Recent Advancements in Polymer/Liposome Assembly for Drug Delivery: From Surface Modifications to Hybrid Vesicles

Polymers, Journal Year: 2021, Volume and Issue: 13(7), P. 1027 - 1027

Published: March 26, 2021

Liposomes are consolidated and attractive biomimetic nanocarriers widely used in the field of drug delivery. The structural versatility liposomes has been exploited for development various carriers topical or systemic delivery drugs bioactive molecules, with possibility increasing their bioavailability stability, modulating directing release, while limiting side effects at same time. Nevertheless, first-generation vesicles suffer from some limitations including physical instability, short vivo circulation lifetime, reduced payload, uncontrolled release properties, low targeting abilities. Therefore, liposome preparation technology soon took advantage improving vesicle performance using both natural synthetic polymers. Polymers can easily be synthesized a controlled manner over wide range molecular weights dispersity range. Their properties tunable therefore allow chemical typical lipids to overcome. Moreover, depending on structure, polymers create simple covering surface intercalate phospholipid bilayer give rise real hybrid structures. This review illustrates main strategies implemented polymer/liposome assembly delivery, look most recent publications without neglecting basic concepts complete understanding by reader.

Language: Английский

---

Functionalized liposomes for targeted breast cancer drug delivery

Bioactive Materials, Journal Year: 2023, Volume and Issue: 24, P. 401 - 437

Published: Jan. 2, 2023

Despite the exceptional progress in breast cancer pathogenesis, prognosis, diagnosis, and treatment strategies, it remains a prominent cause of female mortality worldwide. Additionally, although chemotherapies are effective, they associated with critical limitations, most notably their lack specificity resulting systemic toxicity eventual development multi-drug resistance (MDR) cells. Liposomes have proven to be an invaluable drug delivery system but multitudes liposomal systems developed every year only few been approved for clinical use, none which employ active targeting. In this review, we summarize recent strategies actively targeted surface, transmembrane internal cell receptors, enzymes, direct targeting dual-targeting cancer-associated cells, e.g., stem cells tumor microenvironment, etc.

Language: Английский

---

The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(12), P. 7782 - 7853

Published: May 15, 2023

The high selectivity and affinity of antibodies toward their antigens have made them a highly valuable tool in disease therapy, diagnosis, basic research. A plethora chemical genetic approaches been devised to make accessible more "undruggable" targets equipped with new functions illustrating or regulating biological processes precisely. In this Review, addition introducing how naked various antibody conjugates (such as antibody-drug conjugates, antibody-oligonucleotide antibody-enzyme etc.) work therapeutic applications, special attention has paid chemistry tools helped optimize the outcome (i.e., enhanced efficacy reduced side effects) facilitate multifunctionalization antibodies, focus on emerging fields such targeted protein degradation, real-time live-cell imaging, catalytic labeling decaging spatiotemporal control well engagement inside cells. With advances modern biotechnology, well-designed derivatives via size miniaturization together efficient delivery systems emerged, which gradually improved our understanding important paved way pursue novel for potential treatments diseases.

Language: Английский

---

Recent advances in sensing the inter-biomolecular interactions at the nanoscale – A comprehensive review of AFM-based force spectroscopy

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 238, P. 124089 - 124089

Published: March 21, 2023

Biomolecular interactions underpin most processes inside the cell. Hence, a precise and quantitative understanding of molecular association dissociation events is crucial, not only from fundamental perspective, but also for rational design biomolecular platforms state-of-the-art biomedical industrial applications. In this context, atomic force microscopy (AFM) appears as an invaluable experimental technique, allowing measurement mechanical strength complexes to provide characterization their interaction properties single molecule perspective. present review, recent methodological advances in field are presented with special focus on bioconjugation, immobilization AFM tip functionalization, dynamic spectroscopy measurements, recognition imaging theoretical modeling. We expect work significantly aid grasping principles AFM-based (AFM-FS) technique necessary tools acquaint type data that can be achieved experiments. Furthermore, critical assessment done other nanotechnology techniques better visualize future prospects AFM-FS.

