A global analysis of the value of precision medicine in oncology – The case of non-small cell lung cancer DOI Creative Commons
Thomas Hofmarcher,

Chiara Malmberg,

Peter Lindgren

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Feb. 20, 2023

Biomarker testing is indispensable for the implementation of precision medicine (PM) in oncology. The aim this study was to assess value biomarker from a holistic perspective based on example advanced non-small cell lung cancer (aNSCLC). A partitioned survival model populated with data pivotal clinical trials first-line treatments aNSCLC. Three scenarios were considered; "no testing" encompassing chemotherapy treatment, "sequential EGFR and ALK treatment targeted- or chemotherapy, "multigene covering EGFR, ALK, ROS1, BRAF, NTRK, MET, RET immuno(chemo)therapy. Analyses health outcomes costs run nine countries (Australia, Brazil, China, Germany, Japan, Poland, South Africa, Turkey, United States). 1-year 5-year time horizon applied. Information test accuracy combined country-specific information epidemiology unit costs. Compared no-testing scenario, improved treatment-related adverse events decreased increased testing. Five-year 2% 5-7% 13-19% sequential multigene testing, respectively. highest gains observed East Asia due higher local prevalence targetable mutations. Overall all countries. Although medicines increased, end-of-life care throughout years. Non-health (sick leave disability pension payments) during first year but over horizon. broad use PM aNSCLC leads more efficient assignment improves patients globally, particular prolonged progression-free disease phase overall survival. These require investment medicines. While would initially increase, cost decreases other medical services non-health may partly offset increases.

Language: Английский

PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway? DOI Creative Commons
Yan Peng, Yuanyuan Wang, Cheng Zhou

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: March 24, 2022

Cancer is a severe public health issue that leading cause of mortality globally. It also an impediment to improving life expectancy worldwide. Furthermore, the global burden cancer incidence and death continuously growing. Current therapeutic options are insufficient for patients, tumor complexity heterogeneity necessitate customized medicine or targeted therapy. critical identify potential targets. Aberrant activation PI3K/AKT/mTOR pathway has significant role in carcinogenesis. This review summarized oncogenic PI3K/Akt/mTOR alterations various hallmarks associated with pathway, such as cell proliferation, autophagy, apoptosis, angiogenesis, epithelial-to-mesenchymal transition (EMT), chemoresistance. Importantly, this provided recent advances inhibitor research. Overall, in-depth understanding association between tumorigenesis development therapies targeting will help make clinical decisions.

Language: Английский

Citations

456
Molecular and functional imaging in cancer-targeted therapy: current applications and future directions DOI Creative Commons
Jing‐Wen Bai, Si-Qi Qiu, Guo‐Jun Zhang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Feb. 27, 2023

Targeted anticancer drugs block cancer cell growth by interfering with specific signaling pathways vital to carcinogenesis and tumor rather than harming all rapidly dividing cells as in cytotoxic chemotherapy. The Response Evaluation Criteria Solid Tumor (RECIST) system has been used assess response therapy via changes the size of target lesions measured calipers, conventional anatomically based imaging modalities such computed tomography (CT), magnetic resonance (MRI), other methods. However, RECIST is sometimes inaccurate assessing efficacy targeted because poor correlation between treatment-induced necrosis or shrinkage. This approach might also result delayed identification when does confer a reduction size. Innovative molecular techniques have gained importance dawning era they can visualize, characterize, quantify biological processes at cellular, subcellular, even level anatomical level. review summarizes different pathways, various techniques, developed probes. Moreover, application for evaluating treatment related clinical outcome systematically outlined. In future, more attention should be paid promoting translation sensitivity biocompatible particular, multimodal technologies incorporating advanced artificial intelligence comprehensively accurately cancer-targeted therapy, addition RECIST-based

Language: Английский

Citations

93
Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges DOI Creative Commons
Mahshid Deldar Abad Paskeh, Fatemeh Ghadyani, Mehrdad Hashemi

et al.

Pharmacological Research, Journal Year: 2022, Volume and Issue: 187, P. 106553 - 106553

Published: Nov. 16, 2022

Cancer progression results from activation of various signaling networks. Among these, PI3K/Akt contributes to proliferation, invasion, and inhibition apoptosis. Hepatocellular carcinoma (HCC) is a primary liver cancer with high incidence rate, especially in regions prevalence viral hepatitis infection. Autoimmune disorders, diabetes mellitus, obesity, alcohol consumption, inflammation can also lead initiation development HCC. The treatment HCC depends on the identification oncogenic factors that tumor cells develop resistance therapy. present review article focuses role progression. Activation promotes glucose uptake, favors glycolysis increases cell proliferation. It inhibits both apoptosis autophagy while promoting survival. stimulates epithelial-to-mesenchymal transition (EMT) matrix-metalloproteinase (MMP) expression during metastasis. In addition increasing colony formation capacity facilitating spread cells, angiogenesis. Therefore, silencing prevents aggressive behavior. confer drug resistance, particularly sorafenib, decreases radio-sensitivity cells. Anti-cancer agents, like phytochemicals small molecules suppress by limiting Being upregulated tissues clinical samples, be used as biomarker predict patients' response

Language: Английский

Citations

85
The pharmacokinetic property and pharmacological activity of acteoside: A review DOI Open Access
Yaosheng Xiao,

Qun Ren,

Longhuo Wu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 153, P. 113296 - 113296

Published: June 17, 2022

Acteoside (AC), a phenylpropanoid glycoside isolated from many dicotyledonous plants, has been demonstrated various pharmacological activities, including anti-oxidation, anti-inflammation, anti-cancer, neuroprotection, cardiovascular protection, anti-diabetes, bone and cartilage hepatoprotection, anti-microorganism. However, AC poor bioavailability, which can be potentially improved by different strategies. The health-promoting characteristics of attributed to its mediation in signaling pathways, such as MAPK, NF-κB, PI3K/AKT, TGFβ/Smad, AMPK/mTOR. Interestingly, docking simulation study indicates that an effective candidate inhibit the activity SARS-CoV2 main protease protect against COVID-19. Many clinical trials for have investigated, it shows great potentials drug development.

