A mini review on green nanotechnology and its development in biological effects

Archives of Microbiology, Journal Year: 2023, Volume and Issue: 205(4)

Published: March 22, 2023

The utilization of living organisms for the creation inorganic nanoscale particles is a potential new development in realm biotechnology. An essential milestone nanotechnology process creating dependable and environmentally acceptable metallic nanoparticles. Due to its increasing popularity ease, use ambient biological resources quickly becoming more significant this field study. phrase "green nanotechnology" has gained lot attention refers variety procedures that eliminate or do away with hazardous compounds repair environment. Green nanomaterials can be used biotechnological sectors such as medicine biology, well food textile industries, wastewater treatment agriculture field. construction an updated level knowledge study systems might support revolutionize nanoparticles (NPs) are presented article.

Language: Английский

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Potential Antimicrobial and Antibiofilm Properties of Copper Oxide Nanoparticles: Time-Kill Kinetic Essay and Ultrastructure of Pathogenic Bacterial Cells

Applied Biochemistry and Biotechnology, Journal Year: 2022, Volume and Issue: 195(1), P. 467 - 485

Published: Sept. 10, 2022

Abstract Mycosynthesis of nanoparticle (NP) production is a potential ecofriendly technology for large scale production. In the present study, copper oxide nanoparticles (CuONPs) have been synthesized from live cell filtrate fungus Penicillium chrysogenum . The created CuONPs were characterized via several techniques, namely Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), transmission electron microscope (TEM), scanning (SEM), and energy-dispersive spectroscopy (EDX). Furthermore, biosynthesized performed against biofilm forming Klebsiella oxytoca ATCC 51,983, Escherichia coli 35,218, Staphylococcus aureus 25,923, Bacillus cereus 11,778. anti-bacterial activity result was shown with zone inhibition determined to be 14 ± 0.31 mm, 16 0.53 11 0.57 10 mm respectively. more susceptible minimal inhibitory concentration (MIC) values 6.25 3.12 µg/mL, respectively, while , MIC value 12.5 25 μg/mL, minimum (MBIC) evident, that excellent anti-biofilm at sub-MIC levels reducing formation by 49% 59% results indicated MBIC on higher than 200 μg/mL 256 suggesting these could not inhibit mature formatted in vitro. Overall, all clearly confirmed ability prepared offer smart approach biomedical therapy resistant microorganisms because its promoted antimicrobial action, but only specified purposes.

Language: Английский

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Synthesis of Silver Nanocomposite Based on Carboxymethyl Cellulose: Antibacterial, Antifungal and Anticancer Activities

Polymers, Journal Year: 2022, Volume and Issue: 14(16), P. 3352 - 3352

Published: Aug. 17, 2022

Traditional cancer treatments include surgery, radiation, and chemotherapy. According to medical sources, chemotherapy is still the primary method for curing or treating today has been a major contributor recent decline in mortality. Nanocomposites based on polymers metal nanoparticles have recently received attention of researchers. In current study, nanocomposite was fabricated carboxymethyl cellulose silver (CMC-AgNPs) their antibacterial, antifungal, anticancer activities were evaluated. The antibacterial results revealed that CMC-AgNPs promising activity against Gram-negative (Klebsiella oxytoca Escherichia coli) Gram-positive bacteria (Bacillus cereus Staphylococcus aureus). Moreover, exhibited antifungal filamentous fungi such as Aspergillus fumigatus, A. niger, terreus. Concerning HepG2 hepatocellular cell line, lowest IC50 values (7.9 ± 0.41 µg/mL) recorded CMC-AgNPs, suggesting strong cytotoxic effect liver cells. As result, our findings suggest antitumor these CMC-Ag due induction apoptosis necrosis hepatic cells via increased caspase-8 -9 diminished levels VEGFR-2. conclusion, activities, which can be used pharmaceutical fields.

Language: Английский

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Biosynthesis of Silver and Gold Nanoparticles and Their Efficacy Towards Antibacterial, Antibiofilm, Cytotoxicity, and Antioxidant Activities

Applied Biochemistry and Biotechnology, Journal Year: 2022, Volume and Issue: 195(2), P. 1158 - 1183

Published: Nov. 7, 2022

The World Health Organization (WHO) reports that the emergence of multidrug-resistant and slow advent novel more potent antitumor antimicrobial chemotherapeutics continue to be highest concern for human health. Additionally, stability, low solubility, negative effects existing drugs make them ineffective. Studies into alternative tactics tackle such tenacious diseases was sparked by anticancer antibacterial. Silver (Ag) gold (Au) nanoparticles (NPs) were created from Trichoderma saturnisporum, much productive fungal strain. Functional extracellular enzymes proteins carried out activities synthesis capping generated nano-metals. Characterization done on obtained Ag-NPs Au-NPs through UV-vis, FTIR, XRD, TEM, SEM. versus methicillin-sensitive Staphylococcus aureus (MSSA) methicillin-resistant (MRSA), Pseudomonas aeruginosa, Klebsiella pneumoniae, antibacterial assessed. In particular, effective against pathogenic bacteria than Au-NPs. Furthermore, antibiofilm study shown had activity Ag-NPs. Interestingly, applying DPPH procedure, these noble metallic NPs antioxidant activity, in which IC50 73.5 μg/mL 190.0 μg/mL, respectively. According cytotoxicity evaluation results, alteration cells as loss their typical shape, partial or complete monolayer, granulation, shrinking, cell rounding with normal Vero 693.68 661.24 Au-NPs, While cancer (Mcf7) 370.56 394.79 produced via green have potential employed medical industry beneficial nanocompounds.

