Does Pizza Consumption Favor an Improved Disease Activity in Rheumatoid Arthritis? DOI Open Access
Roberta De Vito, Maria Parpinel, Michela Carola Speciani

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(15), P. 3449 - 3449

Published: Aug. 4, 2023

To our knowledge, no studies so far have investigated the role of pizza and its ingredients in modulating disease activity rheumatoid arthritis (RA). We assessed this question via a recent cross-sectional study including 365 participants from Italy, birthplace pizza. Multiple robust linear logistic regression models were fitted with tertile consumption categories each available pizza-related food item/group (i.e., pizza, refined grains, mozzarella cheese, olive oil) as independent variables, RA measure Disease Activity Score on 28 joints C-reactive protein (DAS28-CRP), Simplified Index (SDAI)) dependent variable. Stratified analyses carried out according to severity or duration. Participants eating half >1 time/week (vs. ≤2 times/month) reported beneficial effects activity, significant reductions ~70% (overall analysis), 80% (the more severe stratum), beta coefficients −0.70 for DAS28-CRP, −3.6 SDAI analysis) −1.10 −5.30 (in long-standing RA, respectively). Among items/groups, cheese oil showed effects, especially stratum. Future cohort are needed confirm effect related items/groups activity.

Language: Английский

Nutritional immunological effects and mechanisms of chemical constituents from the homology of medicine and food DOI
Great Iruoghene Edo, Winifred Ndudi,

Raghda Makia

et al.

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 2, 2024

Language: Английский

Citations

9
Association between weight-adjusted-waist index and the prevalence of rheumatoid arthritis and osteoarthritis: a population-based study DOI Creative Commons
Xiaohua Wang, Lin Xie, Shuo Yang

et al.

BMC Musculoskeletal Disorders, Journal Year: 2023, Volume and Issue: 24(1)

Published: July 20, 2023

The weight-adjusted-waist Index (WWI), an innovative metric for assessing obesity, exhibits superior efficacy in appraising lean muscle and adipose tissue mass relative to both the Body Mass (BMI) Waist Circumference (WC). objective of this research paper is investigate correlation between WWI incidence Rheumatoid Arthritis (RA) Osteoarthritis (OA).In population-based study, we collected data from adult participants aged 20-80 years using National Health Nutrition Examination Survey (NHANES) conducted 2011 2020 analyze association occurrence RA OA. NHANES, a nationally representative cross-sectional survey, designed evaluate health nutritional status U.S.The current incorporates extensive, sample U.S. adults, utilizing weighted multivariate linear regression smoothed curve fitting techniques examine non-linear relationships. Threshold effects were determined through two-part model. Additionally, subgroup analyses interaction tests explore connection OA.Our findings reveal positive OA prevalence, indicating that increase linked heightened risk Conversely, relationship was observed exhibiting significant threshold effect with saturation value 11.21 cm/√kg. A detected left point, while no present two variables right suggesting complex prevalence WWI.This investigation demonstrates as well adults years.

Language: Английский

Citations

20
Pathogenesis of rheumatoid arthritis: one year in review 2023 DOI Open Access
Francesco Mariani, Irene Martelli,

Francesca Pistone

et al.

Clinical and Experimental Rheumatology, Journal Year: 2023, Volume and Issue: unknown

Published: June 19, 2023

Language: Английский

Citations

18
Triterpenes as Potential Drug Candidates for Rheumatoid Arthritis Treatment DOI Creative Commons
Célia Faustino, Lídia Pinheiro, Noélia Duarte

et al.

Life, Journal Year: 2023, Volume and Issue: 13(7), P. 1514 - 1514

Published: July 5, 2023

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by joint inflammation, swelling and pain. Although RA mainly affects the joints, can also have systemic implications. The presence of autoantibodies, such as anti-cyclic citrullinated peptide antibodies rheumatoid factors, hallmark disease. significant cause disability worldwide associated with advancing age, genetic predisposition, infectious agents, obesity smoking, among other risk factors. Currently, treatment depends on anti-inflammatory disease-modifying anti-rheumatic drugs intended to reduce inflammation pain, preventing or slowing down damage progression. However, these are severe side effects upon long-term use, including immunosuppression development opportunistic infections. Natural products, namely triterpenes properties, shown relevant anti-arthritic activity in several animal models without undesirable effects. Therefore, this review covers recent studies (2017-2022) safe promising drug candidates for RA. These bioactive compounds were able produce reduction indices immunological markers. Celastrol, betulinic acid, nimbolide some ginsenosides stand out most treatment.

