Piperlongumine induces apoptosis via the MAPK pathway and ERK‑mediated autophagy in human melanoma cells DOI Creative Commons
Su-Ji Jeon, Eunyoung Choi,

Eun-Ji Han

et al.

International Journal of Molecular Medicine, Journal Year: 2023, Volume and Issue: 52(6)

Published: Oct. 12, 2023

Piperlongumine (PL) is an amide alkaloid with diverse pharmacological effects against cancer, bronchitis and asthma; however, research on its efficacy melanoma lacking. The present study investigated the anticancer of PL A375SM A375P human cells. decreased survival rate cells, as shown by MTT assay, increase apoptotic cells DAPI staining. And induced apoptosis decreasing expression anti‑apoptotic protein Bcl‑2 increasing that pro‑apoptotic proteins cleaved‑PARP Bax. also in via MAPK pathway, pathway proteins, phosphorylated‑(p‑ERK), p‑JNK p‑p38. These were confirmed western blot. In addition, treated showed increased number acidic vesicular organelles acridine orange Also, autophagy 1A/1B‑light chain 3, Beclin 1and mTOR was through When applied following treatment inhibitors 3‑methyladenine hydroxychloroquine, exhibited a cytoprotective effect assay. Pretreatment ERK inhibitor PD98059 JNK SP600125 followed mediated MAPK/ERK summary, provided empirical evidence supporting indicated potential for melanoma.

Language: Английский

Recent advances and applications of novel advanced materials in solid-phase microextraction for natural products DOI

Huang-Fei Jin,

Ying Shi,

Jun Cao

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 178, P. 117858 - 117858

Published: July 6, 2024

Language: Английский

Citations

16
Tailoring traditional Chinese medicine in cancer therapy DOI Creative Commons

Shuiquan Li,

Xi Chen, Hui Shi

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 21, 2025

Language: Английский

Citations

2
Exploration of natural products for the development of promising Cholinesterase inhibitors in Alzheimer’s disease treatment DOI Creative Commons
Hassan Nour, Oussama Abchır,

Nouh Mounadi

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42479 - e42479

Published: Feb. 1, 2025

Cholinesterase enzymes (BuChE and AChE) are privileged biological targets for the symptomatic treatment of Alzheimer's disease. Indeed, inhibition cholinesterase has been proven to improve neurotransmission mechanisms in disease patients. In this investigation, we attempt highlight new inhibitors from natural products. For purpose, secondary metabolites (299 phytoconstituents) twenty-eight Medicinal plants were virtually screened using molecular docking, pharmacokinetic toxicological analysis. Ten phytoconstituents (L82, L86, L92, L121, L148, L187, L211, L221, L228) exhibited their high binding affinity with BuChE, five phytoconstituents, namely L119, L147, L149, L192 L193, strong ability AChE. Subsequently, these evaluated ADMET properties. As result, L221 is predicted be highly bioavailable readily absorbed by human intestinal tract without significant toxicity concerns, making it suitable oral administration. Crucially, can penetrate blood-brain barrier (BBB), allowing effectively reach central nervous system. Molecular dynamics simulations MM-PBSA analysis revealed that best-screened phytoconstituent form thermodynamically favorable stable complex BuChE site. The conducted investigations highlighted promising outcomes orient towards rational development effective inhibitors.

Language: Английский

Citations

2
The Emerging Role of Natural Products in Cancer Treatment DOI
Sumit Ghosh, Sanjib Das, Krishnendu Sinha

et al.

Archives of Toxicology, Journal Year: 2024, Volume and Issue: 98(8), P. 2353 - 2391

Published: May 25, 2024

Language: Английский

Citations

10
Prospects of compounds of herbal plants as anticancer agents: a comprehensive review from molecular pathways DOI Creative Commons
Putri Cahaya Situmorang, Syafruddin Ilyas, Sony Eka Nugraha

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 22, 2024

Cancer refers to the proliferation and multiplication of aberrant cells inside human body, characterized by their capacity proliferate infiltrate various anatomical regions. Numerous biochemical pathways signaling molecules have an impact on cancer auto biogenesis process. The regulation crucial cellular processes necessary for cell survival proliferation, which are triggered phytochemicals, is significantly influenced pathways. These or components regulated phytochemicals. Medicinal plants a significant reservoir diverse anticancer medications employed in chemotherapy. effects phytochemicals mediated several methods, including induction apoptosis, cessation cycle, inhibition kinases, prevention carcinogenic substances. This paper analyzes phytochemistry seven prominent plant constituents, namely, alkaloids, tannins, flavonoids, phenols, steroids, terpenoids, saponins, focusing involvement MAPK/ERK pathway, TNF signaling, death receptors, p53, p38, actin dynamics. Hence, this review has examined range encompassing structural characteristics potential mechanisms. It underscored significance plant-derived bioactive compounds cancer, utilizing molecular In addition, endeavor also seeks incentivize scientists carry out clinical trials derived from plants.

