Epidemiology, risk factors, and awareness of mycetoma among residents in Eastern Sinnar locality, Sudan, 2021

Journal of Global Health, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 10, 2025

Abstract Background Mycetoma is a chronic granulomatous disease affecting the skin, subcutaneous tissues, and bones, particularly in tropical subtropical regions. Sudan, especially its Eastern Sinnar locality, experiences significant burden due to environmental conditions limited access healthcare, while population's lack of awareness understanding often leads delays diagnosis treatment. Methods We conducted descriptive cross-sectional, community-based study Sinnar, investigate prevalence, risk factors, mycetoma among local residents. Using Cochran's formula, we calculated required sample size 400 participants from total population 245 201. Then, randomly selected these five villages chosen through stratified sampling. Data were collected via validated questionnaire assessing sociodemographic characteristics mycetoma-related information, review medical records confirm infection types interviews with Directorate Centre Sinnar. used χ2 tests for associations our analysis, P-values ≤0.05 indicating statistical significance. Results The prevalence was 5.4%, males comprising 76.4% infected cases. However, difference rates between genders not statistically (P = 0.248). While higher certain occupational groups, such as farmers shepherds, association occupation non-significant 0.107). also found no educational level 0.104) or age 0.514), but did detect family history < 0.001), animal ownership 0.004), wearing shoes during work 0.05). Awareness relatively high, 78.3% respondents acknowledging disease, though knowledge gaps remained, regarding transmission, only 36.1% believing it be transmissible. Conclusions highlights need targeted health education programmes, emphasising protective footwear safe animal-handling practices. These findings are crucial informing public strategies aimed at reducing endemic regions

Language: Английский

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Nanotherapeutics and nanotheranostics in miscellaneous fungal infections

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 473 - 491

Published: Jan. 1, 2025

Language: Английский

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Cladosporium species novum Invasive Pulmonary Infection in a Patient with Post-COVID-19 Syndrome and AIDS

Diagnostics, Journal Year: 2025, Volume and Issue: 15(6), P. 781 - 781

Published: March 20, 2025

Background and Clinical Significance: Since the prevalence of fungal lung infections is increasing, certain agents, such as Cladosporium spp., have emerged unexpected causes. spp. fungi are ubiquitous in environments soil, fruits, wine corks; they a part normal human skin flora; known respiratory allergens. Case Presentation: A patient with history post-COVID-19 syndrome AIDS presented pathology indicative an invasive infection. The initial histopathological examination revealed numerous yeast-like cells narrow-based budding, which led to mistaken diagnosis cryptococcosis. However, further detailed sparse hyphae tissue, suggesting more complex Molecular analyses sequence BLAST alignment were performed, ultimately identifying infectious agent “Cladosporium species novum”, rare cause pulmonary cladosporiasis. Conclusions: Invasive cladosporiasis condition, morphological features fungus alone insufficient establish correct diagnosis. comprehensive pathohistological molecular approach bioinformatics tools essential for identification potentially life-threatening pathogens immunocompromised patients.

Language: Английский

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Cordyceps militaris-Derived Bioactive Gels: Therapeutic and Anti-Aging Applications in Dermatology

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 33 - 33

Published: Jan. 3, 2025

Cordyceps militaris is a medicinal mushroom widely utilized in traditional East Asian medicine, recognized for its diverse therapeutic properties. This review explores the potential of C. militaris-derived bioactive gels applications dermatology and skincare, with particular focus on their anti-aging benefits. In response to rising incidence skin cancers growing demand natural ingredients, has emerged as valuable source functional compounds, including cordycepin, polysaccharides, adenosine. These compounds exhibit multiple bioactivities, apoptosis induction, cell cycle arrest, anti-inflammatory effects, which have been shown be particularly effective against melanoma other cancers. Additionally, antioxidant properties enhance resilience by scavenging reactive oxygen species, reducing oxidative stress, promoting collagen synthesis, thereby addressing health requirements. The incorporating into gel-based formulations skincare also examined, either standalone bioactives or combination synergistic ingredients. Emphasis placed necessity clinical trials standardization establish safety, efficacy, reproducibility such applications. By providing safer alternative synthetic agents, represent promising advancement skincare.

