Nutrients,
Journal Year:
2024,
Volume and Issue:
16(24), P. 4305 - 4305
Published: Dec. 13, 2024
Bovine
colostrum
(BC),
the
first
milk
secreted
by
mammals
after
birth,
is
a
trending
alternative
source
for
supplementing
infants
and
children,
offering
benefits
gut
immune
health.
Its
rich
components,
such
as
proteins,
immunoglobulins,
lactoferrin,
glycans,
are
used
to
fortify
diets
support
development.
Preterm
development
crucial,
especially
in
maturation
of
essential
systems,
from
2010
2020,
approximately
15%
all
premature
births
occurred
at
less
than
32
weeks
gestation
worldwide.
This
review
explores
composition,
benefits,
effects
BC
on
general
along
with
preterm
who
require
special
care,
highlights
its
role
growth
also
associated
specific
pediatric
diseases,
including
necrotizing
enterocolitis
(NEC),
infectious
diarrhea,
inflammatory
bowel
disease
(IBD),
short-bowel
syndrome
(SBS),
neonatal
sepsis,
gastrointestinal
respiratory
infections,
some
minor
conditions.
discusses
clinical
trials
regarding
these
conditions
which
occasionally
encountered
infants.
The
anti-inflammatory,
antimicrobial,
immunomodulatory,
antiviral
properties
discussed,
emphasizing
mechanisms
action.
Clinical
trials,
particularly
humans,
provide
evidence
supporting
inclusion
formulas
diets,
although
precise
standards
age,
feeding
time,
amounts
needed
ensure
safety
efficacy.
However,
potential
adverse
effects,
allergic
reactions
caseins
immunoglobulin
E,
must
be
considered.
More
comprehensive
necessary
expand
infant
feeding,
important
components
BC,
should
further
studied
their
synergistic
diseases.
Ultimately,
shows
promise
health
incorporated
into
nutritional
supplements
caution.
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(24), P. 11798 - 11798
Published: Dec. 17, 2024
In
the
past
decade,
increasing
interest
in
healthy
consumption
has
encouraged
development
of
functional
products
yogurt
sector.
Dairy
are
extensively
used
production
foods
because
their
excellent
and
versatile
technological
properties.
Among
dairy
products,
is
one
that
been
most
widely
to
deliver
bioactive
compounds
consumers.
The
market
features
various
types
yogurt,
including
probiotic,
prebiotic,
synbiotic,
high
protein,
lactose
free,
novel
known
as
easy-to-digest
yogurt.
added
ingredients
these
influence
structural,
nutritional,
properties
These
effects
vary
depending
on
chemical
biological
characteristics
each
ingredient.
Additionally,
during
fermentation,
substances
can
impact
number
viability
bacteria
involved,
affecting
quality
storage.
Furthermore,
associated
with
health
benefits.
benefits
linked
not
only
supporting
but
also
altering
course
a
disease
or
alleviating
symptoms.
This
review
article
discusses
its
effects,
incorporating
recent
studies.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(24), P. 4368 - 4368
Published: Dec. 18, 2024
The
brain
contains
many
interconnected
and
complex
cellular
molecular
mechanisms.
Injury
to
the
causes
permanent
dysfunctions
in
these
So,
it
continues
be
an
area
where
surgical
intervention
cannot
performed
except
for
removal
of
tumors
repair
some
aneurysms.
Some
agents
that
can
cross
blood–brain
barrier
reach
neurons
show
neuroprotective
effects
due
their
anti-apoptotic,
anti-inflammatory
antioxidant
properties.
In
particular,
act
by
reducing
or
modulating
accumulation
protein
aggregates
neurodegenerative
diseases
(Alzheimer’s
disease,
Parkinson’s
Huntington’s
Amyotrophic
lateral
sclerosis,
prion
disease)
caused
accumulation.
Substrate
increased
oxidative
stress
stimulates
brain’s
immune
cells,
microglia,
astrocytes,
secrete
proinflammatory
cytokines.
Long-term
chronic
neuroinflammatory
response
triggers
apoptosis.
Brain
damage
is
observed
with
neuronal
apoptosis
functions
are
impaired.
This
situation
negatively
affects
processes
such
as
motor
movements,
memory,
perception,
learning.
Neuroprotective
prevent
molecules
play
a
role
addition,
they
improve
impaired
supporting
neuroplasticity
neurogenesis.
Due
important
roles
central
nervous
system
diseases,
elucidate
review
provides
overview
mechanisms
flavonoids,
which
constitute
large
part
effects,
well
vitamins,
neurotransmitters,
hormones,
amino
acids,
derivatives.
It
thought
understanding
will
enable
development
new
therapeutic
different
treatment
strategies.
Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(20), P. 9183 - 9183
Published: Oct. 10, 2024
Freeze
drying
(FD)
is
a
technique
used
to
preserve
the
bioactive
content
and
flavor
of
samples.
Foods
with
short
shelf
life
due
nature
have
been
preserved
via
FD
in
recent
years.
The
success
thanks
high
retention
ability
compounds
sample.
However,
cost
energy
consumption
limit
its
usage
several
fields.
Freezing,
primary
drying,
secondary
which
take
place
same
device,
are
stages
FD.
In
addition,
parameters,
including
pretreatment,
size,
temperature,
sample
species,
time,
pressure,
affect
process.
These
parameters
controlled
increase
effectiveness
on
Moreover,
has
compared
other
techniques
hot
air
microwave
vacuum
solar
determine
protective
capability.
It
also
applied
valorization
waste
products,
common
problem
worldwide.
For
valorization,
microencapsulation
powder
production
achieved
using
years,
studies
effects
use
various
materials
increased,
providing
new
aspects
for
future
science
food
industry.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(18), P. 3073 - 3073
Published: Sept. 12, 2024
Lactoferrin
is
a
multifunctional
glycoprotein
naturally
found
in
mammalian
secretions,
predominantly
colostrum
and
milk.
As
key
component
of
dairy
foods,
lactoferrin
enhances
viral
protection
boosts
human
health,
owing
to
its
fundamental
properties
including
antiviral,
anti-inflammatory,
immune-modulatory
effects.
Importantly,
the
antiviral
effect
has
been
shown
against
range
viruses
causing
serious
infections
threatening
health.
One
that
exerts
significant
effects
on
papillomavirus
(HPV),
which
most
prevalent
transmitted
infection
affecting
myriad
people
around
world.
high
potential
inhibit
HPV
via
different
mechanisms,
direct
binding
envelope
proteins
or
their
cell
receptors,
thereby
hindering
entry
immune
stimulation
by
triggering
release
some
immune-related
molecules
through
body,
such
as
lymphocytes.
Along
with
HPV,
also
can
coronaviruses
hepatitis
same
manner.
Here,
we
overview
current
knowledge
other
infections.
Cosmetics,
Journal Year:
2024,
Volume and Issue:
11(6), P. 197 - 197
Published: Nov. 20, 2024
Skin
is
a
crucial
organ
for
preserving
the
body’s
equilibrium.
Like
other
parts
of
body,
skin
also
ages
due
to
extrinsic
and
intrinsic
factors,
leading
several
signs
such
as
wrinkles,
spots,
decline
in
elasticity,
causing
range
issues
similar
those
seen
elsewhere
body.
Some
these
factors
include
ultraviolet
(UV)
radiation,
hormonal
disorders,
genetic
loss
moisture,
metabolic
exposure
chemicals,
smoking.
Colostrum,
which
initial
foremilk,
has
shown
positive
effects
on
consequences
factors.
Its
content
richer
than
mature
milk
contains
beneficial
components.
For
instance,
it
includes
hyaluronic
acid,
molecule
that
binds
water
keeps
hydrated;
lactoferrin,
with
high
antimicrobial
properties;
immunoglobulins,
are
responsible
immunity;
growth
increase
amount
collagen,
main
protein
type
skin;
and,
finally,
telomerase
enzyme,
maintains
telomere’s
length
thus,
decelerates
aging
process.
It
recently
become
apparent
using
products
natural
ingredients
essential.
Considering
its
nature,
contents,
effects,
colostrum
stands
out
an
excellent
material
cosmetic
industry,
especially
sector.
Therefore,
aim
this
review
article
demonstrate
potential
application
health
usage
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1404 - 1404
Published: Feb. 7, 2025
Lactoferrin
(LF)
is
an
80
kDa
glycoprotein
that
contains
approximately
700
amino
acids
and
a
member
of
the
transferrin
family.
The
essential
properties
LF,
including
antimicrobial,
antiviral,
anticancer,
anti-inflammatory,
antioxidant,
probiotic
effects,
have
been
studied
for
decades.
iron
chelation
activity
LF
significantly
associated
with
its
antioxidant
properties.
Owing
to
prebiotic
activity,
also
facilitates
growth
beneficial
microorganisms
iron-defense
immediate-effect
on
pathogens.
Additionally,
ability
regulate
cell
signaling
pathways
immune
responses
makes
prominent
modulatory
protein.
These
diverse
characteristics
gained
interest
in
therapeutic
potential.
Studies
suggested
could
serve
as
alternative
source
antibiotics
severe
infections
illnesses.
has
food
industry
potential
additive
fortify
products
such
yogurt,
infant
formula,
meat
derivatives
while
improving
shelf
life
foods
providing
antimicrobial
activity.