Language: Английский

Citations

7
Natural Products Derived from Marine Sponges with Antitumor Potential against Lung Cancer: A Systematic Review DOI Creative Commons
Alba Ortigosa‐Palomo, Francisco Quiñonero, Raúl Ortíz

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(3), P. 101 - 101

Published: Feb. 23, 2024

Non-small-cell lung cancer (NSCLC), the most commonly diagnosed and leading cause of cancer-related death worldwide, has been extensively investigated in last decade terms developing new therapeutic options that increase patient survival. In this context, marine animals are a source new, interesting bioactive molecules have applied to treatment different types cancer. Many efforts made search for strategies improve prognosis patients, including compounds cytotoxic drugs from sponges. Their antitumoral effect can be explained by several cellular molecular mechanisms, such as modulation cell cycle or induction apoptosis. Thus, systematic review aims summarize derived sponges mechanisms which they show antitumor effects against cancer, exploring their limitations challenges associated with discovery. The process was performed three databases (PubMed, SCOPUS, Web Science), yielding total 105 articles identified 10 years, after screening process, 33 were included review. results showed these natural sponge-derived valuable inspiration development drugs. However, more research field is needed translation novel clinic.

Language: Английский

Citations

6
Molecular mechanism of miRNA mediated biosynthesis of secondary metabolites in medicinal plants DOI
Hongwei Li, Ziyi Guo,

Mengwei Xu

et al.

Plant Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: 208, P. 108524 - 108524

Published: March 1, 2024

Language: Английский

Citations

5
Computational investigation into the solvent effect, electron distribution, reactivity profile, pharmacokinetic properties and anti-cancer action of Hemimycalin C DOI

U. Yuktha Vijay,

Sheryl Cherian Parakkal, Riya Datta

et al.

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 126915 - 126915

Published: Jan. 1, 2025

Language: Английский

Citations

0
Anti-proliferative and photodynamic activities of Senna didymobotrya (Fresen.) leaf alkaloid-rich extracts against breast cancer cells DOI Creative Commons
Kolawole A. Olofinsan, Heidi Abrahamse, Blassan P. George

et al.

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 22, 2025

Amongst all neoplastic diseases, breast cancer represents a major cause of death among the female population in developed and developing countries. Since alkaloid drugs are commonly used chemotherapy to manage this disease, study investigated anti-proliferative effectiveness alkaloid-rich fractions Senna didymobotrya leaves only with laser irradiation against MCF-7 cells. A powdered sample plant was extracted 50% ethanol, filtered their pH adjusted acid base solution followed by partitioning chloroform ethyl acetate solvents. Cells were treated 240 μg/mL respective extracts, while those photodynamic therapy groups, cells exposed (405 nm wavelength 10 Jcm−2) 6 h post extracts' administration. Treatment S. extracts significantly decreased ATP concentration overall viability Reactive oxygen species (ROS) levels cell groups light considerably higher than experimental extracts. Moreover, molecular docking analysis revealed involvement hydrophobic bonds interactions plant's alkaloid-derived phytoconstituents' selected protein biomarkers. Although silico suggests that plant-identified phytoconstituents inhibition estrogen receptor-alpha, human epidermal growth factor receptor-2 progesterone receptor proteins involved pathogenesis could explain possible mechanism for observed anticancer effect, more detailed vitro experiments necessary confirm these findings.

Language: Английский

Citations

0
Mechanisms of Plant Secondary Metabolites in Antitumor Activity: Insights into circRNA Modulation DOI
Tatiane Roquete Amparo, Tamires Cunha Almeida, Lucas Resende Dutra Sousa

et al.

Reference series in phytochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 28

Published: Jan. 1, 2025

Language: Английский

Citations

0