenia (SZ), autism spectrum condition (ASC) and bipolar disorder (BD). Although rodent models provide causal evidence this association, we lack detailed understanding of the cellular molecular mechanisms in human model systems. To close gap, characterized response induced pluripotent stem cell (hiPSC-)derived microglia-like cells (MGL) neural progenitor (NPCs) IL-6 monoculture. We observed that forebrain NPCs did not respond acute monoculture at both protein transcript due absence IL6R expression soluble (s)IL6Ra secretion. By contrast, resulted STAT3 phosphorylation IL6, JMJD3 IL10 MGL, confirming activation canonical IL6Ra signaling. Bulk RNAseq identified 156 up-regulated genes (FDR < 0.05) MGL following exposure, including IRF8, REL, HSPA1A/B OXTR, which significantly overlapped an gene set from post-mortem brain tissue individuals schizophrenia. Acute stimulation motility, consistent ontology pathways highlighted data replicating indications IRF8 regulates microglial motility. Finally, induces MGLs secrete CCL1, CXCL1, MIP-1α/β, IL-8, IL-13, IL-16, IL-18, MIF Serpin-E1 after 3h 24h. Our specific effects system, ultimately suggesting microglia-NPC co-culture are required study how influences cortical development vitro.

Language: Английский

Citations

20
Neuroinflammation and schizophrenia – is there a link? DOI Creative Commons
Cristiano Chaves, Serdar Dursun, Massimo Tusconi

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 8, 2024

Keywords: inflammation, schizophrenia, biomarkers, psychiatric genetics, neurobiology, neuroinflammation, psychotic disorders

Language: Английский

Citations

6
Immune-based Machine learning prediction of diagnosis and illness state in schizophrenia and bipolar disorder DOI Creative Commons
Katrien Skorobogatov, Livia De Picker, Ching‐Lien Wu

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 122, P. 422 - 432

Published: Aug. 14, 2024

Schizophrenia and bipolar disorder frequently face significant delay in diagnosis, leading to being missed or misdiagnosed early stages. Both disorders have also been associated with trait state immune abnormalities. Recent machine learning-based studies shown encouraging results using diagnostic biomarkers predictive models, but few focused on immune-based markers. Our main objective was develop supervised learning models predict diagnosis illness schizophrenia only a panel of peripheral kynurenine metabolites cytokines.

Language: Английский

Citations

6
The mechanisms of interactions of psychotropic drugs with liver and brain cytochrome P450 and their significance for drug effect and drug-drug interactions DOI
Władysława A. Daniel, Ewa Bromek, Przemysław J. Danek

et al.

Biochemical Pharmacology, Journal Year: 2022, Volume and Issue: 199, P. 115006 - 115006

Published: March 19, 2022

Language: Английский

Citations

26
Cytokine Imbalance as a Biomarker of Treatment-Resistant Schizophrenia DOI Open Access
N. А. Shnayder, Aiperi K. Khasanova, Anna Strelnik

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11324 - 11324

Published: Sept. 26, 2022

Treatment-resistant schizophrenia (TRS) is an important and unresolved problem in biological clinical psychiatry. Approximately 30% of cases (Sch) are TRS, which may be due to the fact that some patients with TRS suffer from pathogenetically “non-dopamine” Sch, development neuroinflammation supposed play role. The purpose this narrative review attempt summarize data characterizing patterns production pro-inflammatory anti-inflammatory cytokines during therapeutic resistance APs their pathogenetic prognostic significance cytokine imbalance as biomarkers. This demonstrates evaluating contribution maintaining or changing balance can become a new key unlocking mystery Sch developing strategies for treatment psychosis setting acute chronic neuroinflammation. In addition, inconsistency results previous studies on role indicates biomarker, most likely, not serum level one more cytokines, but balance. We have confirmed hypothesis partially supported by variable response immunomodulators were prescribed without taking into account relation between levels TRS.

Language: Английский

Citations

23