Language: Английский

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Antifungal activity, mechanistic insights, and combinatorial effects of Pycnocycla bashagardiana essential oil against Aspergillus fumigatus

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 181, P. 272 - 280

Published: April 23, 2025

Language: Английский

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Control technology of pathogenic biological aerosol: Review and prospect

Building and Environment, Journal Year: 2023, Volume and Issue: 243, P. 110679 - 110679

Published: July 31, 2023

Language: Английский

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Xerophilic and cellulolytic fungi in the indoor air of houses in Havana

International Biodeterioration & Biodegradation, Journal Year: 2024, Volume and Issue: 188, P. 105730 - 105730

Published: Jan. 18, 2024

Fungi with xerophilic and cellulolytic enzymatic activities are abundant indoors considered biodeteriorating agents. This study aimed to characterize the diversity of fungi in indoor air houses Havana examine their relationship environmental factors. Indoor samples were collected from 42 using sedimentation method Petri dishes malt yeast extract agar 50% sucrose filter paper. Both fungal groups successfully isolated 41 sampled houses. In majority rooms, concentrations recorded below threshold indicative contamination. The presence these was mainly related humidity ventilation problems substrates present rooms. Aspergillus found be predominant genus culture methods evaluated at both 28 37 °C. These findings enhance our understanding properties that inhabit environments serve as a warning system presence.

Language: Английский

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The nasal mycobiome of individuals with allergic rhinitis and asthma differs from that of healthy controls in composition, structure and function

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 17, 2024

Allergic rhinitis (AR) and asthma (AS) are two of the most common chronic respiratory diseases a major public health concern. Multiple studies have demonstrated role nasal bacteriome in AR AS, but little is known about airway mycobiome its potential association to inflammatory diseases. Here we used internal transcriber spacers (ITS) 1 2 high-throughput sequencing characterize 339 individuals with AR, (ARAS), AS healthy controls (CT). Seven ten 14 abundant fungal genera ( Malassezia, Alternaria, Cladosporium, Penicillium, Wallemia, Rhodotorula, Sporobolomyces, Naganishia, Vishniacozyma , nd Filobasidium ) cavity differed significantly p ≤ 0.049) between or ARAS, CT. However, none same varied three disease groups. The mycobiomes ARAS patients showed highest intra-group diversity, while CT lowest. Alpha-diversity indices microbial richness evenness only 0.024) CT, all groups significant differences 0.0004) structure (i.e., beta-diversity indices) when compared samples. Thirty metabolic pathways (PICRUSt2) were differentially (Wald’s test) patients, them associated 5-aminoimidazole ribonucleotide (AIR) biosynthesis over (log2 Fold Change &gt;0.75) group. AIR has been pathogenesis plants. Spiec-Easi networks among groups, more similar interactions their members than those mycobiome; this suggests allergic may disrupt connectivity cavity. This study contributes valuable data results understand relationships allergy-related conditions. It demonstrates for first time that mycobiota varies during (with without comorbid asthma) reveals specific taxa, relate disease.

Language: Английский

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CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy

Clinical Reviews in Allergy & Immunology, Journal Year: 2024, Volume and Issue: 66(3), P. 328 - 362

Published: July 12, 2024

Language: Английский

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The study of effective factors in sick building syndrome related to fungi and its control methods

Results in Engineering, Journal Year: 2024, Volume and Issue: 23, P. 102703 - 102703

Published: Aug. 8, 2024

Various biological agents including fungi are effective in the symptoms of sick building syndrome. Fungal growth and activity depend on environmental parameters, which causes different types to be observed indoor environment. In this study, relationship between syndrome fungal was reviewed. Articles were selected by applying a search protocol inclusion criteria. The health consequence environment such as allergies discussed three separate categories. consequences metabolites mycotoxins also Also, factors affecting humidity temperature discussed. Strategies control associated with defined congeries. Identifying caused them can useful using optimum method fungi. Assessment risk for residential office buildings effectiveness strategies improving physical conditions or disinfection reducing it considered future studies.

Language: Английский

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