Language: Английский

Citations

83
Mesenchymal stem cells in the treatment of spinal cord injury: Mechanisms, current advances and future challenges DOI Creative Commons

Yuanliang Xia,

Jianshu Zhu,

Ruohan Yang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 24, 2023

Spinal cord injury (SCI) has considerable impact on patient physical, mental, and financial health. Secondary SCI is associated with inflammation, vascular destruction, subsequent permanent damage to the nervous system. Mesenchymal stem cells (MSCs) have anti-inflammatory properties, promoting regeneration release neuro-nutrients, are a promising strategy for treatment of SCI. Preclinical studies shown that MSCs promote sensory motor function recovery in rats. In clinical trials, been reported improve American Injury Association (ASIA) scores. However, effectiveness treating patients remains controversial. tumorigenesis ensuring survival hostile environment challenging. this article we examine evidence pathophysiological changes occurring after We then review underlying mechanisms summarize potential application practice. Finally, highlight challenges surrounding use discuss future applications.

Language: Английский

Citations

53
Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer DOI Open Access

Diana-Theodora Morgos,

Constantin Ștefani,

Daniela Miricescu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1848 - 1848

Published: Feb. 3, 2024

Gastric cancer (GC) is the fourth leading cause of death worldwide, with more than 1 million cases diagnosed every year.

Language: Английский

Citations

45
PIK3CA mutation as an acquired resistance driver to EGFR-TKIs in non-small cell lung cancer: Clinical challenges and opportunities DOI Creative Commons
Xiaohong Liu,

Wuxuan Mei,

Pengfei Zhang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 202, P. 107123 - 107123

Published: March 2, 2024

Epithelial growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have significantly enhanced the treatment outcomes in non-small cell lung cancer (NSCLC) patients harboring EGFR mutations. However, occurrence of acquired resistance to EGFR-TKIs is an unavoidable outcome observed these patients. Disruption PI3K/AKT/mTOR signaling pathway can contribute emergence TKIs cancer. The PIK3CA mutations following with lead against EGFR-TKIs. This review provides overview current perspectives regarding involvement development Furthermore, we outline state-of-the-art therapeutic strategies targeting We highlight role mutation as mechanism EGFR-mutant NSCLC. Crucially, explore PIK3CA-mediated cancer, aiming optimize effectiveness treatment.

Language: Английский

Citations

18
Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights DOI Creative Commons

Rifika Jain,

Mohamed Ali Hussein,

Shannon Pierce

et al.

Pharmacological Research, Journal Year: 2022, Volume and Issue: 178, P. 106138 - 106138

Published: Feb. 19, 2022

Language: Английский

Citations

64
Chemotherapy Resistance: Role of Mitochondrial and Autophagic Components DOI Open Access

Entaz Bahar,

Sun‐Young Han, Ji‐Ye Kim

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(6), P. 1462 - 1462

Published: March 12, 2022

Cancer chemotherapy resistance is one of the most critical obstacles in cancer therapy. One well-known mechanisms change mitochondrial death pathways which occur when cells are under stressful situations, such as chemotherapy. Mitophagy, or selective autophagy, for cell quality control because it can efficiently break down, remove, and recycle defective damaged mitochondria. As use mitophagy to rapidly sweep away mitochondria order mediate their own drug resistance, influences efficacy tumor well degree resistance. Yet despite importance little known about precise involved. a consequence, identifying potential therapeutic targets by analyzing signal that govern has become vital research goal. In this paper, we review recent advances research, mechanisms, implications our understanding

Language: Английский

Citations

46
State-of-the-art review of theabrownins: from preparation, structural characterization to health-promoting benefits DOI
Lizeng Cheng, Yang Wei,

Lanlan Peng

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(31), P. 11321 - 11340

Published: Aug. 16, 2023

As far as health benefit is concerned, dark tea one of the best beverages in world. Theabrownins are major ingredient contributing to benefits and known "the soft gold tea." A growing body evidence indicated that theabrownins macromolecular pigments with reddish-brown color mellow taste, mainly derived from oxidative polymerization polyphenols. main active ingredients which brings multiple health-promoting effects modulating lipid metabolism, reducing weight gain, attenuating diabetes, mitigating NAFLD, scavenging ROS, preventing tumors. More importantly, it's their substantial generation microbial fermentation endows much stronger hypolipidemic effect compared other types tea. This review firstly summarizes most recent findings on preparation, structural characteristics, theabrownins, emphasizing underlying molecular mechanism, especially different mechanisms behind theabrownins-mediated gut microbiota host's benefits. Furthermore, this points out limitations current research potential future directions, hoping provide updated scientific for better theoretical industrial utilization.

Language: Английский

Citations

27