Reduced graphene oxide coated alginate scaffolds: potential for cardiac patch application DOI Creative Commons
Nafiseh Baheiraei, Mehdi Razavi, Ramin Ghahremanzadeh

et al.

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

Cardiovascular diseases, particularly myocardial infarction (MI), are the leading cause of death worldwide and a major contributor to disability. Cardiac tissue engineering is promising approach for preventing functional damage or improving cardiac function after MI. We aimed introduce novel electroactive patch based on reduced graphene oxide-coated alginate scaffolds due behavior biomaterials regulate cell proliferation, biocompatibility, signal transition.The fabrication patches (ALG) coated with different concentrations oxide (rGO) using sodium hydrosulfite described here. The prepared were thoroughly tested their physicochemical properties cytocompatibility. ALG-rGO also antimicrobial antioxidant properties. Subcutaneous implantation in mice was used evaluate scaffolds' ability induce angiogenesis.The Young modulus increased by increasing rGO concentration from 92 ± 4.51 kPa ALG 431 4.89 ALG-rGO-4 (ALG 0.3% w/v rGO). tensile strength trended similarly. electrical conductivity calculated semi-conductive range (~ 10-4 S/m). Furthermore, when compared scaffolds, human umbilical vein endothelial cells (HUVECs) cultured demonstrated improved viability adhesion. Upregulation VEGFR2 expression at both mRNA protein levels confirmed that coating significantly boosted angiogenic capability against HUVECs. OD620 assay FE-SEM observation antibacterial Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes. showed samples possessed activity 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging UV-vis spectroscopy. Histological evaluations enhanced vascularization subcutaneous implantation.Our findings suggest scaffold accelerating repair damaged heart tissue.

Language: Английский

Biodegradable Natural Hydrogels for Tissue Engineering, Controlled Release, and Soil Remediation DOI Open Access
Ane García-García, Sara Muñana-González, S. Lanceros‐Méndez

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2599 - 2599

Published: Sept. 14, 2024

This article provides insights into hydrogels of the most promising biodegradable natural polymers and their mechanisms degradation, highlighting different possibilities controlling hydrogel degradation rates. Since can be designed as scaffolding materials to mimic physical biochemical properties tissues, these have found widespread application in field tissue engineering controlled release. In same manner, potential water reservoirs, macro- microelement carriers, or matrixes for selective adsorption pollutants make them excellent candidates sustainable soil amendment solutions. Accordingly, this summarizes recent advances fields engineering, release, remediation, emphasizing new opportunities that degradability its tunability offer design applicability hydrogels.

Language: Английский

Citations

14
Marine polysaccharides: Biological activities and applications in drug delivery systems DOI

Hongxu Geng,

Meijun Chen,

Chunjing Guo

et al.

Carbohydrate Research, Journal Year: 2024, Volume and Issue: 538, P. 109071 - 109071

Published: March 4, 2024

Language: Английский

Citations

12
A comprehensive review on natural macromolecular biopolymers for biomedical applications: Recent advancements, current challenges, and future outlooks DOI Creative Commons

Rangasamy Manivannan,

Neha Sharma, Vinay Kumar

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: 8, P. 100536 - 100536

Published: July 24, 2024

Language: Английский

Citations

11
A ternary composite hydrogel based on sodium alginate, carboxymethyl cellulose and copper-doped 58S bioactive glass promotes cutaneous wound healing in vitro and in vivo DOI

Ghazaleh Kohoolat,

Parvin Alizadeh,

Fatemeh Motesadi Zarandi

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129260 - 129260

Published: Jan. 8, 2024

Language: Английский

Citations

10
Multifunctional Casein-Based Wound Dressing Capable of Monitoring and Moderating the Proteolytic Activity of Chronic Wounds DOI Creative Commons
Davood Kolahreez, Laleh Ghasemi‐Mobarakeh, Felice Quartinello

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(2), P. 700 - 714

Published: Jan. 31, 2024

Every 1.2 s, a diabetic foot ulcer is developed, and every 20 one amputation carried out in patients. Monitoring controlling protease activity have been considered as strategy for more efficient management of other chronic wounds. This study aimed to develop casein-based dressing that, by its disappearance, provides information about the proteases simultaneously harnesses proteolytic activity. Casein films were fabricated using an aqueous solution, heat treatment was successfully deployed green clean approach confer hydrolytic stability. Our results showed that films' mechanical characteristics, water absorption, stability could be controlled length treatment, which proved useful tool. An increase duration from 30 min 3 h led toleration 2.4 times higher stress, 2 lower uptake, 3.4 at examined conditions. Selected structures responded Bacillus sp. bacteria's (BSP) human neutrophil elastase (HNE) representatives bacterial nonbacterial found wounds 10 200 ng mL–1 levels, respectively. The hydrolysis accompanied 36% reduction measured universal assay. released casein fragments scavenge 90% radicals. In-vitro cell culture studies hydrolysates not cytotoxic, film had favorable interaction with fibroblast cells, indicating potential scaffold case would extent causes rapid disintegration. In general, these findings hold promise applying developed structure detecting without need any equipment, kits, or expertise and, importantly, highly economical manner. severe, it also serve substrate adhesion growth; this aid healing process.

