Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1346, P. 343767 - 343767
Published: Feb. 3, 2025
Language: Английский
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(30)
Published: Feb. 5, 2023
Therapeutic DNAzymes have unceasingly intrigued the scientific community owing to their prosperous gene regulation capability. The efficacy of against many types diseases has been extensively studied for over two decades. However, high expectations are still not translated clinic because low effectiveness in vivo. Over last five years, several aspects considered optimize DNAzyme-integrated therapeutics, including structural stability, mechanism exploration, cell internalization rate, cofactor activation, and off-target effects. Hence, this review first discusses early monotherapy design DNAzymes. Subsequently, latest modes action reviewed, followed by an elaboration on stabilization strategies considering catalytic core substrate-binding arms. DNAzyme-based synergistic therapy is then examined, highlighting responsive carrier construction, effects, discovered advanced functions, concerns. Beyond this, key clinical advances elucidated showcasing progress. Finally, future trends development challenges DNAzyme-powered therapeutics coming years discussed detail.
Language: Английский
Citations
63
Advanced Industrial and Engineering Polymer Research, Journal Year: 2024, Volume and Issue: unknown
Published: May 1, 2024
Bio-based polymers have garnered significant interest across the manufacturing industry, global economy, and various engineering disciplines such as packaging, tissue engineering, controlled drug delivery, wound dressing, textiles. In current era, bio-based polymers, notably polysaccharides, offer a promising platform for constructing intricate versatile structures in biomedical sector. These encompass applications regenerative medicine (TERM), delivery devices, coatings wearable sensors, thanks to their distinctive features inherent biocompatibility, flexibility, stretchability, mechanical strength, renewability, physiological activity, favorable biological environment. this review, we concise overview of diverse types polysaccharide-based composites, properties, interactions with specific cells tissues. The review encompasses recent progress scaffolds designed cartilage, skin, neural, vascular, cardiac, bone regeneration, employing both conventional modern techniques. Additionally, it delves into development other biodegradable including systems (DDSs), antibacterial on medical electronic devices healthcare Furthermore, also elucidates research directions future perspectives while emphasizing importance regulatory approvals commitment environmental sustainability. This well-organized critical is expected assist practitioners researchers gaining deeper understanding trends, challenges, potential solutions, thereby harnessing immense biomaterials system. utilization polysaccharides sector aligns principles nature, contributing reduction carbon dioxide emissions supporting Sustainable Development Goals United Nations.
Language: Английский
Citations
17
Small Structures, Journal Year: 2023, Volume and Issue: 4(9)
Published: March 29, 2023
Peripheral nerve injuries are challenging to repair clinically due their limited regenerative capacity. Herein, a novel poly(3,4‐ethylenedioxythiophene):poly(4‐styrene sulfonate) (PEDOT:PSS) composited conductive silk conduit with ultrasound (US)‐triggered active release for peripheral regeneration is presented. The composed of fibroin inverse opal tubular scaffolds and the secondary hydrogel filler that contains thermosensitive material (poly( N ‐isopropylacrylamide), PNIPAM), PEDOT:PSS, growth factor (NGF). Benefiting from integration these functional materials factors, conduits show excellent biocompatibility, flexibility, conductivity, bioactivity. In particular, owing thermal effect US temperature responsiveness PNIPAM, filling undergoes volume shrinkage upon triggering, allowing responsive NGF release. Besides, electrical conductivity PEDOT:PSS has been affirmed promote neuron axon outgrowth. Through in vivo experiments, synergistic US‐triggered delivery on accelerating injured demonstrated. These results reveal practical value proposed intelligent preclinical studies.
