Journal of Nanoparticle Research, Journal Year: 2022, Volume and Issue: 24(11)
Published: Nov. 1, 2022
Language: Английский
Expert Opinion on Drug Delivery, Journal Year: 2023, Volume and Issue: 20(7), P. 937 - 954
Published: June 9, 2023
During the last decades, ever-increasing proportion of patients with cancer has been led to serious concerns worldwide. Therefore, development and use novel pharmaceuticals, like nanoparticles (NPs)-based drug delivery systems (DDSs), can be potentially effective in therapy.Poly lactic-co-glycolic acid (PLGA) NPs, as a kind bioavailable, biocompatible, biodegradable polymers, have approved by Food Drug Administration (FDA) for some biomedical pharmaceutical applications. PLGA is comprised lactic (LA) glycolic (GA) their ratio could controlled during various syntheses preparation approaches. LA/GA determines stability degradation time PLGA; lower content GA results fast degradation. There are several approaches preparing NPs that affect aspects, such size, solubility, stability, loading, pharmacokinetics, pharmacodynamics, so on.These indicated sustained release site passive active (via surface modification) DDSs. This review aims provide an overview approach physicochemical mechanism cellular fate, DDSs efficient therapy, status industry nanomedicine.
Language: Английский
Citations
57
Materials Today Bio, Journal Year: 2023, Volume and Issue: 21, P. 100729 - 100729
Published: July 11, 2023
Infectious disease is one of the top 10 causes death worldwide, especially in low-income countries. The extensive use antibiotics has led to an increase antibiotic resistance, which poses a critical threat human health globally. Natural products such as polyphenolic compounds and their derivatives have been shown positive therapeutic effects antibacterial therapy. However, inherent physicochemical properties limit pharmaceutical effects, short half-lives, chemical instability, low bioavailability, poor water solubility. Nanoformulations promising advantages improving activity by controlling release drugs enhancing bioavailability polyphenols. In this review, we listed classification mechanisms compounds. More importantly, nanoformulations for delivery polyphenols agent were summarized, including different types nanoparticles (NPs) polymer-based NPs, metal-based lipid-based nanoscaffolds nanogels, nanofibers, nanoemulsions. At same time, also presented potential biological applications nano-system enhance ability polyphenols, aiming provide new perspective antibiotic-free treatment infectious diseases.
Language: Английский
Citations
49
Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 39, P. 102178 - 102178
Published: July 1, 2024
Inflammatory arthritis is a growing worldwide concern, afflicting millions of individuals and leading to depreciating quality life, significant morbidity, subsequent healthcare burden. Conventional therapies for inflammatory often hold limitations, including systemic cross-reactivities, side effects, inadequate management inflammation. Therefore, "Smart" stimuli-responsive biomaterials are materialized as promising theranostic approaches management. These designed specific external internal stimulation, enabling the sustained release bioactive therapeutic agents during local or administration. Stimuli-responsive allow precise spatiotemporal control over drug release, minimizing exposure, reducing off-target real-time monitoring pathological conditions, driving potential breakthrough in managing arthritis. Owing this prominence, review article expounds on emerging prospects targeting molecular signatures associated with intricately elicit minimal no contradictory effects. In addition, application these disease progression multi-stimuli-responsive comprehended show progress diagnosis treatment. This "single-platted" comprehensive acquaintance clinical-based outcomes navigates microenvironment, proposing an optimistic avenue personalized effective minimized
Language: Английский
Citations
17
Cleaner Materials, Journal Year: 2022, Volume and Issue: 5, P. 100102 - 100102
Published: June 14, 2022
Language: Английский
Citations
52
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4333 - 4333
Published: Feb. 22, 2023
Respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are critical areas of medical research, millions people affected worldwide. In fact, more than 9 million deaths worldwide were associated with respiratory diseases in 2016, equivalent to 15% global deaths, the prevalence is increasing every year population ages. Due inadequate treatment options, treatments for many limited relieving symptoms rather curing disease. Therefore, new therapeutic strategies urgently needed. Poly (lactic-co-glycolic acid) micro/nanoparticles (PLGA M/NPs) have good biocompatibility, biodegradability unique physical chemical properties, making them one most popular effective drug delivery polymers. this review, we summarized synthesis modification methods PLGA M/NPs their applications (asthma, COPD, cystic fibrosis (CF), etc.) also discussed research progress current status diseases. It was concluded that promising vehicles due advantages low toxicity, high bioavailability, loading capacity, plasticity modifiability. And at end, presented an outlook on future directions, aiming provide some ideas directions hopefully promote widespread application clinical treatment.
