Lactobacilli, a Weapon to Counteract Pathogens through the Inhibition of Their Virulence Factors DOI
Andrea Colautti, Elisabetta Orecchia, Giuseppe Comi

et al.

Journal of Bacteriology, Journal Year: 2022, Volume and Issue: 204(11)

Published: Oct. 26, 2022

To date, several studies have reported an alarming increase in pathogen resistance to current antibiotic therapies and treatments. Therefore, the search for effective alternatives counter their spread onset of infections is becoming increasingly important. In this regard, microorganisms former Lactobacillus genus demonstrated ability reduce virulence pathogens. addition production bioactive substances, self- coaggregation, substrate competition, lactobacilli influence gene expression by downregulating genes associated with As many vivo vitro trials, counteract inhibit various factors that favor pathogens, including toxins, biofilm formation, host cell adhesion invasion, downregulation linked quorum sensing. The aim review summarize on inhibition lactobacilli, important microbial group well known industrial medical fields technological probiotic properties benefit human hosts potential provide aid fight against pathogens besides use therapies. Further research could lead identification new strains that, alleviating adverse effects, improve efficacy or play preventive role reducing if regularly taken.

Language: Английский

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on fermented foods DOI Creative Commons
Maria L. Marco, Mary Ellen Sanders, Michael G. Gänzle

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2021, Volume and Issue: 18(3), P. 196 - 208

Published: Jan. 4, 2021

Abstract An expert panel was convened in September 2019 by The International Scientific Association for Probiotics and Prebiotics (ISAPP) to develop a definition fermented foods describe their role the human diet. Although these have been consumed thousands of years, they are receiving increased attention among biologists, nutritionists, technologists, clinicians consumers. Despite this interest, inconsistencies related use term ‘fermented’ led define beverages as “foods made through desired microbial growth enzymatic conversions food components”. This definition, encompassing many varieties foods, is intended clarify what (and not) food. distinction between probiotics further clarified. also addressed current state knowledge on safety, risks health benefits, including an assessment nutritional attributes mechanistic rationale how could improve gastrointestinal general health. latest advancements our understanding ecology systems biology were discussed. Finally, reviewed regulated discussed efforts include them separate category national dietary guidelines.

Language: Английский

Citations

549
Engineered living biomaterials DOI
Aleixandre Rodrigo‐Navarro, Shrikrishnan Sankaran, Matthew J. Dalby

et al.

Nature Reviews Materials, Journal Year: 2021, Volume and Issue: 6(12), P. 1175 - 1190

Published: Aug. 31, 2021

Language: Английский

Citations

336
Engineering living therapeutics with synthetic biology DOI

Andrés Cubillos-Ruiz,

Tingxi Guo, Anna Sokolovska

et al.

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 20(12), P. 941 - 960

Published: Oct. 6, 2021

Language: Английский

Citations

217
Fermentative Lactic Acid Production From Lignocellulosic Feedstocks: From Source to Purified Product DOI Creative Commons
Dragomir Yankov

Frontiers in Chemistry, Journal Year: 2022, Volume and Issue: 10

Published: March 4, 2022

The second (lignocellulosic biomass and industrial wastes) third (algal biomass) generation feedstocks gained substantial interest as a source of various value-added chemicals, produced by fermentation. Lactic acid is valuable platform chemical with both traditional newer applications in many industries. successful fractionation, separation, hydrolysis lignocellulosic result sugars' rich raw material for lactic This review paper aims to summarise the investigations progress last five years production from inexpensive renewable resources. Different aspects are discussed – type materials, pretreatment detoxification methods, acid-producers (bacteria, fungi, yeats), use genetically manipulated microorganisms, separation techniques, different approaches process organization, well main challenges, possible solutions optimization.

Language: Английский

Citations

105
Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic Biology DOI Creative Commons
Kai Jin, Yi Huang, Hailong Che

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

Using synthetic biology techniques, bacteria have been engineered to serve as microrobots for diagnosing diseases and delivering treatments. These can be used individually or in combination microbial consortia. The components within these consortia complement each other, enhancing diagnostic accuracy providing synergistic effects that improve treatment efficacy. application of therapies cancer, intestinal diseases, metabolic disorders underscores their significant potential. impact on the host's native microbiota is crucial, microbes modulate interact with environment, influencing outcomes overall health. Despite numerous advancements, challenges remain. include ensuring long-term survival safety bacteria, developing new chassis gene editing techniques non-model strains, minimising potential toxicity, understanding bacterial interactions host microbiota. This mini-review examines current state disease diagnosis treatment, highlighting challenges, future directions this promising field.

