Methods of Prevention and Mitigation of Autoimmune Diseases - A Review of The Literature DOI Creative Commons
Magdalena Celichowska, Zuzanna Bentkowska, Aleksandra Bogoń

et al.

Quality in Sport, Journal Year: 2024, Volume and Issue: 17, P. 53121 - 53121

Published: July 21, 2024

Introduction and purpose: Autoimmune diseases are conditions where the body’s immune system is unable to distinguish between auto- foreign antigens mistakenly attacks its cells, tissues, organs. In recent years it became major public health concern because of increasing diagnosis rate. Currently, about 5% population in Western countries affected by such diseases, more often women population. The exact cause autoimmune unknown, although most probably results from a combination genetic predisposition, environmental risk factors dysregulation. Development autoantigen-specific lymphocytes autoantibodies might be decisive starting process autoimmunity. Most common medication used treatment nonsteroidal anti-inflammatory drugs (NSADs), glucocorticoids, disease-modifying antirheumatic (DMARDs). Additionally, there biological available for many them. It known that non-pharmacological interventions, as specific diets, supplementation or physical exercise useful mitigate disease even prevent body onset. Materials methods: data article was found using PubMed Google Scholar websites. key words search included: ‘diet autoimmunity’, ‘autoimmunity estrogens’, ‘microbiota autoimmunity’. Articles not written English, conference abstracts only duplicated papers were excluded. Conclusions: There still no cure various prevention mitigation strategies can help manage these improve quality life individuals. However, use some them, evidence-based recommendations available. This review highlights current therapeutic options.

Language: Английский

Etiopathogenesis of Psoriasis: Integration of Proposed Theories DOI
Brenda Fernanda Hernandez-Nicols, Juan José Robledo-Pulido, Anabell Alvarado‐Navarro

et al.

Immunological Investigations, Journal Year: 2024, Volume and Issue: 53(3), P. 348 - 415

Published: Jan. 19, 2024

Psoriasis is a chronic inflammatory disease characterized by squamous and erythematous plaques on the skin involvement of immune system. Global prevalence for psoriasis has been reported around 1–3% with higher incidence in adults similar proportions between men women. The risk factors associated are both extrinsic intrinsic, out which polygenic predisposition highlight latter. etiology not yet fully described, but several hypothesis have proposed: 1) autoimmunity based over-expression antimicrobial peptides such as LL-37, proteins ADAMTSL5, K17, hsp27, or lipids synthesized PLA2G4D enzyme, all may serve autoantigens to promote differentiation autoreactive lymphocytes T unleash response; 2) dysbiosis microbiota gained relevance due observations loss diversity participation pathogenic bacteria Streptococcus spp. Staphylococcus fungi Malassezia Candida virus HPV, HCV, HIV psoriatic plaques; 3) oxidative stress hypothesis, most recent one, describes that cell injury release proinflammatory mediators leads activate Th1/Th17 axis observed caused reactive oxygen species imbalance oxidant antioxidant mechanisms. This review aims describe mechanisms involved three hypotheses etiopathogeneses psoriasis.

Language: Английский

Citations

9
The Skin and Natural Cannabinoids–Topical and Transdermal Applications DOI Creative Commons

Silviu-Iulian Filipiuc,

Anca-Narcisa Neagu,

Cristina Mariana Urîtu

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(7), P. 1049 - 1049

Published: July 24, 2023

The chemical constituents of the

Language: Английский

Citations

20
Cannabidiol and Minor Phytocannabinoids: A Preliminary Study to Assess Their Anti-Melanoma, Anti-Melanogenic, and Anti-Tyrosinase Properties DOI Creative Commons
Katarzyna Gaweł‐Bęben, Karolina Czech, Simon Vlad Luca

