Drug Resistance Updates, Journal Year: 2025, Volume and Issue: 81, P. 101228 - 101228
Published: March 9, 2025
Language: Английский
AJP Cell Physiology, Journal Year: 2023, Volume and Issue: 325(2), P. C483 - C495
Published: July 17, 2023
With an aging population, lung fibrotic diseases are becoming a global health burden. Dysfunctional repair of the alveolar epithelium is key causative process that initiates fibrosis. Normal regeneration relies on functional progenitor cells; however, senescence these cells, which increases with age, hinders their ability to contribute repair. Here, we discuss studies control and consequence cell in fibrosis opportunities for research.
Language: Английский
Citations
26
Food & Function, Journal Year: 2023, Volume and Issue: 14(20), P. 9123 - 9136
Published: Jan. 1, 2023
Ginsenosides resist the aging by regulating multiple signaling pathways.
Language: Английский
Citations
23
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1792 - 1792
Published: Feb. 1, 2024
Cellular senescence is implicated in ageing and associated with a broad spectrum of age-related diseases. Importantly, cell can initiate the program irrespective organism’s age. Various stress signals, including those defined as hallmarks alterations leading to cancer development, oncogene activation, or loss cancer-suppressive functions, trigger cellular senescence. The primary outcome these activation nuclear factor (NF)-κB, thereby inducing senescence-associated secretory phenotype (SASP). Proinflammatory cytokines chemokines, components this phenotype, contribute chronic systemic sterile inflammation, commonly referred inflamm-ageing. This inflammation linked diseases (ARDs), frailty, increased mortality older individuals. Additionally, senescent cells (SCs) accumulate multiple tissues age are believed underlie organism functional decline, demonstrated by models. An escalating effort has been dedicated identify senotherapeutics that selectively target SCs apoptosis; drugs termed senolytics. Concurrently, small molecules suppress phenotypes without causing death known senomorphics. Both natural synthetic senotherapeutics, along immunotherapies employing immune cell-mediated clearance SCs, currently represent most promising strategies combat ARDs. Indeed, it fascinating observe information regarding reaction indicates regulation specific lymphocyte subsets, elevated oldest centenarians, plays role attaining extreme longevity. Regardless, application methods already utilized treatment, such CAR monoclonal antibodies, broadens potential approaches be utilized.
Language: Английский
Citations
15
Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)
Published: May 22, 2024
Abstract Replication stress refers to slowing or stalling of replication fork progression during DNA synthesis that disrupts faithful copying the genome. While long considered a nexus for damage, role in aging is under-appreciated. The consequential promotion organismal phenotypes evidenced by an extensive list hereditary accelerated disorders marked molecular defects factors promote and operate uniquely response. Additionally, recent studies have revealed cellular pathways elicited align with designated hallmarks aging. Here we review advances demonstrating as ultimate driver senescence We discuss clinical implications intriguing links between including application senotherapeutic approaches context stress.
Language: Английский
Citations
14
GeroScience, Journal Year: 2024, Volume and Issue: 46(4), P. 3889 - 3909
Published: March 6, 2024
Abstract Healthy aging has emerged as a crucial issue with the increase in geriatric population worldwide. Food-derived sulfur-containing amino acid ergothioneine (ERGO) is potential dietary supplement, which exhibits various beneficial effects experimental animals although preventive of ERGO on and/or age-related impairments such frailty and cognitive impairment are unclear. We investigated daily oral supplementation dissolved drinking water lifespan, frailty, male mice from 7 weeks age to end their lives. Ingestion 4 ~ 5 mg/kg/day remarkably extended lifespan mice. The longevity effect was further supported by life non-frailty spans Caenorhabditis elegans presence ERGO. Compared control group, group showed significantly lower declines weight, fat mass, average maximum movement velocities at 88 age. This compatible dramatical suppression increments plasma biomarkers (BMs) chemokine ligand 9, creatinine, symmetric dimethylarginine, urea, asymmetric quinolinic acid, kynurenine. intake also rescued learning memory ability, might be associated decline hippocampal neurogenesis TDP43 protein aggregation promotion microglial shift M2 phenotype ingestion. may promote healthy mice, possibly through multiple biological mechanisms.
