Nanomaterials in the Wound Healing Process: New Insights and Advancements

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 300 - 300

Published: Feb. 21, 2024

Wounds, which are becoming more common as a result of traumas, surgery, burns, and chronic illnesses like diabetes, remain critical medical problem. Infectious bacteria impact the healing process, particularly if its biofilm (biological films) leads to prolonged effect. Nanomaterials have emerged promising candidates in field wound due their unique properties versatile applications. New insights into interactions between nanomaterials microenvironments shed light on mechanisms underlying therapeutic effects. However, significantly minimal amount research has been carried out see these promote process. In this review, we provided an outline various types that studied for wounds infection prevention. Overall, utilization holds great promise continues evolve, providing new opportunities development effective efficient care therapies.

Language: Английский

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Investigating Nanomaterials for Improved Barrier Properties in Food Packaging

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(2)

Published: Jan. 13, 2025

This review examines the potential of nanomaterials in revolutionizing food packaging, focusing on their role enhancing barrier properties and extending shelf life packaged foods. Traditional packaging materials often fall short effectively protecting against oxygen, moisture, UV light, resulting diminished quality shorter life. Nanomaterials, including nanoclays, metal oxide nanoparticles (e.g., ZnO, TiO₂), carbon-based graphene, carbon nanotubes), biodegradable options like cellulose nanocrystals, have emerged as promising solutions. These offer exceptional gas moisture properties, antimicrobial effects, protection capabilities. The provides an in-depth exploration various nanomaterials, highlighting distinctive mechanisms; such tortuosity which enhance performance by limiting permeability. It also discusses recent advancements integrating into both flexible rigid systems, well active intelligent that employs nanosensors for real-time monitoring freshness spoilage. Despite potential, challenges toxicity concerns, environmental impacts, economic constraints to large-scale adoption are addressed. emphasizes need future research dual-function can simultaneously improve enable sensing. innovations could transform technologies, promoting enhanced safety sustainability.

Language: Английский

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Nanoparticles for Biomedical Application and Their Synthesis

Polymers, Journal Year: 2022, Volume and Issue: 14(22), P. 4961 - 4961

Published: Nov. 16, 2022

Tremendous developments in nanotechnology have revolutionized the impact of nanoparticles (NPs) scientific community and, more recently, society. Nanomaterials are by their definition materials that at least one dimension range 1 to 100 nm. Nanoparticles found many types different technological and applications innovations, from delicate electronics state-of-the-art medical treatments. Medicine has recognized importance polymer coated with NPs utilizes them widely thanks excellent physical, chemical, antibacterial, antimicrobial, protective properties. Emphasis is given biomedical application, as nanoscale structures biological molecules. Through this, they can achieve important features such targeted drug delivery, imaging, photo thermal therapy, sensors. Moreover, manipulating a “nano-scale” range, characteristic be modified order obtain desired properties needed particular fields, electronic, optical, surface plasmon resonance, physic-chemical features.

Language: Английский

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Green synthesis of iron oxide nanoparticles using Bombax malabaricum for antioxidant, antimicrobial and photocatalytic applications

Journal of Cleaner Production, Journal Year: 2023, Volume and Issue: 406, P. 136916 - 136916

Published: March 30, 2023

Language: Английский

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An Explorative Review on Advanced Approaches to Overcome Bacterial Resistance by Curbing Bacterial Biofilm Formation

Infection and Drug Resistance, Journal Year: 2023, Volume and Issue: Volume 16, P. 19 - 49

Published: Jan. 1, 2023

Abstract: The continuous emergence of multidrug-resistant pathogens evoked the development innovative approaches targeting virulence factors unique to their pathogenic cascade. These aimed explore anti-virulence or anti-infective therapies. There are evident concerns regarding bacterial ability create a superstructure, biofilm. Biofilm formation is crucial factor causing difficult-to-treat, localized, and systemic infections. microenvironments biofilm reduce efficacy antibiotics evade host’s immunity. Producing not limited specific group bacteria; however, Pseudomonas aeruginosa, Acinetobacter baumannii , Staphylococcus aureus biofilms exemplary models. This review discusses as link antimicrobial resistance. In addition, it explores insights into multi-targeted physiological mechanisms combat biofilms, including natural compounds, phages, photodynamic therapy (aPDT), CRISPR-Cas gene editing, nano-mediated techniques. Keywords: aPDT, CRISPR, nanotechnology

Language: Английский

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Bacterial-mediated synthesis and characterization of copper oxide nanoparticles with antibacterial, antioxidant, and anticancer potentials

