Aqueous Extract of Cinnamon (Cinnamomum spp.): Role in Cancer and Inflammation DOI Creative Commons
Shubrata Khedkar, Minhaj Ahmad Khan

Evidence-based Complementary and Alternative Medicine, Journal Year: 2023, Volume and Issue: 2023(1)

Published: Jan. 1, 2023

Cinnamon ( Cinnamomum spp.; family Lauraceae), a plant widely used as spice and flavoring agent in the perfume industry, has high therapeutic value. However, components chemical properties of cinnamon extracts vary depending on part plant, method, solvent for extraction. Green extraction methods using safe green solvents have gained increased interest recent years. Water is an environmentally friendly preparing extracts. This review focuses various preparation techniques aqueous extract cinnamon, its major bioactive components, their beneficial roles different pathological conditions, specifically cancer inflammation. The contains several compounds, such cinnamaldehyde, cinnamic acid, polyphenols, exerts anticancer anti‐inflammatory by altering key apoptotic angiogenic factors. whole better than purified fractions, indicating synergistic effect between components. Studies indicated that immense potential, to understand effects, extensive characterization potential be with other therapies should explored.

Language: Английский

Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer’s disease from bench to bedside DOI
Fahadul Islam, Mohamed H. Nafady, Md. Rezaul Islam

et al.

Molecular Neurobiology, Journal Year: 2022, Volume and Issue: 59(7), P. 4384 - 4404

Published: May 12, 2022

Language: Английский

Citations

58
Multiple health benefits of curcumin and its therapeutic potential DOI
Muddaser Shah, Waheed Murad, Sidra Mubin

et al.

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(29), P. 43732 - 43744

Published: April 20, 2022

Language: Английский

Citations

48
Multifaceted role of polyphenols in the treatment and management of neurodegenerative diseases DOI
Fahadul Islam, Md. Mohaimenul Islam,

Atkia Farzana Khan Meem

et al.

Chemosphere, Journal Year: 2022, Volume and Issue: 307, P. 136020 - 136020

Published: Aug. 16, 2022

Language: Английский

Citations

46
Multifunctional Therapeutic Approach of Nanomedicines against Inflammation in Cancer and Aging DOI Creative Commons
Md. Mominur Rahman, Fahadul Islam,

Sadia Afsana Mim

et al.

Journal of Nanomaterials, Journal Year: 2022, Volume and Issue: 2022(1)

Published: Jan. 1, 2022

Cancer is a fatal disorder that affects people across the globe, yet existing therapeutics are ineffective. The development of submicrometer transport for optimizing biodistribution systemically provided medications focus nanomedicine. Nanoparticle‐ (NP‐) based treatments may enable novel therapeutic approaches to combat this deadly disorder. In multifunctional, multimodal imaging, and drug delivery carriers, NPs generally play major role. They have emerged as potential strategies invention innovative procedures in last decade. exponential growth nanotechnologies recent years has increased public awareness application these approaches. Many tumor‐targeted nanomedicines been studied cancer therapy, there clear evidence significant improvement index antineoplastic drugs. Age‐related factors such metabolic physiological alterations old age inadequate animal models currently understudied nanomedicine pharmacology. This review highlighted most important targeting approaches, well awareness, advancements, future prospects age‐related variations, studies.

Language: Английский

Citations

42
Therapeutic Potential of Polyphenols and Other Micronutrients of Marine Origin DOI Creative Commons
Leonel Pereira, João Cotas

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(6), P. 323 - 323

Published: May 26, 2023

Polyphenols are compounds found in various plants and foods, known for their antioxidant anti-inflammatory properties. Recently, researchers have been exploring the therapeutic potential of marine polyphenols other minor nutrients that algae, fish crustaceans. These unique chemical structures exhibit diverse biological properties, including anti-inflammatory, antioxidant, antimicrobial antitumor action. Due to these being investigated as possible agents treatment a wide variety conditions, such cardiovascular disease, diabetes, neurodegenerative diseases cancer. This review focuses on applications human health, also, phenolic classes, extraction methods, purification techniques future compounds.