Language: Английский

Citations

12
National trends in rheumatoid arthritis and osteoarthritis prevalence in South Korea, 1998–2021 DOI Creative Commons
Jaeyu Park, Myeongcheol Lee, Hojae Lee

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Nov. 9, 2023

Abstract Studies on the trends in prevalence of rheumatoid arthritis (RA) and osteoarthritis (OA) are limited, particularly during COVID-19 pandemic. This study aimed to analyze temporal trend RA OA South Korean adults from 1998 2021, including pandemic period. The Korea National Health Nutrition Examination Survey (KNHANES) data aged ≥ 19 years were analyzed investigate 2021. compared by years, β diff (β difference) was calculated. Odds ratios (ORs) computed for each disease examine changes before order determine impact prevalence. Among 163,221 adults, showed a steady decrease 2005 (RA: 1.91% 2005–2007 1.55% 2016–2019 OA: 9.75% 8.27% 2016–2019), but there slight increased after onset 1.23% 2020 1.36% 2021 8.04% 2021). Vulnerable groups, participants 60 (versus 19–60 ratio ORs: 1.222; 95% CI 1.011–1.477), urban residents (ratio 1.289; 1.007–1.650), with higher education level 1.360; 1.119–1.653) ORs OA, whereas no vulnerable population observed RA. Our findings provide an insight into long-term among adult highlight novel perspective

Language: Английский

Citations

12
Rheumatoid arthritis: a comprehensive overview of genetic markers, emerging therapies, and personalized medicine DOI Open Access
Laiba Shakeel, Ayesha Shaukat, Nawal Khaliq

et al.

Annals of Medicine and Surgery, Journal Year: 2025, Volume and Issue: 87(2), P. 696 - 710

Published: Jan. 6, 2025

Language: Английский

Citations

0
Rheumatoid Arthritis Prevalence and Risk Factors in Korean Adults: A Focus on Age and Sex Differences DOI Creative Commons
Do‐Youn Lee

Medical Sciences, Journal Year: 2025, Volume and Issue: 13(1), P. 17 - 17

Published: Feb. 9, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects the joints, causing swelling, pain, stiffness, and functional decline. This study aims to clarify prevalence risk factors of RA based on sex age among Korean adults, providing essential data for targeted prevention management strategies. We analyzed from Korea National Health Nutrition Examination Survey 2016-2021, comprising 25,166 participants aged 20 older. Sociodemographics, health status, behavior were evaluated, with defined self-reported diagnosis. A complex sampling design was utilized ensure representative results multiple logistic regression employed determine linked RA. The overall adults 1.1%, showing significant sex-based disparity: 0.6% 1.7% in men women, respectively. increased age, peaking at 3.5% individuals over 70. identified education level, subjective as key predictors Among men, included level higher observed only elementary poor perceived health. For status main factors, increasing markedly older groups, particularly those 70 above. highlights distinct by age. Key predictors-education age-suggest tailored interventions addressing these are crucial reducing burden enhancing outcomes affected populations.