Language: Английский

Citations

10
Hydrogels loaded with MSC‐derived small extracellular vesicles: A novel cell‐free tissue engineering system for diabetic wound management DOI Creative Commons
Weicheng Zhong,

Hao Meng,

Liqian Ma

et al.

View, Journal Year: 2024, Volume and Issue: 5(4)

Published: July 18, 2024

Abstract With the aging and obesity era, increasing incidence of diabetes diabetic complications, especially non‐healing wounds, imposes a serious economic burden on both patients society. The complex microenvironments, including hyperglycemia, bacterial infection, ischemia, nerve damage, lead to prolonged inflammation proliferation phase wounds. Mesenchymal stem cell‐derived small extracellular vesicles (MSC‐sEVs), which contain rich variety therapeutic molecules, have been chased for decades because their potential roles in cellular communication, tissue regeneration, drug delivery. As powerful tools controlled‐sustained release sEVs, biocompatible hydrogels applied wide range biomedical applications. Herein, we first summarize pathological features such as angiopathy, neuropathy, immune cell dysfunction. Then, discuss biological properties, performance, stability pure MSC‐sEVs. After that, components, application patterns, responsiveness hydrogels. Next, loading avenues MSC‐sEVs into hydrogel, behaviors sEVs from hydrogels, influence crosslinking method hydrogel‐sEV composites. Finally, provide an overview current applications loaded with novel cell‐free engineering system managing wounds propose critical unsolved issues. This review is expected meaningful guidance developing wound management.

Language: Английский

Citations

10
Biofabrication paradigms in corneal regeneration: bridging bioprinting techniques, natural bioinks, and stem cell therapeutics DOI
Pankaj Pal, Sharda Sambhakar, Sarvesh Paliwal

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: 35(5), P. 717 - 755

Published: Jan. 12, 2024

Corneal diseases are a major cause of vision loss worldwide. Traditional methods like corneal transplants from donors effective but face challenges limited donor availability and the risk graft rejection. Therefore, new treatment essential. This review examines growing field bioprinting biofabrication in tissue engineering. We begin by discussing various such as stereolithography, inkjet, extrusion printing, highlighting their strengths weaknesses for eye-related uses. also explore how biological tissues made suitable through process called decellularization, which can be achieved using chemical, physical, or methods. The then looks at natural materials, known bioinks, used bioprinting. focus on materials gelatin, collagen, fibrin, chitin, chitosan, silk fibroin, alginate, examining mechanical properties. importance hydrogel scaffolds, particularly those based collagen other is discussed context repairing tissue. Another key area we cover use stem cells regeneration. pay special attention to limbal epithelial mesenchymal stromal cells, roles this process. concludes with an overview latest advancements bioprinting, early techniques advanced delivering bioengineered materials. In summary, presents current state future potential creating functional tissues, developments ongoing view towards restoring vision.

Language: Английский

Citations

9
A review of recent progress in alginate-based nanocomposite materials for tissue engineering applications DOI

Mahmoud H. Abu Elella,

Amira M Kamel,

Eduardo Alberto López-Maldonado

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 297, P. 139840 - 139840

Published: Jan. 13, 2025

Language: Английский

Citations

1
Recent Progress in Alginate-based Nanocomposites for Bone Tissue Engineering Applications DOI

Sundaravadhanan Lekhavadhani,

Sushma Babu,

Abinaya Shanmugavadivu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114570 - 114570

Published: Feb. 18, 2025

Language: Английский

Citations

1
Unveiling the potential of biomaterials and their synergistic fusion in tissue engineering DOI Creative Commons
Eva Sanchez Armengol, Nathalie Hock,

Sila Saribal

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 196, P. 106761 - 106761

Published: April 3, 2024

Inspired by nature, tissue engineering aims to employ intricate mechanisms for advanced clinical interventions, unlocking inherent biological potential and propelling medical breakthroughs. Therefore, medical, pharmaceutical fields are growing interest in organ replacement, repair, regeneration this technology. Three primary currently used engineering: transplantation of cells (I), injection growth factors (II) cellular seeding scaffolds (III). However, develop presenting highest potential, reinforcement with polymeric materials is interest. For instance, natural synthetic polymers can be used. Regardless, chitosan keratin two biopolymers great biocompatibility, biodegradability non-antigenic properties purposes offering restoration revitalization. combination has been studied results exhibit highly porous providing optimal environment cultivation. This review give an historical as well current overview engineering, involved the field.

Language: Английский

Citations

8