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(5), P. 648 - 648

Published: April 26, 2023

Currently, there is an increased interest from both scientists and consumers in the application of cannabis/hemp/phytocannabinoids skin-related disorders. However, most previous investigations assessed pharmacological properties hemp extracts, cannabidiol (CBD), or tetrahydrocannabinol (THC), with very few studies focusing on minor phytocannabinoids hemp. In this context, current work explored vitro anti-melanoma, anti-melanogenic, anti-tyrosinase effects (CBD) three phytocannabinoids, namely cannabigerol (CBG), cannabinol (CBN), cannabichromene (CBC). Among tested human malignant melanoma cells (A375, SH4, G361), only A375 were highly susceptible to 48 h treatment four (IC50 values between 12.02 25.13 μg/mL). When melanogenesis was induced murine B16F10 by α-melanocyte stimulating hormone (αMSH), CBD, CBG, CBN significantly decreased extracellular (29.76–45.14% αMSH+ cells) intracellular (60.59–67.87% melanin content at 5 μg/mL. Lastly, (50–200 μg/mL) inhibited mushroom tyrosinase, whereas CBG CBC (100–200 down-regulated tyrosinase activity; contrast, CBD practically inactive. The data show that inhibition might not be responsible for reducing biosynthesis α-MSH-treated cells. By evaluating first time preliminary confirming similar study can expand utilization and, particular, novel cosmeceutical products skin care.

Language: Английский

Citations

19
Stability, biofunctional, and antimicrobial characteristics of cannabidiol isolate for the design of topical formulations DOI Creative Commons
Sreejarani Kesavan Pillai, Nazia H. Kera, Phumelele Kleyi

et al.

Soft Matter, Journal Year: 2024, Volume and Issue: 20(10), P. 2348 - 2360

Published: Jan. 1, 2024

Cannabidiol's stability and functional properties were investigated. The phytocannabinoid showed excellent antioxidant, anti-collagenase along with antimicrobial against Gram-positive bacterial fungal species which suggest opportunities as an ingredient in topical products.

Language: Английский

Citations

5
Cannabinoids for the treatment of autoimmune and inflammatory skin diseases: A systematic review DOI Creative Commons
Ai Kuzumi, Takashi Yamashita, Takemichi Fukasawa

et al.

Experimental Dermatology, Journal Year: 2024, Volume and Issue: 33(3)

Published: March 1, 2024

Abstract In recent years, the medical use of cannabinoids has attracted growing attention worldwide. particular, anti‐inflammatory properties led to their emergence as potential therapeutic options for autoimmune and inflammatory disorders. Recent studies have also shown that cannabinoid receptors are widely expressed endogenous ligands in skin, suggesting skin its own endocannabinoid system. The aim this review is discuss effects diseases. Following an overview system, we describe cellular molecular mechanisms health disease. We then clinical diseases including systemic sclerosis (SSc), dermatomyositis (DM), psoriasis (Pso) atopic dermatitis (AD). A primary literature search was conducted July 2023, using PubMed Web Science. total 15 articles were included after excluding reviews, non‐human vitro from 389 non‐duplicated articles. Available evidence suggests may be beneficial SSc, DM, Pso AD. However, further studies, ideally randomized controlled trials, needed evaluate

Language: Английский

Citations

4
Anti-Infective Screening of Selected Nine Cannabinoids Against Clostridium perfringens and Influenza A (H5N1) Neuraminidases, and SARS-CoV-2 Main Protease and Spike Protein Interactions DOI Creative Commons
Thanet Pitakbut, Oliver Kayser

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 185 - 185

Published: March 12, 2025

Recently, cannabinoids have gained scientific interest as a promising anti-infective natural product class, reported in several studies. However, the existing knowledge is mainly limited to common like THC and CBD. Therefore, this study aims fill gap by investigating potential of nine selected (both rare cannabinoids): THC, CBD, CBC, CBE, CBF, CBG, CBL, CBN, CBT against Clostridium perfringens Influenza A (H5N1) neuraminidases SARS-CoV-2 main protease spike protein–human ACE2 interaction using standard vitro biochemical enzyme-binding assay. As result, authors’ knowledge, first demonstrate most effect CBG over others its class C. influenza interaction. In comparison CBD were second third candidates. Meanwhile, other derivatives, such CBT, showed at least one effect. Our findings during early drug discovery process indicate cannabinoids, which can be considered for further investigation biological setup.