Language: Английский

Citations

0
Time-restricted feeding alleviates arthritis symptoms augmented by high-fat diet DOI Creative Commons

Zsófia Búr,

Bernadett Vendl,

Ágnes Réka Sűdy

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 13, 2025

Rheumatoid arthritis (RA) affects approximately 1% of the global population. Its hallmark symptoms include severe pain and joint stiffness, which significantly diminish life quality. RA’s development is influenced by multiple factors including unhealthy lifestyle habits. Calorie-rich diets, particularly those high in fat resulting obesity, are associated with RA exacerbate its symptoms. Consequently, dietary modifications recommended as a complementary treatment. However, adherence often low due to restrictive changes required nutrient composition or caloric intake. Our previous findings indicate that time-restricted feeding (TRF) benefits leukocyte rhythm mitigates autoimmune responses. In this study we explored impact TRF on severity K/BxN serum-transfer (STA) mice subjected high-fat diet. Three schedules were implemented: control (Ctrl) constant access standard chow, diet group (HF) ad libitum food access, (HF-TRF) 10-hour window during active phase. After four weeks conditioning, STA was induced. Although macroscopic markers inflammation did not differ between Ctrl HF groups, histological analysis revealed increased mice, expanded edema, pannus formation, bone erosion, elevated synovial neutrophil infiltration serum leptin levels. Importantly, all these inflammatory reduced HF-TRF group, along IL-1β monocyte/macrophage counts. results can severity, potentially serving preventive method sustainable therapeutic support for management.

Language: Английский

Citations

0
Impact of comorbidities, diabetes, and smoking on sustained outcomes in rheumatoid arthritis: a retrospective study DOI Creative Commons

Zhaklin Apostolova,

T. Shivacheva, Tsvetoslav Georgiev

et al.

Reumatologia/Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Objectives Rheumatoid arthritis (RA) is a chronic autoimmune disease significantly impacting patients’ quality of life (QoL) and necessitating complex, long-term treatment. This study aimed to assess the therapeutic outcomes biologic therapies in real-world clinical setting, focusing on achievement maintenance low activity (LDA) among RA patients, while also investigating factors influencing these outcomes. Material methods A retrospective observational analysis was conducted 190 patients receiving tumor necrosis factor α (TNF-α) or interleukin (IL)-6 inhibitors. Disease evaluated using Activity Score 28 (DAS28) at baseline, 6 months, 12 months. Based DAS28 with C-reactive protein (DAS28-CRP) values, categorized into 2 main groups: remission/low (target achieved) when DAS28-CRP value less than 3.2, insufficient response exceeded 3.2. Results The group consisted predominantly women (85.8%), mean age 58.7 years duration 12.5 years. We found that 45.8% achieved single-point LDA, 39.5% sustaining this after Notably, comorbidities such as diabetes smoking negatively affected likelihood maintaining LDA. Statistical revealed without had higher chance retaining sustained LDA (OR = 0.100; p 0.014). Conclusions These findings emphasize need for personalized treatment approaches consider lifestyle enhance efficacy management. Consequently, highlights critical importance ongoing monitoring indivi­dualized strategies improve QoL RA.

Language: Английский

Citations

0
Welche Rolle spielen Adipositas und damit verbundene Stoffwechselstörungen bei der rheumatoiden Arthritis? DOI

Wiebke Diederich,

Tim Hollstein, Corinna Geisler

et al.

Arthritis und Rheuma, Journal Year: 2025, Volume and Issue: 45(02), P. 110 - 116

Published: April 1, 2025

Zusammenfassung Dieser Artikel beschreibt die Rolle metabolischer Störungen bei rheumatoider Arthritis (RA) mit Fokus auf den Zusammenhängen Adipositas und der damit einhergehenden metabolischen Inflammation. begünstigt chronische Entzündungen durch vermehrte Freisetzung von Entzündungsmarkern aus dem Fettgewebe beeinflusst so das Fortschreiten, Schweregrad Therapieansprechen RA. Weitere metabolische Risikofaktoren, wie des Glukose- Fettstoffwechsels, ungünstige Lebensstilfaktoren fördern entzündliche Prozesse zusätzlich führen zu einem erhöhten kardiovaskulären Risiko RA-Patienten. Gemeinsame therapeutische Ansätze zur Verminderung zugrundeliegenden Inflammation umfassen Gewichtsreduktion, eine antientzündliche Ernährung Einsatz spezifischer antirheumatischer Medikamente, sowohl Entzündungsprozesse als auch Begleiterkrankungen wirken. Mit einer integrierten Behandlungsstrategie, Entzündungsgeschehen, Risikoprofil Betroffenen berücksichtigt, können Versorgung verbessert unerwünschte Effekte minimiert werden.

Citations

0