Language: Английский
Citations
26
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116024 - 116024
Published: Dec. 19, 2023
Bioactive macromolecular drugs known as Growth Factors (GFs), approved by the Food and Drug Administration (FDA), have found successful application in clinical practice. They hold significant promise for addressing peripheral nerve injuries (PNIs). Peripheral guidance conduits (NGCs) loaded with GFs, context of tissue engineering, can ensure sustained efficient release these bioactive compounds. This, turn, maintains a stable, long-term, effective GF concentration essential treating damaged nerves. regeneration is complex process that entails secretion various GFs. Following PNI, GFs play pivotal role promoting cell growth survival, axon myelin sheath regeneration, differentiation, angiogenesis. also regulate regenerative microenvironment, stimulate plasticity changes post-nerve injury, and, consequently, expedite structure function repair. Both exogenous endogenous including NGF, BDNF, NT-3, GDNF, IGF-1, bFGF, VEGF, been successfully onto NGCs using techniques like physical adsorption, blend doping, chemical covalent binding, engineered transfection. These approaches effectively promoted repair Numerous studies demonstrated similar functional therapeutic outcomes compared to autologous transplantation. This evidence underscores substantial potential domain In this article, we provide an overview drug delivery systems utilizing NGCs. Looking ahead, commercial materials facilitate nerves maintain functionality distant target organs through
Language: Английский
Citations
23
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129557 - 129557
Published: Jan. 17, 2024
Language: Английский
Citations
11
Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: 6(3), P. 713 - 726
Published: Jan. 29, 2024
Language: Английский
Citations
11
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 20, 2024
Several studies suggest that topographical patterns influence nerve cell fate. Efforts have been made to improve functionality through this approach, focusing on therapeutic strategies enhance function and support structures. However, inadequate orientation can impede long-term efficiency, affecting tissue repair. Therefore, enhancing neurites/axons directional growth is crucial for better outcomes, reducing coiling, ensuring accurate fiber connections. Conflicting results exist regarding the effects of micro- or nano-patterns migration, growth, immunogenic response, angiogenesis, complicating their clinical use. Nevertheless, advances in lithography, electrospinning, casting, molding techniques intentionally control fate neuronal cells are being explored rapidly sustainably efficiency. It appears be accomplished by combining with nanomaterials, biological gradients, electrical stimulation. Despite promising unclear mechanism action, presence cones various directions, restriction outcomes morphological functional markers presented challenges utilizing method. This review seeks clarify how affect morphology function, highlighting potential benefits orientation, especially combined approaches.
Language: Английский
Citations
11
Advanced Science, Journal Year: 2023, Volume and Issue: 10(20)
Published: April 29, 2023
Fibrous scaffolds have shown their advantages in tissue engineering, such as peripheral nerve regeneration, while most of the existing fiber-shaped are with simple structures, and vitro performance for regeneration lacks systematic analysis. Here, novel nerve-on-a-chip derived biomimicking microfibers presented. The controllable core-shell structures functionalities generated through capillary microfluidic devices. By integrating these into a multitrack-architectured chip, coculturing them cells well gradient bioactive elements, capabilities systematically assessing performances fiber formation hollow at level is constructed. Based on rat sciatic injury model, rapid promotion ability demonstrated optimized function recovery vivo, which implies credibility evaluation regeneration. Thus, it convinced that organ-on-a-chip will undoubtedly open up new chapter evaluating biological vivo engineering.
Language: Английский
Citations
21
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 640 - 640
Published: Feb. 14, 2023
When a traumatic event causes complete denervation, muscle functional recovery is highly compromised. A possible solution to this issue the implantation of biodegradable polymeric tubular scaffold, providing biomimetic environment support nerve regeneration process. However, in case consistent peripheral damage, capabilities are poor. Hence, crucial challenge field development micro- nanostructured carriers for controlled and sustained release molecules enhance regeneration. The aim these systems favor cellular processes that increase outcome. Drug delivery (DDSs) interesting solutions framework, due possibility specifically targeting active principle within site interest, maximizing its therapeutical efficacy. scope review highlight recent advances regarding study DDS discuss their potential regenerative performance those clinical scenarios characterized by severe damage.
Language: Английский
Citations
17
Bioactive Materials, Journal Year: 2024, Volume and Issue: 40, P. 503 - 523
Published: June 29, 2024
Language: Английский
Citations
8