Language: Английский

Citations

39
Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis DOI Creative Commons

Haiyang Kou,

Lei Huang, Meng Jin

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 31, 2023

The aim of this study is to evaluate the effectiveness and safety curcumin in rheumatoid arthritis patients.

Language: Английский

Citations

37
Antiaging effects of dietary supplements and natural products DOI Creative Commons

Lulu Gao,

Xudong Liu, Xiaoyan Luo

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 27, 2023

Aging is an inevitable process influenced by genetics, lifestyles, and environments. With the rapid social economic development in recent decades, proportion of elderly has increased rapidly worldwide, many aging-related diseases have shown upward trend, including nervous system diseases, cardiovascular metabolic cancer. The rising burden become urgent global health challenge requires immediate attention solutions. Natural products been used for a long time to treat various human diseases. primary cellular pathways that mediate longevity-extending effects natural involve nutrient-sensing pathways. Among them, sirtuin, AMP-activated protein kinase, mammalian target rapamycin, p53, insulin/insulin-like growth factor-1 signaling are most widely studied. Several studies reviewed individual compounds on aging along with underlying mechanisms. from food sources, such as polyphenols, saponins, alkaloids, polysaccharides, classified antiaging promote prolong life via In this article, we several recently identified potential properties highlighted their molecular discovery use dietary supplements can prevent multiple humans will be beneficial. Thus, review provides theoretical background existing agents.

Language: Английский

Citations

28
Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review DOI
Jinjin Pei, Chella Perumal Palanisamy, Prabhu Manickam Natarajan

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102393 - 102393

Published: June 24, 2024

Language: Английский

Citations

10
Nanocurcumin in myocardial infarction therapy: emerging trends and future directions DOI Creative Commons

Mei Lv,

Qing Sun,

YU Yi-lin

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 8, 2025

Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide. Curcumin has been observed to significantly reduce pathological processes associated with MI. Its clinical application limited due its low bioavailability, rapid degradation, poor solubility. Advancements in nanotechnology can be used enhance therapeutic potentials nano-formulation enhances solubility, stability, allowing more precise delivery ischemic cardiac tissue. nanoparticles have successfully infarct size, maintain heart function by modulating essential molecular pathways liposomal formulations provide sustained release higher tissue penetration improved pharmacokinetics enhanced efficacy. Preclinical studies revealed that nanocurcumin drastically lower oxidative stress indicators, inflammatory cytokines, damage. Micelles composed polymers demonstrated high biocompatibility targeting capabilities increased cardio-protective effects. Research trials are for comprehensive analysis efficacy curcumin-based nano-therapeutics cardiovascular condition lowering risk

Language: Английский

Citations

1
Green nanotechnology: nanoparticle synthesis using Curcuma amada , Curcuma caesia , Curcuma longa , and Curcuma zedoaria DOI Creative Commons

Avinash Gangal,

Neeraj Kumar Sethiya,

Manisha Duseja

et al.

Green Chemistry Letters and Reviews, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 13, 2025

Translating the conventional methods to produce novel materials with intriguing properties is much needed in current scenario. It was well established that particles nanoscale exhibit superior activity than their bulk counterpart. Recently, biogenic synthesis has gained extensive attention for synthesizing a wide range of nanomaterials including metal/metal oxides, hybrid, and bioinspired nano-materials, respectively. In this context, we have summarized reviewed fundamental mechanisms strategies, especially non-metal, metal, metal oxide nanoparticles using four different natural sources Curcuma viz. amada, caesia, longa, zedoaria, conclusion, content presented article will provide ready-to-use information future improvements value addition related nanoparticle production through green approach species as discussed. Finally, these were also found be more reliable, sustainable, eco-friendly per protocols.

Language: Английский

Citations

1