Karbala International Journal of Modern Science,
Journal Year:
2023,
Volume and Issue:
9(3)
Published: June 27, 2023
Eutectic
formation
in
allantoin-octadecenedioic
acid
system
(AOM)
has
been
studied.
The
binary
phase
diagram
revealed
the
existence
of
eutectic
at
Xallantoin
=
0.7.
Dioic
caused
disruption
network
allantoin
and
induced
defects,
ultimately
causing
reduction
crystallinity
as
shown
by
XRD
SEM
analysis.
thermal
stability
TGA
graphs
was
negligibly
altered
after
mixture
formation.
Classical
hydrogen
bonding
alkyl
interactions
were
predicted
using
software
Avogadro
BIOVIA
Discovery
Studio.
functionalities
involved
taking
place
studied
through
in-depth
FT-IR
spectroscopy.
showed
efficacy
for
cutaneous
wound
healing
oryctolagus
cuniculus
domesticus,
hence
it
could
be
used
therapeutic
regulation
control
bioactivity.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Patients
and
healthcare
systems
face
significant
social
financial
challenges
due
to
the
increasing
number
of
individuals
with
chronic
external
internal
wounds
that
fail
heal.
The
complexity
healing
process
remains
a
serious
health
concern,
despite
effectiveness
conventional
wound
dressings
in
promoting
healing.
Recent
advancements
materials
science
fabrication
techniques
have
led
development
innovative
enhance
To
further
expedite
process,
novel
approaches
such
as
nanoparticles,
3D-printed
dressings,
biomolecule-infused
emerged,
along
cell-based
methods.
Additionally,
gene
therapy
technologies
are
being
harnessed
generate
stem
cell
derivatives
more
functional,
selective,
responsive
than
their
natural
counterparts.
This
review
highlights
potential
biomaterials,
3D
bioprinting,
gene-
therapies
However,
it
also
underscores
necessity
for
research
address
existing
integrate
these
strategies
into
standard
clinical
practice.
ChemSusChem,
Journal Year:
2023,
Volume and Issue:
16(20)
Published: July 18, 2023
Abstract
In
the
spirit
of
circular
economy
and
sustainable
chemistry,
use
environmentally
friendly
chemical
products
in
pharmacy
has
become
a
hot
topic.
recent
years,
organic
solvents
have
been
subject
great
range
restriction
policies
due
to
their
harmful
effects
on
environment
toxicity
human
health.
parallel,
deep
eutectic
(DESs)
emerged
as
suitable
greener
with
beneficial
environmental
impacts
rich
palette
physicochemical
advantages
related
low
cost
biocompatibility.
Additionally,
DESs
can
enable
remarkable
solubilizing
effect
for
several
active
pharmaceutical
ingredients
(APIs),
thus
forming
therapeutic
(TheDESs).
this
work,
special
attention
is
paid
DESs,
presenting
precise
definition,
classification,
methods
preparation,
characterization.
A
description
natural
(NaDESs),
i.
e.,
present
sources,
also
reported.
Moreover,
review
article
first
one
detail
different
approaches
judiciously
selecting
constituents
order
minimize
number
experiments.
The
role
biomedical
sectors
impact
development
successful
therapies
are
discussed.
Gels,
Journal Year:
2024,
Volume and Issue:
10(2), P. 107 - 107
Published: Jan. 28, 2024
Natural
deep
eutectic
solvents
(NaDES)
represent
a
new
generation
of
green,
non-flammable
solvents,
useful
as
an
efficient
alternative
to
the
well-known
ionic
liquids.
They
can
be
easily
prepared
and
exhibit
unexpected
solubilizing
power
for
lipophilic
molecules,
although
those
hydrophilic
nature
are
mostly
used.
For
their
unique
properties,
they
recommend
different
cosmetic
pharmaceutical
applications,
ranging
from
sustainable
extraction,
obtaining
ready-to-use
ingredients,
development
biocompatible
drug
delivery
responsive
systems.
In
biomedical
field,
NaDES
used
biopolymer
modifiers,
acting
compounds
also
known
“therapeutic
systems”,
being
able
solubilize
stabilize
chemical
galenical
formulations.
The
aim
this
review
is
give
overview
current
knowledge
regarding
natural
specifically
applied
in
fields.
work
could
help
disclose
opportunities
challenges
implementation
not
only
green
but
potential
pathways
deliver
bioactive
ingredients
innovative
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(21), P. 14793 - 14806
Published: Jan. 1, 2024
Therapeutic
deep
eutectic
solvents
(THEDSs)
are
the
best
exemplification
of
green
alternative
formulations
active
pharmaceutical
ingredients
(APIs)
that
offer
superlative
properties
APIs.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(19), P. 6927 - 6927
Published: Oct. 4, 2023
The
current
work
was
aimed
at
the
development
of
a
topical
drug
delivery
system
for
azelaic
acid
(AzA)
acne
treatment.
systems
tested
this
purpose
were
deep
eutectic
(DESs)
prepared
from
choline
chloride
(CC),
malonic
(MA),
and
PEG
400.
Three
CC
to
MA
eight
different
MA:
CC:
PEG400
ratios
tested.
physical
appearance
formulations
ranged
solid
liquid
semisolid.
Only
those
that
showed
suitable
viscosity
considered
further
investigations.
A
mixture
made
1:1:6
(MCP
116)
best
characteristics
in
terms
viscosity,
contact
angle,
spreadability,
partition
coefficient,
vitro
diffusion.
Moreover,
MCP116
close
rheological
properties
commercially
available
market
lead
treatment
product
(Skinorin®).
In
addition,
formula
synergistic
antibacterial
activity
between
moiety
DES
AzA.
diffusion
studies
using
polyamide
membranes
demonstrated
superior
over
pure
commercial
product.
No
signs
skin
irritation
edema
observed
when
applied
rabbit
skin.
Additionally,
found
be,
physically
chemically,
highly
stable
4,
25,
40
°C
one-month
stability
study.
