Exploring Cyclodextrin-Based Nanosponges as Drug Delivery Systems: Understanding the Physicochemical Factors Influencing Drug Loading and Release Kinetics

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3527 - 3527

Published: March 20, 2024

Cyclodextrin-based nanosponges (CDNSs) are complex macromolecular structures composed of individual cyclodextrins (CDs) and nanochannels created between cross-linked CD units cross-linkers. Due to their unique structural physicochemical properties, CDNSs can possess even more beneficial pharmaceutical features than single CDs. In this comprehensive review, various aspects related summarized. Particular attention was paid overviewing methods synthesis, analysis using analytical methods, such as DLS, PXRD, TGA, DSC, FT-IR, NMR, phase solubility studies. Also, due the significant role in research industry, drug loading, release studies, kinetics profile evaluation drug–CDNS complexes were carefully reviewed. The aim paper is find relationships identify crucial characteristics that influential for convenient delivery systems.

Language: Английский

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Nanosponges for Drug Delivery and Cancer Therapy: Recent Advances

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(14), P. 2440 - 2440

Published: July 16, 2022

Nanosponges with three-dimensional (3D) porous structures, narrow size distribution, and high entrapment efficiency are widely engineered for cancer therapy drug delivery purposes. They protect the molecular agents from degradation help to improve solubility of lipophilic therapeutic agents/drugs targeted options in addition being magnetized attain suitable magnetic features. Nanosponge-based systems have been applied specificity, biocompatibility, degradability, prolonged release behavior. In this context, loading within nanosponges is influenced by crystallization degree. Notably, 3D printing technologies can be development novel nanosponge-based biomedical applications. The impacts polymers, cross-linkers, type drugs, temperature, mechanism release, fabrication methods, substitution degree ought analytically evaluated. Eco-friendly techniques manufacturing still need uncovered existing such as solvent techniques, ultrasound-assisted preparation, melting strategies, emulsion diffusion methods. Herein, recent advancements associated potential (chiefly, cyclodextrin-based, DNAzyme, ethylcellulose nanosponges) deliberated, focusing on important challenges future perspectives.

Language: Английский

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Novel super porous nanosponge-based drug delivery system synthesized from cyclodextrin/polymer for anti-fungal medication

Reactive and Functional Polymers, Journal Year: 2024, Volume and Issue: 196, P. 105830 - 105830

Published: Jan. 6, 2024

Language: Английский

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QBD approach for the development of hesperetin loaded colloidal nanosponges for sustained delivery: In-vitro, ex-vivo, and in-vivo assessment

OpenNano, Journal Year: 2022, Volume and Issue: 7, P. 100045 - 100045

Published: April 27, 2022

Hesperetin (HT) is a polyphenolic compound with anti-carcinogenic, tumor necrosis, and anti-oxidant properties. The present study reports the fabrication, optimization, evaluation of HT-loaded nanosponges (HTN)- based gel (HTNG) for sustained anti-inflammatory effect. HTN formulation was prepared by quasi emulsion solvent diffusion method using 42 factorial design. subjected to different solid liquid state characterizations subsequently loaded in carbopol gel. effects pro-inflammatory cytokines (IL- 1β IL-6) were evaluated RAW 264.7 macrophage cells, potential tested rats. Tiny, porous, spherical retarded drug release (39.98%) up 8 h compared pure (70.74%) physical mixture (73.72%) followed Higuchi-matrix model. HTNG had strong downregulating effect on cytokines. It showed no skin irritation 18.52% permeation at h. Further, HTNG-treated rats exhibited 33.16% inflammation inhibition control group. In conclusion, significantly topical delivery could circumvent bioavailability issues associated HT.

Language: Английский

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Nanosponges as an Emerging Platform for Cancer Treatment and Diagnosis

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(7)

Published: Oct. 31, 2023

Abstract Nanosponges are unique sponge‐like carrier systems with numerous cavities and a mesh‐like network throughout their surface. They categorized into three types based on the material of construction, i.e., polymer‐, inorganic‐, bio‐derived material‐based nanosponges. Unlike conventional nanoparticles, nanosponges bear countless interconnected voids that enables maximum drug, imaging probe, or photosensitizer loading via absorption, encapsulation, conjugation, complexion. The can be further sealed using suitable lipids polymers to avoid leakage drugs at non‐target site, protect therapeutics from biological conditions, control release for prolonged period. Recently, have grasped attention researchers in area cancer by overcoming drawbacks associated delivery immunotherapeutic, targeted therapeutic, chemotherapeutic agents. Interestingly, several reports also witnessed potential theranostics. Owing this supremacy, could an apt platform therapy diagnosis. current review discusses general aspects, types, preparation methods In addition, ambit treating different is meticulously discussed, along detailed descriptions corresponding patents. Furthermore, role phototherapy theranostics selectively canvassed.

Language: Английский

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Nanosponge: A promising and intriguing strategy in medical and pharmaceutical Science

Heliyon, Journal Year: 2023, Volume and Issue: 10(1), P. e23303 - e23303

Published: Dec. 6, 2023

The complicated chemical reactions involved in the production of newer drug delivery systems have mainly impeded efforts to build successful targeted for a prolonged duration time. Nanosponges, recently created colloidal system, potential overcome issues with medication toxicity, decreased bioavailability, and release over wide area because they can be modified work both hydrophilic hydrophobic types drugs. Nanosponges are small sized three-dimensional network having porous cavity. They prepared easily by crosslinking cyclodextrins different compounds. Due Cyclodextrin's outstanding biocompatibility, stability, safety, number Cyclodextrin-based been developed promptly. nanosponge system possesses various applications ailments such as cancer, autoimmune diseases, theranostic applications, enhanced etc. This review elaborates on benefits drawbacks, preparation techniques, factors affecting their preparation, characterization most current developments nanosponges.

