Advances in polysaccharide‐based materials for biomedical and pharmaceutical applications: A comprehensive review DOI
Jiahao Li,

Hanan Hassan Ahmed,

Ali M. Hussein

et al.

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Polysaccharides, the most abundant biopolymers in nature, have attracted attention of researchers and clinicians due to its practicality biomedical pharmaceutical sciences. These biomaterials high bioavailability play structural functional roles living organisms. Polysaccharides are classified into several groups based on their origin, including plant polysaccharides marine (like chitosan, hyaluronic acid, dextran, alginates, etc.) with specific applications. possess unique physicochemical (such as surface groups, solubility, stability), mechanical strength tensile), antioxidant activity, biocompatibility, biodegradability, renewability, non-immunogenicity) characteristics which made them excellent platforms for a wide variety Ease extraction different preparation approaches mentioned other potential properties that further improved They drug/bioactive encapsulation capacity sustained/controlled release manner vivo microenvironments. The anti-inflammatory immunomodulation, stimuli-responsive release, passive active delivery considered features these indicated practical applications sciences, biosensors, tissue engineering, implantation, wound healing, vascular grafting, vaccines. This review highlights advances polysaccharide-based materials

Language: Английский

Chitosan-based nanofibrous scaffolds for biomedical and pharmaceutical applications: A comprehensive review DOI
Yasir Q. Аlmajidi, Sivasankaran Ponnusankar, MVNL Chaitanya

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130683 - 130683

Published: March 6, 2024

Language: Английский

Citations

31
Advances in chitosan-based blends as potential drug delivery systems: A review DOI
Mohamed J. Saadh, Chou‐Yi Hsu, Mohammed Ahmed Mustafa

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132916 - 132916

Published: June 5, 2024

Language: Английский

Citations

19
Advances in chitosan-based hydrogels for pharmaceutical and biomedical applications: A comprehensive review DOI
Yasir Qasim Almajidi, Jitendra Gupta,

Fatime Satar Sheri

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127278 - 127278

Published: Oct. 6, 2023

Language: Английский

Citations

34
Lactylation‐Driven HECTD2 Limits the Response of Hepatocellular Carcinoma to Lenvatinib DOI Creative Commons
Runyu Dong, Yao Fei,

Yi‐Ren He

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract Drug resistance remains a major hurdle for the therapeutic efficacy of lenvatinib in hepatocellular carcinoma (HCC). However, underlying mechanisms remain largely undetermined. Unbiased proteomic screening is performed to identify potential regulators HCC. Patient‐derived organoids, patient‐derived xenograft mouse models, and DEN/CCl 4 induced HCC models are constructed evaluate effects HECTD2 both vitro vivo. found be highly expressed lenvatinib‐resistant cell lines, patient tissues, organoids xenografts. In vivo experiments demonstrated that overexpression limits response treatment. Mechanistically, functions as an E3 ubiquitin ligase KEAP1, which contributes degradation KEAP1 protein. Subsequently, KEAP1/NRF2 signaling pathway initiates antioxidative cells. Lactylation histone 3 on lysine residue 18 facilitates transcription HECTD2. Notably, PLGA‐PEG nanoparticle‐based drug delivery system synthesized, effectively targeting The NPs achieved tumor‐targeting, controlled‐release, biocompatibility, making them promising strategy mitigating resistance. This study identifies nanotherapeutic target overcoming resistance, providing theoretical basis translational application

Language: Английский

Citations

1
Application of PLGA in Tumor Immunotherapy DOI Open Access

Jiashuai Wu,

Xiaopeng Wang,

Yunduan Wang

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(9), P. 1253 - 1253

Published: April 30, 2024

Biodegradable polymers have been extensively researched in the field of biomedicine. Polylactic-co-glycolic acid (PLGA), a biodegradable polymer material, has widely used drug delivery systems and shown great potential various medical fields, including vaccines, tissue engineering such as bone regeneration wound healing, 3D printing. Cancer, group diseases with high mortality rates worldwide, recently garnered significant attention immune therapy research. In recent years, there growing interest function PLGA tumor immunotherapy. immunotherapy, can serve carrier to load antigens on its surface, thereby enhancing system’s ability attack cells. Additionally, be formulate vaccines immunoadjuvants, efficacy nanoparticles (NPs) also enhance effectiveness immunotherapy by regulating activity differentiation cells, improving expression presentation antigens. Furthermore, due diverse physical properties surface modifications PLGA, it wider range applications through loading types drugs or other innovative substances. We aim highlight advances challenges plga oncology stimulate further research development PLGA-based approaches, more effective personalized cancer therapies.

