Animals,
Journal Year:
2024,
Volume and Issue:
14(3), P. 409 - 409
Published: Jan. 26, 2024
This
experiment
aimed
to
investigate
the
mitigating
effect
of
CUR
on
growth
performance
and
liver
intestinal
health
broilers
fed
AFB1-contaminated
diets.
In
this
study,
320
one-day-old
healthy
male
Arbor
Acres
(AA)
were
randomly
divided
into
four
groups,
including
Control
group
(fed
basal
diet),
AFB1
diet
containing
1
mg/kg
AFB1),
AFB1+CUR
with
500
CUR),
eight
replicates
ten
animals
per
a
28
d
experimental
period.
terms
performance,
addition
significantly
improved
AFB1-induced
significant
reductions
in
final
body
weight
day
mean
daily
gain
(p
<
0.05)
increased
ratio
feed
intake
0.05).
health,
improvements
histological
lesions
occurred
compared
group,
higher
glutathione
peroxidase
(GSH-Px),
catalase
(CAT),
total
superoxide
dismutase
(T-SOD)
activities
levels
nuclear
factor
erythroid
2-related
2
(Nrf2),
Kelch-like
ECH-associated
protein
(Keap-1),
heme
oxygenase
(HO-1),
NAD(P)H
quinone
oxidoreductase
(NQO-1)
gene
expression
relative
length
ileum
0.05),
elevated
height
ileal
villi
reduced
D-Lactate
(D-LA)
diamine
oxidase
(DAO)
broiler
serum
GSH,
CAT,
T-SOD
tissues
Nrf2,
HO-1,
NQO-1
genes
group.
conclusion,
showed
protective
against
damage
intestine
caused
by
through
Nrf2
signaling
pathway,
thereby
improving
exposed
AFB1.
Cells,
Journal Year:
2021,
Volume and Issue:
10(6), P. 1309 - 1309
Published: May 25, 2021
Alzheimer's
disease
(AD)
is
the
number
one
neurovegetative
disease,
but
its
treatment
options
are
relatively
few
and
ineffective.
In
efforts
to
discover
new
strategies
for
AD
therapy,
natural
products
have
aroused
interest
in
research
community
pharmaceutical
industry
their
neuroprotective
activity,
targeting
different
pathological
mechanisms
associated
with
AD.
A
wide
variety
of
from
origins
been
evaluated
preclinically
clinically
preventing
attenuating
multifactorial
pathologies
This
review
mainly
focuses
on
possible
that
may
be
beneficial
product
mixtures
or
extracts
sources
demonstrated
activity
preclinical
and/or
clinical
studies.
It
believed
containing
multiple
bioactive
compounds
can
work
additively
synergistically
exhibit
might
an
effective
approach
drug
discovery.
Frontiers in Endocrinology,
Journal Year:
2021,
Volume and Issue:
12
Published: May 3, 2021
Diabetes
mellitus
(DM)
is
an
ensemble
of
metabolic
conditions
that
have
reached
pandemic
proportions
worldwide.
Pathology's
multifactorial
nature
makes
patient
management,
including
lifelong
drug
therapy
and
lifestyle
modification,
extremely
challenging.
Currently,
there
growing
evidence
about
the
effectiveness
using
herbal
supplements
in
preventing
controlling
DM.
Curcumin
a
bioactive
component
found
Curcuma
longa,
which
exhibits
several
physiological
pharmacological
properties
such
as
antioxidant,
anti-inflammatory,
anticancer,
neuroprotective,
anti-diabetic
activities.
For
these
reasons,
our
objective
to
systematically
review
effects
longa
or
curcumin
on
Databases
PUBMED
EMBASE
were
searched,
final
selection
included
sixteen
studies
fulfilled
inclusion
criteria.
The
results
showed
curcumin's
activity
might
be
due
its
capacity
suppress
oxidative
stress
inflammatory
process.
Also,
it
significantly
reduces
fasting
blood
glucose,
glycated
hemoglobin,
body
mass
index.
Nanocurcumin
also
associated
with
significant
reduction
triglycerides,
VLDL-c,
total
cholesterol,
LDL-c,
HDL-c,
serum
C
reactive
protein,
plasma
malonaldehyde.
Therefore,
can
considered
therapeutic
approach
patients
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
36, P. 203 - 220
Published: March 5, 2024
Ulcerative
colitis
(UC)
is
characterized
by
chronic
inflammatory
processes
of
the
intestinal
tract
unknown
origin.
Current
treatments
lack
understanding
on
how
to
effectively
alleviate
oxidative
stress,
relieve
inflammation,
as
well
modulate
gut
microbiota
for
maintaining
homeostasis
synchronously.
In
this
study,
a
novel
drug
delivery
system
based
metal
polyphenol
network
(MPN)
was
constructed
via
coordination
between
epigallocatechin
gallate
(EGCG)
and
Fe
Animals,
Journal Year:
2024,
Volume and Issue:
14(3), P. 409 - 409
Published: Jan. 26, 2024
This
experiment
aimed
to
investigate
the
mitigating
effect
of
CUR
on
growth
performance
and
liver
intestinal
health
broilers
fed
AFB1-contaminated
diets.
In
this
study,
320
one-day-old
healthy
male
Arbor
Acres
(AA)
were
randomly
divided
into
four
groups,
including
Control
group
(fed
basal
diet),
AFB1
diet
containing
1
mg/kg
AFB1),
AFB1+CUR
with
500
CUR),
eight
replicates
ten
animals
per
a
28
d
experimental
period.
terms
performance,
addition
significantly
improved
AFB1-induced
significant
reductions
in
final
body
weight
day
mean
daily
gain
(p
<
0.05)
increased
ratio
feed
intake
0.05).
health,
improvements
histological
lesions
occurred
compared
group,
higher
glutathione
peroxidase
(GSH-Px),
catalase
(CAT),
total
superoxide
dismutase
(T-SOD)
activities
levels
nuclear
factor
erythroid
2-related
2
(Nrf2),
Kelch-like
ECH-associated
protein
(Keap-1),
heme
oxygenase
(HO-1),
NAD(P)H
quinone
oxidoreductase
(NQO-1)
gene
expression
relative
length
ileum
0.05),
elevated
height
ileal
villi
reduced
D-Lactate
(D-LA)
diamine
oxidase
(DAO)
broiler
serum
GSH,
CAT,
T-SOD
tissues
Nrf2,
HO-1,
NQO-1
genes
group.
conclusion,
showed
protective
against
damage
intestine
caused
by
through
Nrf2
signaling
pathway,
thereby
improving
exposed
AFB1.
