Nanoscale Advances, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Safe implementation of nanotechnology-based products in biomedical applications necessitates an extensive understanding the (bio)transformations that nanoparticles undergo living organisms.
Language: Английский
Nanomaterials, Journal Year: 2021, Volume and Issue: 11(5), P. 1203 - 1203
Published: May 1, 2021
The activation of magnetic nanoparticles in hyperthermia treatment by an external alternating field is a promising technique for targeted cancer therapy. generates heat the tumor area, which utilized to kill cancerous cells. Depending on type and site be targeted, various types nanoparticles, with variable coating materials different shape surface charge, have been developed. tunable physical chemical properties enhance their heating efficiency. Moreover, efficiency directly related product values applied frequency. Protein corona formation another important parameter affecting MNPs hyperthermia. This review provides basics hyperthermia, mechanisms losses, thermal doses therapy, strategies improve purpose this build bridge between synthesis/coating practical application
Language: Английский
Citations
162
Nanomaterials, Journal Year: 2022, Volume and Issue: 12(11), P. 1807 - 1807
Published: May 25, 2022
Until now, strategies used to treat cancer are imperfect, and this generates the need search for better safer solutions. The biggest issue is lack of selective interaction with neoplastic cells, which associated occurrence side effects significantly reduces effectiveness therapies. use nanoparticles in can counteract these problems. One most promising magnetite. Implementation nanoparticle improve various treatment methods such as hyperthermia, targeted drug delivery, genotherapy, protein therapy. In first case, its feature makes magnetite useful magnetic hyperthermia. Interaction altered field heat. This process results raised temperature only a desired part patient body. other therapies, magnetite-based could serve carrier types therapeutic load. would direct drug-related pathological site. Therefore, material be gene therapy or delivery. Since treatment, they extensively studied. Herein, we summarize latest finding on applicability nanoparticles, also addressing critical problems faced by smart nanomedicine oncological
Language: Английский
Citations
138
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 236 - 236
Published: Jan. 10, 2023
Despite significant advances in cancer therapy over the years, its complex pathological process still represents a major health challenge when seeking effective treatment and improved healthcare. With advent of nanotechnologies, nanomedicine-based has been widely explored as promising technology able to handle requirements clinical sector. Superparamagnetic iron oxide nanoparticles (SPION) have at forefront nanotechnology development since mid-1990s, thanks their former role contrast agents for magnetic resonance imaging. Though use MRI probes discontinued due an unfavorable cost/benefit ratio, several innovative applications therapeutic tools prompted renewal interest. The unique characteristics SPION, i.e., properties enabling specific response submitted high frequency (magnetic hyperthermia) or low (magneto-mechanical therapy) alternating field, ability generate reactive oxygen species (either intrinsically activated using various stimuli), make them particularly adapted therapy. This review provides comprehensive description fundamental aspects SPION formulation highlights recent approaches regarding vivo field
Language: Английский
Citations
97
International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(14), P. 7651 - 7651
Published: July 17, 2021
Magnetic nanoparticles (MNPs) have a wide range of applications; an area particular interest is magnetic particle imaging (MPI). MPI modality that utilizes superparamagnetic iron oxide particles (SPIONs) as tracer to produce highly sensitive and specific images in broad applications, including cardiovascular, neuroimaging, tumor imaging, hyperthermia cellular tracking. While there are hurdles overcome, accessibility products, understanding safety toxicity profiles, has the potential revolutionize research clinical biomedical imaging. This review will explore brief history MPI, MNP synthesis methods, current future concerns associated with this newly emerging modality.
Language: Английский
Citations
80
Journal of Communications Technology and Electronics, Journal Year: 2022, Volume and Issue: 67(2), P. 101 - 116
Published: Feb. 1, 2022
Language: Английский
Citations
55
Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 352, P. 1024 - 1047
Published: Nov. 17, 2022
Language: Английский
Citations
52
Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(11), P. 2388 - 2388
Published: Nov. 5, 2022
Cancer immunotherapy has tremendous promise, but it yet to be clinically applied in a wider variety of tumor situations. Many therapeutic combinations are envisaged improve their effectiveness. In this way, strategies capable inducing immunogenic cell death (e.g., doxorubicin, radiotherapy, hyperthermia) and the reprogramming immunosuppressive microenvironment (TME) M2-to-M1-like macrophages repolarization tumor-associated (TAMs)) particularly appealing enhance efficacy approved immunotherapies immune checkpoint inhibitors, ICIs). Due modular construction versatility, iron oxide-based nanomedicines such as superparamagnetic oxide nanoparticles (SPIONs) can combine these different approaches single agent. SPIONs have already shown safety biocompatibility possess both drug-delivery chemotherapy, ICIs) magnetic capabilities hyperthermia (MHT), resonance imaging). review, we will discuss multiple applications cancer immunotherapy, focusing on theranostic properties target TAMs generate MHT. The first section review briefly describe targets for NPs. following sections deal with overall (including MHT). last is dedicated SPION-induced response through its effects
Language: Английский
Citations
39
Nanomaterials, Journal Year: 2023, Volume and Issue: 13(5), P. 876 - 876
Published: Feb. 26, 2023
Cancer remains the most devastating disease, being one of main factors death and morbidity worldwide since ancient times. Although early diagnosis treatment represent correct approach in fight against cancer, traditional therapies, such as chemotherapy, radiotherapy, targeted therapy, immunotherapy, have some limitations (lack specificity, cytotoxicity, multidrug resistance). These a continuous challenge for determining optimal therapies cancer. seen significant achievements with advent nanotechnology wide range nanoparticles. Due to their special advantages, low toxicity, high stability, good permeability, biocompatibility, improved retention effect, precise targeting, nanoparticles sizes ranging from 1 nm 100 been successfully used cancer by solving conventional treatment, but also overcoming resistance. Additionally, choosing best diagnosis, management is extremely important. The use magnetic (MNPs) represents an effective alternative simultaneous using nano-theranostic particles that facilitate early-stage detection selective destruction cells. specific properties, control dimensions surface through judicious choice synthesis methods, possibility targeting target organ applying internal field, make these alternatives This review discusses MNPs provides future perspectives field.
Language: Английский
Citations
32
Materials Horizons, Journal Year: 2023, Volume and Issue: 10(11), P. 4757 - 4775
Published: Jan. 1, 2023
Magnetic nanoparticles offer versatile opportunities for anti-cancer therapy, stemming from a single metal element, iron, naturally processed by the human body. Applications range magnetic hyperthermia to emerging fields of photothermal therapy and ferroptosis induction.
Language: Английский
Citations
25
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Oct. 6, 2023
In the quest for cancer treatment modalities with greater effectiveness, combination of tumor immunotherapy and nanoparticle-based hyperthermia has emerged as a promising frontier. The present article provides comprehensive review recent advances cutting-edge research in this burgeoning field examines how these two strategies can be effectively integrated. Tumor immunotherapy, which harnesses immune system to recognize attack cells, shown considerable promise. Concurrently, hyperthermia, utilizes nanotechnology promote selective cell death by raising temperature an innovative therapeutic approach. While both have individually potential, may amplify anti-tumor responses, improved outcomes reduced side effects. Key studies illustrating synergistic effects approaches are highlighted, current challenges future prospects discussed. As we stand on precipice new era treatment, underscores importance continued collaboration bringing treatments from bench bedside.
Language: Английский
Citations
23