Language: Английский

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Green Biosynthesis of Selenium Nanoparticles Using Orange Peel Waste: Characterization, Antibacterial and Antibiofilm Activities against Multidrug-Resistant Bacteria

Life, Journal Year: 2022, Volume and Issue: 12(6), P. 893 - 893

Published: June 15, 2022

There is an increase of pathogenic multidrug-resistant bacteria globally due to the misuse antibiotics. Recently, more scientists used metal nanoparticles counteract antibacterial resistance. In this study, orange peel waste (OPW) was for selenium nanoparticles' (Se-NPs) biosynthesis through green and ecofriendly method, their applications as antibiofilm agents. Green biosynthesized Se-NPs were characterized using FTIR, XRD, SEM, EDAX, TEM. Characterization results revealed that highly crystalline, spherical, polydisperse, had sizes in range 16-95 nm. The evaluated activities against bacteria. Results illustrated exhibited potential activity Gram-positive (S. aureus ATCC 29213 biofilm-producing clinical isolates S. aureus) Gram-negative (Pseudomonas aeruginosa PAO1, MDR, biofilm, quorum-sensing producing MDR P. aeruginosa, E. coli, K. pneumonia). Moreover, most sensitive at 1000 µg/mL, where inhibition zone 35 mm MIC 25 µg/mL. Furthermore, 0.25 0.5 decreased biofilm significantly. largest noticed pneumonia, which 62% 92% MIC, respectively. conclusion, successfully OPW method promising bacteria, can be later fighting resistant

Language: Английский

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Nanocomposite based on gold nanoparticles and carboxymethyl cellulose: Synthesis, characterization, antimicrobial, and anticancer activities

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 77, P. 103874 - 103874

Published: Oct. 7, 2022

Language: Английский

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Phytofabrication of zinc oxide nanoparticles with advanced characterization and its antioxidant, anticancer, and antimicrobial activity against pathogenic microorganisms

Biomass Conversion and Biorefinery, Journal Year: 2022, Volume and Issue: 13(1), P. 417 - 430

Published: Oct. 28, 2022

Language: Английский

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Antibacterial Activity of Green Synthesized Silver Nanoparticles Using Lawsonia inermis Against Common Pathogens from Urinary Tract Infection

Applied Biochemistry and Biotechnology, Journal Year: 2023, Volume and Issue: 196(1), P. 85 - 98

Published: April 26, 2023

Abstract New and creative methodologies for the fabrication of silver nanoparticles (Ag-NPs), which are exploited in a wide range consumer items, significant interest. Hence, this research emphasizes biological approach Ag-NPs through Egyptian henna leaves ( Lawsonia inermis Linn.) extracts analysis prepared Ag-NPs. Plant extract components were identified by gas chromatography mass spectrometry (GC-mass). The analyses carried out UV–visible (UV–Vis), X-ray diffraction (XRD), transmission electron microscope (TEM), scanning (SEM), Fourier transform infrared (FTIR) analysis. UV–Vis reveals that have maximum peak at 460 nm visible light. Structural characterization recorded peaks corresponded to Bragg’s diffractions nano-crystal, with average crystallite sizes varying from 28 60 nm. Antibacterial activities examined, it is observed all microorganisms very sensitive biologically synthesized

Language: Английский

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Baker’s Yeast-Mediated Silver Nanoparticles: Characterisation and Antimicrobial Biogenic Tool for Suppressing Pathogenic Microbes

BioNanoScience, Journal Year: 2022, Volume and Issue: 12(4), P. 1220 - 1229

Published: Aug. 18, 2022

Language: Английский

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Antifungal Activity of Biosynthesized Silver Nanoparticles (AgNPs) against Aspergilli Causing Aspergillosis: Ultrastructure Study

Journal of Functional Biomaterials, Journal Year: 2022, Volume and Issue: 13(4), P. 242 - 242

Published: Nov. 15, 2022

Currently, nanoparticles and nanomaterials are widely used for biomedical applications. In the present study, silver (AgNPs) were successfully biosynthesized using a cell-free extract (CFE) of Bacillus thuringiensis MAE 6 through green ecofriendly method. The size AgNPs was 32.7 nm, their crystalline nature confirmed by XRD, according to characterization results. A surface plasmon resonance spectrum obtained at 420 nm. Nanoparticles further characterized DLS FTIR analyses, which provided information on size, stability, functional groups. revealed less cytotoxicity against normal Vero cell line [IC50 = 155 μg/mL]. Moreover, exhibited promising antifungal activity four most common Aspergillus, including Aspergillus niger, A. terreus, flavus, fumigatus concentrations 500 μg/mL where inhibition zones 16, 20, 26, 19 mm, respectively. addition, MICs 125, 62.5, 15.62, 62.5 μg/mL, Furthermore, ultrastructural study effect AgNPs, wall's integrity homogeneity lost; membrane had separated from wall intruded into cytoplasm. conclusion, CFE B. can be as agent species causing Aspergillosis.

Language: Английский

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