Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(13), P. 7273 - 7273

Published: June 30, 2022

Ageing and chronic degenerative pathologies demonstrate the shared characteristics of high bioavailability reactive oxygen species (ROS) oxidative stress, chronic/persistent inflammation, glycation, mitochondrial abnormalities. Excessive ROS production results in nucleic acid protein destruction, thereby altering cellular structure functional outcome. To stabilise increased modulate human body produces antioxidants, “free radical scavengers”, that inhibit or delay cell damage. Reinforcing antioxidant defence system and/or counteracting deleterious repercussions immoderate nitrogen (RONS) is critical may curb progression ageing syndromes. Various therapeutic methods for stress reduction have been developed. However, scientific investigations are required to assess their efficacy. In this review, we summarise interconnected mechanism inflammation contributes pathologies, including neurodegenerative diseases, such as Alzheimer’s disease (AD) Parkinson’s (PD), cardiovascular diseases CVD, diabetes mellitus (DM), kidney (CKD). We also highlight potential counteractive measures combat diseases.

Language: Английский

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Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1532 - 1532

Published: Jan. 28, 2022

Cisplatin and other platinum-based drugs, such as carboplatin, ormaplatin, oxaliplatin, have been widely used to treat a multitude of human cancers. However, considerable proportion patients often relapse due drug resistance and/or toxicity multiple organs including the liver, kidneys, gastrointestinal tract, cardiovascular, hematologic, nervous systems. In this study, we sought provide comprehensive review current state science highlighting use cisplatin in cancer therapy, with special emphasis on its molecular mechanisms action, treatment modalities combination therapy natural products. Hence, searched literature using various scientific databases., MEDLINE, PubMed, Google Scholar, relevant sources, collect publications cisplatin, products, uses treatment, modes therapeutic strategies. Our search results revealed that new strategic approaches for evaluated some degree success. Scientific evidence from both vitro vivo studies demonstrates many medicinal plants contain bioactive compounds are promising candidates diseases, therefore represent an excellent source discovery. preclinical studies, it has demonstrated products not only enhance activity but also attenuate chemotherapy-induced toxicity. Many experimental reported exert their action by triggering apoptosis through modulation mitogen-activated protein kinase (MAPK) p53 signal transduction pathways enhancement chemosensitivity. Furthermore, protect against cisplatin-induced organ modulating several gene transcription factors inducing cell death necrosis. addition, formulations polymeric, lipid, inorganic, carbon-based nano-drug delivery systems found delay release, prolong half-life, reduce systemic while formulations, nanocapsules, nanogels, hydrogels, penetration, target cells, inhibit tumor progression.

Language: Английский

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Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 9

Published: Jan. 10, 2023

The yellow polyphenolic pigment known as curcumin, originating from the rhizome of turmeric plant Curcuma longa L., has been utilized for ages in ancient medicine, well cooking and food coloring. Recently, biological activities curcumin have thoroughly investigated. studies mainly focused on their antioxidant, antitumor, anti-inflammatory, neuroprotective, hepatoprotective, cardioprotective impacts. This review seeks to provide an in-depth, detailed discussion usage within processing industries its effect health support disease prevention. Curcumin’s bioavailability, bio-efficacy, bio-safety characteristics, side effects quality standards, are also discussed. Finally, curcumin’s multifaceted uses, appeal enhancement, agro-industrial techniques counteracting instability low nanotechnology drug delivery systems increase prospective clinical use tactics all

Language: Английский

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Curcumin-Based Nanoformulations: A Promising Adjuvant towards Cancer Treatment

Molecules, Journal Year: 2022, Volume and Issue: 27(16), P. 5236 - 5236

Published: Aug. 16, 2022

Throughout the United States, cancer remains second leading cause of death. Traditional treatments induce significant medical toxic effects and unpleasant adverse reactions, making them inappropriate for long-term use. Consequently, anticancer-drug resistance relapse are frequent in certain situations. Thus, there is an urgent necessity to find effective antitumor medications that specific have few consequences. Curcumin a polyphenol derivative found turmeric plant (Curcuma longa L.), provides chemopreventive, antitumor, chemo-, radio-sensitizing properties. In this paper, we summarize new nano-based formulations polyphenolic curcumin because growing interest its application against cancers tumors. According recent studies, use nanoparticles can overcome hydrophobic nature curcumin, as well improving stability cellular bioavailability vitro vivo. Several strategies nanocurcumin production been developed, each with own set advantages unique features. Because majority curcumin-based nanoformulation evidence still conceptual stage, numerous issues impeding provision possible therapeutic option. To support science, further work necessary develop viable anti-cancer adjuvant. review, cover various nanoformulations implications uses cancer, current state clinical studies patents. We address knowledge gaps future research orientations required feasible treatment candidate.

