Biological markers of sepsis DOI Creative Commons
Lubov V. Radygina, Larisa V. Mochalova

Microbiology Independent Research Journal (MIR Journal), Journal Year: 2023, Volume and Issue: 10(1)

Published: Jan. 1, 2023

ABSTRACT Currently, the issues of early sepsis diagnosis, assessment effectiveness therapies conducted, and disease prognosis are extremely relevant. In case sepsis, timely medical assistance is complicated by ambiguity symptoms absence a specific diagnostic test. Therefore, search for biomarkers with diagnostic, prognostic, therapeutic potential underway in centers worldwide. This review summarizes research results regarding values – their sensitivity, specificity, prognostic value as presented scientific publications indexed international databases.

Language: Английский

Serum Lactate Is an Indicator for Short-Term and Long-Term Mortality in Patients with Acute Pancreatitis DOI

Zhao Yang Zeng,

Rong Huang, Hang Lin

et al.

Digestive Diseases and Sciences, Journal Year: 2024, Volume and Issue: 69(6), P. 2223 - 2234

Published: April 9, 2024

Language: Английский

Citations

4
Monocyte distribution width (MDW) kinetic for monitoring sepsis in intensive care unit DOI
Luisa Agnello, Anna Maria Ciaccio, Fabio Del Ben

et al.

Diagnosis, Journal Year: 2024, Volume and Issue: 11(4), P. 422 - 429

Published: April 22, 2024

Abstract Objectives Monocyte distribution width (MDW) is a measure of monocyte anisocytosis. In this study, we assessed the role MDW, in comparison to C-reactive protein (CRP), procalcitonin (PCT), and lactate, as screening prognostic biomarker sepsis intensive care unit (ICU) by longitudinally measuring it first 5 days hospital stay. Methods We considered all consecutive patients admitted ICU. At admission, were classified septic or not according Sepsis-3 criteria. CRP, PCT, lactate measured daily hospitalization. ICU mortality was also recorded. Results included 193 patients, 62 with 131 without (controls). 58% 26 % respectively, died during MDW showed highest accuracy for detection, superior (AUC 0.840, 0.755, 0.708, 0.622, respectively). no predicts sepsis. The kinetic biomarkers hospitalization associated mortality. Noteworthy, above all, best accuracy. Specifically, an increase decrease from day 1–4 significantly survival, respectively. Conclusions reliable diagnostic biomarker, better than traditional biomarkers.

Language: Английский

Citations

4
Predictive biomarkers of mortality in patients with severe COVID-19 hospitalized in intensive care unit DOI Creative Commons
Sandrelli Meridiana de Fátima Ramos dos Santos Medeiros, Bruna Maria Nepomuceno Sousa Lino, Vinícius Pietta Perez

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 30, 2024

This study was performed to identify predictive markers of worse outcomes in patients with severe COVID-19 an intensive care unit.

Language: Английский

Citations

4
Immune Cell-Based versus Albumin-Based Ratios as Outcome Predictors in Critically Ill COVID-19 Patients DOI Creative Commons
Snježana Zeba, Maja Šurbatović, Ivo Udovičić

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 73 - 90

Published: Jan. 1, 2025

Purpose: The aim of the retrospective, single-center study was to assess prognostic value immune cell-based and albumin-based ratios regarding lethal outcome in critically ill COVID-19 patients. Patients Methods: We analyzed 612 adult patients admitted intensive care unit (ICU) between April 2020 November 2022. Blood measurement on admission ICU encompassed complete blood count (CBC), IL-6, C-reactive protein (CRP), albumin, lactate, lactate dehydrogenase (LDH), serum bicarbonate, arterial base deficit/excess (BD/E), D-dimer. All measured calculated parameters were compared survivors nonsurvivors, with measure being hospital mortality. Results: Immune [NLR - Neutrophil-to-Lymphocyte Ratio, MLR Monocyte-to-Lymphocyte PLR Platelet-to-Lymphocyte MPV Mean Platelet Volume, MPV/PC Volume-to-Platelet Count Derived (d-)NLR ratio neutrophil divided by result white cell (WBC) – count), N/LP Neutrophil x 100/Lymphocyte count, CLR (CRP)-to-Lymphocyte CPR CRP-to-Platelet LLR Lactate (LDH)-to-Lymphocyte Systemic Inflammation Index (SII) platelet neutrophil/lymphocyte Response (SIRI) monocyte/lymphocyte count] investigated. White counts significantly higher, while lymphocyte lower nonsurvivors. MPV, MPV/PC, NLR, d-NLR, MLR, N/LP, CRP, LDH, CPR, CLR, LLR, SII, SIRI values higher Monocyte did not differ groups. Albumin-based included CRP-to-Albumin Ratio (CAR), Lactate-to-Albumin (LAR) LDH-to-Albumin (LDH/ALB). Conclusion: only independent predictor outcomes at is LDH/ALB ratio. Most other moderate, although highly significant predictors mortality Keywords: LDH/albumin ratio, ill, COVID-19,

Language: Английский

Citations

0
The Role of Monocyte Distribution Width (MDW) in the Prediction of Death in Adult Patients with Sepsis DOI Creative Commons
Dimitrios Theodoridis, Angeliki Tsifi, Emmanouil Magiorkinis

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 427 - 427

Published: Feb. 15, 2025

Sepsis is a life-threatening condition; it major cause of hospital mortality worldwide and constitutes global health problem. This research investigates the use MDW as predictor for septic patients. was double-center prospective cohort study adult Septic patients were identified categorized into two categories: those who improved died. Blood drawn from three times, on first, third, fifth day their admission to hospital. evaluated biomarker predict patient outcome. In addition, existing inflammatory markers recorded in all The able patient's average found be significantly higher died records. For example, an value 28.4 first shown best cut-off determining fatal outcomes; receiver operating characteristic (ROC) analysis revealed area under curve 0.71 (95% Confidence Interval-CI: 0.57-0.84) with sensitivity 64.7% specificity 88.2%. conclusion, MDW, addition being marker that can quickly detect sepsis more effectively than other biomarkers, which proven by numerous studies, could also used indicator work attempt direction.

