Nanomaterials-incorporated hydrogels for 3D bioprinting technology DOI Creative Commons
Jungbin Yoon, Hohyeon Han, Jinah Jang

et al.

Nano Convergence, Journal Year: 2023, Volume and Issue: 10(1)

Published: Nov. 15, 2023

Abstract In the field of tissue engineering and regenerative medicine, various hydrogels derived from extracellular matrix have been utilized for creating engineered tissues implantable scaffolds. While these hold immense promise in healthcare landscape, conventional bioinks based on ECM face several challenges, particularly terms lacking necessary mechanical properties required 3D bioprinting process. To address limitations, researchers are actively exploring novel nanomaterial-reinforced both functional aspects. this review, we focused discussing recent advancements fabrication monitoring systems using nanobioinks nanomaterials via technology. We highlighted synergistic benefits combining numerous into imposing geometrical effects by Furthermore, also elaborated critical issues remaining at moment, such as inhomogeneous dispersion consequent technical practical issues, complex structures with nanomaterials. Finally, plausible outlooks facilitating use biofabrication advancing function tissues.

Language: Английский

Electrospun silk fibroin/fibrin vascular scaffold with superior mechanical properties and biocompatibility for applications in tissue engineering DOI Creative Commons
Lei Yang,

Xu Wang,

Man Xiong

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 16, 2024

Abstract Electrospun scaffolds play important roles in the fields of regenerative medicine and vascular tissue engineering. The aim research described here was to develop a scaffold that mimics structural functional properties natural scaffolding. mechanical artificial represent key issue for successful transplantation small diameter engineering blood vessels. We blended silk fibroin (SF) fibrin fabricate composite using electrospinning overcome shortcomings with respect its properties. Subsequently, we then carefully investigated morphological, properties, hydrophilicity, hemocompatibility, degradation, cytocompatibility biocompatibility SF/fibrin (0:100), (15:85), (25:75), (35:65) scaffolds. Based on these vitro results, implanted (25:75) subcutaneously analyzed vivo degradation histocompatibility. fiber structure hybrid smooth uniform, diameters were relatively small. Compared scaffold, clearly displayed increased strength, but hydrophilicity weakened correspondingly. All showed excellent compatibility appropriate biodegradation rates. proliferation adhesion MSCs. results animal experiments confirmed faster than SF effectively promoted regeneration cell infiltration. all, electrospun balanced controllable biomechanical degradability, good compatibility. Thus, this proved be an ideal candidate material

Language: Английский

Citations

18
Harnessing Electrospun Nanofibers for Comprehensive Oral Disease Management: Current Trends and Future Perspectives DOI

R.S. Gupta,

Giriraj Pandey,

Ajay Kumar

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106681 - 106681

Published: Feb. 7, 2025

Language: Английский

Citations

4
Recent progress in biopolymer-based electrospun nanofibers and their potential biomedical applications: A review DOI
Dinesh K. Patel,

So-Yeon Won,

Eunseo Jung

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 293, P. 139426 - 139426

Published: Jan. 1, 2025

Language: Английский

Citations

3
Carrageenans for tissue engineering and regenerative medicine applications: A review DOI
Arman Jafari, Mojtaba Farahani, Mahsa Sedighi

et al.

Carbohydrate Polymers, Journal Year: 2021, Volume and Issue: 281, P. 119045 - 119045

Published: Dec. 30, 2021

Language: Английский

Citations

82
Functionalized Antimicrobial Nanofibers: Design Criteria and Recent Advances DOI Creative Commons

Nazirah Hamdan,

Alisa Yamin,

Shafida Abd Hamid

et al.

Journal of Functional Biomaterials, Journal Year: 2021, Volume and Issue: 12(4), P. 59 - 59

Published: Oct. 28, 2021

The rise of antibiotic resistance has become a major threat to human health and it is spreading globally. It can cause common infectious diseases be difficult treat leads higher medical costs increased mortality. Hence, multifunctional polymeric nanofibers with distinctive structures unique physiochemical properties have emerged as neo-tool target biofilm overcome deadly bacterial infections. This review emphasizes electrospun nanofibers’ design criteria that utilized enhance their therapeutic activity for antimicrobial therapy. Also, we present recent progress in designing the surface functionalization non-antibiotic agents effective antibacterial Lastly, discuss future trends remaining challenges nanofibers.

Language: Английский

Citations

65
Advances in the Preparation of Nanofiber Dressings by Electrospinning for Promoting Diabetic Wound Healing DOI Creative Commons
Yukang Liu, Chaofei Li, Zhangbin Feng

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 12(12), P. 1727 - 1727

Published: Nov. 22, 2022

Chronic diabetic wounds are one of the main complications diabetes, manifested by persistent inflammation, decreased epithelialization motility, and impaired wound healing. This will not only lead to repeated hospitalization patients, but also bear expensive costs. In severe cases, it can amputation, sepsis or death. Electrospun nanofibers membranes have characteristics high porosity, specific surface area, easy functionalization structure, so they be used as a safe effective platform in treatment great application potential. article briefly reviewed pathogenesis chronic types dressings commonly used, then development electrospinning technology recent years advantages electrospun wounds. Finally, reports different nanofiber on summarized, method using multi-drug combination therapy is emphasized, which provides new ideas for

Language: Английский

Citations

65
Polymeric Nanofibers for Drug Delivery Applications: A Recent Review DOI Creative Commons

Xiaoge Duan,

Hailan Chen, Chunxian Guo

et al.

