Critical Reviews in Biotechnology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 27
Published: May 6, 2024
The
rapid
increase
in
antimicrobial
resistance
(AMR)
projects
a
"global
emergency"
and
necessitates
need
to
discover
alternative
resources
for
combating
drug-resistant
pathogens
or
"superbugs."
One
of
the
key
themes
"One
Health
Concept"
is
based
on
fact
that
interconnected
network
humans,
environment,
animal
habitats
majorly
contribute
selection
spread
AMR.
Moreover,
injudicious
overuse
antibiotics
healthcare,
associated
disciplines,
further
aggravates
concern.
prevalence
persistence
AMR
global
economic
burden
are
constantly
witnessing
an
upsurge
due
fewer
therapeutic
options,
rising
mortality
statistics,
expensive
healthcare.
present
decade
has
witnessed
extensive
exploration
utilization
bio-based
harnessing
potential
efficacies.
discovery
characterization
diverse
chemical
entities
from
endophytes
as
potent
antimicrobials
define
important
yet
less-explored
area
natural
product-mediated
drug
discovery.
Endophytes-produced
show
efficacies
targeting
microbial
synthetic
biology
(SB)
mediated
engineering
yield
enhancement,
forms
prospective
research.
In
keeping
with
urgent
requirements
new/novel
growing
concerns
about
pathogenic
microbes
AMR,
this
paper
comprehensively
reviews
emerging
trends,
prospects,
challenges
their
effective
production
via
SB.
This
literature
review
would
serve
platform
novel
bioactive
biological
organisms
"novel
therapeutics"
address
Frontiers in Plant Science,
Journal Year:
2023,
Volume and Issue:
14
Published: July 10, 2023
The
most
significant
issues
that
humans
face
today
include
a
growing
population,
an
altering
climate,
reliance
on
pesticides,
the
appearance
of
novel
infectious
agents,
and
accumulation
industrial
waste.
production
agricultural
goods
has
also
been
subject
to
great
number
shifts,
often
known
as
revolutions,
which
have
influenced
by
progression
civilization,
technology,
general
human
advancement.
Sustainable
measures
can
be
applied
in
agriculture,
environment,
medicine,
industry
are
needed
lessen
harmful
effects
aforementioned
problems.
Endophytes,
might
bacterial
or
fungal,
could
successful
solution.
They
protect
plants
promote
growth
producing
phytohormones
providing
biotic
abiotic
stress
tolerance.
Endophytes
produce
diverse
type
bioactive
compounds
such
alkaloids,
saponins,
flavonoids,
tannins,
terpenoids,
quinones,
chinones,
phenolic
acids
etc.
for
various
therapeutic
advantages
anticancer,
antitumor,
antidiabetic,
antifungal,
antiviral,
antimicrobial,
antimalarial,
antioxidant
activity.
Proteases,
pectinases,
amylases,
cellulases,
xylanases,
laccases,
lipases,
other
types
enzymes
vital
many
different
industries
produced
endophytes.
Due
presence
all
these
endophytes,
they
preferred
sources
green
synthesis
nanoparticles.
This
review
aims
comprehend
contributions
uses
endophytes
medicinal,
sectors
bio-nanotechnology
with
their
mechanism
action.
Encyclopedia,
Journal Year:
2023,
Volume and Issue:
3(2), P. 759 - 780
Published: June 19, 2023
There
has
been
renewed
interest
in
the
application
of
endophytic
fungi
to
control
phytopathogenic
fungi,
which
cause
significant
damage
crop
health,
ultimately
leading
losses
agricultural
productivity.
Endophytic
inhibit
pathogens
via
different
modes
action—mycoparasitism,
competition
(for
nutrients
and
ecological
niches),
antibiosis,
induction
plant
defense—thus
demonstrating
ability
a
wide
range
growth
phases
habitats.
However,
many
studies
have
conducted
under
laboratory
conditions,
there
is
huge
lack
real
field
testing
was
performed.
Aspergillus,
Clonostachys,
Coniothyrium,
Trichoderma,
Verticillium
proven
be
most
effective
fungal
biocontrol
agents.
Trichoderma
regarded
as
promising
group
commercial
formulations.
In
this
study,
we
attempted
emphasize
significance
endophytes
controlling
while
reporting
recent
advances
biology
application.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(13), P. 5025 - 5025
Published: June 27, 2023
In
this
study,
we
investigated
in
vitro
the
potential
of
Trichoderma
harzianum
to
produce
bioactive
secondary
metabolites
that
can
be
used
as
alternatives
synthetic
compounds.
The
study
focused
on
analyzing
two
extracts
T.
using
ethyl
acetate
and
n-butanol
solvents
with
different
polarities.
were
examined
phytochemical
analysis
determine
content
polyphenols,
flavonoids,
tannins,
alkaloids.
Thin-layer
chromatography
(TLC)
Gas
chromatography-mass
spectroscopy
(GC-MS)
profile
volatile
organic
(VOCs)
present
extracts.
Furthermore,
tested
for
their
antifungal
ability
poison
food
technique.
For
measuring
antioxidant
activity,
1,1-diphenyl-2-picryl-hydrazyl
(DPPH)
test
was
used.
shown
have
a
significantly
high
tannins
alkaloids,
noticeable
difference
between
GC-MS
identified
33
compounds
numerous
benefits
could
agriculture
medicinal
industry.
Moreover,
strong
activity
against
Sclerotinia
sclerotiorum
by
94.44%,
Alternaria
sp.
77.04%,
Fusarium
solani
51.48;
similarly,
IC50
estimated
extract
71.47%
56.01%.
This
leads
conclusion
VOCs
play
significant
role
an
agent
when
taking
into
account
advantageous
chemicals
noted
However,
our
knowledge,
is
first
Algeria
presenting
detailed
profiling
extracts,
n-butanol.
