Clinical effects of curcumin in enhancing cancer therapy: A systematic review

BMC Cancer, Journal Year: 2020, Volume and Issue: 20(1)

Published: Aug. 24, 2020

Abstract Background Curcumin is herbal compound that has been shown to have anti-cancer effects in pre-clinical and clinical studies. The of curcumin include inhibiting the carcinogenesis, angiogenesis, tumour growth. This study aims determine Clinical different types cancers using systematic review approach. Methods A methodology adopted for undertaking detailed analysis cancer therapy. results presented this paper an outcome extracting findings studies selected from articles published international databases including SID, MagIran, IranMedex, IranDoc, Google Scholar, ScienceDirect, Scopus, PubMed Web Science (ISI). These were thoroughly searched, relevant publications based on plausible keywords, accordance with aims, as follows: prevalence, curcumin, features, cancer. Results are derived several consumption chemotherapy drugs, highlighting increases effectiveness radiotherapy which improving patient’s survival time, increasing expression anti-metastatic proteins along reducing their side effects. Conclusion comprehensive confirms reduces or radiotherapy, resulting patients’ quality life. number reported that, increased patient time decreased tumor markers’ level.

Language: Английский

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Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance

Pharmacological Research, Journal Year: 2021, Volume and Issue: 167, P. 105575 - 105575

Published: March 24, 2021

Language: Английский

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Protective effects of curcumin against traumatic brain injury

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 154, P. 113621 - 113621

Published: Aug. 29, 2022

Neuroinflammation is a key pathophysiological mechanism implicated in the neurodegenerative condition. One such condition implicating neuroinflammation traumatic brain injury (TBI). Over past decades, various alternative natural compounds, as curcumin, have been investigated novel therapeutic options to mitigate pathways and clinical sequelae involved TBI. As main component of turmeric (Curcuma longa), curcumin has broad range properties due its considerable antioxidative anti-inflammatory actions. This review discusses pleiotropic mechanisms, side effects, curcumin's delivery central nervous system (CNS), immunomodulatory protective effects on Clinical trials, vivo, vitro studies were extracted from different scientific databases, including PubMed, Scopus, Google Scholar, assess or derivatives Findings reveal that exhibited some TBI via modulation cell signaling toll-like receptor-4 (TLR-4), nuclear factor kappa B (NF-κB), Nod-like receptor family proteins (NLRPs). Moreover, upregulates brain-derived Neurotrophic Factor/Tropomyosin kinase (BDNF/TrkB) pathway, phosphatidylinositol-3-kinase/protein (PI3K/AKT), erythroid 2-related 2 (Nrf2), which crucial functions pathophysiological-mediated pathways. Curcumin displays beneficial capacities models, although more experiments are required clarify precise mechanisms function

Language: Английский

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Curcumin suppresses tumorigenesis by ferroptosis in breast cancer

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(1), P. e0261370 - e0261370

Published: Jan. 18, 2022

Breast cancer (BC) is one of the most common malignant tumors found in females. Previous studies have demonstrated that curcumin, which a type polyphenol compound extracted from Curcuma longa underground rhizome, able to inhibit survival cells. However, functional role and mechanism curcumin BC are still unclear. The Cell Counting Kit-8 assay was performed examine effects on cell viability lines MDA-MB-453 MCF-7. levels lipid reactive oxygen species (ROS), malondialdehyde (MDA) production, intracellular Fe 2+ were determined assess ferroptosis. Western blot analysis also carried out detect protein levels. Finally, antitumorigenic effect identified xenograft tumor model. In present study, results indicated could dose-dependently suppress both MCF-7 Further revealed facilitated solute carrier family 1 member 5 (SLC1A5)-mediated ferroptosis cells by enhancing ROS levels, peroxidation end-product MDA accumulation, vivo experiments significantly hamper growth. Collectively, exhibited activity promoting SLC1A5-mediated ferroptosis, suggests its use as potential therapeutic agent for treatment BC.