Language: Английский

---

Nanoparticles advanced from preclinical studies to clinical trials for lung cancer therapy

Cancer Nanotechnology, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 28, 2023

Abstract Lung cancer is the leading cause of mortality. As a heterogeneous disease, it has different subtypes and various treatment modalities. In addition to conventional surgery, radiotherapy chemotherapy, targeted therapy immunotherapy have also been applied in clinics. However, drug resistance systemic toxicity still cannot be avoided. Based on unique properties nanoparticles, provides new idea for lung therapy, especially immunotherapy. When nanoparticles are used as carriers drugs with special physical properties, nanodrug delivery system ensures accuracy targeting stability while increasing permeability aggregation tumor tissues, showing good anti-tumor effects. This review introduces including polymer liposome quantum dots, dendrimers, gold their applications tissues. addition, specific application nanoparticle-based preclinical studies clinical trials discussed.

Language: Английский

---

Innovative nanomaterials for cancer diagnosis, imaging, and therapy: Drug delivery applications

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 82, P. 104357 - 104357

Published: March 12, 2023

Language: Английский

---

Disruption of Communication: Recent Advances in Antibiofilm Materials with Anti-Quorum Sensing Properties

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(11), P. 13353 - 13383

Published: March 11, 2024

Biofilm contamination presents a significant threat to public health, the food industry, and aquatic/marine-related applications. In recent decades, although various methods have emerged combat biofilm contamination, intricate persistent nature of biofilms makes complete eradication challenging. Therefore, innovative alternative solutions are imperative for addressing formation. Instead solely focusing on mature biofilms, strategically advantageous measures involve delay or prevention formation surfaces. Quorum sensing, communication system enabling bacteria coordinate their behavior based population density, plays pivotal role in numerous microbial species. Materials possessing antibiofilm properties that target quorum sensing gained considerable attention potential prevent This Review consolidates research progress utilization materials with antiquorum combating These can be categorized into three distinct types: (i) nanomaterials, (ii) surfaces, (iii) hydrogels capabilities. Finally, concludes brief discussion current challenges outlines avenues future research.

Language: Английский

---

Mitochondria-targeted iridium(III) complexes encapsulated in liposome induce cell death through ferroptosis and gasdermin-mediated pyroptosis

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 265, P. 116112 - 116112

Published: Jan. 1, 2024

Language: Английский

---

A state-of-the-art review of the recent advances of theranostic liposome hybrid nanoparticles in cancer treatment and diagnosis

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 27, 2025

Theranostics is a way of treating illness that blends medicine with testing. Specific characteristics should be present in the best theranostic agents for cancer: (1) drugs safe and non-toxic; (2) they able to treat cancer selectively; (3) build up only cancerous tissue. Liposomes (LPs) are one most efficient drug delivery methods based on nanotechnology. Stealth LPs commercial have recently had an impact treatment. Using valuable information from each imaging technique, along multimodality functionality liposomal therapeutic agents, makes them very appealing personalized monitoring how well working against vivo predicting therapies will work. On other hand, their use as nanoparticle systems currently research development phase. Nanoscale system innovation has made LP-nanoparticle hybrid structures useful combining methods. LP-hybrid nanoparticles better at killing cells than LP counterparts, making excellent options vitro applications. Hybrid liposomes (HLs) could used future carriers find targets. This would combine features synthetic biological systems. Overarchingly, this article provided comprehensive overview many types detection, therapy, analysis. An evaluation pros cons HLs detection treatment also been conducted. The study included recent significant We conclude by outlining potential benefits drawbacks approach concurrent different malignancies, its prospects.

Language: Английский

---

Brain-Targeting Drug Delivery Systems: The State Of The Art In Treatment Of Glioblastoma

Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101443 - 101443

Published: Jan. 5, 2025

Glioblastoma (GBM) is the most prevalent primary malignant brain tumor, characterized by a high mortality rate and poor prognosis. The blood-brain barrier (BBB) blood-tumor (BTB) present significant obstacles to efficacy of tumor-targeted pharmacotherapy, thereby impeding therapeutic potential numerous candidate drugs. Targeting delivery adequate doses drug across BBB treat GBM has become prominent research area in recent years. This emphasis driven exploration evaluation diverse technologies for with some already undergoing clinical trials. review provides thorough overview advancements challenges targeted treatment. It specifically emphasizes systemic administration strategies assess their limitations Furthermore, this highlights promising future directions development intelligent systems aimed at overcoming current enhancing against GBM. These not only support foundational on but also offer methodological approaches applications.

Language: Английский

---