Language: Английский

Citations

0
Pathogenic bacteria features of central line-associated bloodstream infections in ICU patients: focus on the early predictive value of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios DOI Creative Commons

Yuzhen Li,

Yanyan Li, Jiqin Wang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 30, 2025

Objective Explore and analyze CLABSI pathogenic bacteria characteristics in ICU patients the value of PCT, NLR, PLR early infection prediction. Methods 926 with central venous catheters Minhang Hospital from January 2021 to December 2023 were enrolled. They grouped by co-infection status. NLR levels measured, patient data analyzed, summarized, their predictive evaluated via ROC curve. Results From 2023, among CVC, 73 diagnosed CLABSI, an rate 7.88%. A total 81 strains isolated, including 60.50% (49/81) Gram - positive bacteria, 35.80% (29/81) negative 3.70% (3/81) fungi. The main exhibited high resistance penicillin, erythromycin, clindamycin, oxacillin, a exceeding 70%, yet sensitive vancomycin, linezolid, tetracycline. had piperacillin, piperacillin/tazobactam, Aztreonam, gentamicin, over more cefoperazone/sulbactam, imipenem, amikacin. Age, site catheterization, duration employment double cavity all factors that exerted influence on (with p < 0.05). peripheral blood PLR, PCT infected group higher than those non (p areas under curve (AUCs) 0.814, 0.798, 0.856, respectively, largest AUC for PCT. When cut off point was 2.75 ng/ml, Youden index largest. AUCs combination three combined 0.877, 0.903, 0.857, 0.917. Conclusion prediction means is remarkable significance. It can provide precious reference clinical diagnostic treatment strategies.

Language: Английский

Citations

0
Monocyte distribution width as an early predictor of short-term outcome in adult patients with sepsis DOI
Yin Liu, Ruizhi Wang,

Shihua Zhong

et al.

Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2023, Volume and Issue: 62(3), P. 562 - 571

Published: Oct. 10, 2023

Monocyte distribution width (MDW) is a quantitative measurement of monocyte anisocytosis and has been proposed as an efficient marker for early sepsis detection. This study aimed to assess the prognostic potential MDW in septic patients.

Language: Английский

Citations

8
Interleukin-6 and the determinants of severe COVID-19: A retrospective cohort study DOI Creative Commons
Wael Hafez, Prashant Nasa, Ahmed Khairy

et al.

Medicine, Journal Year: 2023, Volume and Issue: 102(45), P. e36037 - e36037

Published: Nov. 10, 2023

Cytokines, notably interleukin-6 (IL-6), increase considerably in patients with severe corona virus disease 2019 (COVID-19). This vigorous immune response may cause end-organ failure or death; hence, measuring IL-6 the context of patient characteristics help predict outcomes and encourage early comprehensive therapy. study investigated association between serum levels, COVID-19 severity, demographic, clinical, biochemical characteristics. inpatients NMC hospitals were November 2020 2021. Several variables related to severity have been examined. The included 374 inpatients, 235 whom had a median age 51. elderly an increased risk (73.8%) compared young adults (71%), higher white blood cells, D-dimer, Lactate dehydrogenase, creatinine, ferritin, prothrombin time, Procalcitonin, fibrinogen levels (P < .001). C-reactive protein, troponin, intensive care unit admission, score, mortality significantly associated = .05) univariate analysis, but this significance disappeared multivariate analysis. IL-6, along other demographic clinical affected severity. These at assist establishing outcome strategies. Large-scale research is needed emphasize COVID-19.

Language: Английский

Citations

6
Novel inflammatory biomarkers in the prognosis of COVID-19 DOI Creative Commons

Kegang Zhan,

Luhan Wang, Hao Lin

et al.

Therapeutic Advances in Respiratory Disease, Journal Year: 2023, Volume and Issue: 17

Published: Jan. 1, 2023

The central role of inflammatory progression in the development Coronavirus disease 2019 (COVID-19), especially severe cases, is indisputable. However, some novel biomarkers prognosis COVID-19 remains controversial.

Language: Английский

Citations

3
The Need for Standardized Guidelines for the Use of Monocyte Distribution Width (MDW) in the Early Diagnosis of Sepsis DOI Open Access
Andrea Piccioni,

Fabio Spagnuolo,

Silvia Baroni

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 15(1), P. 5 - 5

Published: Dec. 27, 2024

Sepsis is a complex and potentially life-threatening syndrome characterized by an abnormal immune response to infection, which can lead organ dysfunction, septic shock, death. Early diagnosis crucial improving prognosis reducing hospital management costs. This narrative review aims summarize evaluate the current literature on role of monocyte distribution width (MDW) as diagnostic biomarker for sepsis, highlighting its advantages, limitations, potential clinical applications. MDW measures volumetric monocytes, reflecting monocytic anisocytosis, detected using advanced hematological analyzers. In 2019, it was approved FDA sepsis due ability identify systemic inflammatory at early stage. Thirty-one studies analyzed us have shown that increased value associated with higher risk combination parameters (such qSOFA) other biomarkers (CRP, PCT) enhance sensitivity stratification capacity. Despite high sensitivity, has lower specificity compared more established such procalcitonin, thus requiring multimodal integration accurate diagnosis. The use in emergency intensive care settings represents opportunity improve critical patient management, particularly when combined markers tools. However, further are needed define universal cut-off confirm validity different contexts pathological scenarios.

Language: Английский

Citations

0