Language: Английский

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Nanosponge hydrogel of octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate of Alcaligenes faecalis

Applied Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 108(1)

Published: Jan. 12, 2024

Abstract Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propanoate (ODHP) was extracted in a previous study from the culture broth of soil isolate Alcaligenes faecalis MT332429 and showed promising antimycotic activity. This aimed to formulate ODHP loaded β-cyclodextrins (CD) nanosponge (NS) hydrogel (HG) control skin fungal ailments since nanosponges augment retention tested agents skin. Box-Behnken design used produce optimized NS formulation, where entrapment efficiency percent (EE%), polydispersity index (PDI), particle size (PS) were assigned as dependent parameters, while independent process parameters polyvinyl alcohol % (w/v %), polymer-linker ratio, homogenization time, speed. The carbopol 940 then created by incorporating nanosponges. fit Higuchi’s kinetic release model best, according vitro drug release. Stability photodegradation studies revealed that NS-HG remained stable under conditions. formulation also higher antifungal activity against Candida albicans compared fluconazole. In vivo ODHP-NS-HG increased survival rates, wound contraction, healing gap inhibited inflammation other groups. histopathological examinations Masson’s trichrome staining improved records collagen deposition. Moreover, permeability through rats’ 1.5-folds isoconazole 1%. Therefore, based on these results, is potential carrier for enhanced topical delivery ODHP. Our pioneering research development produced naturally bacteria. Key points • successfully formulated statistically . new formula exhibited good stability, release, C. fluconazole Ex permeability, analysis high evidenced measurement various biochemical examination

Language: Английский

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Application of 32 factorial design for loratadine-loaded nanosponge in topical gel formulation: comprehensive in-vitro and ex vivo evaluations

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 16, 2024

Abstract Loratadine (LoR) is a highly lipophilic and practically insoluble in water, hence having low oral bioavailability. As it formulated as topical gel, competitively binds with the receptors, thus reducing side-effects. The objective of this study was to prepare LoR loaded nanosponge (LoR-NS) gel for delivery. Nine different formulations emulsion were prepared by solvent evaporation method polyvinyl alcohol (PVA), ethyl cellulose (EC), dichloromethane (DCM). Based on 3 2 Full Factorial Design (FFD), optimization carried out varying concentration LOR:EC ratio stirring rate. preparations subjected evaluation particle size (PS), vitro release, zeta potential (ZP) entrapment efficiency (EE). results revealed that NS dispersion nanosized sustained release profiles significant PS. optimised formulation incorporated into carbopol 934P hydrogel. then examined surface morphological characterizations using scanning electron microscopy (SEM) which depicted spherical NS. Stability studies, undertaken months at 40 ± °C/75 5% RH, concluded stability formulation. did not cause skin irritation. Therefore, hydrogel proved be promising applicant novel drug delivery system (NDDS) safe, controlled application.

Language: Английский

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Current advances in nanodrug delivery systems for malaria prevention and treatment

Discover Nano, Journal Year: 2023, Volume and Issue: 18(1)

Published: April 20, 2023

Abstract Malaria is a life-threatening, blood-borne disease with over two hundred million cases throughout the world and more prevalent in Sub-Saharan Africa than anywhere else world. Over years, several treatment agents have been developed for malaria; however, most of these active pharmaceutical ingredients exhibit poor aqueous solubility low bioavailability may result drug-resistant parasites, thus increasing malaria eventually, deaths. Factors such as therapeutics led to better appreciation nanomaterials. The ability nanomaterials function drug carriers high loading capacity targeted delivery, good biocompatibility, toxicity renders them an appealing alternative conventional therapy. Nanomaterials dendrimers liposomes demonstrated be capable enhancing efficacy antimalarial drugs. This review discusses recent development their benefits delivery potential malaria.

Language: Английский

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PREPARATION AND CHARACTERIZATION OF FLUCONAZOLE TOPICAL NANOSPONGE HYDROGEL

International Journal of Pharmacy and Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 18 - 26

Published: April 1, 2024

Objective: The study aimed to develop a polymeric nanosponge-based hydrogel system for enhanced topical application of fluconazole, an antifungal drug. Methods: Nanosponges were formulated using the emulsion solvent diffusion method various polymers like hydroxypropyl methylcellulose, ethylcellulose and Eudragit RS 100. Polyvinyl alcohol ethanol used prepare aqueous dispersed phases. in appropriate amount gelling agent Carbopol 940 get nanosponge gel. Drug–polymer interaction has been carried out by FTIR spectroscopy. prepared nanosponges evaluated tests production yield, drug entrapment efficiency, compatibility SEM studies. was tested pH, content, spreadability, vitro kinetic Results: efficiency fluconazole found range 52.3±0.84% 80.8±0.36% all formulations, respectively. spreadability gel formulation between 5.20±0.19 7.187±0.85. Particle size analysis showed that average particle ethyl cellulose (F5) be 334 nm. zeta potential be-10.4 mV, indicating had moderate stability. DSC studies pure suggested formulations stable there no chemical with polymer other excipients. optimised (FG5) released 90.90% 8 h. Conclusion: Fluconazole could successfully method. promising results under condition thus, exists scope evaluation developed further pharmacokinetic studies, test models.

Language: Английский

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