Language: Английский
Citations
40
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3375 - 3375
Published: Feb. 8, 2023
Gene therapy has attracted much attention because of its unique mechanism action, non-toxicity, and good tolerance, which can kill cancer cells without damaging healthy tissues. siRNA-based gene downregulate, enhance, or correct expression by introducing some nucleic acid into patient Routine treatment hemophilia requires frequent intravenous injections missing clotting protein. The high cost combined causes most patients to lack the best resources. siRNA potential lasting even curing diseases. Compared with traditional surgery chemotherapy, fewer side effects less damage normal cells. available therapies for degenerative diseases only alleviate symptoms patients, while drugs upregulate expression, modify epigenetic changes, stop disease. In addition, also plays an important role in cardiovascular diseases, gastrointestinal hepatitis B. However, free is easily degraded nuclease a short half-life blood. Research found that be delivered specific through appropriate vector selection design improve therapeutic effect. application viral vectors limited their immunogenicity low capacity, non-viral are widely used immunogenicity, production cost, safety. This paper reviews common recent years introduces advantages disadvantages, as well latest examples.
Language: Английский
Citations
30
Biomedicines, Journal Year: 2023, Volume and Issue: 11(4), P. 1124 - 1124
Published: April 7, 2023
Nano-engineered medical products first appeared in the last decade. The current research this area focuses on developing safe drugs with minimal adverse effects associated pharmacologically active cargo. Transdermal drug delivery, an alternative to oral administration, offers patient convenience, avoids first-pass hepatic metabolism, provides local targeting, and reduces effective toxicities. Nanomaterials provide alternatives conventional transdermal delivery including patches, gels, sprays, lotions, but it is crucial understand transport mechanisms involved. This article reviews recent trends emphasizes nano-formulations currently vogue.
Language: Английский
Citations
30
Gels, Journal Year: 2024, Volume and Issue: 10(8), P. 497 - 497
Published: July 26, 2024
Poly(lactic-co-glycolic acid) (PLGA) hydrogels are highly utilized in biomedical research due to their biocompatibility, biodegradability, and other versatile properties. This review comprehensively explores synthesis, properties, sustained release mechanisms, applications drug delivery. The introduction underscores the significance of PLGA addressing challenges like short half-lives systemic toxicity conventional formulations. Synthesis methods, including emulsion solvent evaporation, casting, electrospinning, thermal gelation, photopolymerization, described detail role tailoring hydrogel properties for specific is highlighted. Sustained mechanisms—such as diffusion-controlled, degradation-controlled, swelling-controlled, combined systems—are analyzed alongside key kinetic models (zero-order, first-order, Higuchi, Peppas models) designing controlled delivery systems. Applications discussed, highlighting effectiveness localized chemotherapy cancer, well antibiotics antimicrobials combat infections. Challenges future prospects with a focus on improving loading efficiency, control promoting clinical translation. In summary, provide promising platform therapeutic agents meet diverse requirements. Future advancements materials science engineering anticipated further optimize efficacy applicability settings. consolidates current understanding outlines directions hydrogels, emphasizing potential revolutionize improve patient outcomes.
Language: Английский
Citations
13
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105564 - 105564
Published: March 12, 2024
The nasal route has routinely been used in the local delivery of drugs, however with innovations nanotechnology, there increased interest exploring this more for systemic, and brain/CNS delivery. This is because safe, non-invasive, medications can be self-administered to achieve rapid therapeutic drug levels minimal doses. Polymeric nanoparticles (NPs) such as PLGA NPs have a wide range applications delivery, due their large surface area modification targeting ligands polymers which enhances cellular uptake, bioavailability at target sites. review covers recent research on use small molecule drugs macromolecules via route. It some background information about challenges delivering most common polymer coatings are highlighted. Finally, patents clinical trials also covered.
Language: Английский
Citations
11
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 273 - 273
Published: Feb. 15, 2024
Recently, nanotechnologies have become increasingly prominent in the field of bone tissue engineering (BTE), offering substantial potential to advance forward. These advancements manifest two primary ways: localized application nanoengineered materials enhance regeneration and their use as nanovehicles for delivering bioactive compounds. Despite significant progress development substitutes over past few decades, it is worth noting that quest identify optimal biomaterial remains a subject intense debate. Ever since its initial discovery, poly(lactic-co-glycolic acid) (PLGA) has found widespread BTE due favorable biocompatibility customizable biodegradability. This review provides an overview contemporary using PLGA polymers. The covers some properties PLGA, with special focus on modifications these towards regeneration. Furthermore, we delve into techniques synthesizing nanoparticles (NPs), diverse forms which NPs can be fabricated, molecules exhibit therapeutic promoting Additionally, addressed current concerns regarding safety PLGA-based products available market. Finally, briefly discussed challenges proposed strategies functionally fabrication BTE. We envisage utilization NP holds potent tool advancing therapies intractable diseases.
Language: Английский
Citations
8