Language: Английский

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Herbal Therapies for Cancer Treatment: A Review of Phytotherapeutic Efficacy

Biologics, Journal Year: 2024, Volume and Issue: Volume 18, P. 229 - 255

Published: Sept. 1, 2024

Natural products have proven to be promising anti-cancer agents due their diverse chemical structures and bioactivity.This review examines central role in cancer treatment, focusing on mechanisms of action therapeutic benefits.Medicinal plants contain bioactive compounds, such as flavonoids, alkaloids, terpenoids polyphenols, which exhibit various anticancer properties.These compounds induce apoptosis, inhibit cell proliferation cycle progression, interfere with microtubule formation, act topoisomerase targets, angiogenesis, modulate key signaling pathways, improve the tumor microenvironment, reverse drug resistance activate immune cells.Herbal drugs offer advantages, particularly selective toxicity against cells, reducing adverse side effects associated conventional chemotherapy.Recent studies clinical trials highlight benefits herbal medicines alleviating effects, improving tolerance chemotherapy occurrence synergistic treatments.For example, medicine SH003 was found safe potentially effective treatment solid cancers, while Fucoidan showed anti-inflammatory properties that are beneficial for patients advanced cancer.The current research landscape is extensive.Numerous investigating efficacy, safety cancers lung, prostate, breast hepatocellular carcinoma.Promising developments include polypharmacological approach, combination therapies, immunomodulation improvement quality life.However, there still challenges development use natural drugs, need further into action, possible interactions optimal dosage.Standardizing extracts, bioavailability delivery, overcoming regulatory acceptance hurdles critical issues addressed.Nonetheless, warrant investigation development.Multidisciplinary collaboration essential advance therapy integrate these mainstream treatment.

Language: Английский

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Loading curcumin on hyperbranched polymers functionalized Zein via the phenol-yne click reaction as pH-responsive drug delivery system for chemotherapy and photodynamic therapy

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139750 - 139750

Published: Jan. 1, 2025

Language: Английский

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Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer

Nutrients, Journal Year: 2020, Volume and Issue: 12(3), P. 679 - 679

Published: March 2, 2020

Prostate cancer (PCa) is a heterogeneous disease and ranked as the second leading cause of cancer-related deaths in males worldwide. The global burden PCa keeps rising regardless emerging cutting-edge technologies for treatment drug designation. There are number options which effectively treating localised androgen-dependent (ADPC) through hormonal surgery treatments. However, over time, these cancerous cells progress to androgen-independent (AIPC) continuously grow despite hormone depletion. At this particular stage, androgen depletion therapy (ADT) no longer effective rendered hormone-insensitive capable growing absence androgen. AIPC lethal type leads poor prognosis major contributor death rates. A natural product-derived compound, curcumin has been identified pleiotropic compound influencing modulating diverse range molecular targets signalling pathways order exhibit its medicinal properties. Due such multi-targeted behaviour, benefits paramount combating wide diseases including inflammation disease. Curcumin exhibits anti-cancer properties by suppressing growth survival, inflammation, invasion, cell proliferation well possesses ability induce apoptosis malignant cells. In review, we investigate mechanism multiple receptor (AR) signalling, activating protein-1 (AP-1), phosphatidylinositol 3-kinases/the serine/threonine kinase (PI3K/Akt/mTOR), wingless (Wnt)/ß-catenin nuclear factor kappa-B (NF-κB), B-cell lymphoma 2 (Bcl-2) cyclin D1 implicated development progression both types PCa, ADPC AIPC. addition, role microRNAs clinical trials on effects patients were also reviewed.

