Advances in Clinical Medicine, Journal Year: 2023, Volume and Issue: 13(10), P. 16723 - 16730
Published: Jan. 1, 2023
Language: Английский
Acta Tropica, Journal Year: 2025, Volume and Issue: unknown, P. 107578 - 107578
Published: March 1, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4293 - 4293
Published: May 1, 2025
An increasing body of research indicates that the circulating microbiome plays a significant role in cancer initiation and progression treatment response. The genomic characteristics microorganisms may influence tumor immune microenvironment, thereby affecting therapeutic outcomes. However, whether can serve as prognostic biomarker for cervical patients its mechanistic microenvironment still requires further investigation. Univariate, Lasso, multivariate Cox regression analyses were utilized to identify microbial signatures associated with overall survival (OS) cancer. A Microbial Abundance Prognostic Score (MAPS) model was constructed based on these findings. nomogram integrated clinical features MAPSs developed predict OS rates Blood data combined matched RNA-seq analyze differences between high- low-MAPS groups, elucidating impact MAPS microenvironment. Finally, potential application predicting efficacy immunotherapy chemotherapy assessed. predictive model, which includes 15 microorganisms, has shown independent value Integrating into improved accuracy predictions. Combined gene revealed interactions microbiomes drug sensitivity analysis indicated predictor chemotherapy’s efficacy. Our findings suggest hold promise novel biomarkers inform personalized strategies Further large-scale multicenter studies are warranted validate utility MAPS.
Language: Английский
Citations
0
BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)
Published: Feb. 20, 2024
Abstract Chlamydia trachomatis (CT) is the most common sexually transmitted infections globally, and CT infection can enhance HPV persistence. Epidemiological analysis has shown that patients with CT/HPV coinfection have a higher risk of developing cervical cancer exhibit more rapid progression to than alone. However, mechanism not been fully elucidated. Here, we report supports persistence by further suppressing functions Langerhans cells (LCs); in particular, activates PI3K pathway inhibits MAPK pathways LCs, these are frequently involved regulation immune responses. also impairs LC reducing antigen-presenting ability density LCs. Moreover, alter T-cell subsets, resulting fewer CD4 + CD8 T infiltrating Tregs. decreases /CD8 cell ratio below 1, induces greater lymphocytes’ apoptosis infection, thus impairing cell-mediated immunity accelerating progress cancer.
Language: Английский
Citations
3
Diagnostics, Journal Year: 2024, Volume and Issue: 14(9), P. 968 - 968
Published: May 6, 2024
Background: The current manuscript’s aim was to determine the human papillomavirus (HPV) genotype-specific prevalence and distribution among individuals, males, females, of different ages in region Apulia, Italy, highlighting possible variables involved carcinogenicity mechanism. In addition, we proposed two hypothetical models HPV’s molecular dynamics, intending clarify impact prevention therapeutic strategies, explicitly modeled by recent survey data. Methods: We presented clinical data from 9647 participants tested for either high-risk (HR) or low-risk (LR) HPV at affiliated Bari Policlinic University Hospital 2011 2022. DNA detection performed using nested-polymerase chain reaction (PCR) multiplex real-time PCR assay. Statistical analysis showed significant associations all genders both HR- LR-HPV types. A major number pairwise were detected higher-risk types females lower-risk males. Results: overall 50.5% (n-4.869) vs. 49.5% (n-4.778) study population, which 74.4% (n-3621) found be (HR-HPV) genotypes 57.7% (n-2.807) (LR-HPV) genotypes, males 58% 49%; three most prevalent HR-HPV 53 (n707-15%), 16 (n704-14%), 31 (n589-12%), LR-HPV, they 42 (19%), 6 (16%), 54 (13%); 56% patients screened ≤ 30 years old, 53% between 40 46% 41–50 51–60 finally, 44% subjects >60 old. Conclusions: Our provided comprehensive epidemiological on genotype participants, could serve as a reference practice, it implied necessity more effective screening methods carcinogenesis covering use specific investigations. Although this is predominantly descriptive study, obtained offer not only fairly unique trend compared other studies realities latitudes but also lead us focus infection within groups young people adults hypothesize involvement dysbiosis, stem cells, retrotransposition
Language: Английский
Citations
2
Computers in Biology and Medicine, Journal Year: 2023, Volume and Issue: 167, P. 107586 - 107586
Published: Oct. 17, 2023
Language: Английский
Citations
5
Microorganisms, Journal Year: 2024, Volume and Issue: 12(6), P. 1126 - 1126
Published: May 31, 2024
Some infectious agents have the potential to cause specific modifications in cellular microenvironment that could be propitious carcinogenesis process. Currently, there are viruses and bacteria, such as human papillomavirus (HPV) Helicobacter pylori, well established risk factors for neoplasia. Chlamydia trachomatis (CT) infections one of most common bacterial sexually transmitted worldwide, recent European data confirmed a continuous rise across Europe. The infection is often asymptomatic both sexes, requiring screening program early detection. Notwithstanding, not all countries Europe it. can chronic persistent infections, resulting inflammation, plausible biological mechanisms link genital with tumorigenesis. Herein, we aimed understand epidemiological plausibility CT causing endometrial, ovarian, cervical tumors. Also, covered some best suitable vitro techniques used study this association. In addition, defend point view personalized medicine strategy treat those patients through discovery biomarkers allow This review supports need development further fundamental studies area, order investigate establish role chlamydial oncogenesis.