Language: Английский

Citations

3
Lactic acid bacteria: Nature, Characterization, Mode of action, Products and Applications DOI
Patrick Othuke Akpoghelie, Great Iruoghene Edo,

Ali B.M. Ali

et al.

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

3
Histamine accumulation in dairy products: Microbial causes, techniques for the detection of histamine‐producing microbiota, and potential solutions DOI
Marta Moniente, Diego García‐Gonzalo, Ignacio Ontañón

et al.

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2021, Volume and Issue: 20(2), P. 1481 - 1523

Published: Jan. 27, 2021

Histamine poisoning is a significant public health and safety concern. Intoxication from ingestion of food containing high amounts histamine may cause mild or severe symptoms that can even culminate in cardiac arrest. Nonetheless, although levels dairy products are not subject to any regulation, important outbreaks adverse effects have been reported due intake with content, especially ripened cheeses. Histamine, biogenic amine, accumulate as result the metabolism starter nonstarter lactic acid bacteria, well yeasts contribute ripening flavoring final product, spoilage bacteria. The aim this review describe microbiological causes presence fermented milk products, propose control measures potential methods for obtaining histamine-free products. Thus, manuscript focuses on histamine-producing microbiota highlighting detection bacteria through traditional novel techniques. In addition, aims explore prevent access raw materials, formation such careful selection cultures lacking ability produce histamine, implementation effective processing technologies reduce microbiota. Finally, removal already formed histamine-degrading microorganisms by enzymatic degradation will also be explored.

Language: Английский

Citations

72
Lactic acid separation and recovery from fermentation broth by ion-exchange resin: A review DOI Creative Commons
Nur Akmal Solehah Din, Seng Joe Lim, Mohamad Yusof Maskat

et al.

Bioresources and Bioprocessing, Journal Year: 2021, Volume and Issue: 8(1)

Published: April 20, 2021

Abstract Lactic acid has become one of the most important chemical substances used in various sectors. Its global market demand significantly increased recent years, with a CAGR 18.7% from 2019 to 2025. Fermentation been considered preferred method for producing high-purity lactic industry over synthesis. However, recovery and separation microbial fermentation media are relatively complicated expensive, especially process relating second-generation (2G) recovery. This article reviews development progress related broth. Various aspects discussed thoroughly, such as mechanism production through fermentation, crucial factors that influence process, conventional advanced methods. review's highlight is by adsorption technique using ion-exchange resins brief focus on potential in-site strategies alongside influenced ion exchange. Apart that, other techniques, neutralization, liquid–liquid extraction, membrane separation, distillation, also thoroughly reviewed.

Language: Английский

Citations

61
Recent developments of lactic acid bacteria and their metabolites on foodborne pathogens and spoilage bacteria: Facts and gaps DOI
Hafize Fidan, Tuba Esatbeyoglu, Vida Šimat

et al.

Food Bioscience, Journal Year: 2022, Volume and Issue: 47, P. 101741 - 101741

Published: April 30, 2022

Language: Английский

Citations

55
Genetically engineered bacterium: Principles, practices, and prospects DOI Creative Commons
Yiting Liu, Jing Feng,

Hangcheng Pan

et al.

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 13, 2022

Advances in synthetic biology and the clinical application of bacteriotherapy enable use genetically engineered bacteria (GEB) to combat various diseases. GEB act as a small ‘machine factory’ intestine or other tissues continuously produce heterologous proteins molecular compounds and, thus, diagnose cure disease work an adjuvant reagent for treatment by regulating immune system. Although achievements GEBs therapy diseases are promising, practical implementation this new therapeutic modality remains grand challenge, especially at initial stage. In review, we introduce development their advantages management, summarize latest research advances microbial genetic techniques, discuss administration routes, performance indicators limitations used platforms management. We also present several examples applications cancers metabolic further highlight great potential near future.

Language: Английский

Citations

51