Journal of Materials Science Materials in Medicine, Journal Year: 2022, Volume and Issue: 33(12)

Published: Dec. 3, 2022

With the rapid development of biomaterials and biotechnologies, various functional materials-based drug delivery systems (DDS) are developed to overcome limitations traditional release formulations, such as uncontrollable concentration in target organs/tissues unavoidable adverse reactions. Polymer nanofibers exhibit promising characteristics including easy preparation, adjustable features wettability elasticity, tailored surface interface properties, surface-to-volume ratio, used develop new DDS. Different kinds drugs can be incorporated into polymer nanofibers. Additionally, their kinetics modulated via preparation components, component proportions, processes, enabling applications several fields. A timely comprehensive summary polymeric for DDS is thus highly needed. This review first describes common methods nanofiber fabrication, followed by introducing controlled techniques loading from Thus, were summarized, particularly focusing on relation between physiochemical properties performance. It ended listing future perspectives. Graphical abstract.

Language: Английский

Citations

57
Natural Polymer‐Derived Bioscaffolds for Peripheral Nerve Regeneration DOI
Hui Zhang, Jiahui Guo, Yu Wang

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(41)

Published: Aug. 5, 2022

Abstract In recent decades, artificial nerve scaffolds have become a promising substitute for peripheral repair. Considerable efforts been devoted to improving the therapeutic effectiveness of scaffolds. Among numerous biomaterials tissue engineering fabrication, natural polymers are considered as tremendous candidates because their excellent biocompatibility, low toxicity, high cell affinity, wide source, and environmental protection. With development technology, variety polymer‐derived emerged, which endowed with biological properties appropriate physicochemical performances gradually adapt needs regeneration. Significantly, intergradation exogenous biomolecules onto is able avoid stability, rapid degradation, redistribution direct drugs in vivo, thereby enhancing regeneration functional reconstruction. Here, derived from polymers, applications continuous administration comprehensively carefully reviewed, providing an advanced perspective field.

Language: Английский

Citations

56
Synergistic Effect of Co-Delivering Ciprofloxacin and Tetracycline Hydrochloride for Promoted Wound Healing by Utilizing Coaxial PCL/Gelatin Nanofiber Membrane DOI Open Access

Mengxia Lin,

Yuan Liu, Junwei Gao

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1895 - 1895

Published: Feb. 8, 2022

Combining multiple drugs or biologically active substances for wound healing could not only resist the formation of multidrug resistant pathogens, but also achieve better therapeutic effects. Herein, hydrophobic fluoroquinolone antibiotic ciprofloxacin (CIP) and hydrophilic broad-spectrum tetracycline hydrochloride (TH) were introduced into coaxial polycaprolactone/gelatin (PCL/GEL) nanofiber mat with CIP loaded PCL (core layer) TH GEL (shell layer), developing antibacterial dressing co-delivering two antibiotics (PCL-CIP/GEL-TH). The nanostructure, physical properties, drug release, property, in vitro cytotoxicity investigated accordingly. results revealed that shows a long-lasting release five days, reaching releasing rate 80.71%, while cumulative reached 83.51% rapid behavior 12 h. activity demonstrated mesh possesses strong against E. coli S. aureus. In addition, mats showed superior biocompatibility toward human skin fibroblast cells (hSFCs). This study indicates developed PCL-CIP/GEL-TH membranes hold enormous potential as materials.

Language: Английский

Citations

53
Mimicking the Natural Basement Membrane for Advanced Tissue Engineering DOI Creative Commons

Puja Jain,

Sebastian Rauer,

Martin Möller

et al.

Biomacromolecules, Journal Year: 2022, Volume and Issue: 23(8), P. 3081 - 3103

Published: July 15, 2022

Advancements in the field of tissue engineering have led to elucidation physical and chemical characteristics physiological basement membranes (BM) as specialized forms extracellular matrix. Efforts recapitulate intricate structure biological composition BM encountered various advancements due its impact on cell fate, function, regulation. More attention has been paid synthesizing biocompatible biofunctional fibrillar scaffolds that closely mimic natural BM. Specific modifications biomimetic paved way for development vitro models like alveolar-capillary barrier, airway models, skin, blood-brain kidney metastatic which can be used personalized drug screening, understanding pathological pathways, implants. In this Review, we focus structure, composition, functions vivo ongoing efforts it synthetically. Light shed advantages limitations including porous polymeric membranes, hydrogels, electrospun This Review further elaborates justifies significance mimics engineering, particular organ model systems.

Language: Английский

Citations

50