Prior
using
industry,
safety
toxicity
processing
are
necessary
be
investigated.
investigations
crucial
addressing
harm
or
side
effects
ensuring
healthy
lifestyle.
This
review
discusses
attributes
particularly
exploitation
industry.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
This
study
systematically
evaluated
the
effects
of
media
milling
on
physicochemical
properties,
bioactive
compound
content,
and
functional
applications
fresh
jujube
(Ziziphus
jujuba
Mill.)
juice.
Optimization
experiments
identified
ideal
conditions
for
nanoparticle
production,
including
5%
solid
content
a
180
min
duration,
resulting
in
significantly
reduced
particle
sizes─volume-weighted
average
diameter
(from
229.0
±
1.0
to
25.0
0.2
μm)
number-weighted
7.2
0.0
0.1
μm)─and
improved
dispersion
stability.
Media
enhanced
key
properties
such
as
zeta
potential,
viscosity,
suspension
stability,
while
also
modifying
color
pH.
The
process
notably
increased
compounds,
total
flavonoids
2.9
3.8
mg
catechin
equivalent
(CE)/g
dry
weight
(DW))
triterpenoids
15.4
1.2
28.0
4.9
oleanolic
acid
(OAE)/g
DW).
antioxidant
activity
before
after
milling,
assessed
using
2,2-diphenyl-1-picrylhydrazyl
(DPPH),
ferric
reducing
power
(FRAP),
2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic
acid)
(ABTS)
assays,
remained
comparable.
Fermentation
with
Lactiplantibacillus
plantarum
demonstrated
that
both
blended
media-milled
juice
can
serve
effective
substrates
substrate
utilization
lactic
production.
Anti-inflammatory
assays
RAW
264.7
macrophages
revealed
nitric
oxide
production
lower
levels
pro-inflammatory
cytokines
IL-1β,
showcasing
juice's
potential
modulate
inflammation.
In
dextran
sodium
sulfate
(DSS)-induced
colitis
mouse
model,
safety,
though
it
did
not
show
significant
protective
effects.
These
findings
position
promising
food
ingredient
health
promotion
disease
management.
Foods,
Journal Year:
2025,
Volume and Issue:
14(7), P. 1102 - 1102
Published: March 22, 2025
Shubat
is
a
traditional
fermented
camel
milk
drink
that
originated
in
Central
Asia,
with
especially
deep
cultural
roots
Kazakhstan.
However,
systematic
studies
on
the
microbial
ecology
and
functional
genes
of
remain
scarce.
As
distinctive
fer-mented
food,
its
diversity
properties
have
not
been
fully
ex-plored.
This
study
investigates
potential
by
using
advanced
metagenomic
techniques.
Its
community
mainly
composed
bacteria
(96.6%),
Lactobacillus,
Lactococcus,
Streptococcus
being
dominant
genera.
Functional
annotations
through
EggNOG,
KEGG,
CAZy
databases
highlighted
metabolic
versatility
Shubat's
microbiota.
Key
pathways
included
amino
acid
carbohydrate
metabolism,
vitamin
biosynthesis,
central
carbon
emphasizing
their
roles
fermentation
nutritional
enhancement.
The
identification
various
enzymes
related
to
chemical
synthesis
further
emphasizes
contribution
microbiota
unique
flavor
texture.
only
provides
an
important
basis
for
scientific
understanding
but
also
expands
application
possibilities
food
field
health
nutrition
confers
modern
value
significance
food.
integration
science
tradition
has
facilitated
development
microbiology
paved
new
global
dissemination
foods
foods.
BIO Web of Conferences,
Journal Year:
2025,
Volume and Issue:
171, P. 01007 - 01007
Published: Jan. 1, 2025
The
Black
Orchid
(
Coelogyne
pandurata
Lindl.)
is
a
species
with
promising
secondary
metabolite
content,
including
total
phenolics,
flavonoids,
and
antioxidant
capacity,
making
it
highly
valuable
for
horticultural
applications.
This
research
investigated
the
influence
of
Paclobutrazol
application
on
phenolic
flavonoid
capacity
Orchid.
study
was
conducted
using
randomized
complete
block
design
(RCBD)
treatments
at
concentrations
0,
50,
100,
150
ppm.
Each
experimental
unit
three
replicates.
data
were
analyzed
ANOVA,
followed
by
Tukey’s
HSD
test
5%
significance
level
to
compare
treatment
means.
Total
phenolic,
flavonoid,
capacities
analysed
Nano-spectrophotometer.
Results
indicated
that
ppm
significantly
increased
concentration
in
leaves,
showing
significant
difference
compared
control.
However,
no
effect
observed
content
or
activity
either
leaves
bulbs.