Language: Английский

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Unlocking hidden potential: advancements, approaches, and obstacles in repurposing drugs for cancer therapy

British Journal of Cancer, Journal Year: 2023, Volume and Issue: 130(5), P. 703 - 715

Published: Nov. 27, 2023

Language: Английский

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Targeting inflammation as cancer therapy

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: March 22, 2024

Abstract Inflammation has accompanied human beings since the emergence of wounds and infections. In past decades, numerous efforts have been undertaken to explore potential role inflammation in cancer, from tumor development, invasion, metastasis resistance tumors treatment. Inflammation-targeted agents not only demonstrate suppress cancer but also improve efficacy other therapeutic modalities. this review, we describe highly dynamic complex inflammatory microenvironment, with discussion on key mediators including cells, cytokines, their downstream intracellular pathways. addition, especially address development highlight action mechanisms inflammation-targeted therapies antitumor response. Finally, summarize results both preclinical clinical studies up date illustrate translation therapies.

Language: Английский

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Androgen receptor dynamics in prostate cancer: from disease progression to treatment resistance

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 11, 2025

Prostate cancer is the most common among men worldwide, especially in those over 65, and a leading cause of cancer-related mortality. The disease typically advances from an androgen-dependent state to castration-resistant prostate (CRPC), which poses significant treatment challenges. androgen receptor (AR) on X chromosome central driver this process, activating genes that govern proliferation survival. Mutations amplifications AR are closely associated with progression resistance. While traditional therapies such as deprivation therapy (ADT) antagonists like enzalutamide have been effective, resistance persists due reactivation signaling through mechanisms ligand-independent activation. Recent research highlights role epigenetic modifications enhancing activity drug tumor microenvironment, particularly interactions cancer-associated fibroblasts (CAFs) tumor-associated macrophages (TAMs), further complicates by promoting aggressive behavior immune evasion. Future directions include developing next-generation antagonists, identifying AR-related biomarkers for personalized therapy, exploring combinations checkpoint inhibitors. Additionally, basal cell-lumen-derived organoids provide innovative models can enhance understanding strategies cancer.

Language: Английский

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Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy

ACS Combinatorial Science, Journal Year: 2020, Volume and Issue: 22(12), P. 669 - 700

Published: Oct. 23, 2020

Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel, docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy because the outstanding therapeutic activity multitargeting capability these compounds. However, poor solubility bioavailability compounds have limited their efficacy therapy. To circumvent this hurdle, nanocarriers been designed to improve antitumor aforementioned Nevertheless, treatment still a challenge, demanding novel strategies. It well-known that combination products gene advantageous over monotherapy. Delivery multiple agents/small interfering RNA (siRNA) potent gene-editing tool can maximize synergistic effects against tumor cells. In present review, co-delivery compounds/siRNA nanovehicles are highlighted provide backdrop for future research.

Language: Английский

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The Multifaced Actions of Curcumin in Pregnancy Outcome

Antioxidants, Journal Year: 2021, Volume and Issue: 10(1), P. 126 - 126

Published: Jan. 17, 2021

Curcumin, also known as diferuloylmethane, is the main polyphenolic substance present in rhizomes of Curcuma longa L. This plant showed many beneficial effects and has been used since ancient times for both food pharmaceutical purposes. Due to its pleiotropic functions, curcumin consumption human diet become very common thanks fact that this natural compound considered quite safe it does not have serious side effects. Its functions an anti-inflammatory, anti-oxidant, neuroprotective, immunomodulatory, anti-toxicant, anti-apoptotic, anti-diabetic are already widely demonstrated. There numerous studies concerning on various pathologies including cancer, diabetes arthritis while during pregnancy performed only animal models. Data role anti-inflammatory suggest a possible use managing complications such Preeclampsia (PE), Gestational Diabetes Mellitus (GDM), Fetal Growth Restriction (FGR), PreTerm Birth (PTB), exposure toxic agents pathogens. The aim review data support clinical trials gestation complications.

Language: Английский

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The therapeutic potential of curcumin and its related substances in turmeric: From raw material selection to application strategies

Journal of Food and Drug Analysis, Journal Year: 2023, Volume and Issue: 31(2), P. 194 - 211

Published: June 15, 2023

Turmeric (Curcuma longa L.) is a medicinal plant used extensively in Chinese and Indian traditional medicine as home remedy for various diseases. It has been medical purposes centuries. Today, turmeric become one of the most popular herbs, spices, functional supplements worldwide. Curcuminoids are linear diarylheptanoids from rhizomes that include curcumin two related compounds: demethoxycurcumin bisdemethoxycurcumin, which active components C. plant, play crucial role numerous functions. This review summarises composition properties regarding its antioxidant, anti-inflammatory, anti-diabetic, anti-colorectal cancer, other physiological activity. In addition, dilemma application due to low water solubility bioavailability was discussed. Finally, this article provides three novel strategies based on previous studies: using analogues substances, gut microbiota regulation, curcumin-loaded exosome vesicles turmeric-derived exosome-like overcome limitations.

Language: Английский

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