Language: Английский

Citations

7
Recent advances on chitosan/hyaluronic acid-based stimuli-responsive hydrogels and composites for cancer treatment: A comprehensive review DOI

Fahad Alsaikhan,

Bagher Farhood

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135893 - 135893

Published: Sept. 1, 2024

Language: Английский

Citations

7
Recent advances in polysaccharide-based drug delivery systems for cancer therapy: a comprehensive review DOI Creative Commons
Chou‐Yi Hsu, Omer Qutaiba B. Allela,

Ali M. Hussein

et al.

Artificial Cells Nanomedicine and Biotechnology, Journal Year: 2024, Volume and Issue: 52(1), P. 564 - 586

Published: Dec. 5, 2024

Cancer has a high rate of incidence and mortality throughout the world. Although several conventional approaches have been developed for treatment cancer, such as surgery, chemotherapy, radiotherapy thermal therapy, they remarkable disadvantages which result in inefficient cancer. For example, immunogenicity, prolonged treatment, non-specificity, metastasis cost are considered major drawbacks chemotherapy. Therefore, there is fundamental requirement development breakthrough technologies cancer suppression. Polysaccharide-based drug delivery systems (DDSs) most reliable carriers therapy. Polysaccharides, kind practical biomaterials, divided into types, including chitosan, alginates, dextran, hyaluronic acid, cyclodextrin, pectin, etc. Polysaccharides extracted from different natural resources (like herbal, marine, microorganisms, etc.). The potential features polysaccharides made them candidates therapeutics to sites; simple purification, ease modification functionalization, hydrophilicity, serum stability, appropriate loading capacity, biocompatibility, bioavailability, biodegradability stimuli-responsive sustained release manner considerable aspects these biopolymers. This review highlights applications polysaccharides-based DDSs pharmaceutical science

Language: Английский

Citations

7
Co-delivery of berberine and gold nanoparticles on liposomes for photodynamic therapy against 3D lung cancer cells DOI Creative Commons
Kave Moloudi, Heidi Abrahamse, Blassan P. George

et al.

Materials Advances, Journal Year: 2024, Volume and Issue: 5(15), P. 6185 - 6195

Published: Jan. 1, 2024

Using a new nanocomplex (Lipo@AuNPs@BBR) in photodynamic therapy on A549 spheroid cells.

Language: Английский

Citations

6
Advances in the polymeric nanoparticulate delivery systems for RNA therapeutics DOI

Sristi,

Waleed Hassan Almalki, Ritu Karwasra

et al.

Progress in molecular biology and translational science, Journal Year: 2024, Volume and Issue: unknown, P. 219 - 248

Published: Jan. 1, 2024

Language: Английский

Citations

4
The In Vivo Biological Fate of Protein Corona: A Comparative PET Study of the Fate of Soft and Hard Protein Corona in Healthy Animal Models DOI

Angel Martinez Villacorta,

Angelika Mielcarek, María Gómez Martínez

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: April 2, 2024

Abstract Radiolabeling and nuclear imaging techniques are used to investigate the biodistribution patterns of soft hard protein corona around poly (lactic‐co‐glycolic acid) nanoparticles (PLGA NPs) after administration healthy mice. Soft coronas 131 I‐labeled BSA or serum formed on PLGA NPs functionalized with either polyehtylenimine (PEI) bovine albumin (BSA). The exchangeability is assessed in vitro by gamma counting exposing non‐labeled BSA, serum, simulated body fluid. PEI form larger more stable than NPs. exchangeable ones. vivo fate coated preformed 18 F‐labeled positron emission tomography (PET) following intravenous administration. While shows a similar free F high activity blood kidney, follows characteristic nanoparticles, accumulating lungs, liver, spleen. These results show that fates different, easily exchanged proteins from body, while largely retained nanoparticle surface.

Language: Английский

Citations

4