Language: Английский

Citations

0
Therapeutic Potential of Minor Cannabinoids in Dermatological Diseases—A Synthetic Review DOI Creative Commons

E Kwiecien,

Dorota Kowalczuk

Molecules, Journal Year: 2023, Volume and Issue: 28(16), P. 6149 - 6149

Published: Aug. 20, 2023

Dermatological diseases pose a significant burden on the quality of life individuals and can be challenging to treat effectively. In this aspect, cannabinoids are gaining increasing importance due their therapeutic potential in various disease entities including skin diseases. synthetic review, we comprehensively analyzed existing literature field dermatological applications lesser-known subgroup cannabinoids, so-called minor such as cannabidivarin (CBDV), cannabidiforol (CBDP), cannabichromene (CBC), tetrahydrocannabivarin (THCV), cannabigerolic acid (CBGA), cannabigerol (CBG), cannabielsoin (CBE), cannabimovone (CBM) or cannabinol (CBN), while drawing attention unique pharmacological properties. We systematically searched available databases for relevant studies data provide an overview current thematic knowledge. looked through full-text, bibliographic factographic databases, especially Scopus, Web Science, PubMed, Polish Scientific Journals Database, selected most papers. Our review highlights that exhibit diverse activities, anti-inflammatory, analgesic, antimicrobial, anti-itch Several have reported efficacy mitigating symptoms associated with psoriasis, eczema, acne, pruritus. Furthermore, shown regulating sebum production, crucial factor acne pathogenesis. The findings suggest hold promise management Further preclinical clinical investigations warranted elucidate mechanisms action, determine optimal dosage regimens, assess long-term safety profiles. Incorporating into therapies could potentially offer novel treatment options patients improve overall well-being.

Language: Английский

Citations

8
Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway DOI Open Access
Marjan Talebi,

Mohammad Mehdi Sadoughi,

Seyed Abdulmajid Ayatollahi

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115805 - 115805

Published: Oct. 31, 2023

Cannabidiol (CBD), a cannabinoid that does not create psychoactive activities, has been identified as having multitude of therapeutic benefits. This study delves into the chemical properties, pharmacokinetics, safety and toxicity, pharmacological effects, most importantly, association between potential CBD nuclear factor erythroid 2-related 2 (Nrf2) signaling pathway. The relationship Nrf2 is closely linked to certain proteins are associated with cardiovascular dysfunctions, cancers, neurodegenerative conditions. Specifically, connected initiation progression diverse health issues, including nephrotoxicity, bladder-related diseases, oral mucositis, obesity, myocardial injury angiogenesis, skin-related inflammations, psychotic disorders, neuropathic pain, Huntington's disease, Alzheimer's Parkinson's neuroinflammation, Amyotrophic Lateral Sclerosis, Multiple Sclerosis. zone great interest in medical field, it significantly impact treatment prevention wide-ranging Additional investigation necessary entirely apprehend mechanisms underlying this crucial interplay develop effective interventions.

Language: Английский

Citations

8
Hemp macromolecules: Crafting sustainable solutions for food and packaging innovation DOI
Rekha Chawla, Zhongxiang Fang

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132823 - 132823

Published: June 7, 2024

Language: Английский

Citations

2
The Perspective of Cannabidiol in Psoriasis Therapy DOI Creative Commons
Ana Maria Alexandra Stănescu, Gabriel Cristian Bejan, Mihaela Daniela Baltă

et al.

Psoriasis Targets and Therapy, Journal Year: 2024, Volume and Issue: Volume 14, P. 51 - 61

Published: June 1, 2024

Abstract: Psoriasis is a chronic skin condition that can significantly impact the quality of life those affected. As an autoimmune disease, it lead to itchy, painful, and scaly patches on skin. Although various treatments, including topical creams, phototherapy, systemic medications, are currently available, they may not always offer effective relief have side effects. Researchers thus been exploring potential benefits non-psychoactive compounds such as CBD, found in Cannabis sativa plants, for treating psoriasis. CBD treatment reduce inflammation, oxidative stress, itching, abnormal proliferation keratinocytes, increase hydration. This review aims provide overview existing literature uses psoriasis treatment. Keywords: psoriasis, cannabidiol, compounds,

Language: Английский

Citations

2