Long-term high-fat diet consumption by mice throughout adulthood induces neurobehavioral alterations and hippocampal neuronal remodeling accompanied by augmented microglial lipid accumulation

Brain Behavior and Immunity, Journal Year: 2021, Volume and Issue: 100, P. 155 - 171

Published: Nov. 27, 2021

Language: Английский

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Body mass index and inflammation in depression and treatment-resistant depression: a Mendelian randomisation study

BMC Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 14, 2023

Major depressive disorder (MDD) has a significant impact on global burden of disease. Complications in clinical management can occur when response to pharmacological modalities is considered inadequate and symptoms persist (treatment-resistant depression (TRD)). We aim investigate inflammation, proxied by C-reactive protein (CRP) levels, body mass index (BMI) as putative causal risk factors for subsequent treatment resistance, leveraging genetic information avoid confounding via Mendelian randomisation (MR).We used the European UK Biobank subcohort ([Formula: see text]), mental health questionnaire (MHQ) records. For previously curated phenotype based general practitioner (GP) records prescription data was employed. applied univariable multivariable MR models genetically predict exposures assess their contribution range outcomes. univariable, mediation techniques address our research question with maximum rigour. In addition, we developed novel statistical procedure apply pleiotropy-robust one sample employed Bayesian bootstrap accurately quantify estimate uncertainty analysis which outperforms standard approaches sparse binary Given flexibility one-sample design, evaluated age sex moderators effects.In models, predicted BMI positively associated outcomes, including MDD text] CI): 0.133(0.072, 0.205)) TRD (0.347(0.002, 0.682)), larger magnitude females acting moderator effect severity (0.22(0.050, 0.389)). Multivariable analyses suggested an independent not through CRP (0.395(0.004, 0.732)). Our that partly mediated BMI. Individuals text]) observationally had higher compared individuals alone healthy controls.Our work supports assertion exerts questionnaire-based phenotypes, being stronger younger individuals. show this inflammation levels effects do jointly estimated This consistent previous evidence suggesting overweight contributed even absence any metabolic consequences. It appears persists account influencing MDD.

Language: Английский

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Association between weight-adjusted-waist index and depression in US adults: A cross-sectional study

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 355, P. 299 - 307

Published: March 26, 2024

Language: Английский

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Microbiome and immuno-metabolic dysregulation in patients with major depressive disorder with atypical clinical presentation

Neuropharmacology, Journal Year: 2023, Volume and Issue: 235, P. 109568 - 109568

Published: May 12, 2023

Depression is highly prevalent (6% 1-year prevalence) and the second leading cause of disability worldwide. Available treatment options for depression are far from optimal, with response rates only around 50%. This most likely related to a heterogeneous clinical presentation major disorder (MDD), suggesting different manifestations underlying pathophysiological mechanisms. Poorer outcomes first-line antidepressants were reported in MDD patients endorsing an "atypical" symptom profile that characterized by preserved reactivity mood, increased appetite, hypersomnia, heavy sensation limbs, interpersonal rejection sensitivity. In recent years, evidence has emerged immunometabolic biological dysregulation important mechanism depression, which maps more consistently atypical features. last few years human microbial residents have as key influencing variable associated dysregulations depression. The microbiome plays critical role training development components host's innate adaptive immune systems, while system orchestrates maintenance features host-microbe symbiosis. Moreover, being metabolically active ecosystem commensal microbes may huge impact on signaling pathways, involved mechanisms depressive symptoms. this review, we discuss interplay between imbalance context Although research field its infancy, targeting determinants homogeneous presentations offer new avenues novel therapeutic strategies treatment-resistant article part Special Issue "Microbiome & Brain: Mechanisms Maladies".