Language: Английский
Citations
11
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3319 - 3319
Published: March 14, 2024
The population of cancer survivors has markedly increased due to the rapid improvements in treatment. However, experience accelerated aging, which leads chronic diseases and other age-related conditions, such as frailty. Those conditions may persist years after diagnosis Cellular senescence, a hallmark is one mechanisms that contribute aging survivors. Several measures, including measures based on clinical markers biomarkers, have been proposed estimate process, some them shown associations with mortality frailty anti-aging interventions, lifestyle changes drugs, proposed. Future research, particularly large-scale studies, needed determine efficiency these interventions before considering their application clinics. This review focuses cellular senescence survivors, assessment process using high prevalence population, well possible opportunities for interventions. A deeper understanding will development effective strategies mitigate improve quality life.
Language: Английский
Citations
9
Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 220, P. 111959 - 111959
Published: June 29, 2024
Oligodendrocyte precursor cells (OPCs) comprise 5-8 % of the adult glial cell population and stand out as most proliferative type in central nervous system (CNS). OPCs are responsible for generating oligodendrocytes (OLs), myelinating CNS. However, OPC functions decline we age, resulting impaired differentiation inadequate remyelination. This review explores cellular molecular changes associated with aging, their impact on functionality. Furthermore, it examines aging within context multiple sclerosis Alzheimer's disease, both neurodegenerative conditions wherein aged exacerbate disease progression by impeding Moreover, various pharmacological interventions targeting pathways related to senescence discussed potential strategies rejuvenate OPCs. Enhancing our understanding mechanisms holds promise developing new therapies improve remyelination repair age-related disorders.
Language: Английский
Citations
6
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10535 - 10535
Published: Sept. 30, 2024
Progress made by the medical community in increasing lifespans comes with costs of incidence and prevalence age-related diseases, neurodegenerative ones included. Aging is associated a series morphological changes at tissue cellular levels brain, as well impairments signaling pathways gene transcription, which lead to synaptic dysfunction cognitive decline. Although we are not able pinpoint exact differences between healthy aging neurodegeneration, research increasingly highlights involvement neuroinflammation chronic systemic inflammation (inflammaging) development age-associated via pathogenic cascades, triggered dysfunctions circadian clock, gut dysbiosis, immunosenescence, or impaired cholinergic signaling. In addition, gender susceptibility course neurodegeneration that appear be mediated glial cells emphasize need for future this area an individualized therapeutic approach. rejuvenation still its very early infancy, accumulated knowledge on various involved promoting senescence opens perspective interfering these preventing delaying senescence.
Language: Английский
Citations
6
Biology, Journal Year: 2022, Volume and Issue: 11(12), P. 1731 - 1731
Published: Nov. 29, 2022
Cellular senescence has gained increasing attention in the field of aging research. Senescent cells have been implicated biological processes, tumorigenesis, development, and wound repair amongst other processes pathologies. Recent findings reveal that senescent can both promote inhibit cutaneous healing processes. Relating acute chronic wounds will help to clarify their role inform our understanding cell heterogeneity. To this apparent contradiction guide future research therapeutic we review rapidly growing cellular its biology.
Language: Английский
Citations
24
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15963 - 15963
Published: Nov. 4, 2023
Human skin aging is associated with functional deterioration on multiple levels of physiology, necessitating the development effective senotherapeutics. The well-tolerated neurohormone melatonin unfolds anti-aging properties in vitro and vivo, but it remains unclear whether these effects translate to aged human ex vivo. We tested this organ-cultured, full-thickness eyelid (5-6 donors; 49-77 years) by adding culture medium, followed assessment core biomarkers via quantitative immunohistochemistry. Over 6 days, 200 µM significantly downregulated intraepidermal activity aging-promoting mTORC1 pathway (as visualized reduced S6 phosphorylation) MMP-1 protein expression epidermis compared vehicle-treated control skin. Conversely, transmembrane collagen 17A1, a key stem cell niche matrix molecule that declines aging, mitochondrial markers (e.g., TFAM, MTCO-1, VDAC/porin) were upregulated. Interestingly, 100 also increased epidermal VEGF-A protein, which required sufficient for inducing rejuvenation. In dermis, fibrillin-1 improved fibrillin structural organization, indicating an elastic fiber network. contrast, other (SIRT-1, lamin-B1, p16INK4, I) remained unchanged. This vivo study provides proof principle indeed exerts long-suspected never conclusively demonstrated surprisingly differential dermis.
Language: Английский
Citations
13