Antimicrobial efficacy of Mentha piperata-derived biogenic zinc oxide nanoparticles against UTI-resistant pathogens

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 11, 2023

Abstract Misuse of antibiotics leads to the worldwide spread antibiotic resistance, which motivates scientists create new antibiotics. The recurring UTI due antibiotics-resistant microorganism’s challenges globally. biogenic nanoparticles have potential meet escalating requirements novel antimicrobial agents. green synthesis (NPs) gained more attention their reliable applications against resistant microbes. current study evaluates ZnO NPs Mentha piperata extract pathogens urinary tract infections by agar well diffusion assay. revealed comparatively maximum inhibition in comparison synthetic two bacterial strains ( Proteus mirabilis , Pseudomonas aeruginosa ) and a fungal strain Candida albicans ).The synthesized alone activities than combination plant (PE) NPs, PE alone. physiochemical features characterized through UV–Vis spectroscopy, FTIR, XRD, SEM, EDX. spectroscopy 281.85 nm wavelengths; XRD pattern crystalline structure NPs. FTIR analysis presence carboxylic nitro groups, could be attributed extract. SEM spherical hollow symmetry electrostatic forces. via EDX confirmed Zn oxygen sample. provide pivotal information such as quality effectiveness. excellent dose-dependent activity pathogenic isolates from UTI-resistant patients. higher concentration ZnONPs interacts with cell membrane triggers oxidative burst. They may bind enzymes proteins brings epigenetic alteration disruption or death.

Language: Английский

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Progress in the Prevalence, Classification and Drug Resistance Mechanisms of Methicillin-Resistant Staphylococcus aureus

Infection and Drug Resistance, Journal Year: 2023, Volume and Issue: Volume 16, P. 3271 - 3292

Published: May 1, 2023

Staphylococcus aureus is a common human pathogen with variety of virulence factors, which can cause multiple infectious diseases. In recent decades, due to the constant evolution and abuse antibiotics, was becoming more resistant, infection rate MRSA remained high, clinical treatment became difficult. The genetic diversity mainly represented by continuous emergence epidemic strains, resulting in changes clones. Different classes resulted different epidemics resistance characteristics, could affect symptoms treatments. had also spread from traditional hospitals community livestock environments, new clones established relationship between animals humans, promoting further MRSA. Since mechanism very complex, it important clarify these mechanisms at molecular level for We firstly described SCCmec elements, discussed types SCCmec, its drug expression regulations. Then, we how vanA operon makes resistant vancomycin regulation. Finally, brief introduction given biofilms efflux pump systems. Analyzing help study anti-infective drugs alleviate At end review, summarized strategies infection, including anti-biofilm agents inhibitors. To sum up, here reviewed characteristics aureus, classifications, (SCCmec element, operon, biofilm active system) novel therapy strategies, so as provide theoretical basis infection.

Language: Английский

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Antibiotic prescribing patterns and carriage of antibiotic-resistant Escherichia coli and Enterococcus species in healthy individuals from selected communities in Lusaka and Ndola districts, Zambia

JAC-Antimicrobial Resistance, Journal Year: 2024, Volume and Issue: 6(2)

Published: March 5, 2024

Abstract Objectives This study assessed antibiotic prescribing patterns in primary healthcare facilities and antimicrobial resistance (AMR) profiles of commensal Escherichia coli enterococci isolated from pregnant women children under 5 years age. Materials methods cross-sectional was conducted Lusaka Ndola districts Zambia. Prescription pattern data were obtained hospital pharmacies. Identification susceptibility E. determined by conventional methods, while confirmation both pathogens AMR genes PCR. Data analysed using WHONET SPSS version 25.0. Results Most prescribed antibiotics at the belonged to Access group WHO Access, Watch Reserve (AWaRe) classification. All adhered AWaRe framework ≥60% belonging group. However, highest antibiotics. ampicillin ranged 71% 77% co-trimoxazole 74% 80%, enterococcal tetracycline 59%–64%. MDR (75%) isolates, XDR isolates (97%). The identified included blaCTX-M, sul2 qnrA, those erm(B), erm(C) erm(A). Conclusions Resistance These findings highlight need use local formulate country-specific treatment guidelines line with classification enforce regulations that prohibit easy access

Language: Английский

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Self-assembling short peptide amphiphiles as versatile delivery agents: a new frontier in antibacterial research

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(60), P. 7687 - 7696

Published: Jan. 1, 2024

Self-assembling short peptide amphiphiles, crafted through a minimalistic approach, spontaneously generate well-ordered nanostructures, facilitating the creation of precise nanostructured biomaterials for diverse biomedical applications. The seamless integration bioactive metal ions and nanoparticles endows them with potential to serve as pioneering materials in combating bacterial infections. Nanomanipulation these molecules' binary structures enables effective penetration membranes, forming structured nanoarchitectures antibacterial properties. Through comprehensive exploration, we attempt reveal innovative particularly conjugation cations nanoparticles, offering insights future research trajectories.