Language: Английский

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Body composition, lifestyle, and depression: a prospective study in the UK biobank

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 6, 2024

Abstract Background Obesity has been related to depression and adhering healthy lifestyle was beneficial lower the risk of depression; however, little is known about relationship between body composition fat distribution with influence on association depression. Therefore, we aimed investigate whether were associated adverse events Methods We included 330,131 participants without at baseline in UK Biobank (mean age, 56.9 years; 53.83% females). The assessment sourced from health outcomes across self-report, primary care, hospital inpatient data, death data. Body determined by bioelectrical impedance. Seven lifestyles (no current smoking, moderate alcohol consumption, regular physical activity, diet, less sedentary behavior, sleep pattern, appropriate social connection) used generate a score. Results During median 11.7 years follow-up, 7576 incident occurred. All measures positively risk, Hazard ratios (HR) for uppermost tertile (T3) versus lowest (T1) ranging 1.26 (95% CI: 1.15–1.39) trunk fat-free mass (TFFM) 1.78 (1.62–1.97) leg percentage (LFP). In addition, found significant interactions mass-related indices, especially (LFM) ( p = 1.65 × 10 −9 ), score depression, which associations more evident among low measurement. Conclusions High levels an increased risk. Adverse may weaken link reduced

Language: Английский

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The vicious cycle of depression and obesity

Nature, Journal Year: 2022, Volume and Issue: 608(7924), P. S42 - S43

Published: Aug. 24, 2022

Language: Английский

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Glucagon-Like Peptide 1 Receptor Agonists in Psychiatry

Journal of Clinical Psychopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: April 18, 2024

From the 1Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom 2South London Maudsley NHS Foundation Trust, 3Lindner Center HOPE, Mason, OH 4Department Psychiatry Behavioral University Cincinnati Cincinnati, OH. Received February 13, 2024; accepted after revision 24, 2024. Address correspondence to: Hubertus Himmerich, MD, Centre SE5 8AF (e-mail: [email protected]).

Language: Английский

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Diet Overall and Hypocaloric Diets Are Associated With Improvements in Depression but Not Anxiety in People With Metabolic Conditions: A Systematic Review and Meta-Analysis

Advances in Nutrition, Journal Year: 2024, Volume and Issue: 15(2), P. 100169 - 100169

Published: Jan. 5, 2024

The risk of depression and anxiety is higher in people with metabolic conditions, but whether dietary approaches, which are central to the management can also improve uncertain. primary aim this systematic review meta-analysis was evaluate effects interventions on adults conditions. secondary hypocaloric isocaloric these outcomes. Four databases (MEDLINE, PsychINFO, EMBASE, CINAHL) were searched from inception March 2023. Randomized controlled trials (RCTs) including conditions (type 2 diabetes mellitus, hyperlipidemia, hypertension, and/or overweight/obesity) that assessed as outcomes included. Overall, 13 RCTs included review, ≤13 meta-analysis. Estimates pooled using random-effect for compared controls. Improvements scores found meta-analytic models all [pooled estimate standardized mean difference (SMD) = -0.20 (95% CI: -0.35, -0.05); P 0.007] only diets [SMD -0.27 -0.44, -0.10); 0.002]. There no improvements -0.14 -0.38, 0.10); 0.27]. In addition, there significant any scores. improved depression, not anxiety. These findings suggest play an important role This has been registered PROSPERO (CRD42021252307).

Language: Английский

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The role of the intestinal microbiota in the pathogenesis of host depression and mechanism of TPs relieving depression

Food & Function, Journal Year: 2021, Volume and Issue: 12(17), P. 7651 - 7663

Published: Jan. 1, 2021

Depression is a prevalent neuropsychiatric disease with high recurrence rate, affecting over 350 million people worldwide. Intestinal flora disorders and gut-brain-axis (GBA) dysfunction may cause mental disorders. Alterations in the intestinal composition could increase permeability of gut barrier, activate systemic inflammation immune responses, regulate release efficacy monoamine neurotransmitters, alter activity function hypothalamic-pituitary-adrenal (HPA) axis, modify abundance brain-derived neurotrophic factor (BDNF); all these showed close correlation occurrence depression. In addition, disturbance related to circadian rhythm disorders, which aggravate symptoms Tea polyphenols (TPs) have been found antidepressant effects. Therefore, reciprocity between provides new opportunity for TPs depression relying on flora. this review, we discussed relationship dysbiosis pathogenesis mechanism relieving via GBA.

Language: Английский

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Interventions targeting comorbid depression and overweight/obesity: A systematic review

Journal of Affective Disorders, Journal Year: 2022, Volume and Issue: 314, P. 222 - 232

Published: July 22, 2022

Language: Английский

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