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: March 6, 2023

The application of novel bacterial strains for effective biosynthesis nanoparticles minimizes negative environmental impact and eliminates challenges available approaches. In the present study, cell-free extract Stenotrophomonas sp. BS95. was used synthesis copper oxide (CuONPs). Characterization crude calcined CuONPs carried out by UV-vis spectroscopy, X-ray diffraction (XRD), fourier transform infrared (FTIR) zeta potential, dynamic light scattering, field emission scanning electron microscopy, transmission atomic force microscopy. Afterward, biogenic were evaluated antibacterial, antioxidant, cytotoxic effects using broth micro-dilution method, DPPH assay alamarBlue assay, respectively. Finally, molecular mechanisms behind anticancer ascertained real time PCR. absorbance spectra registered surface plasmon resonance peaks at 286 nm 420 CuONPs, FTIR exhibited bands associated with organic functional groups proteins, confirming capping functionalization CuONPs. average crystallite size determined as 18.24 21.3 XRD, potentials −28.57 ± 5.13 −29.47 4.78 mV, respectively, indicating their high stability. Electron microscopy revealed that roughly spherical particles an 35.24 4.64 43.68 2.31 nm, Biogenic induced antibacterial minimal inhibitory concentrations ranging from 62.5 to 1,000 μg/ml against Gram-negative Gram-positive strains. antioxidant activity found be 83% 2.64% 78% 1.73%, More intriguingly, exerted considerable on human colon gastric adenocarcinoma cells, while low toxicity normal cells. Anticancer confirmed significant changes in expression apoptosis-related genes, including P53 , BAX BCL2 CCND1 . Hence, biosynthesized could considered potential antimicrobial, agents.

Language: Английский

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Recent advance on nanoparticles or nanomaterials with anti-multidrug resistant bacteria and anti-bacterial biofilm properties: A systematic review

Heliyon, Journal Year: 2023, Volume and Issue: 9(11), P. e22105 - e22105

Published: Nov. 1, 2023

With the wide spread of Multidrug-resistant bacteria (MDR) due to transfer and acquisition antibiotic resistance genes formation microbial biofilm, various researchers around world are looking for a solution overcome these resistances. One potential strategy best candidate infections is using an effective nanomaterial with antibacterial properties against them. analysis: In this study, we overview nanomaterials anti-MDR anti-biofilm properties. Hence, systematically explored biomedical databases (Web Sciences, Google Scholar, PubMed, Scopus) categorize related studies about activities from 2007 December 2022. total, forty-one were investigated find information during 2007-2022. According collected documents, nineteen types showed putative effects such as Cu, Ag, Au, Au/Pt, TiO2, Al2O3, ZnO, Se, CuO, Cu/Ni, Cu/Zn, Fe3O4, Au/Fe3O4, Au/Ag, Graphene O, CuS. addition, seven them considered agents Au/Ag. studies, each has been designed different methods their standard strains, clinical MDR bacterial biofilms have in-vitro in-vivo conditions. destructive mechanism on structures. Various nanoparticles (NP) introduced designing new drug medical equipment preventing infectious disease outbreaks by biofilm.

Language: Английский

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Sustainable bioactivity enhancement of ZnO–Ag nanoparticles in antimicrobial, antibiofilm, lung cancer, and photocatalytic applications

RSC Advances, Journal Year: 2023, Volume and Issue: 13(38), P. 26663 - 26682

Published: Jan. 1, 2023

Green synthesized ZnO and ZnO–Ag NPs using a plant extract. SEM image validate the final product. Characterized by FTIR, XRD, zeta, XPS, etc. Following this, their anticancer, antibacterial, photocatalytic potentials are evaluated.

Language: Английский

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Green Synthesis, Characterization and Bioactivity of Mangifera indica Seed-Wrapped Zinc Oxide Nanoparticles

Molecules, Journal Year: 2023, Volume and Issue: 28(6), P. 2818 - 2818

Published: March 21, 2023

In the realm of nanoparticles, metal-based nanoparticles have traditionally been regarded as pioneering category. Compared to other zinc oxide several advantages, including optical and biological properties, which provide them a significant competitive advantage in clinical applications. current investigation, we used an aqueous Mangifera indica seed extract synthesize (ZnO NPs). UV-Vis spectroscopy, Fourier transform infrared spectroscopy analysis, atomic force X-ray diffraction, scanning electron microscopy, transmission microscopy were characterize synthesized ZnO NPs. The assessed for their potential inhibit bacterial growth protect cells from free radical damage. According study's findings, that had modified with aid mango seeds very efficient preventing development tested bacteria also powerful antioxidants.

Language: Английский

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Alternative mechanisms of action of metallic nanoparticles to mitigate the global spread of antibiotic-resistant bacteria

The Cell Surface, Journal Year: 2023, Volume and Issue: 10, P. 100112 - 100112

Published: Oct. 20, 2023

One of the biggest issues for medical professionals and a serious global concern is emergence multi-drug-resistant bacteria, which result overuse or misuse antimicrobial agents. To combat this urgent problem, new drugs with alternative mechanisms action are continuously replacing conventional antimicrobials. Nanotechnology-fueled innovations provide patients hope overcoming drug resistance. The aim present work was to document potential metallic nanoparticles against bacterial pathogens. Cell wall interaction membrane penetration, reactive oxygen species (ROS) production, DNA damage, protein synthesis inhibition were some generalised recognised in current study. In vitro vivo studies demonstrated that toxicity concerns development resistance (NPs) harden use NP products treatment drug-resistant Therefore, researchers across globe should actively engage solving above-mentioned issues.

Language: Английский

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