Language: Английский

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Prevention and potential remedies for antibiotic resistance: current research and future prospects

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 3, 2024

The increasing threat of antibiotic resistance and shrinking treatment options for infections have pushed mankind into a difficult position. looming the return pre-antibiotic era has caused sense urgency to protect conserve potency therapy. One perverse effects is dissemination its causative agents from non-clinically important strains clinically vice versa. popular saying "Prevention better than cure" appropriate tackling resistance. On one hand, new effective antibiotics are required; on other measures use antibiotics, along with increased awareness in general public related use, essential. Awareness, especially resistance, dissemination, potential threats, can help greatly controlling abuse containment Antibiotic drugs' effectiveness be enhanced by producing novel analogs or adding adjuvants current antibiotics. Combinatorial therapy proven successful treating multidrug-resistant (MDR) bacterial infections. This review aims highlight global situation discuss methods used monitor, prevent, inhibit, reverse mechanisms fight against

Language: Английский

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Native Infective Endocarditis: A State-of-the-Art-Review

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1481 - 1481

Published: July 19, 2024

Native valve infective endocarditis (NVE) is a global phenomenon, defined by infection of native heart and involving the endocardial surface. The causes epidemiology disease have evolved in recent decades, with doubling average patient age. A higher incidence was observed patients implanted cardiac devices that can result right-sided tricuspid valve. microbiology has also changed. Previously, staphylococci, which are most often associated health-care contact invasive procedures, were common cause disease. This now been superseded streptococci. While innovative diagnostic therapeutic strategies emerged, mortality rates not improved remain at 30%, than for many cancer diagnoses. lack randomized trials logistical constraints impede clinical management, long-standing controversies such as use antibiotic prophylaxis persist. state art review addresses practice, controversies, to combat this potentially devastating multidisciplinary team will be established provide care presumptive NVE. composition include specialists cardiology, cardiovascular surgery, infectious prompt administration combination antimicrobial therapy essential effective NVE treatment. Additionally, meticulous evaluation each necessary order identify any indications immediate surgery. With intention promoting more comprehensive understanding procedural management furnish clinicians reference, current evidence utilization distinct diagnosis treatment presented.

Language: Английский

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Native Infective Endocarditis: A State of the Art Review

Published: June 10, 2024

Native infective endocarditis is a global phenomenon, defined by infection of native heart valve and involving the endocardial surface. The causes epidemiology disease have evolved in recent decades, with doubling average patient age. A higher incidence was observed patients implanted cardiac devices that can result right-sided tricuspid valve. microbiology has also changed. Previously, staphylococci, which are most often associated health-care contact invasive procedures, were common cause disease. Nevertheless, this now been superseded streptococci. While innovative diagnostic therapeutic strategies emerged, mortality rates not improved over past year remain at 30%, than for many cancer diagnoses. lack randomized trials logistical constraints impede clinical management, long-standing controversies such as use antibiotic prophylaxis persist. This state art review addresses practice, controversies, to combat potentially devastating

Language: Английский

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Homogeneous vs. heterogeneous photo-Fenton elimination of antibiotic-resistant bacteria bearing intracellular or extracellular resistance: Do resistance mechanisms interfere with disinfection pathways?

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(2), P. 112147 - 112147

Published: Feb. 6, 2024

The present study aimed to fill the knowledge gap between implications of intracellular and extracellular antibiotic resistance mechanisms may inflict on inactivation pathways photo-Fenton process under mild conditions. It was thus designed as a cross-comparison effect homogeneous heterogeneous (near-neutral pH, [Fe]=1 mg/L, [H2O2]=10 mg/L) seven strains Staphylococcus aureus exhibiting different resistance, or susceptibility. Additionally, variations in tolerance (MIC test) relative changes presence genes were qualitatively monitored during treatment using PCR. results suggest that antibiotics does not confer enhanced photo-Fenton, it attained 4-logU reduction within 50–100 min for all strains, regardless status. Strains express do pose risk; however, external their defense against occasionally interfere with process. This phenomenon mainly linked cell wall thickening some externally resistant compared susceptible homologues. Eventually, by conferring antibiotics, this alteration reduce susceptibility Fenton-related reagents either reducing diffusion rendering walls less prone leaching upon attacks. In addition, remained unchanged lowered threshold. Moreover, system considerably detection 90 respect hv, hv/H2O2, photo-Fenton. conclusion, could be an effective hindering spread but conditions should aim maximize degradation ARG, concentration decreases more slowly than bacteria.

Language: Английский

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Vaccines and monoclonal antibodies to prevent healthcare-associated bacterial infections

Clinical Microbiology Reviews, Journal Year: 2024, Volume and Issue: 37(3)

Published: Aug. 9, 2024

SUMMARY Healthcare-associated infections (HAIs) represent a burden for public health with high prevalence and death rates associated them. Pathogens potential antimicrobial resistance, such as ESKAPE pathogens ( E nterococcus faecium, S taphylococcus aureus, K lebsiella pneumoniae, A cinetobacter baumannii, P seudomonas aeruginosa, nterobacter species ) Clostridioides difficile , are responsible most HAIs. Despite the implementation of infection prevention control intervention, globally, HAIs is stable they mainly due to endogenous pathogens. It undeniable that complementary measures, prophylactic approaches by active or passive immunization needed. Specific groups at-risk (elderly people, chronic condition immunocompromised) also healthcare workers key targets. Medical procedures specific interventions known be at risk HAIs, in addition hospital environmental exposure. Vaccines monoclonal antibodies can seen attractive preventive In this review, we present an overview vaccines clinical development major bacterial Based on current state knowledge, look challenges future perspectives improve these means.

Language: Английский

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Rational utilization of 1,2,3-triazole scaffold in anti-MRSA drug development: Design strategies, structural insights and pharmacological outcomes

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1295, P. 136557 - 136557

Published: Sept. 2, 2023

Language: Английский

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