Sustainability,
Journal Year:
2022,
Volume and Issue:
14(17), P. 10839 - 10839
Published: Aug. 31, 2022
Current
strategies
for
increasing
food
production
rely
heavily
on
the
use
of
agrichemicals
to
improve
plant
growth
and
resistance
disease.
However,
many
these
chemicals
have
been
shown
negative
impacts
human
health
environment.
Nanotechnology
presents
itself
as
one
promising
technologies
that
can
be
employed
overcome
challenges,
but,
in
same
way
harmful,
so
too
nanotechnology
lines
cause
harm.
In
an
effort
produce
nanoparticles
(NPs)
environmentally
friendly
sustainable
manner,
biological
synthesis
pathways
using
microbes
plants
are
being
explored
developed.
Synthesis
NPs
endophytic
microbiomes
is
approaches
showing
great
potential,
offering
alternatives
current
adding
value
agricultural
systems.
This
review
potential
synthesized
(primarily
bacteria
fungi)
enhance
disease
resistance,
ultimately
making
agriculture
more
sustainable.
The
future
focus
exploration
this
important
technique
advocated.
Journal of Fungi,
Journal Year:
2023,
Volume and Issue:
9(10), P. 997 - 997
Published: Oct. 8, 2023
The
study
examines
the
intricate
relationship
between
plants
and
endophytic
fungi
inhabiting
their
tissues.
These
harmoniously
coexist
with
plants,
forming
a
distinct
symbiotic
connection
that
has
caught
scientific
attention
due
to
its
potential
implications
for
plant
health
growth.
diverse
range
of
bioactive
compounds
produced
by
these
holds
significant
promise
human
health.
review
covers
various
aspects
this
topic,
starting
introducing
microorganisms,
explaining
colonization
different
parts,
illuminating
roles
in
enhancing
defense
against
diseases
promoting
emphasizes
widespread
occurrence
diversity
microorganisms
among
species
while
highlighting
complexities
significance
isolating
extracting
from
them.
It
focuses
on
benefits
compounds,
including
capacity
exhibit
antioxidant,
anti-inflammatory,
antimicrobial,
anticancer
effects.
delves
into
mechanisms
behind
health-promoting
effects,
spotlighting
how
interact
cellular
receptors,
signaling
pathways,
gene
expression.
In
conclusion,
provides
comprehensive
overview
fungi.
outlines
multifaceted
impact,
applications,
future
research
avenues
medicine.
Journal of Basic Microbiology,
Journal Year:
2023,
Volume and Issue:
63(7), P. 690 - 708
Published: March 30, 2023
Abstract
Medicinal
plants
are
an
important
source
of
bioactive
compounds
and
have
been
used
to
isolate
various
having
industrial
applications.
The
demand
for
derived
molecules
is
increasing
gradually.
However,
the
extensive
use
these
extract
has
threatened
many
plant
species.
Moreover,
extracting
from
laborious,
costly,
time‐consuming.
So,
some
alternative
sources
strategies
urgently
needed
produce
similar
that
origin.
interest
in
new
recently
shifted
endophytic
fungi
because
their
host
plant.
Endophytic
live
mutualistic
association
within
healthy
tissue
without
causing
disease
symptoms
These
a
treasure
house
novel
broad
pharmaceutical,
industrial,
agricultural
rapid
increase
publications
this
domain
over
last
three
decades
proves
natural
product
biologists
chemists
paying
great
attention
products
fungi.
Though
endophytes
but
there
need
advanced
technologies
like
clustered
regularly
interspaced
short
palindromic
repeats
CRISPR‐associated
protein
9
(CRISPR‐Cas9)
epigenetic
modifiers
enhance
production
This
review
provides
overview
applications
produced
by
rationale
behind
selecting
specific
fungal
endophyte
isolation.
Overall,
study
presents
current
state
knowledge
highlights
potential
developing
therapies
drug‐resistant
infections.
Journal of Fungi,
Journal Year:
2024,
Volume and Issue:
10(3), P. 195 - 195
Published: March 4, 2024
Polygala
crotalarioides,
a
perennial
herbaceous
plant
found
in
southwest
China,
has
the
potential
to
be
used
treatment
of
Alzheimer’s
disease.
Endophytic
fungi
that
reside
within
medicinal
herbs
play
an
important
ecological
role
their
host
plants
and
can
serve
as
valuable
source
for
identifying
active
components.
However,
little
is
known
about
diversity,
structure
endophytic
P.
crotalarioides.
In
this
study,
we
investigated
community
diversity
leaves,
stems,
roots
crotalarioides
at
both
1-
2-year-growth
stages
using
modern
culture-independent
method
(high-throughput
sequencing,
HTS)
culture-based
methods.
Using
HTS,
our
results
revealed
richness
varied
depending
on
organs
growth
stages.
Specifically,
stems
leaves
exhibited
significantly
higher
compared
roots.
Additionally,
highest
was
observed
2-year-old
plants.
At
genus
level,
Fusarium,
Colletotrichum,
Phoma
were
most
abundant
1-year-old
samples,
while
Cercospora,
Apiotrichum,
Fusarium
prevalent
samples.
A
total
55
fungal
strains
belonging
two
phyla
24
genera
isolated
from
150
tissue
segments
The
anti-acetylcholinesterase
activity
these
isolates
evaluated
vitro
five
them,
Phialophora
mustea
PCAM010,
Diaporthe
nobilis
PCBM027,
oxysporum
LP41,
F.
SR60,
herbarum
SM81,
showed
strong
(>50%
inhibition
rate).
These
findings
will
theoretical
basis
practical
guide
comprehending
structural
composition,
biological
bioactivity