Language: Английский
Citations
1
Annals of Epidemiology, Journal Year: 2024, Volume and Issue: 100, P. 16 - 26
Published: Oct. 22, 2024
Language: Английский
Citations
1
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(10), P. e0312947 - e0312947
Published: Oct. 29, 2024
Objective To determine the prevalence of genital infections (GIs), including sexual transmitted STIs: Neisseria gonorrhoeae , Chlamydia trachomatis Mycoplasma genitalium Trichomonas vaginalis and opportunistic pathogens that generally do not cause STIs, non-classic STI: Ureaplasma urealyticum parvum hominis in women with high-risk oncogenic human papillomavirus (hr-HPV) infection their association cervical lesions. Methods A cross-sectional study was carried out 231 hr-HPV positive women. Of these, 46 has histologically confirmed intraepithelial neoplasia 3 (CIN3) or more (including CIN3 cancer lesions-CIN3+). GIs were detected by multiplex real time PCR. Odds ratios (OR) estimated to explore possible associations between presence absence CIN3+ Additionally, we examined sociodemographic, sexual, clinical characteristics GIs. Results In total, there 174/231 cases corresponding an overall 75.3% (95%CI: 69.4–80.4), being STIs most common (72.3%) compared (12.6%). The prevalent STI U . (49.8%) C (7.4%), respectively. odds presenting times higher under years older counterparts (OR: 3.32, 95%CI: 1.74–6.16), a normal Pap smear inflammation those without 3.31, 1.15–9.77). equally present Conclusion We observed smear, but no CIN3+, as some them are very likely part vaginal flora, suggesting such appear be cofactors carcinogenesis, although larger prospective studies needed.
Language: Английский
Citations
1
Ukrainian Scientific Medical Youth Journal, Journal Year: 2024, Volume and Issue: 144(1), P. 175 - 184
Published: March 28, 2024
the article summarizes issue of prevention cervical cancer - most common disease associated with human papillomavirus (HPV). The main goal this study is to generalize etiology cancer, note unique opportunities for its prevention, as well develop screening tests HPV one effective strategies. Explore how current diagnostics detect E6/E7 DNA or mRNA in cervical/vaginal specimens using molecular technologies. To find out whether are more sensitive than cytology visual examination acetic acid primary method, and even clinically valuable detecting subtle cytological changes a hybrid test. Through detailed literature sources, their systematization approaches solving problem, it was found that technical laboratory capabilities very limited underserved places, so women have travel long distances make some efforts prevent treat cancer. relevance pathology lies fact serious public health problem fourth worldwide, accounting about 604,000 new cases every year. And practical implementation an program can face many problems, measures must be taken overcome these problems without compromising detection disease. These could include reducing frequency WHO global strategy offer at ages 35 45, implementing high-throughput testing technology, improving access vaginal remote areas. Improving informational education those who do not want undergo gynecological examination. Another important implement see-and-treat approach healthcare delivery platform requires technician skills. In addition, development large-scale specific technologies much cheaper easier use non-laboratory setting currently available options should priority facilities. At same time, there need initiate affordable readily intermediate secondary test optimal specificity triage separate insignificant infections require colposcopy. results may interest care physicians, gynecologists, oncologists, therapists.
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2024, Volume and Issue: 6(7)
Published: June 25, 2024
Abstract The emergence of cancer-causing bacteria and viruses that have become resistant to either antibiotics or viral treatment is often attributed their overuse in people livestock. Intriguingly, the class antidepressant drugs, such as selective serotonin reuptake inhibitors (SSRIs), may also contribute generating microorganisms with a profound disturbing role local cervix-vagina homeostasis. Therefore, we proposed possible involvement SSRIs onset growth cervical cancer (CC), which based on some empirical considerations, (i) number women diagnosed post-menopausal CC almost equivalent depressive problems, (ii) proven affection both vaginal intestinal microbiota, (iii) essential microbiota immune response against oncogenic pathogens, including human papillomavirus Chlamydia trachomatis ( C. ), (IV) favoring rise antibiotic-resistant microorganisms, (V) inhibitory effect estradiol-serotonin-prolactin axis. These features are important overproduction reactive oxygen species, responsible for different harmful activities higher cell membrane permeability porosity, hyperstimulation transcription, translational activities, overall stress check-point genes involved ATP synthesis, DNA breaks, abnormal mutations. This paper's results suggested reconsidering efficacy long-term use since increase prescriptions mainly due rather than diagnoses per se, secondly little known about consequences use. evidence supports drugs increasing risk was searched discussed.
Language: Английский
Citations
0