Language: Английский

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Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Nov. 3, 2021

Traditional Chinese medicine plays a significant role in the treatment of various diseases and has attracted increasing attention for clinical applications. Vascular affecting vasculature heart, cerebrovascular disease, atherosclerosis, diabetic complications have compromised quality life affected individuals increase burden on health care services. Berberine, naturally occurring isoquinoline alkaloid form Rhizoma coptidis , is widely used China as folk its antibacterial anti-inflammatory properties. Promisingly, an number studies identified several cellular molecular targets berberine, indicating potential alternative therapeutic strategy vascular diseases, well providing novel evidence that supports berberine to combat diseases. The purpose this review comprehensively systematically describe agent including pharmacological effects, mechanisms, pharmacokinetics. According data published so far, shows remarkable anti-inflammatory, antioxidant, antiapoptotic, antiautophagic activity via regulation multiple signaling pathways, AMP-activated protein kinase (AMPK), nuclear factor κB (NF-κB), mitogen-activated silent information regulator 1 (SIRT-1), hypoxia-inducible 1α (HIF-1α), endothelial growth phosphoinositide 3-kinase (PI3K), B (Akt), janus 2 (JAK-2), Ca 2+ channels, endoplasmic reticulum stress. Moreover, we discuss existing limitations give corresponding measures. In addition, propose some research perspectives challenges, provide solid base from which further can excavate effective drugs monomers.

Language: Английский

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Molecular Targets of Natural Compounds with Anti-Cancer Properties

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(24), P. 13659 - 13659

Published: Dec. 20, 2021

Cancer is the second leading cause of death in humans. Despite rapid developments diagnostic methods and therapies, metastasis resistance to administrated drugs are main obstacles successful treatment. Therefore, challenge should be diagnosis design optimal therapeutic strategies for patients increase their chances responding positively treatment life expectancy. In many types cancer, a deregulation multiple pathways has been found. This includes disturbances cellular metabolism, cell cycle, apoptosis, angiogenesis, or epigenetic modifications. Additionally, signals received from microenvironment may significantly contribute cancer development. Chemical agents obtained natural sources seem very attractive alternatives synthetic compounds. They can exhibit similar anti-cancer potential, usually with reduced side effects. It was reported that compounds fruits vegetables, e.g., polyphenols, flavonoids, stilbenes, carotenoids acetogenins, might effective against cells vitro vivo. Several published results indicate activity on protein expression by its influence transcription factors. could also involved alterations response, signaling Such components used our diet protection. this review, activities compounds, including properties, described. The proliferation, signal transduction modifications highlighted.

Language: Английский

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Breast Cancer Targeting of a Drug Delivery System through Postsynthetic Modification of Curcumin@N₃-bio-MOF-100 via Click Chemistry

Inorganic Chemistry, Journal Year: 2021, Volume and Issue: 60(16), P. 11739 - 11744

Published: June 8, 2021

Metal–organic frameworks (MOFs) offer many opportunities for applications across biology and medicine. Their wide range of chemical composition makes toxicologically acceptable formulation possible, their high level functionality enables possible as delivery systems therapeutics agents. Surface modifications have been used in drug to minimize interaction with the bulk, improving specificity targeted carriers. Herein, we discuss a strategy achieve tumor-targeting drug-loaded MOF using "click" chemistry anchor functional folic acid (FA) molecules on surface N3-bio-MOF-100. Using curcumin (CCM) an anticancer drug, observed loading encapsulation efficiencies (DLEs) 24.02 25.64% after soaking N3-bio-MOF-100 CCM solutions 1 day 3 days, respectively. The success postsynthetic modification FA was confirmed by 1H NMR spectroscopy, Fourier transform infrared spectroscopy (FTIR), liquid chromatography–mass spectrometry (LC-MS). stimuli-responsive release studies demonstrated increase released under acidic microenvironments. Moreover, cell viability assay performed 4T1 (breast cancer) line presence CCM@N3-bio-MOF-100 CCM@N3-bio-MOF-100/FA carriers confirm its biological compatibility. In addition, cellular uptake study conducted evaluate targeting tumor cells.

Language: Английский

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